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151. 发明申请

US20080103135A1 PHENYLALKYNES 有权
标题翻译：苯乙烯
公开(公告)号：US20080103135A1
公开(公告)日：2008-05-01
申请号：US11874321
申请日：2007-10-18
申请人： Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
发明人： Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
IPC分类号： A61K31/54 , A61K31/445 , A61P25/00 , C07D401/02 , C07D417/02 , C07D239/02 , A61K31/5375
CPC分类号： C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要： Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译：取代的式（I）的苯炔基，含有它们的组合物，以及制备和使用它们来治疗组胺介导的病症的方法。

152. 发明申请

US20080074045A1 ORGANIC ELECTROLUMINESCENCE DEVICE 审中-公开
标题翻译：有机电致发光器件
公开(公告)号：US20080074045A1
公开(公告)日：2008-03-27
申请号：US11947899
申请日：2007-11-30
申请人： Sanae Tagami , Hidetsugu Ikeda , Chishio Hosokawa , Takashi Arakane
发明人： Sanae Tagami , Hidetsugu Ikeda , Chishio Hosokawa , Takashi Arakane
IPC分类号： H01L51/54
CPC分类号： H01L51/0056 , C07C13/62 , C07C13/70 , C07C211/61 , C07C217/92 , C07C217/94 , C07C229/68 , C07C255/42 , C07C255/58 , C07C2601/14 , C07C2603/54 , C07D219/14 , C07D223/14 , C07D223/26 , C07D223/28 , C07D279/26 , C07D295/02 , C07D295/135 , C07D295/155 , C07D471/06 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1037 , H01L51/0054 , H01L51/0059 , H01L51/006 , H01L51/0081 , H01L51/5012 , H01L51/5048 , H05B33/14 , Y10S428/917
摘要： An organic electroluminescence device which exhibits an excellent purity of color and a high efficiency of light emission, has a long life and emits reddish light and a novel compound having these characteristics are provided. The organic electroluminescence device comprises an organic layer disposed between at least one pair of electrodes, wherein the organic layer comprises a compound having a fluoranthene skeleton structure substituted at least with an amine group or an alkenyl group.
摘要翻译：具有优异的颜色纯度和高发光效率的有机电致发光元件具有使用寿命长并发出红光，并具有这些特性的新型化合物。有机电致发光器件包括设置在至少一对电极之间的有机层，其中有机层包含具有至少被胺基或烯基取代的荧蒽骨架结构的化合物。

153. 发明授权

US07288540B2 Phenylalkynes 有权
标题翻译：苯基炔
公开(公告)号：US07288540B2
公开(公告)日：2007-10-30
申请号：US11490394
申请日：2006-07-20
申请人： Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
发明人： Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
IPC分类号： C07D413/06 , A61K31/5377
CPC分类号： C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要： Substituted phenylalkynes of formula (I) compositions containing them and their methods of use to treat histamine related disorders are described, wherein R1, R2, R3, R4, R5 and n are as defined.
摘要翻译：描述了含有它们的式（I）的组合物的取代苯炔基及其用于治疗组胺相关病症的方法，其中R 1，R 2，R 3， R 4，R 4，R 5和n如上所定义。

154. 发明申请

US20060084657A1 Piperazine derivative 审中-公开
标题翻译：哌嗪衍生物
公开(公告)号：US20060084657A1
公开(公告)日：2006-04-20
申请号：US10499011
申请日：2002-12-19
申请人： Atsuro Nakazato , Takaaki Ishii , Dai Nozawa
发明人： Atsuro Nakazato , Takaaki Ishii , Dai Nozawa
IPC分类号： A61K31/496 , A61K31/497 , A61K31/506 , A61K31/517 , C07D403/14
CPC分类号： C07D239/26 , A61K31/496 , A61K31/517 , C07D209/48 , C07D231/12 , C07D233/70 , C07D233/84 , C07D239/96 , C07D261/08 , C07D263/32 , C07D277/28 , C07D277/34 , C07D277/40 , C07D277/56 , C07D295/02 , C07D295/13 , C07D307/91 , C07D311/90 , C07D313/18
摘要： A piperazine derivative represented by the formula (1): wherein n is an integer of 1 to 8; R1 represents hydrogen or C1-10 alkyl; A represents CH or nitrogen; Ar1 represents phenyl or substituted phenyl; and Y represents a group represented by the formula Y1-Y2-Ar2 or Y3-Y4(Ar5)-Ar6 or a pharmaceutically acceptable salt of the derivative. The novel piperazine derivative has MC4 receptor antagonistic activity.
摘要翻译：由式（1）表示的哌嗪衍生物：其中n为1至8的整数; R 1表示氢或C 1-10烷基; A表示CH或氮; Ar 1表示苯基或取代的苯基; Y表示由式Y 1 -Y 2 -OR 2或Y 3 -Y 3表示的基团。（Ar 5） - Ar 6或其衍生物的药学上可接受的盐。新型哌嗪衍生物具有MC4受体拮抗作用。

155. 发明申请

US20040002604A1 Phenylalkynes 审中-公开
标题翻译：苯基炔
公开(公告)号：US20040002604A1
公开(公告)日：2004-01-01
申请号：US10464582
申请日：2003-06-17
发明人： Richard Apodaca , Xiaohu Deng , Jill A. Jablonowski , Neelakandha Mani , Chennagiri R. Pandit , Wei Xiao
IPC分类号： C07D413/02 , C07D43/02
CPC分类号： C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要： Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译：取代的式（I）的苯炔基，含有它们的组合物，以及制备和使用它们来治疗组胺介导的病症的方法。

156. 发明授权

US4632989A Isocyanurate preparation 失效
标题翻译：异氰脲酸盐制剂
公开(公告)号：US4632989A
公开(公告)日：1986-12-30
申请号：US737837
申请日：1985-05-28
申请人： Dale F. Regelman
发明人： Dale F. Regelman
IPC分类号： C07D251/34 , C07D295/02 , C08G18/02 , C08G18/16 , C08G18/79
CPC分类号： C07D295/02 , C07C255/00 , C07C265/00 , C07C265/12 , C08G18/022 , C08G18/168 , C08G18/791
摘要： Disclosed are novel compositions capable of catalytically trimerizing organic isocyanates said compositions comprising solutions of the reaction products obtained by reacting in an inert solvent in substantially equimolar proportions electron-rich ketene-aminals with electron-poor olefins having the respective formulae (I) and (II) ##STR1## The variously substituted electron-rich ketene-aminals (I), as the name implies, have high electron density associated with the double bond because of the two tertiary amine groups while the electron-poor olefins (II) have the opposite situation due to the presence of electron withdrawing substituents R.sub.9 and R.sub.10.Also disclosed is an improved process for trimerizing organic isocyanates using the above catalyst compositions including the preparation of polyisocyanurate polymers and isocyanurate-modified polyisocyanates.
摘要翻译：公开了能够催化三聚有机异氰酸酯的新型组合物，所述组合物包含通过在惰性溶剂中基本上等摩尔比例的富含电子的乙烯酮 - 胺与具有各自式（I）和（II）的电子不足烯烃反应而获得的反应产物的溶液（I）如下所述，不同取代的富电子酮乙烯酮（I）由于两个叔胺基团而具有与双键相关的高电子密度，而电子由于吸电子取代基R9和R10的存在，α-烯烃（II）具有相反的情况。还公开了使用上述催化剂组合物三聚有机异氰酸酯的改进方法，包括制备聚异氰脲酸酯聚合物和异氰脲酸酯改性的多异氰酸酯。

157. 发明授权

US4414220A Organic diamine therapeutic compositions 失效
标题翻译：有机二胺治疗组合物
公开(公告)号：US4414220A
公开(公告)日：1983-11-08
申请号：US353514
申请日：1982-03-01
申请人： John L. Belletire
发明人： John L. Belletire
IPC分类号： C07D209/44 , C07D211/10 , C07D213/38 , C07D213/53 , C07D213/82 , C07D295/02 , C07D295/073 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/52 , C07D307/68 , A61K31/445 , C07D401/10
CPC分类号： C07D213/53 , C07D209/44 , C07D211/10 , C07D213/38 , C07D213/82 , C07D295/02 , C07D295/073 , C07D295/096 , C07D295/135 , C07D295/155 , C07D307/52 , C07D307/68 , Y10S514/866
摘要： A series of organic diamine base compounds derived from either an aromatic, alicyclic or heterocyclic ring and possessing, for the most part, an intervening methylene group between the ring and the aforesaid basic moiety have been prepared, including their pharmaceutically acceptable acid addition salts as well as oral pharmaceutical compositions containing same. These particular compounds are found to be useful in therapy as oral hypoglycemic agents. Preferred member compounds include 1,1'-[1,2-phenylenebis(methylene)]bispiperidine, 2,3-dihydro-2-[2-(1-piperidinomethyl)phenylmethyl]-1H-isoindole and 2,3-dihydro-2-[2-(4-morpholinomethyl)phenylmethyl]-1H-isoindole. Alternate methods of preparation are provided and the two principal synthetic routes leading to these compounds are described in some detail.
摘要翻译：已经制备了一系列衍生自芳族，脂环族或杂环的有机二胺基化合物，并且大部分在环和前述碱性部分之间具有中间的亚甲基，包括其药学上可接受的酸加成盐作为含有其的口服药物组合物。发现这些特定化合物可用于作为口服降血糖药的治疗。优选的成员化合物包括1,1' - [1,2-亚苯基双（亚甲基）]双哌啶，2,3-二氢-2- [2-（1-哌啶基甲基）苯甲基] -1H-异吲哚和2,3-二氢 - 2- [2-（4-吗啉代甲基）苯基甲基] -1H-异吲哚。提供了替代的制备方法，并且进一步描述了导致这些化合物的两种主要合成途径。

158. 发明授权

US4312830A Tertiary amino-substituted thiazines 失效
标题翻译：三氨基取代噻嗪
公开(公告)号：US4312830A
公开(公告)日：1982-01-26
申请号：US161989
申请日：1980-06-23
申请人： Patrick M. Quinlan
发明人： Patrick M. Quinlan
IPC分类号： C07D295/02 , C07D295/13 , C23F11/04 , C23F11/16 , C23F11/14
CPC分类号： C07D295/02 , C07D295/13 , C23F11/04 , C23F11/16 , Y10S507/939
摘要： This invention relates to tertiary amino-substituted thiazines; the process of preparing such thiazines; and uses thereof, for example, as corrosion inhibitors, microbiocides, etc.
摘要翻译：本发明涉及叔氨基取代的噻嗪; 制备此类噻嗪的过程; 及其用途，例如腐蚀抑制剂，杀微生物剂等

159. 发明授权

US4263433A Tertiary amino-substituted thiazines 失效
公开(公告)号：US4263433A
公开(公告)日：1981-04-21
申请号：US713706
申请日：1976-08-12
申请人： Patrick M. Quinlan
发明人： Patrick M. Quinlan
IPC分类号： C07D295/02 , C07D295/13 , C07D279/10 , C07D417/06 , C07D417/12 , C07D417/14
CPC分类号： C07D295/02 , C07D295/13
摘要： This invention relates to tertiary aminosubstituted thiazines; the process of preparing such thiazines; and uses thereof, for example, as corrosion inhibitors, microbiocides, etc.

160. 发明授权

US4146559A Cycloaliphatic diamines 失效
标题翻译：循环泵
公开(公告)号：US4146559A
公开(公告)日：1979-03-27
申请号：US827767
申请日：1977-08-25
申请人： Manfred Bock , Rudolf Braden , Josef Pedain
发明人： Manfred Bock , Rudolf Braden , Josef Pedain
IPC分类号： C07C215/14 , C07C67/00 , C07C209/00 , C07C209/26 , C07C209/52 , C07C211/36 , C07C213/00 , C07C217/08 , C07D295/02 , C08G18/10 , C08G18/32 , C07C87/40 , C07C87/28
CPC分类号： C07D295/02 , C08G18/10 , C08G18/3234
摘要： Compounds are disclosed which correspond to the general formula: ##STR1## in which N AND M WHICH ARE THE SAME OR DIFFERENT HAVE THE VALUES 0, 1 OR 2,R, r.sub.1 and R.sub.2 which are the same or different, represent hydrogen or CH.sub.3 -groupsAnd either(a) R.sub.3 and R.sub.5 represent hydrogen and R.sub.4 and R.sub.6 represent hydrogen, a C.sub.1 -C.sub.18 alkyl group, or a cycloalkyl group with 5 to 8 carbon atoms,Or(b) R.sub.3, R.sub.4, R.sub.5 and R.sub.6 independently represent C.sub.1 -C.sub.18 alkyl groups, or cycloalkyl groups containing 5 to 8 carbon atoms,Or(c) R.sub.3 and R.sub.4 together and R.sub.5 and R.sub.6 together, in conjunction with the nitrogen atom, form a heterocyclic C.sub.4 -C.sub.6 ring which may be interrupted by oxygen and/or nitrogen and which may be substituted by alkyl groups and/or hydroxyl alkyl groups with 1 to 4 carbon atoms.These compounds are produced by hydrogenating the corresponding diketones in the presence of ammonia or a primary or secondary aliphatic or cycloaliphatic amine.

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