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    • 14. 发明授权
    • Hydrothermal growth of heterogeneous single crystals for solid state laser applications
    • 用于固态激光应用的异相单晶的水热生长
    • US09014228B1
    • 2015-04-21
    • US12832119
    • 2010-07-08
    • Joseph W. KolisColin D. McMillenJ. Matthew MannJohn M. Ballato
    • Joseph W. KolisColin D. McMillenJ. Matthew MannJohn M. Ballato
    • H01S3/16
    • H01S3/1611C30B7/10C30B29/16C30B29/28C30B29/30
    • Disclosed are heterogeneous crystals for use in a laser cavity and methods of forming the crystals. A crystal can be a monolithic crystal containing regions that are based upon the same host material but differ from one another according to some material feature such that they can perform various functions related to lasing. Disclosed methods include hydrothermal growth techniques for the growth of differing epitaxial layers on a host. A host material can be doped in one region with a suitable active lasing ion and can be formed with another region that is undoped and can act as an endcap, a waveguide cladding layer, or a substrate to provide strength and/or contact to a heat sink. Regions can be formed with controlled thickness in conjunction. Following formation, a heterogeneous crystal can be cut, polished and coated with mirror films at each end for use in a laser cavity.
    • 公开了用于激光腔的异质晶体和形成晶体的方法。 晶体可以是包含基于相同主体材料但根据某些材料特征彼此不同的区域的单晶晶体,使得它们可以执行与激光相关的各种功能。 公开的方法包括用于在主机上生长不同外延层的水热生长技术。 主体材料可以在具有合适的有源激光离子的一个区域中掺杂,并且可以与未掺杂的另一区域形成并且可以用作端盖,波导包层或基板以提供强度和/或接触热量 水槽。 区域可以形成为具有受控厚度的结合。 形成后,可以在各个端部切割,抛光和涂覆镜面膜,以用于激光腔。
    • 15. 发明授权
    • Elastin stabilization of connective tissue
    • 结缔组织弹性蛋白稳定
    • US08100961B2
    • 2012-01-24
    • US12748849
    • 2010-03-29
    • Narendra R. VyavahareJason C. IsenburgDan T. Simionescu
    • Narendra R. VyavahareJason C. IsenburgDan T. Simionescu
    • A61F2/82C07H15/203A61M29/00
    • A61K31/7024
    • A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents employ certain unique properties of phenolic compounds to develop a protocol for reducing elastin degradation, such as that occurring during aneurysm formation in vasculature. According to the invention, elastin can be stabilized in vivo and destruction of connective tissue, such as that leading to life-threatening aneurysms in vasculature, can be tempered or halted all together. The treatment agents can be delivered or administered acutely or chronically according to various delivery methods, including sustained release methods incorporating perivascular or endovascular patches, use of microsphere carriers, hydrogels, or osmotic pumps.
    • 提供了一种方法和产品,用于治疗由于组织结构破坏而变弱的结缔组织,特别是由于弹性蛋白降解。 处理剂使用酚类化合物的某些独特性质来开发用于减少弹性蛋白降解的方案,例如在脉管系统中的动脉瘤形成期间发生的方案。 根据本发明,弹性蛋白可以在体内稳定,并且结缔组织的破坏,例如导致脉管系统中危及生命的动脉瘤的结缔组织可以一起被调节或停止。 根据各种递送方法,包括血管周围或血管内贴片的缓释方法,微球载体,水凝胶或渗透泵的使用,治疗剂可以急性或慢性递送或施用。
    • 16. 发明授权
    • Macromonomer for preparation of a degradable hydrogel
    • 用于制备可降解水凝胶的大分子单体
    • US07754241B1
    • 2010-07-13
    • US11271405
    • 2005-11-10
    • Charles K. WebbNaren R. Vyavahare
    • Charles K. WebbNaren R. Vyavahare
    • A61K9/14A61K9/00C12N11/08C12N11/04C07K17/04C07K17/08
    • C12N5/0068A61K47/60A61L27/18A61L27/52A61L27/58Y10S530/815Y10S530/817C08L71/02
    • A degradable hydrogel and a method of making a degradable hydrogel is disclosed herein. The method comprises obtaining a hydrophilic polymer having at least two hydroxyl groups, reacting the hydrophilic polymer with a di-functional monomer comprised of an acid halide group and an alkyl halide group to form an intermediate having an ester bond and a terminal alkyl halide group, reacting the terminal alkyl halide group of the intermediate with a metallic salt of a vinyl acid monomer to form a macromonomer comprised of an ester, an alkyl group spacer, and a terminal vinyl group, and polymerizing the macromonomer to form a degradable hydrogel. A method is also disclosed for varying the degradation rate of the hydrogel as a function of the chemical composition of the alkyl group spacer in the terminal linkage of the macromonomer.
    • 本文公开了可降解水凝胶和制备可降解水凝胶的方法。 该方法包括获得具有至少两个羟基的亲水性聚合物,使亲水性聚合物与由酰卤基团和烷基卤基团组成的二官能单体反应形成具有酯键和末端烷基卤基团的中间体, 使中间体的末端烷基卤化物基团与乙烯基酸单体的金属盐反应形成由酯,烷基间隔基和末端乙烯基组成的大分子单体,并聚合大分子单体以形成可降解的水凝胶。 还公开了改变水凝胶的降解速率的方法,其作为大分子单体的末端键中的烷基间隔基的化学组成的函数。