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    • 140. 发明授权
    • Spectrophotometric identification of microbe subspecies
    • 分光光度法鉴定微生物亚种
    • US08237107B2
    • 2012-08-07
    • US12834504
    • 2010-07-12
    • Thomas MaierMarkus Kostrzewa
    • Thomas MaierMarkus Kostrzewa
    • B01D59/44H01J49/00
    • G01N33/6848C12Q1/04G01N2560/00G06F19/24
    • A dual-stage method is provided for identifying a microbe by, for example, its species or its subspecies. The method includes measuring a mass spectrum of the microbe using a mass spectrometer, calculating indicators for similarities between reference mass spectra in a library and the measured mass spectrum, selecting a group of reference mass spectra similar to the measured mass spectrum, determining a distinguishing weight for each mass signal of the reference mass spectra in the group, where the distinguishing weights emphasize differences between the reference mass spectra in the group, and calculating indicators for similarities between the reference mass spectra in the group and the measured mass spectrum as a function of the distinguishing weights.
    • 提供了用于通过例如其物种或其亚种鉴定微生物的双阶段方法。 该方法包括使用质谱仪测量微生物的质谱,计算文库中参考质谱与测量质谱之间的相似性的指标,选择与测得的质谱相似的一组参考质谱,确定鉴别重量 对于组中参考质谱的每个质量信号,其中区分权重强调组中参考质谱之间的差异,并且计算组中参考质谱与测量质谱之间的相似性的指标,作为 区别权重。