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141. 发明授权

US08140155B2 Intermittent pacing therapy delivery statistics 有权
标题翻译：间歇性起搏治疗递送统计
公开(公告)号：US08140155B2
公开(公告)日：2012-03-20
申请号：US12401194
申请日：2009-03-10
申请人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
发明人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3688
摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode and stores a statistic related to the stress augmentation mode in a stress augmentation cycle memory area.
摘要翻译：本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替，并将与应力增加模式相关的统计量存储在应力增加周期存储区域中。

142. 发明授权

US08019416B2 Reduction of AV delay for treatment of cardiac disease 有权
标题翻译：减少AV延迟治疗心脏病
公开(公告)号：US08019416B2
公开(公告)日：2011-09-13
申请号：US11615383
申请日：2006-12-22
申请人： Joseph M. Pastore , Rodney W. Salo , Julio C. Spinelli , Allan C. Shuros , Andres Belalcazar
发明人： Joseph M. Pastore , Rodney W. Salo , Julio C. Spinelli , Allan C. Shuros , Andres Belalcazar
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36564 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently reduce the AVD interval for beneficial effect in patients with compromised ventricular function (e.g., HF patients and post-MI patients). The AVD interval may be reduced in an AVD reduction mode, by shortening the AVD in an atrial triggered ventricular pacing mode or by switching to a non-atrial triggered ventricular pacing mode (e.g., VVI) and delivering paces at a rate above the intrinsic rate. The physiological effects of AVD reduction may be either positive or negative on cardiac output, depending upon the individual patient.
摘要翻译：用于输送心室起搏的可植入起搏装置可以被配置为间歇地减小AVD间隔，以在患有心室功能受损的患者（例如，HF患者和MI后患者）中产生有益效果。通过在心房触发的心室起搏模式中缩短AVD或者通过切换到非心房触发的心室起搏模式（例如，VVI）并以高于内在速率的速率递送步进，AVD间期可以减小AVD减小模式。取决于个体患者，AVD减少的生理作用可能是心输出量的正或负。

143. 发明申请

US20110178565A1 AUTOMATIC MECHANICAL ALTERNANS DETECTION 有权
标题翻译：自动机械检测
公开(公告)号：US20110178565A1
公开(公告)日：2011-07-21
申请号：US13007107
申请日：2011-01-14
申请人： Dan Li , Allan C. Shuros , Arjun Sharma
发明人： Dan Li , Allan C. Shuros , Arjun Sharma
IPC分类号： A61N1/365 , A61B5/02
CPC分类号： A61N1/3627 , A61B5/0215 , A61B5/0452 , A61B5/0538 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , G06F19/00
摘要： This document discusses, among other things, a cardiac mechanical alternans (MA) detector circuit. In an example, the mechanical alternans detector circuit is configured to determine a mechanical alternans (MA) condition. In an example, the MA detector circuit can include a physiologic impedance input configured to receive physiologic information indicative of mechanical alternans. In an example, the MA detector circuit can include an intravascular pressure input configured to receive physiologic information indicative of mechanical alternans.
摘要翻译：本文件还讨论了心脏机械交替（MA）检测器电路。在一个示例中，机械交替检测器电路被配置为确定机械交替（MA）条件。在一个示例中，MA检测器电路可以包括构造成接收指示机械交替的生理信息的生理阻抗输入。在一个示例中，MA检测器电路可以包括构造成接收指示机械交替的生理信息的血管内压力输入。

144. 发明授权

US07941216B2 Method and device for treating myocardial ischemia 有权
标题翻译：治疗心肌缺血的方法和装置
公开(公告)号：US07941216B2
公开(公告)日：2011-05-10
申请号：US11561049
申请日：2006-11-17
申请人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
发明人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.
摘要翻译：描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。

145. 发明申请

US20110071411A1 METHOD AND APPARATUS FOR SENSING MECHANICAL ENERGY OF AN IMPLANTABLE LEAD 有权
标题翻译：用于传感可塑性引线的机械能的方法和装置
公开(公告)号：US20110071411A1
公开(公告)日：2011-03-24
申请号：US12876426
申请日：2010-09-07
申请人： Allan C. Shuros , Dan Li , Krzysztof Z. Siejko , John H. Tangren
发明人： Allan C. Shuros , Dan Li , Krzysztof Z. Siejko , John H. Tangren
IPC分类号： A61N1/365 , A61B5/02 , A61N1/39
CPC分类号： A61B5/02158 , A61B5/02133 , A61B5/02405 , A61N1/36514 , A61N1/36578
摘要： An apparatus comprises an implantable sensor and a signal analyzer circuit communicatively coupled to the implantable sensor. The implantable sensor is configured for coupling to an implantable lead and the implantable sensor provides an electrical vibration sensor signal representative of mechanical vibration of the implantable lead. The signal analyzer circuit is configured to determine a baseline of the vibration sensor signal, detect a change in the vibration sensor signal from the baseline vibration sensor signal, and provide an indication of the change to a user or process.
摘要翻译：一种装置包括可植入传感器和通信地耦合到可植入传感器的信号分析器电路。可植入传感器被配置为联接到可植入引线，并且可植入传感器提供表示可植入引线的机械振动的电振动传感器信号。信号分析器电路被配置为确定振动传感器信号的基线，从基线振动传感器信号检测振动传感器信号的变化，并且向用户或过程提供变化的指示。

146. 发明申请

US20110040344A1 MYOCARDIAL INFARCTION TREATMENT SYSTEM WITH ELECTRONIC REPOSITIONING 有权
标题翻译：具有电子记录功能的MYOCARDIAL INFARCTION治疗系统
公开(公告)号：US20110040344A1
公开(公告)日：2011-02-17
申请号：US12793206
申请日：2010-06-03
申请人： Eric A. Mokelke , Allan C. Shuros , James A. Esler
发明人： Eric A. Mokelke , Allan C. Shuros , James A. Esler
IPC分类号： A61B17/22 , A61N1/36
CPC分类号： A61N1/368 , A61B17/3207 , A61B2017/00557 , A61B2017/00893 , A61N1/056 , A61N1/36578 , A61N2001/0585
摘要： Methods and devices for treating a blockage in the coronary arterial system are provided. Some blockages in the coronary arterial system restrict the blood flow to a portion of the heart, causing ischemia or infarction. Such blockages may be treated by displacing, removing and/or breaking up the blockage, which allows blood to reperfuse into the infarcted portion of the heart. Before, during, and/or after the reperfusion, cardioprotective pacing is provided to the heart. The devices have multiple electrodes in order to provide multiple locations at which the cardioprotective pacing may be delivered. The devices are adapted to deliver cardioprotective pacing to the heart via the electrode that results in a relatively high level of dyssynchrony of the heart.
摘要翻译：提供了治疗冠状动脉系统阻塞的方法和装置。冠状动脉系统中的一些阻塞物将血流限制到心脏的一部分，导致局部缺血或梗死。可以通过移位，去除和/或破坏堵塞来治疗这种阻塞，其允许血液再灌注到心脏的梗死部分。在再灌注之前，期间和/或之后，向心脏提供心脏保护起搏。这些装置具有多个电极，以便提供可以输送心脏保护起搏的多个位置。该装置适于通过电极向心脏输送心脏保护性起搏，导致心脏相对较高水平的不同步。

147. 发明申请

US20100292745A1 METHOD AND APPARATUS FOR SAFETY CONTROL DURING CARDIAC PACING MODE TRANSITION 有权
标题翻译： CARDIAC PACING MODE TRANSITION期间安全控制的方法和装置
公开(公告)号：US20100292745A1
公开(公告)日：2010-11-18
申请号：US12768925
申请日：2010-04-28
申请人： Allan C. Shuros , Eric A. Mokelke
发明人： Allan C. Shuros , Eric A. Mokelke
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/368 , A61N1/3688
摘要： A cardiac pacing system introduces a transitional period when pacing mode changes, such as when pacing starts and stops, or when one or more pacing parameter values change substantially. For each pacing parameter that changes substantially when the pacing mode changes, its value is adjusted incrementally over the transitional period to protect the heart from potentially harmful conditions associated with an abrupt change in the value of that pacing parameter.
摘要翻译：心脏起搏系统引入起搏模式改变的过渡时期，例如起搏开始和停止时，或当一个或多个起搏参数值发生显着变化时。对于每个起搏参数，当起搏模式发生变化时，其参数会发生显着变化，其过渡期间会逐渐调整其值，以保护心脏免受与该起搏参数值突然变化相关的潜在有害状况。

148. 发明授权

US07778707B2 Method and device for myocardial stress redistribution 有权
标题翻译：心肌应激再分配的方法和装置
公开(公告)号：US07778707B2
公开(公告)日：2010-08-17
申请号：US11689032
申请日：2007-03-21
申请人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/368
CPC分类号： A61N1/3627
摘要： Methods and devices are described for delivering electrical stimulation to the heart in a manner that advantageously redistributes myocardial stress during systole for therapeutic purposes in the treatment of, for example, post-MI and HF patients. Pre-excitation pacing may be applied to deliberately de-stress a particular myocardial region that may be expected to undergo deleterious remodeling, such as the area around a myocardial infarct or a hypertrophying region or to deliberately stress a region remote from the pre-excitation pacing site in order to exert a cardioprotective conditioning effect, similar to the beneficial effects of exercise. Pre-excitation pacing may be advantageously combined with inotropic electrical stimulation applied to the stressed region.
摘要翻译：描述了将方法和装置以有效地将收缩期内的心肌应力重新分配到治疗目的的治疗目的的心脏和心脏病和心脏病患者的方式，以向心脏递送电刺激。预激发起搏可以用于故意地减压可能预期会发生有害重建的特定心肌区域，例如心肌梗塞或肥大区域周围的区域，或者故意强迫远离预激励起搏的区域为了发挥心脏保护性调理作用，类似于运动的有益效果。预激发起搏可以有利地与施加到应激区域的变力电刺激组合。

149. 发明授权

US07744618B2 Device and method for modulating renal function 有权
标题翻译：调节肾功能的装置和方法
公开(公告)号：US07744618B2
公开(公告)日：2010-06-29
申请号：US11567907
申请日：2006-12-07
申请人： Allan C. Shuros , M. Jason Brooke , Tasneem Poonawala
发明人： Allan C. Shuros , M. Jason Brooke , Tasneem Poonawala
IPC分类号： A61M29/00
CPC分类号： A61N1/3606 , A61M25/00 , A61N1/05 , A61N1/36007 , A61N1/36135
摘要： Renal function may be modulated by an implantable device having one or more leads or catheters disposed near the kidney via the lymphatic system. In one embodiment, lymphatic drainage from the kidney is modulated to increase or decrease tubular reabsorption of salt and water. The renal function modulation therapy may be delivered in an open-loop or closed-loop fashion, with the latter dependent upon a physiological variable such as blood pressure or cardiac output.
摘要翻译：肾功能可以由具有通过淋巴系统设置在肾附近的一个或多个引线或导管的可植入装置调节。在一个实施方案中，来自肾脏的淋巴引流被调节以增加或减少盐和水的管状再吸收。肾功能调节治疗可以以开环或闭环方式递送，后者取决于诸如血压或心输出量的生理变量。

150. 发明授权

US07734341B2 Method and apparatus for gastrointestinal stimulation via the lymphatic system 有权
标题翻译：通过淋巴系统进行胃肠道刺激的方法和装置
公开(公告)号：US07734341B2
公开(公告)日：2010-06-08
申请号：US11422418
申请日：2006-06-06
申请人： Allan C. Shuros
发明人： Allan C. Shuros
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： An implantable gastrointestinal (GI) stimulation system includes an implantable medical device and at least one stimulus delivery device configured to be placed in one or more lymphatic vessels of a patient, such as the patient's thoracic duct and/or vessels branching from the thoracic duct. In one embodiment, the implantable medical device includes a GI stimulation circuit to deliver electrical stimulation pulses to one or more target regions adjacent to a lymphatic vessel through the stimulus delivery device. In one embodiment, to control obesity, the electrical stimulation pulses are delivered to the organs and/or nerves of the GI tract to create a sensation of satiety and/or to expedite food movement through the GI tract.
摘要翻译：植入式胃肠（GI）刺激系统包括可植入医疗装置和至少一个刺激递送装置，其被配置为放置在患者的一个或多个淋巴管中，例如患者的胸导管和/或从胸导管分支的血管。在一个实施例中，可植入医疗装置包括GI刺激电路，以通过刺激输送装置将电刺激脉冲输送到与淋巴管相邻的一个或多个目标区域。在一个实施方案中，为了控制肥胖，将电刺激脉冲输送到胃肠道的器官和/或神经以产生饱腹感和/或加速通过胃肠道的食物运动。

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