专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20120238745A1 Fluorescent dyes 审中-公开
标题翻译：荧光染料
公开(公告)号：US20120238745A1
公开(公告)日：2012-09-20
申请号：US13374729
申请日：2012-01-09
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C07D487/14 , C07D513/14 , C07D498/14
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

12. 发明授权

US08257926B2 Methods for detecting nucleic acid hybridization 有权
标题翻译：核酸杂交检测方法
公开(公告)号：US08257926B2
公开(公告)日：2012-09-04
申请号：US13136137
申请日：2011-07-25
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C12Q1/68 , G01N33/53 , C07D225/00 , C07D209/56
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

13. 发明授权

US07989638B2 Conjugates of biological substances 有权
标题翻译：生物物质结合物
公开(公告)号：US07989638B2
公开(公告)日：2011-08-02
申请号：US12804065
申请日：2010-07-12
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C07D209/02 , C07D209/04 , C07D209/56 , C12Q1/68
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

14. 发明申请

US20110027900A1 Thiol quantitation assays and related methods 有权
标题翻译：硫醇定量测定及相关方法
公开(公告)号：US20110027900A1
公开(公告)日：2011-02-03
申请号：US12804739
申请日：2010-07-28
申请人： Jianjun He , Anita Hong , Qingzheng Wang , Raman Khosrow Afshar , Ming Zhu , Vera Rakhmanova
发明人： Jianjun He , Anita Hong , Qingzheng Wang , Raman Khosrow Afshar , Ming Zhu , Vera Rakhmanova
IPC分类号： G01N33/00 , C09B29/36
CPC分类号： C09B7/00 , Y10T436/18 , Y10T436/182
摘要： The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.
摘要翻译：本发明一般涉及硫醇定量测定，进行测定的方法和用于测定中的化合物。更具体地涉及包括一种或多种二硫化物和相关分子和方法的测定。二硫化物含有FRET对。

15. 发明申请

US20130210113A1 SMALL MOLECULE DYE CONJUGATES 审中-公开
标题翻译：小分子染色体
公开(公告)号：US20130210113A1
公开(公告)日：2013-08-15
申请号：US13694635
申请日：2012-12-18
申请人： AnaSpec Incorporated
发明人： Jhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C07D487/14
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

16. 发明授权

US08258292B2 Methods of making dyes 有权
标题翻译：染色方法
公开(公告)号：US08258292B2
公开(公告)日：2012-09-04
申请号：US12287074
申请日：2008-10-06
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C07D487/14
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

17. 发明申请

US20120123109A1 Luminescence quenching compounds 有权
标题翻译：发光淬灭化合物
公开(公告)号：US20120123109A1
公开(公告)日：2012-05-17
申请号：US13374728
申请日：2012-01-09
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang
IPC分类号： C07H21/00 , C07D409/14
CPC分类号： C07D409/14 , C07D209/60 , C07D403/14 , C07D409/04 , C07D409/06 , C07D417/14 , C07D471/04 , C07H21/04 , C07J43/00 , G01N33/542 , G01N33/582
摘要： The quenching compounds of the invention are weakly luminescent cyanines that are substituted by one or more heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable luminescence and efficiently quench a broad spectrum of luminescent compounds. The chemically reactive quenching compounds possess utility for labeling a wide variety of substances, including biomolecules. These labeled substances are highly useful for a variety of energy-transfer assays and applications.
摘要翻译：本发明的淬灭化合物是被一个或多个杂芳族猝灭部分取代的弱发光花青素。本发明的淬灭化合物表现出很少或不可观察到的发光，并有效地淬灭广谱的发光化合物。化学反应猝灭化合物具有用于标记各种物质（包括生物分子）的效用。这些标记的物质对于各种能量转移测定和应用是非常有用的。

18. 发明授权

US08105829B2 Fluorometric analysis kit 有权
标题翻译：荧光分析试剂盒
公开(公告)号：US08105829B2
公开(公告)日：2012-01-31
申请号：US12925505
申请日：2010-10-21
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang , Xiang Guobing
IPC分类号： C12N5/071 , C12N1/20 , C07D487/14 , C07K2/00 , C08H1/00 , C07H99/00 , C07H19/00 , C07H21/00
CPC分类号： C09B23/06 , C07D487/14 , C07D487/22 , C07D498/22 , C09B23/0066 , C09B23/02 , G01N33/52 , G01N33/533 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了在1位和3'-位之间分子内交联的化学反应性碳菁染料，它们的生物缀合物及其用途。 1,3'-交联的碳氰酸酯优于光谱相似的1,1'-交联或非交联染料的共轭物。本发明包括具有一个或多个苯并氮的衍生化合物。

19. 发明授权

US08093411B2 Cyanine dyes and their applications as luminescence quenching compounds 有权
标题翻译：花青染料及其作为发光淬灭剂的应用
公开(公告)号：US08093411B2
公开(公告)日：2012-01-10
申请号：US12807180
申请日：2010-08-30
申请人： Zhenjun Diwu , Jianheng Zhang , Yi Tang
发明人： Zhenjun Diwu , Jianheng Zhang , Yi Tang
IPC分类号： C07D209/46 , C07D209/02
CPC分类号： C07D409/14 , C07D209/60 , C07D403/14 , C07D409/04 , C07D409/06 , C07D417/14 , C07D471/04 , C07H21/04 , C07J43/00 , G01N33/542 , G01N33/582
摘要： The quenching compounds of the invention are weakly luminescent cyanines that are substituted by one or more heteroaromatic quenching moieties. The quenching compounds of the invention exhibit little or no observable luminescence and efficiently quench a broad spectrum of luminescent compounds. The chemically reactive quenching compounds possess utility for labeling a wide variety of substances, including biomolecules. These labeled substances are highly useful for a variety of energy-transfer assays and applications.
摘要翻译：本发明的淬灭化合物是被一个或多个杂芳族猝灭部分取代的弱发光花青素。本发明的淬灭化合物表现出很少或不可观察到的发光，并有效地淬灭广谱的发光化合物。化学反应猝灭化合物具有用于标记各种物质（包括生物分子）的效用。这些标记的物质对于各种能量转移测定和应用是非常有用的。

20. 发明授权

US08329390B2 Detection of transmembrane potentials using N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonols 有权
标题翻译：使用N，N，N'-三烷基硫代巴比妥酸衍生的聚甲硫氨酸氧杂多糖检测跨膜电位
公开(公告)号：US08329390B2
公开(公告)日：2012-12-11
申请号：US11212203
申请日：2005-08-25
申请人： Zhenjun Diwu , Jianjun He , Yi Tang
发明人： Zhenjun Diwu , Jianjun He , Yi Tang
IPC分类号： C12Q1/00 , C07D403/00 , C07D239/10 , C07D239/66
CPC分类号： C07D239/66 , G01N33/52
摘要： The present invention relates generally to the detection and measurement of transmembrane potentials using an N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonol (shown below). In particular, the present invention is directed to compositions and optical methods for determining transmembrane potentials across the plasma membrane of biological cells using a slightly hydrophobic N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonols. The method comprises a slightly hydrophobic N,N,N′-trialkyl thiobarbituric acid-derived polymethine oxonol anion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in the potential of the membrane. In one aspect the method is used to identify compounds which modulate membrane potentials in biological membranes. wherein R1, R2, and R3 are independently selected from the group consisting of hydrogen, alkyl, haloalkyl and heteroalkyl; n is an integer from 1 to 3; Z is Na, K, ammonium or other biologically acceptable salt.
摘要翻译：本发明一般涉及使用N，N，N'-三烷基硫代巴比妥酸衍生的聚甲基氧杂多酚（如下所示）检测和测量跨膜电位。特别地，本发明涉及使用稍微疏水的N，N，N'-三烷基硫代巴比妥酸衍生的聚甲基氧杂多糖测定生物细胞质膜跨膜电位的组合物和光学方法。该方法包括一种稍微疏水的N，N，N'-三烷基硫代巴比妥酸衍生的聚甲基氧杂氮杂阴离子，其能够响应膜的电位变化而从膜的第一面再分配到膜的第二面。在一个方面，该方法用于鉴定调节生物膜中膜电位的化合物。其中R1，R2和R3独立地选自氢，烷基，卤代烷基和杂烷基; n为1〜3的整数， Z是Na，K，铵或其他生物可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式