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131. 发明申请

US20050119227A1 Cyclic amine bace-1 inhibitors having a benzamide substituent 有权
标题翻译：具有苯甲酰胺取代基的环胺类Bace-1抑制剂
公开(公告)号：US20050119227A1
公开(公告)日：2005-06-02
申请号：US10910987
申请日：2004-08-04
申请人： Jared Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas Hobbs , Thuy Le , Jeffrey Lowrie , Kurt Saionz , Suresh Babu
发明人： Jared Cumming , Ulrich Iserloh , Andrew Stamford , Corey Strickland , Johannes Voigt , Yusheng Wu , Ying Huang , Yan Xia , Samuel Chackalamannil , Tao Guo , Douglas Hobbs , Thuy Le , Jeffrey Lowrie , Kurt Saionz , Suresh Babu
IPC分类号： A61K31/55 , A61K31/553 , A61K31/554 , A61K31/675 , C07D207/09 , C07D211/26 , C07D217/18 , C07D241/04 , C07D243/08 , C07D401/06 , C07D403/12 , C07D403/14 , C07D413/06 , C07F9/38
CPC分类号： C07D243/08 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/26 , C07D209/52 , C07D211/26 , C07D211/46 , C07D217/18 , C07D233/32 , C07D241/04 , C07D241/08 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/06 , C07D409/12 , C07D413/06
摘要： Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is R is —C(O)—N(R27)(R28) or and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of treating cognitive or neurodegenerative diseases such as Alzheimer's disease. Also disclosed are pharmaceutical compositions and methods of treating cognitive or neurodegenerative diseases comprising the compounds of formula I in combination with a β-secretase inhibitor other than those of formula I, an HMG-CoA reductase inhibitor, a gamma-secretase inhibitor, a non-steroidal anti-inflammatory agent, an N-methyl-D-aspartate receptor antagonist, a cholinesterase inhibitor or an anti-amyloid antibody.
摘要翻译：公开了下式的化合物或其药学上可接受的盐或溶剂化物，其中R 1是R是-C（O）-N（R 27） > 28 ）或其余变量如说明书中所定义。还公开了包含式I化合物的药物组合物。还公开了治疗认知或神经变性疾病如阿尔茨海默病的方法。还公开了治疗认知或神经变性疾病的药物组合物和方法，其包含式I化合物与除式I以外的β-分泌酶抑制剂，HMG-CoA还原酶抑制剂，γ-分泌酶抑制剂，甾族抗炎剂，N-甲基-D-天冬氨酸受体拮抗剂，胆碱酯酶抑制剂或抗淀粉样蛋白抗体。

132. 发明申请

US20050108022A1 System and mechanism to create autonomic business process solutions 审中-公开
标题翻译：系统和机制创建自主业务流程解决方案
公开(公告)号：US20050108022A1
公开(公告)日：2005-05-19
申请号：US10706040
申请日：2003-11-13
申请人： Kamal Bhattacharya , Ying Huang , Jun-Jang Jeng , Shubir Kapoor , Santhosh Kumaran , Yingjie Li , Anil Nigam , Frederick Wu , Liangzhao Zeng
发明人： Kamal Bhattacharya , Ying Huang , Jun-Jang Jeng , Shubir Kapoor , Santhosh Kumaran , Yingjie Li , Anil Nigam , Frederick Wu , Liangzhao Zeng
IPC分类号： G06Q10/00 , G06F17/60
CPC分类号： G06Q10/06 , G06Q10/06375
摘要： Automomic business processes management solutions have capabilities to adapt themselves to changes in the business environment. These autonomic business solutions are built by wiring together autonomic solution components called BPbots (Business Process robots). BPbots are granular solution components representing an aspect of a business process. In general, BPbots consist of two parts, an execution module and a managerial module. The execution module represents the standard, non-autonomic solution component, such as a standard process flow model describing the long-running flow or business adapter describing the communication of the solution with service providers (such as applications). The managerial module is responsible for the autonomic behavior of the BPbot. The managerial component has the ability to monitor the execution module, analyze the performance, plan new, more appropriate execution patterns and change the behavior of the execution module according to the new plan.
摘要翻译：自动化业务流程管理解决方案具有适应业务环境变化的能力。这些自主业务解决方案是通过将称为BPbots（业务流程机器人）的自主解决方案组件连接在一起构建的。 BPbots是代表业务流程方面的细粒度的解决方案组件。一般来说，BPbots由两部分组成，一个执行模块和一个管理模块。执行模块表示标准的非自主性解决方案组件，例如描述长时间运行的流程或描述与服务提供商（例如应用程序）的解决方案通信的业务适配器的标准流程模型。管理模块负责BPbot的自主行为。管理组件能够监视执行模块，分析性能，计划新的更合适的执行模式，并根据新计划改变执行模块的行为。

133. 发明申请

US20050038100A1 Substituted urea neuropeptide Y Y5 receptor antagonists 审中-公开
标题翻译：取代的尿素神经肽Y Y5受体拮抗剂
公开(公告)号：US20050038100A1
公开(公告)日：2005-02-17
申请号：US10933016
申请日：2004-09-01
申请人： William Greenlee , Ying Huang , Joseph Kelly , Stuart McCombie , Andrew Stamford , Yusheng Wu
发明人： William Greenlee , Ying Huang , Joseph Kelly , Stuart McCombie , Andrew Stamford , Yusheng Wu
IPC分类号： C07C275/30 , C07C311/07 , C07D211/58 , C07D211/96 , C07D401/04 , C07D401/06 , C07D409/12 , C07D409/14 , C07D417/04 , A61K31/40 , A61K31/17 , C07D207/46
CPC分类号： C07D401/04 , C07C275/30 , C07C311/07 , C07C2601/14 , C07D211/58 , C07D211/96 , C07D401/06 , C07D409/12 , C07D409/14 , C07D417/04
摘要： A novel class of compounds such as antagonists of the neuropeptide Y Y5 receptor, methods of making such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration of one or more diseases associated with the neuropeptide Y Y5 receptor are disclosed.
摘要翻译：一类新颖的化合物，例如神经肽Y Y5受体的拮抗剂，制备此类化合物的方法，含有一种或多种这类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及治疗，预防或改善方法公开了与神经肽Y Y5受体相关的一种或多种疾病。

134. 发明申请

US20050031076A1 Remote baggage screening method 审中-公开
标题翻译：远程行李筛选方法
公开(公告)号：US20050031076A1
公开(公告)日：2005-02-10
申请号：US10929917
申请日：2004-08-30
申请人： Keith McClelland , Craig Dawson , Ying Huang , Andrea Whitson
发明人： Keith McClelland , Craig Dawson , Ying Huang , Andrea Whitson
IPC分类号： B64F1/36 , G01V5/00 , H04L29/06 , H04L29/08 , G01N23/04
CPC分类号： G01V5/0083 , B64F1/368 , G06Q10/02 , H04L29/06 , H04L67/02 , H04L67/12 , H04L69/329
摘要： A method of advance baggage screening includes steps of transmitting a threat file corresponding to an item under inspection to a processing center, analyzing the threat file according to a detection algorithm at the processing center to determine a screening result for the item under inspection, and transmitting the screening result to a remotely located operator interface for access by an operator.
摘要翻译：一种提前行李检查方法包括将与被检查项目相对应的威胁文件传送到处理中心的步骤，根据处理中心的检测算法对威胁文件进行分析，以确定被检查项目的筛选结果，以及发送筛选结果到远程位置的操作员界面以供操作员访问。

135. 发明授权

US06707879B2 Remote baggage screening system, software and method 有权
标题翻译：远程行李检查系统，软件和方法
公开(公告)号：US06707879B2
公开(公告)日：2004-03-16
申请号：US10116714
申请日：2002-04-03
申请人： Keith M. McClelland , Craig Dawson , Ying Huang , Andrea L. Whitson
发明人： Keith M. McClelland , Craig Dawson , Ying Huang , Andrea L. Whitson
IPC分类号： G01N2304
CPC分类号： G01V5/0083 , B64F1/368 , G06Q10/02 , H04L29/06 , H04L67/02 , H04L67/12 , H04L69/329
摘要： A system for remote inspection of items including at least one inspection machine constructed to examine an item under inspection to obtain information about the item, a database coupled to the at least one inspection machine that receives and stores the information about the item in an item file, the item including a unique item identifier, and an item file inspection device that receives the item file, analyzes data contained in the item file and records screening information based on an analysis of the item file. The system also includes a server that controls transfer of the item file and the screening information between the database and the item file inspection device. The screening information is linked with the item file using the unique item identifier. The item file inspection device is located remote from the at least one inspection machine.
摘要翻译：一种用于远程检查物品的系统，所述系统包括至少一个检查机构，所述检查机构被构造成检查被检查的物品以获取有关物品的信息;数据库，耦合到所述至少一个检验机器，所述数据库接收并存储关于所述物品的信息在物品文件，所述项目包括唯一的项目标识符，以及项目文件检查装置，其接收所述项目文件，分析所述项目文件中包含的数据，并且基于所述项目文件的分析来记录筛选信息。该系统还包括一个控制项目文件的传送和数据库与项目文件检查装置之间的筛选信息的服务器。筛选信息使用唯一的项目标识符与项目文件链接。所述物品文件检查装置位于远离所述至少一个检查机器的位置。

136. 发明授权

US06667319B2 Neuropeptide Y Y5 receptor antagonists 失效
标题翻译：神经肽Y Y5受体拮抗剂
公开(公告)号：US06667319B2
公开(公告)日：2003-12-23
申请号：US10202239
申请日：2002-07-24
申请人： Andrew W. Stamford , Ying Huang , Guoqing Li
发明人： Andrew W. Stamford , Ying Huang , Guoqing Li
IPC分类号： A61K314468
CPC分类号： C07D409/14 , C07D211/58 , C07D211/96 , C07D401/12 , C07D401/14
摘要： The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
摘要翻译：本发明公开了作为NPY Y5的新型受体拮抗剂的化合物及其制备方法。在另一个实施方案中，本发明公开了包含这种NPY Y5受体拮抗剂的药物组合物以及使用它们治疗肥胖，代谢紊乱，进食障碍如食欲过盛和糖尿病的方法。

137. 发明授权

US06632828B2 Substituted imidazole neuropeptide Y Y5 receptor antagonists 失效
标题翻译：取代咪唑神经肽Y Y5受体拮抗剂
公开(公告)号：US06632828B2
公开(公告)日：2003-10-14
申请号：US10200966
申请日：2002-07-23
申请人： Andrew W. Stamford , Craig D. Boyle , Ying Huang
发明人： Andrew W. Stamford , Craig D. Boyle , Ying Huang
IPC分类号： A61K314545
CPC分类号： C07D233/64 , C07D233/88 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： Compounds of the formula I or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is ═CH— or ═N—; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, —S-alkyl, or —CN. R is alkyl, —CF3, cycloalkyl, heterocycloalkyl, heterocycloalkyl-alkyl, heteroarylalky or adamantyl, or optionally substituted phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl, thiazolyl, pyrazinyl, 1,2,5,6-tetrahydropyridine or wherein R10 and R11 are hydrogen, alkyl or together form a cycloalkyl, are disclosed, as well as pharmaceutical compositions and methods of using said compounds in the treatment of eating disorders and diabetes.
摘要翻译：式I化合物或其药学上可接受的盐，溶剂化物或N-氧化物，其中X为= CH-或= N-; Y为H，卤素，三卤代烷基，烷基，烯基，环烷基，环烷基，SH，-S-烷基或-CN。R是烷基，-CF 3，环烷基，杂环烷基，杂环烷基 - 烷基，杂芳基烷基或金刚烷基，或任选取代的苯基，苯氧基烷基，苯硫基烷基，吡啶基，噻吩基，噻唑基，吡嗪基，1,2,5,6-四氢吡啶，或其中R“H”> 10 SP> 是氢，烷基或一起形成环烷基，以及使用所述化合物治疗进食障碍和糖尿病的药物组合物和方法。

138. 发明授权

US06531407B1 Method, structure and process flow to reduce line-line capacitance with low-K material 有权
标题翻译：方法，结构和工艺流程，以低K材料降低线路电容
公开(公告)号：US06531407B1
公开(公告)日：2003-03-11
申请号：US09653153
申请日：2000-08-31
申请人： Ying Huang , Er-Xuan Ping
发明人： Ying Huang , Er-Xuan Ping
IPC分类号： H01L2131
CPC分类号： H01L21/76844 , H01L21/76832 , H01L21/76834 , H01L21/76837 , H01L21/76852 , H01L21/76885 , H01L23/5222 , H01L23/5329 , H01L2924/0002 , H01L2924/00
摘要： An improved method, structure and process flow for reducing line-line capacitance using low dielectric constant (K) materials is provided. Embodiments in accordance with the present invention form structures for semiconductor devices having a single level of interconnection as well as semiconductor devices having multiple levels of interconnection. In embodiments of the present invention, an initial dielectric structure is formed having a first low-K material overlaid with a standard-K material. In subsequent processing, conductive interconnects are formed and the standard-K material replaced with a second low-K material. In some embodiments of the present invention, the first and-second low-K materials are the same material, in some embodiments the first and second low-K materials are different materials. Embodiments of the present invention having multiple levels of conductive interconnects are formed by employing methods and materials analogous to those used to form the first level of conductive interconnect and dielectric material disposed there between. Embodiments of the present invention employ low-K materials formed by spin-on processes as well as low-K materials formed by CVD processes.
摘要翻译：提供了使用低介电常数（K）材料降低线路电容的改进方法，结构和工艺流程。根据本发明的实施例形成具有单级互连的半导体器件的结构以及具有多个互连级别的半导体器件。在本发明的实施例中，形成具有覆盖有标准K材料的第一低K材料的初始电介质结构。在随后的处理中，形成导电互连，并用第二低K材料代替标准K材料。在本发明的一些实施方案中，第一和第二低K材料是相同的材料，在一些实施方案中，第一和第二低K材料是不同的材料。具有多层导电互连的本发明的实施例通过采用类似于用于形成第一级导电布线和介于其之间的介电材料的方法和材料而形成。本发明的实施例采用通过旋涂工艺形成的低K材料以及通过CVD工艺形成的低K材料。

139. 发明授权

US06287832B1 Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation 有权
$Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation$
标题翻译：使用广义介电电泳和场流分馏法进行分馏的方法和装置
公开(公告)号：US06287832B1
公开(公告)日：2001-09-11
申请号：US09395890
申请日：1999-09-14
申请人： Frederick F. Becker , Peter R. C. Gascoyne , Ying Huang , Xiao-Bo Wang
发明人： Frederick F. Becker , Peter R. C. Gascoyne , Ying Huang , Xiao-Bo Wang
IPC分类号： C12N1300
CPC分类号： G01N30/0005 , B03C5/028 , G01N2030/0035 , G01N2030/0065
摘要： The present disclosure is directed to a novel apparatus and novel methods for the separation, characterization, and manipulation of matter. In particular, the invention combines the use of frequency-dependent dielectric and conductive properties of particulate matter and solubilized matter with the properties of the suspending and transporting medium to discriminate and separate such matter. The apparatus includes a chamber having at least one electrode element and at least one inlet and one output port into which cells are introduced and removed from the chamber. Matter carried through the chamber in a fluid stream is then displaced within the fluid by a dielectrophoretic (DEP) force caused by the energized electrode. Following displacement within the fluid, matter travels through the chamber at velocities according to the velocity profile of the chamber. After the matter has transmitted through the chamber, it exits at the opposite end of the chamber at a characteristic position. Methods according to the invention involve using the apparatus for discriminating and separating matter for research, diagnosis of a condition, and therapeutic purposes. Examples of such methods may include separation of mixtures of cells, such as cancer cells from normal cells, separation of parasitized erythrocytes from normal erythrocytes, separation of nucleic acids, and others.
摘要翻译：本公开涉及用于分离，表征和操纵物质的新型装置和新颖方法。特别地，本发明结合了使用频率依赖的电介质和颗粒物质和溶解物质的导电性质与悬浮和输送介质的性质，以区分和分离这种物质。该装置包括具有至少一个电极元件和至少一个入口和一个输出端口的腔室，细胞从腔室中被引入和移出。然后通过流体流中的腔室进行的物质由通电电极引起的介电电泳（DEP）力在流体内移动。在流体内移动之后，物质按照腔室的速度分布以速度行进通过腔室。在事件已经通过室之后，其在特定位置处在室的相对端处离开。根据本发明的方法涉及使用该装置来鉴别和分离用于研究，病症诊断和治疗目的的物质。这些方法的实例可以包括分离细胞混合物，例如来自正常细胞的癌细胞，从正常红细胞分离寄生的红细胞，分离核酸等。

140. 发明授权

US5554702A Coated polycarbonate and method for making the same 失效
标题翻译：涂布聚碳酸酯及其制造方法
公开(公告)号：US5554702A
公开(公告)日：1996-09-10
申请号：US351765
申请日：1994-12-08
申请人： James P. Bell , Ying Huang , Yunchao Yu
发明人： James P. Bell , Ying Huang , Yunchao Yu
IPC分类号： C08G64/42 , C08J7/04 , C08G64/14
CPC分类号： C08J7/04 , C08G64/42 , C08J2369/00 , Y10T428/31507
摘要： A polymeric coupling agent for chemically linking a scratch resistant coating composition to a polycarbonate substrate is disclosed. The agent is a product of the reaction between polycarbonate and 3-glycidoxypropyltrimethoxysilane (GPS) in the presence of a quaternary ammonium salt. The reaction in the solid state produces a GPS-modified polycarbonate having a bimodal molecular weight distribution which is effective in promoting the adhesion of a scratch resistant coating to a polycarbonate substrate.
摘要翻译：公开了一种用于将耐刮擦涂料组合物与聚碳酸酯基材化学连接的聚合偶联剂。该试剂是在季铵盐存在下聚碳酸酯和3-缩水甘油氧基丙基三甲氧基硅烷（GPS）之间的反应产物。固态反应产生具有双峰分子量分布的GPS改性聚碳酸酯，其有效促进耐刮涂层与聚碳酸酯基材的粘合。

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