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141. 发明授权

US5919629A Polynucleotide probe and detection method for novel human clathrin-associated protein 失效
标题翻译：新型人类网格蛋白相关蛋白的多核苷酸探针和检测方法
公开(公告)号：US5919629A
公开(公告)日：1999-07-06
申请号：US98900
申请日：1998-06-17
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention provides a human clathrin-associated protein (HAP19) and polynucleotides which identify and encode HAP19. The invention also provides expression vectors and host cells and a method for producing HAP19. The invention also provides antibodies or antagonists specifically binding HAP19, and their use, in the prevention and treatment of diseases associated with expression of HAP19. The invention also provides diagnostic assays.
摘要翻译：本发明提供了人类网格蛋白相关蛋白（HAP19）和识别和编码HAP19的多核苷酸。本发明还提供表达载体和宿主细胞以及生产HAP19的方法。本发明还提供了特异性结合HAP19的抗体或拮抗剂及其在预防和治疗与HAP19表达相关的疾病中的用途。本发明还提供诊断测定。

142. 发明授权

US5912143A Polynucleotides encoding a human mage protein homolog 失效
标题翻译：编码人类法师蛋白同源物的多核苷酸
公开(公告)号：US5912143A
公开(公告)日：1999-06-15
申请号：US773870
申请日：1996-12-27
申请人： Olga Bandman , Surya K. Goli
发明人： Olga Bandman , Surya K. Goli
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/10 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/28 , A61P35/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12P21/06 , C07H21/02 , C12N5/00 , C12N15/00
CPC分类号： C07K14/4748 , A61K38/00
摘要： The present invention provides a human MAGE-like protein (MAGELP) and polynucleotides which identify and encode MAGELP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding MAGELP and a method for producing MAGELP. The invention also provides for agonists, antibodies, or antagonists specifically binding MAGELP, and their use, in the prevention and treatment of diseases associated with expression of MAGELP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding MAGELP for the treatment of diseases associated with the expression of MAGELP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding MAGELP.
摘要翻译：本发明提供了人MAGE样蛋白（MAGELP）和识别和编码MAGELP的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码MAGELP的核酸序列和产生MAGELP的方法的宿主细胞。本发明还提供了特异性结合MAGELP的激动剂，抗体或拮抗剂及其在预防和治疗与MAGELP表达相关的疾病中的用途。此外，本发明提供了反义分子用于编码MAGELP的多核苷酸用于治疗与MAGELP表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合MAGELP的抗体的诊断测定法。

143. 发明授权

US5892016A Human tumor suppressor 失效
标题翻译：人类肿瘤抑制因子
公开(公告)号：US5892016A
公开(公告)日：1999-04-06
申请号：US786999
申请日：1997-01-23
申请人： Sam La Brie , Surya K. Goli
发明人： Sam La Brie , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , G01N33/574 , C07H21/04 , C07K1/00
CPC分类号： C07K14/4703 , G01N33/574 , A61K38/00
摘要： The present invention provides a novel human tumor suppressor (NHTS) and polynucleotides which identify and encode NHTS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHTS and a method for producing NHTS. The invention also provides for agonists, antibodies, or antagonists specifically binding NHTS, and their use, in the prevention and treatment of diseases associated with expression of NHTS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHTS for the a treatment of diseases associated with the expression of NHTS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHTS.
摘要翻译：本发明提供了新型人肿瘤抑制因子（NHTS）和识别和编码NHTS的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码NHTS的核酸序列和产生NHTS的方法。本发明还提供了特异性结合NHTS的激动剂，抗体或拮抗剂及其在预防和治疗与NHTS表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码NHTS的多核苷酸用于治疗与NHTS表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHTS的抗体的诊断测定法。

144. 发明授权

US5889170A Human integral membrane protein 失效
标题翻译：人体内膜蛋白
公开(公告)号：US5889170A
公开(公告)日：1999-03-30
申请号：US791338
申请日：1997-01-31
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/705 , C12N1/21 , C12N15/12 , C07H21/04 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a novel human integral membrane (IMP-2) and polynucleotides which identify and encode IMP-2. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding IMP-2 and a method for producing IMP-2. The invention also provides for agonists, antibodies, or antagonists specifically binding IMP-2, and their use, in the prevention and treatment of diseases associated with expression of IMP-2. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding IMP-2 for the treatment of diseases associated with the expression of IMP-2. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding IMP-2.
摘要翻译：本发明提供了一种新型人体内膜（IMP-2）和识别和编码IMP-2的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码IMP-2的核酸序列和产生IMP-2的方法的宿主细胞。本发明还提供特异性结合IMP-2的激动剂，抗体或拮抗剂及其在预防和治疗与IMP-2表达相关的疾病中的用途。此外，本发明提供了反义分子用于编码IMP-2的多核苷酸用于治疗与IMP-2表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合IMP-2的抗体的诊断测定法。

145. 发明授权

US5869291A Rab proteins 失效
公开(公告)号：US5869291A
公开(公告)日：1999-02-09
申请号：US773423
申请日：1996-12-27
申请人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman
发明人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman
IPC分类号： A61K38/00 , C12N9/16 , C12Q1/68 , C07H21/04 , C12N1/20 , C12N15/63
CPC分类号： C12Q1/6883 , C12N9/16 , A61K38/00 , C12Q2600/158
摘要： The present invention provides three Rab proteins (designated individually as HRABS-1, HRABS-2, and HRABS-3, and collectively as HRABS) and polynucleotides which identify and encode HRABS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HRABS and a method for producing HRABS. The invention also provides for use of HRABS and agonists, antibodies, or antagonists specifically binding HRABS, in the prevention and treatment of diseases associated with expression of HRABS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HRABS for the treatment of diseases associated with the expression of HRABS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HRABS.

146. 发明授权

US5869256A Human coatomer vesicle protein 失效
标题翻译：人外套囊泡蛋白
公开(公告)号：US5869256A
公开(公告)日：1999-02-09
申请号：US807050
申请日：1997-02-24
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , C07H21/04 , C07K13/00
CPC分类号： C07K14/47 , C12Q1/6876 , A61K38/00
摘要： The present invention provides a human coatomer vesicle protein (HECOP) and polynucleotides which identify and encode HECOP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HECOP and a method for producing HECOP. The invention also provides the use of HECOP and antagonists specifically binding HECOP in the prevention and treatment of diseases associated with expression of HECOP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HECOP.
摘要翻译：本发明提供了人外皮蛋白囊泡蛋白（HECOP）和识别和编码HECOP的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HECOP的核酸序列和生产HECOP的方法。本发明还提供了特异性结合HECOP的HECOP和拮抗剂在预防和治疗与HECOP表达相关的疾病中的用途。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合HECOP的抗体的诊断测定法。

147. 发明授权

US5858715A Human apoptosis-associated protein 失效
公开(公告)号：US5858715A
公开(公告)日：1999-01-12
申请号：US790572
申请日：1997-01-29
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N1/00 , C12N15/63
CPC分类号： C07K14/4747 , C07K14/4746 , A61K38/00
摘要： The present invention provides a novel human apoptosis-associated protein (NHAAP) and polynucleotides which identify and encode NHAAP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHAAP and a method for producing NHAAP. The invention also provides for agonists, antibodies, or antagonists specifically binding NHAAP, and their use, in the prevention and treatment of diseases associated with expression of NHAAP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHAAP for the treatment of diseases associated with the expression of NHAAP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHAAP.

148. 发明授权

US5853997A Human protein phosphatase 失效
公开(公告)号：US5853997A
公开(公告)日：1998-12-29
申请号：US873093
申请日：1997-06-11
申请人： Olga Bandman , Surya K. Goli , Preeti Lal , Neil C. Corley , Hong Zhang
发明人： Olga Bandman , Surya K. Goli , Preeti Lal , Neil C. Corley , Hong Zhang
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K45/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N9/16 , C12N15/55 , C12Q1/68 , C07H21/04 , C12N1/20
CPC分类号： C12N9/16 , A61K38/00
摘要： The invention provides a human protein phosphatase (PROPHO) and polynucleotides which identify and encode PROPHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PROPHO.

149. 发明授权

US5851799A Histone-like protein 失效
公开(公告)号：US5851799A
公开(公告)日：1998-12-22
申请号：US821009
申请日：1997-03-19
申请人： Olga Bandman , Surya K. Goli , Hong Zhang
发明人： Olga Bandman , Surya K. Goli , Hong Zhang
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12P21/06 , C07H21/02 , C07H21/04 , C07K1/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human histone-like protein (HLP) and polynucleotides which identify and encode HLP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for producing HTP and for treating disorders associated with the expression of HLP.

150. 发明授权

US5851774A Human MLF3 protein 失效
标题翻译：人类MLF3蛋白
公开(公告)号：US5851774A
公开(公告)日：1998-12-22
申请号：US805965
申请日：1997-02-25
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00
摘要： The present invention provides a novel human integral membrane (MLF3) and polynucleotides which identify and encode MLF3. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding MLF3 and a method for producing MLF3. The invention also provides for agonists, antibodies, or antagonists specifically binding MLF3, and their use, in the prevention and treatment of diseases associated with expression of MLF3. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding MLF3 for the treatment of diseases associated with the expression of MLF3. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding MLF3.
摘要翻译：本发明提供了一种新型人体内膜（MLF3）和识别和编码MLF3的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码MLF3的核酸序列的宿主细胞和生产MLF3的方法。本发明还提供特异性结合MLF3的激动剂，抗体或拮抗剂及其在预防和治疗与MLF3表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码MLF3的多核苷酸用于治疗与MLF3表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合MLF3的抗体的诊断测定法。

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