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    • 141. 发明申请
    • CYCLIN-DEPENDENT PROTEIN KINASES INHIBITORS OF SCUTELLARIA FLAVONOID ORGANIC AMINE DERIVATIVES, SYNTHESIS AND USE THEREOF
    • 环孢菌素依赖性蛋白激酶抑制剂佛兰西兰有机胺衍生物,合成及其用途
    • US20100197619A1
    • 2010-08-05
    • US12676121
    • 2009-07-07
    • Shixuan ZhangYongming BaoYuming SunKangjian LiLiang ZouJigang MaXiaodan SunHaiyan ShangJing Li
    • Shixuan ZhangYongming BaoYuming SunKangjian LiLiang ZouJigang MaXiaodan SunHaiyan ShangJing Li
    • A61K31/7048C07H17/06A61P35/00A61P31/18
    • A61K31/496A61K31/7048A61K36/539C07D311/30
    • The present invention provides a series of cyclin-dependent protein kinases (Cdks) inhibitors, Scutellaria flavonoid organic amine derivatives, synthesis and use thereof. The preparation method is as follows: taking Baicalein (or Wogonin) from Scutellaria baicalensis as lead compound, mixting it with formaldehyde solution and organic amine compounds based on the molar ratio of 1:1-1.2:1-1.2, adding methanol of duplicate weight than baicalein and reacting at 50-70° C., filtering the sediment and washing and then drying so as to get the product with a content of not less than 97% (weight). Similar to Flavopiridol and P276-00, the activity of baicalein organic amine derivatives inhibiting Cdks has an increase of 50 times compared with that of Baicalin. It can selectively induce apoptosis of the proliferative phase cancer cells, which has scarcely any influence to the normal structure, and it belongs to anticancer drugs of cell cycle inhibitor kind. The product has a rich source of raw materials and has simple process, high purity, low cost, clear metabolic mechanism, high efficiency and low toxicity, which can be made into oral preparations or injections together with acid salts and is expected to become high efficient and low toxicity anti-cancer and AIDS drugs.
    • 本发明提供了一系列细胞周期蛋白依赖性蛋白激酶(Cdks)抑制剂,黄芩类黄酮有机胺衍生物,其合成和用途。 制备方法如下:以黄芩黄芩苷(或Wogonin)为铅化合物,以1:1-1.2:1-1.2的摩尔比与甲醛溶液和有机胺化合物混合,加入重量重量的甲醇 比黄芩苷在50-70℃下反应,过滤沉淀物,然后洗涤,然后干燥,得到含量不小于97%(重量)的产品。 与黄酮类药物和P276-00类似,抑制镉的黄芩素有机胺衍生物的活性与黄芩苷相比增加了50倍。 可选择性诱导增殖期癌细胞凋亡,对正常结构几乎没有任何影响,属于细胞周期抑制剂类抗癌药物。 该产品原料丰富,工艺简单,纯度高,成本低,代谢机理清晰,效率高,毒性低,可与酸性盐一起口服制剂或注射,预计效率高 和低毒性抗癌和艾滋病药物。
    • 142. 再颁专利
    • Hybrid nanostructured materials based in II-VI semiconductors
    • 基于II-VI半导体的混合纳米结构材料
    • USRE41427E1
    • 2010-07-13
    • US11129759
    • 2005-05-13
    • Jing LiXiaoying Huang
    • Jing LiXiaoying Huang
    • H01L31/00
    • H01L51/0032C07F13/005
    • Hybrid crystalline organic-inorganic quantum confined systems are disclosed, which contain alternating layers of a bifunctional organic ligand and a II-VI semiconducting chalcogenide, wherein the semiconducting chalcogenide layers contain chalcogenides have the formula MQ, in which M is independently selected from II-VI semiconductor cationic species and Q is independently selected from S, Se and Te; and the bifunctional organic ligands of each organic ligand layer are bonded by a first functional group to an element M of an adjacent II-VI semiconducting chalcogenide layer and by a second functional group to an element M from the adjacent opposing II-VI semiconducting chalcogenide layer, so that the adjacent opposing II-VI semiconducting chalcogenide layers are linked by the bifunctional organic ligands of the organic ligand layers. Optical absorption experiments show that these systems produce a significant blue shift in their optical absorption edges, 1.2-1.5 eV, compared to a shift of 1.0 electron volt by the best grown II-VI or II-V semiconducting quantum colloidal dots. In addition, the II-VI confined layers in these systems possess a perfectly periodic arrangement.
    • 公开了混合结晶有机 - 无机量子限制系统,其包含双官能有机配体和II-VI半导体硫族化物的交替层,其中半导体硫族化物层含有硫属化物,其具有式MQ,其中M独立地选自II-VI 半导体阳离子种类和Q独立地选自S,Se和Te; 并且每个有机配体层的双官能有机配体通过第一官能团与相邻的II-VI半导体硫族化物层的元素M和第二官能团与来自相邻的相反的II-VI半导体硫族化物层的元素M键合 ,使得相邻的相对的II-VI半导体硫族化物层通过有机配体层的双官能有机配体连接。 光学吸收实验表明,与通过最佳生长的II-VI或II-V半导体量子胶体点的1.0电子伏特的偏移相比,这些系统在其光吸收边缘产生显着的蓝移,为1.2-1.5eV。 此外,这些系统中的II-VI限制层具有完美的周期性排列。
    • 144. 发明授权
    • Editing, creating, and verifying reorganization of flowchart, and transforming between flowchart and tree diagram
    • 编辑,创建和验证流程图重组,以及流程图和树形图之间的转换
    • US07647577B2
    • 2010-01-12
    • US11140194
    • 2005-05-27
    • Jian WangJun ZhuSheng YeJing LiHai Qi LiangYing LiuYing Nan Zuo
    • Jian WangJun ZhuSheng YeJing LiHai Qi LiangYing LiuYing Nan Zuo
    • G06F9/44G06F9/45
    • G06F8/10
    • Provides methods for transforming a flowchart to an equivalent tree diagram, methods for transforming an equivalent tree diagram to a flowchart, methods for verifying reorganization of a flowchart, methods for editing a flowchart, methods for creating a flowchart and a flowchart editor. A flowchart includes one or more logic structures and one or more processing activities in said one or more logic structures. The method for transforming a flowchart to an equivalent tree diagram comprises: traversing said flowchart; transforming said one or more logic structures in said flowchart to one or more branching nodes in said tree diagram; and transforming one or more processing activities in said logic structures of said flowchart to one or more leaf nodes below corresponding branching nodes in said tree diagram. Further, edition of a flowchart and verification of reorganization of a flowchart are performed by utilizing an equivalent tree diagram.
    • 提供将流程图转换为等效树图的方法,将等效树图变换为流程图的方法,用于验证流程图重组的方法,用于编辑流程图的方法,用于创建流程图的方法和流程图编辑器。 流程图包括所述一个或多个逻辑结构中的一个或多个逻辑结构和一个或多个处理活动。 将流程图变换为等效树图的方法包括:遍历所述流程图; 将所述流程图中的一个或多个逻辑结构转换成所述树形图中的一个或多个分支节点; 以及将所述流程图的所述逻辑结构中的一个或多个处理活动转换为所述树形图中的相应分支节点之下的一个或多个叶节点。 此外,通过利用等效树图来执行流程图的编辑和流程图的重组的验证。
    • 150. 发明申请
    • Particle-in-binder X-ray sensitive coating using polyimide binder
    • 使用聚酰亚胺粘合剂的粒子粘合剂X射线敏感涂层
    • US20070122543A1
    • 2007-05-31
    • US11288554
    • 2005-11-29
    • Brian YanoffZhaoping WuKun TaoYunfeng SunJun XiaoLiping ZhengWenqing PengJing Li
    • Brian YanoffZhaoping WuKun TaoYunfeng SunJun XiaoLiping ZhengWenqing PengJing Li
    • B05D5/12H01B1/12
    • G01T1/24
    • An X-ray sensitive coating (22) for a flat panel direct conversion X-ray detector for medical or industrial imaging. A composite particle-in-binder (PIB) material (22) may contain X-ray photoconductive particles (23) such as PbO (lead monoxide) in a binder of polyimide (23). This PIB material may be prepared in precursor paste form, and applied as a coating (22) onto a thin film transistor array (26) having a storage capacitor (31) at each pixel (30). The coating (22) is cured, and an electrically conducting layer (34) is applied to the exposed surface of the coating (22), to provide a bias voltage. X-ray photons striking the photoconductive particles (23) cause localized electrical conduction proportional to the number of photons. This charges respective capacitors (31) that provide image data input to a computer.
    • 用于医疗或工业成像的平板直接转换X射线检测器的X射线敏感涂层(22)。 复合粒子 - 粘合剂(PIB)材料(22)可以在聚酰亚胺(23)的粘合剂中含有X射线光电导颗粒(例如PbO(一氧化铅))。 该PIB材料可以以前体浆料形式制备,并作为涂层(22)施加到在每个像素(30)处具有存储电容器(31)的薄膜晶体管阵列(26)上。 固化涂层(22),并且将导电层(34)施加到涂层(22)的暴露表面,以提供偏置电压。 撞击光导电颗粒(23)的X射线光子引起与光子数成比例的局部电传导。 这样,向计算机提供输入图像数据的各个电容器(31)。