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131. 发明授权

US09370736B2 Flexible filter device for capturing of particles or cells in a fluid 有权
标题翻译：用于捕获流体中的颗粒或细胞的柔性过滤装置
公开(公告)号：US09370736B2
公开(公告)日：2016-06-21
申请号：US13744051
申请日：2013-01-17
申请人： THE PENN STATE RESEARCH FOUNDATION
发明人： Siyang Zheng , Ramdane Harouaka , Mingda Zhou , Yin-Ting Yeh
IPC分类号： B01D29/52 , B01D33/37 , B01D63/08 , A61M1/00 , A61M1/36
CPC分类号： B01D29/52 , A61M1/0056 , A61M1/3633 , B01D33/37 , B01D63/087 , B01D63/088 , B01D2313/13
摘要： A filtering device includes a housing and one or more flexible filter arrays. The flexible filter arrays can be coupled to the housing. Each flexible filter array can include a plurality of members and one or more support members. The plurality of members each can have a proximal and a distal end, the plurality of members being spaced apart by a predetermined distance. The one or more support members can be coupled to one or more of the plurality of members. Each of the plurality of members can be configured to deflect relative to the one or more support members.
摘要翻译：过滤装置包括壳体和一个或多个柔性过滤器阵列。柔性过滤器阵列可以联接到壳体。每个柔性过滤器阵列可以包括多个构件和一个或多个支撑构件。多个构件各自可以具有近端和远端，多个构件间隔开预定距离。一个或多个支撑构件可以联接到多个构件中的一个或多个。多个构件中的每一个可被构造成相对于一个或多个支撑构件偏转。

132. 发明授权

US09330809B2 Electrically conducting composites, methods of manufacture thereof and articles comprising the same 有权
标题翻译：导电复合材料，其制造方法和包含其的制品
公开(公告)号：US09330809B2
公开(公告)日：2016-05-03
申请号：US14335313
申请日：2014-07-18
申请人： Dow Global Technologies LLC , Rohm and Haas Electronic Materials LLC , The Penn State Research Foundation
发明人： Elissei Iagodkine , George L. Athens , Enrique Daniel Gomez , Brandon Howard Smith
IPC分类号： H01B1/00 , H01L51/00 , H01B1/12 , H01L31/00 , C08K5/56 , H01L51/05
CPC分类号： H01B1/127 , C08G2261/1412 , C08G2261/212 , C08G2261/3223 , C08G2261/51 , C08G2261/512 , C08G2261/92 , C08K5/56 , H01L31/00 , H01L51/0037 , H01L51/0083 , H01L51/0566 , C08L65/00
摘要： Disclosed herein is a composition comprising a regioregular polyalkylthiophene and/or a regioregular poly[2,5-bis(3-alkylthiophen-2-yl)thieno(3,2-b)thiophene]; and a metallocene; where the metallocene is present in an amount of greater than 75 wt %, based on the total weight of the composition; where the charge mobility is increased by a factor of 3 or more over compositions having 50 wt % of ferrocene or less with the remainder being a regioregular polyalkylthiophene and/or a regioregular poly[2,5-bis(3-alkylthiophen-2-yl)thieno(3,2-b)thiophene]. Disclosed herein too is a method of manufacturing a thin film comprising dissolving a regioregular polyalkylthiophene and/or a regioregular poly[2,5-bis(3-alkylthiophen-2-yl)thieno(3,2-b)thiophene] in a solvent to form a solution; dissolving a metallocene in the solution; where the metallocene is present in an amount of 75 wt % or greater based on the total weight of the ferrocene and the regioregular polyalkylthiophene and/or the regioregular poly[2,5-bis(3-alkylthiophen-2-yl)thieno(3,2-b)thiophene]; disposing the solution on a substrate; and annealing the substrate.
摘要翻译：本文公开了包含区域性多烷基噻吩和/或区域性聚[2,5-双（3-烷基噻吩-2-基）噻吩并（3,2-b）噻吩]的组合物。和茂金属; 其中基于组合物的总重量，茂金属以大于75重量％的量存在; 其中电荷迁移率在具有50重量％二茂铁或更少的组合物的情况下增加3倍或更多，其余为区域性多烷基噻吩和/或区域性聚[2,5-双（3-烷基噻吩-2-基））噻吩并（3,2-b）噻吩]。本文还公开了一种制造薄膜的方法，其包括将溶解有约数量的聚烷基噻吩和/或区域性聚[2,5-双（3-烷基噻吩-2-基）噻吩并（3,2-b）噻吩]溶解在溶剂中形成解决方案; 将金属茂溶解在溶液中; 其中金属茂以二茂铁和区域性多烷基噻吩和/或区域性聚[2,5-双（3-烷基噻吩-2-基）噻吩并（3）的总重量）的总重量的75重量％或更大的量存在，2-b）噻吩]; 将溶液置于基材上; 并退火衬底。

133. 发明授权

US09322057B2 Methods for nucleic acid manipulation 有权
公开(公告)号：US09322057B2
公开(公告)日：2016-04-26
申请号：US14107733
申请日：2013-12-16
申请人： THE PENN STATE RESEARCH FOUNDATION
发明人： Stephen J Benkovic , Frank Salinas
IPC分类号： C12Q1/68 , C12N15/10 , C12P19/34
CPC分类号： C12P19/34 , C12N15/1027 , C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q2521/507 , C12Q2521/513 , C12Q2527/125
摘要： A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity polymerase to permit the replication and amplification of the target nucleic acid sequence. In preferred embodiments, the polymerase comprises a polymerase holoenzyme. In further preferred embodiments, the recombination factor is bacteriophage T4 UvsX protein or homologs from other species, and the polymerase holoenzyme comprises a polymerase enzyme, a clamp protein and a clamp loader protein, derived from viral, bacteriophage, prokaryotic, archaebacterial, or eukaryotic systems.

134. 发明授权

US09309508B2 Boronic and borinic acid compound as inhibitors of sulfenic acid-containing proteins 有权
标题翻译：硼酸和硼酸化合物作为含亚磺酸蛋白质的抑制剂
公开(公告)号：US09309508B2
公开(公告)日：2016-04-12
申请号：US14576613
申请日：2014-12-19
申请人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
发明人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
IPC分类号： C12N9/99 , C12N9/88
CPC分类号： C12N9/99 , C12N9/88 , C12Y402/01084
摘要： A boronic or borinic acid compound is used to inhibit the activity of a sulfenic acid-containing protein. Thus, a biologically-active sulfenic acid-containing protein is contacted with an activity-inhibiting effective amount of a boronic or borinic acid compound of Formula I or a salt, hydrate or solvate thereof, whose components are disclosed within, and that contact is maintained for a time sufficient to inhibit the biological activity of the protein.
摘要翻译：使用硼酸或硼酸化合物抑制含亚磺酸的蛋白质的活性。因此，含有生物活性的含亚磺酸的蛋白质与活性抑制有效量的式I的硼酸或硼酸化合物或其盐，水合物或溶剂合物接触，其组分在其中公开，并且保持接触足以抑制蛋白质的生物活性。

135. 发明授权

US09284193B2 Method for preparing graphene oxide films and fibers 有权
标题翻译：制备氧化石墨烯薄膜和纤维的方法
公开(公告)号：US09284193B2
公开(公告)日：2016-03-15
申请号：US14519937
申请日：2014-10-21
申请人： The Penn State Research Foundation , Shinshu University
发明人： Rodolfo Cruz-Silva , Aaron Morelos , Mauricio Terrones , Ana Laura Elias , Nestor Perea-Lopez , Morinobu Endo
IPC分类号： C01B31/04 , H01B1/04 , C09D5/24 , B01D39/20
CPC分类号： C01B31/043 , B01D39/2065 , B01D2239/065 , B01D2239/1233 , C01B32/194 , C01B32/23 , C08K3/04 , C08K3/18 , C09D5/24 , C09D7/70 , D01D5/426 , D01F9/12 , D01F11/10 , D01F11/14 , H01B1/04 , Y10T428/2918 , Y10T428/31678 , Y10T428/31993 , Y10T442/277 , Y10T442/2861 , Y10T442/2984
摘要： We report a method of preparation of highly elastic graphene oxide films, and their transformation into graphene oxide fibers and electrically conductive graphene fibers by spinning. Methods typically include: 1) oxidation of graphite to graphene oxide, 2) preparation of graphene oxide slurry with high solid contents and residues of sulfuric acid impurities. 3) preparation of large area films by bar-coating or dropcasting the graphene oxide dispersion and drying at low temperature. 4) spinning the graphene oxide film into a fiber, and 5) thermal or chemical reduction of the graphene oxide fiber into an electrically conductive graphene fiber. The resulting films and fiber have excellent mechanical properties, improved morphology as compared with current graphene oxide fibers, high electrical conductivity upon thermal reduction, and improved field emission properties.
摘要翻译：我们报告了一种制备高弹性石墨烯氧化物膜的方法，并且通过旋转将其转化为氧化石墨烯氧化纤维和导电石墨烯纤维。方法通常包括：1）将石墨氧化成石墨烯氧化物，2）制备具有高固体含量和硫酸杂质残留物的石墨烯氧化物浆料。 3）通过棒状涂布或滴加石墨烯氧化物分散体并在低温下干燥来制备大面积膜。 4）将石墨烯氧化膜旋转成纤维，和5）将石墨烯氧化物纤维热或化学还原成导电石墨烯纤维。所得到的膜和纤维具有优异的机械性能，与目前的氧化烯氧化物纤维相比具有改进的形态，热还原时的高导电性和改善的场致发射性能。

136. 发明授权

US09225011B2 Doped carbon-sulfur species nanocomposite cathode for Li—S batteries 有权
标题翻译： Li-S电池掺杂碳硫物质纳米复合阴极
公开(公告)号：US09225011B2
公开(公告)日：2015-12-29
申请号：US13938527
申请日：2013-07-10
申请人： The Penn State Research Foundation
发明人： Donghai Wang , Tianren Xu , Jiangxuan Song
IPC分类号： H01M4/136 , H01M4/133 , H01M10/052 , H01M4/62
CPC分类号： H01M4/136 , H01M4/133 , H01M4/625 , H01M10/052 , Y02E60/122
摘要： We report a heteroatom-doped carbon framework that acts both as conductive network and polysulfide immobilizer for lithium-sulfur cathodes. The doped carbon forms chemical bonding with elemental sulfur and/or sulfur compound. This can significantly inhibit the diffusion of lithium polysulfides in the electrolyte, leading to high capacity retention and high coulombic efficiency.
摘要翻译：我们报道了一种杂原子掺杂的碳框架，它既用作锂硫阴极的导电网络和多硫化物固定剂。掺杂碳与元素硫和/或硫化合物形成化学键合。这可以显着抑制锂多硫化物在电解液中的扩散，导致高容量保留和高库仑效率。

137. 发明授权

US09140767B2 Isotropic metamaterial lens for magnetic imaging applications 有权
标题翻译：用于磁性成像应用的各向异性超材料透镜
公开(公告)号：US09140767B2
公开(公告)日：2015-09-22
申请号：US13462384
申请日：2012-05-02
申请人： Douglas H. Werner , Clara R. Baleine
发明人： Douglas H. Werner , Clara R. Baleine
IPC分类号： G01R33/36 , G01N24/08 , G01R33/30 , G01R33/44
CPC分类号： G01R33/36 , G01N24/084 , G01R33/302 , G01R33/441
摘要： Examples of the present invention include metamaterial lenses that allow enhanced resolution imaging, for example in MRI apparatus. An example metamaterial may be configured to have μ=−1 along three orthogonal axes. Superior performance was demonstrated using such improved designs, and in some examples, imaging resolution better than λ/500 was obtained. The use of one or more lumped reactive elements in a unit cell, such as one or more lumped capacitors and/or one or more lumped inductors, allowed unit cell dimensions and hence resolution to be dramatically enhanced. In some examples, a cubic unit cell was used with an essentially isotropic magnetic permeability of μ=−1 obtained at an operating electromagnetic frequency and wavelength (λ).
摘要翻译：本发明的实例包括允许增强分辨率成像的超材料透镜，例如在MRI装置中。示例超材料可以被配置为沿着三个正交轴具有μ= -1。使用这种改进的设计证明了优异的性能，并且在一些示例中，获得比λ/ 500更好的成像分辨率。在诸如一个或多个集总电容器和/或一个或多个集总电感器之类的单元电池中使用一个或多个集总无功元件允许单元电池尺寸和因此分辨率被显着提高。在一些实例中，使用在工作电磁频率和波长（λ）下获得的基本上各向同性磁导率μ= -1的立方晶胞。

138. 发明授权

US09109057B2 Methods and materials for hydrocarbon recovery 有权
标题翻译：烃回收方法和材料
公开(公告)号：US09109057B2
公开(公告)日：2015-08-18
申请号：US13213736
申请日：2011-08-19
申请人： Tze Chiang Chung , Xue Pei Yuan
发明人： Tze Chiang Chung , Xue Pei Yuan
IPC分类号： C08F10/00 , C09K3/32 , C02F1/28 , C02F1/68 , C08F210/14 , C08F210/16
CPC分类号： C09K3/32 , B01J20/267 , C02F1/285 , C02F1/681 , C02F2101/32 , C02F2103/007 , C02F2303/16 , C08F10/00 , C08F210/14 , C08F210/16 , C08F212/08 , Y02W10/37 , C08F212/36 , C08F2500/03 , C08F236/20
摘要： Crosslinked polyolefins for use in recovering or containing hydrocarbons such as hydrocarbons contained in oil, are disclosed. Advantageously, the crosslinked polyolefins absorb the hydrocarbon to form a gel that can be collected and processed by heat to release the collected hydrocarbons.
摘要翻译：公开了用于回收或包含烃如烃中所含烃的交联聚烯烃。有利地，交联的聚烯烃吸收烃以形成可以通过热量收集和加工以释放所收集的烃的凝胶。

139. 发明授权

US09107947B2 Anti-cancer compositions and methods 有权
标题翻译：抗癌成分和方法
公开(公告)号：US09107947B2
公开(公告)日：2015-08-18
申请号：US14169639
申请日：2014-01-31
申请人： The Penn State Research Foundation
发明人： Gavin P. Robertson , Chandagalu D. Raghavendra Gowda , Dhimant H. Desai , Shantu G. Amin
IPC分类号： A61K9/127 , C07D231/10 , A61K45/06 , A61K31/415 , A61K31/095 , C07D231/42
CPC分类号： A61K31/415 , A61K9/0014 , A61K9/127 , A61K9/1271 , A61K31/095 , A61K38/063 , A61K45/06 , C07D231/10 , C07D231/12 , C07D231/42 , A61K2300/00
摘要： Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject having or suspected of having cancer are provided according to aspects of the present invention which include administering a therapeutically effective amount of a pharmaceutical composition including a selenium-containing COX-2 inhibitor.
摘要翻译：根据本发明的方面提供了包含一种或多种含硒COX-2抑制剂的组合物和药物组合物。根据本发明的方面提供了治疗患有或怀疑患有癌症的受试者的方法，其包括施用治疗有效量的包含含硒COX-2抑制剂的药物组合物。

140. 发明授权

US09095840B2 Nitrogen-containing activated carbon material 有权
标题翻译：含氮活性炭材料
公开(公告)号：US09095840B2
公开(公告)日：2015-08-04
申请号：US13733770
申请日：2013-01-03
申请人： The Penn State Research Foundation
发明人： Frederick Scott Cannon , Nicole Robitaille Brown , Timothy M. Byrne , Pin Hou , Robert Parette , Xin Gu , Colin C. Cash , Cesar Nieto Delgado , Siqi Hong
IPC分类号： B01J20/28 , C02F1/28 , B01J20/20 , B01J20/32 , C02F101/10 , C02F101/12 , C02F101/16 , C02F101/22 , C02F101/30 , C02F103/06
CPC分类号： B01J20/28011 , B01J20/20 , B01J20/3204 , B01J20/3248 , C02F1/281 , C02F1/283 , C02F2101/101 , C02F2101/103 , C02F2101/12 , C02F2101/163 , C02F2101/22 , C02F2101/30 , C02F2103/06 , Y10T428/2982
摘要： An activated carbon material for removing a contaminant from a liquid. The activated carbon material can be a plurality carbon grains that have a pore volume of approximately 0.1 milliliters per gram (mL/g) in the range of less than about 15 angstroms in width. The carbon grains can also have or contain a nitrogen-containing species having a concentration of more than 2 atomic percent nitrogen. A plurality of the carbon grains can be used to make a contactor that is operable to remove or reduce perchlorate having a concentration of 20 parts per billion (ppb) to less than 4 ppb from 4,500 bed volumes of water with the nitrogen-containing species leaching off of the carbon grains less than 0.1 mg/L. The activated carbon material can also be electrochemically regenerated.
摘要翻译：用于从液体中除去污染物的活性炭材料。活性炭材料可以是在小于约15埃的范围内具有约0.1毫升/克（mL / g）的孔体积的多个碳颗粒。碳颗粒也可以含有或含有浓度大于2原子％氮的含氮物质。可以使用多个碳颗粒来制造接触器，该接触器可操作以从具有含氮物质浸出的4,500床体积的水中除去或降低浓度为20ppm（ppb）至小于4ppb的高氯酸盐碳颗粒的含量小于0.1mg / L。活性炭材料也可以电化学再生。

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