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131. 发明申请

US20080032367A1 PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF 有权
公开(公告)号：US20080032367A1
公开(公告)日：2008-02-07
申请号：US11781871
申请日：2007-07-23
申请人： Craig Weaver , Ross Zirkle , James Metz
发明人： Craig Weaver , Ross Zirkle , James Metz
IPC分类号： C12P7/64 , C12N1/20 , C12N15/00 , C12N15/11 , C12N5/04
CPC分类号： C12P7/6472 , C07K14/195 , C12N9/001 , C12N9/1029 , C12N15/52 , C12N15/8247 , C12P7/62 , C12P7/6427
摘要： Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

132. 发明申请

US20080032366A1 Enhanced Production of Lipids Containing Polyenoic Fatty Acid by Very High Density Cultures of Eukaryotic Microbes in Fermentors 有权
公开(公告)号：US20080032366A1
公开(公告)日：2008-02-07
申请号：US11745533
申请日：2007-05-08
申请人： Richard Bailey , Don DiMasi , Jon Hansen , Peter Mirrasoul , Craig Ruecker , George Veeder , Tatsuo Kaneko , William Barclay
发明人： Richard Bailey , Don DiMasi , Jon Hansen , Peter Mirrasoul , Craig Ruecker , George Veeder , Tatsuo Kaneko , William Barclay
IPC分类号： C12P7/64 , C12N1/38
CPC分类号： A23K50/80 , A23D9/00 , A23K20/158 , A23L29/065 , A23V2002/00 , C11B1/10 , C12N1/00 , C12N1/12 , C12P7/6409 , C12P7/6427 , C12P7/6472 , Y10S435/911
摘要： The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.

133. 发明申请

US20080032365A1 Enhanced Production of Lipids Containing Polyenoic Fatty Acid by Very High Density Cultures of Eukaryotic Microbes in Fermentors 有权
公开(公告)号：US20080032365A1
公开(公告)日：2008-02-07
申请号：US11745526
申请日：2007-05-08
申请人： Richard Bailey , Don DiMasi , Jon Hansen , Peter Mirrasoul , Craig Ruecker , George Veeder , Tatsuo Kaneko , William Barclay
发明人： Richard Bailey , Don DiMasi , Jon Hansen , Peter Mirrasoul , Craig Ruecker , George Veeder , Tatsuo Kaneko , William Barclay
IPC分类号： C12P7/64
CPC分类号： A23K50/80 , A23D9/00 , A23K20/158 , A23L29/065 , A23V2002/00 , C11B1/10 , C12N1/00 , C12N1/12 , C12P7/6409 , C12P7/6427 , C12P7/6472 , Y10S435/911
摘要： The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.

134. 发明申请

US20080032360A1 Enhanced Production of Lipids Containing Polyenoic Fatty Acid by Very High Density Cultures of Eukaryotic Microbes in Fermentors 有权
标题翻译：通过发酵罐中真核微生物的非常高密度培养物增强生产含有多烯酸脂肪酸的脂质
公开(公告)号：US20080032360A1
公开(公告)日：2008-02-07
申请号：US11745490
申请日：2007-05-08
申请人： Richard Bailey , Don DiMasi , John Hansen , Peter Mirrasoul , Craig Ruecker , George Veeder , Tatsuo Kaneko , William Barclay
发明人： Richard Bailey , Don DiMasi , John Hansen , Peter Mirrasoul , Craig Ruecker , George Veeder , Tatsuo Kaneko , William Barclay
IPC分类号： C12P7/64
CPC分类号： A23K50/80 , A23D9/00 , A23K20/158 , A23L29/065 , A23V2002/00 , C11B1/10 , C12N1/00 , C12N1/12 , C12P7/6409 , C12P7/6427 , C12P7/6472 , Y10S435/911
摘要： The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
摘要翻译：本发明提供了一种生长真核微生物的方法，其能够产生脂质，特别是含有多烯脂肪酸的脂质。本发明还提供了一种生产真核微生物脂质的方法。

135. 发明申请

US20080032358A1 Production of DHA in Microalgae in Low pH Medium 审中-公开
公开(公告)号：US20080032358A1
公开(公告)日：2008-02-07
申请号：US11738429
申请日：2007-04-20
申请人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
IPC分类号： C12P7/64 , C12N1/12
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.

136. 发明申请

US20080032357A1 Production of DHA in Microalgae in Low pH Medium 有权
公开(公告)号：US20080032357A1
公开(公告)日：2008-02-07
申请号：US11738425
申请日：2007-04-20
申请人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
IPC分类号： C12P7/64 , C12N1/12
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.

137. 发明申请

US20080032352A1 Production of DHA in Microalgae in Low pH Medium 审中-公开
公开(公告)号：US20080032352A1
公开(公告)日：2008-02-07
申请号：US11738410
申请日：2007-04-20
申请人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
发明人： Paul Behrens , John Thompson , Kirk Apt , Joseph Pfeifer , James Wynn , James Lippmeier , Jaouad Fichtali , Jon Hansen
IPC分类号： C12P7/64 , C12N1/12
CPC分类号： C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
摘要： Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.

138. 发明申请

US20080026108A1 Encapsulated Labile Compound Compositions and Methods of Making the Same 有权
标题翻译：封装的不定期复合组合物及其制备方法
公开(公告)号：US20080026108A1
公开(公告)日：2008-01-31
申请号：US11767366
申请日：2007-06-22
申请人： Srinivasan Subramanian , Brian Connolly , William Hendrickson
发明人： Srinivasan Subramanian , Brian Connolly , William Hendrickson
IPC分类号： A23L1/00 , A23L1/27 , A23L1/302
CPC分类号： A23K20/20 , A23K20/142 , A23K20/158 , A23K20/174 , A23K20/179 , A23K20/184 , A23K40/25 , A23K40/30 , A23L27/72 , A23L33/12 , A23L33/135 , A23L33/15 , A23L33/16 , A23L33/175
摘要： Products comprising labile compounds, such as polyunsaturated fatty acids, and having first and second encapsulants are disclosed. A first encapsulant can be a spray dried coating and the second encapsulant can be a prill coating. Methods of making the same are provided.
摘要翻译：公开了包含不稳定化合物的产品，例如多不饱和脂肪酸，并且具有第一和第二密封剂。第一密封剂可以是喷雾干燥的涂层，第二密封剂可以是颗粒涂层。提供了制备方法。

139. 发明申请

US20070270494A1 POLYUNSATURATED FATTY ACID PRODUCTION IN HETEROLOGOUS ORGANISMS USING PUFA POLYKETIDE SYNTHASE SYSTEMS 有权
标题翻译：使用多不饱和脂多糖合成酶系统进行异构体生物聚合脂肪酸生产
公开(公告)号：US20070270494A1
公开(公告)日：2007-11-22
申请号：US11686856
申请日：2007-03-15
申请人： James Metz , Jerry Kuner , James Lippmeier
发明人： James Metz , Jerry Kuner , James Lippmeier
IPC分类号： A61K31/20 , A01H5/00 , C07H21/00 , C12N1/00 , C12N15/82 , C12N9/00 , C12N5/10 , C12N15/74 , C11B11/00 , A23D7/00
CPC分类号： C12N9/1029 , C12N9/93 , C12N15/8247 , C12P7/6427 , C12P7/6472 , Y02P20/52
摘要： Disclosed are novel acyl-CoA synthetases and novel acyltransferases, nucleic acid molecules encoding the same, recombinant nucleic acid molecules and recombinant host cells comprising such nucleic acid molecules, genetically modified organisms (microorganisms and plants) comprising the same, and methods of making and using the same. Also disclosed are genetically modified organisms (e.g., plants, microorganisms) that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system or PUFA synthase), wherein the organisms have been modified to express an acyl-CoA synthetase, to express an acyl transferase, to delete or inactivate a fatty acid synthase (FAS) expressed by the organism, to reduce competition for malonyl CoA with the PUFA synthase or to increase the level of malonyl CoA in the organism, and in one aspect, to inhibit KASII or KASIII. Additional modifications, and methods to make and use such organisms, in addition to PUFAs and oils obtained from such organisms, are disclosed, alone with various products including such PUFAs and oils.
摘要翻译：公开了新型酰基辅酶A合成酶和新型酰基转移酶，编码该酰基转移酶的核酸分子，重组核酸分子和包含该核酸分子的重组宿主细胞，包含该核酸分子的转基因生物（微生物和植物），以及制备和使用一样。还公开了经遗传修饰以表达用于生产PUFA（PUFA PKS系统或PUFA合酶）的PKS样系统的遗传修饰生物体（例如，植物，微生物），其中生物体被修饰以表达酰基 -CoA合成酶，以表达酰基转移酶，以删除或失活由生物体表达的脂肪酸合酶（FAS），以减少与PUFA合酶的丙二酰辅酶A竞争或增加生物体中丙二酰辅酶A的水平，以及一方面抑制KASII或KASIII。除了PUFA和从这些生物获得的油之外，还公开了另外的修饰和制造和使用这些生物体的方法，其中包括各种产品，包括这种PUFA和油。

140. 发明申请

US20070244192A1 PLANT SEED OILS CONTAINING POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译：含有多种脂肪酸的植物种子油
公开(公告)号：US20070244192A1
公开(公告)日：2007-10-18
申请号：US11686866
申请日：2007-03-15
申请人： James Metz
发明人： James Metz
IPC分类号： A01H5/10 , A01H5/00 , A23D9/00 , A61K31/202
CPC分类号： C12N15/8247 , A23D9/00
摘要： Disclosed are plants that have been genetically modified to express a PKS-like system for the production of PUFAs (a PUFA PKS system), wherein oils produced by the plant contain at least one PUFA produced by the PUFA PKS system and are free of the mixed shorter-chain and less unsaturated PUFAs that are fatty acid products produced by the modification of products of the FAS system in standard fatty acid pathways. Also disclosed are the oil seeds, oils, and products comprising such oils produced by this system, as well as methods for producing such plants.
摘要翻译：公开了已被遗传修饰以表达用于生产PUFA（PUFA PKS系统）的PKS样系统的植物，其中由植物产生的油含有由PUFA PKS系统产生的至少一种PUFA，并且不含混合短链和不饱和PUFA是通过在标准脂肪酸途径中改性FAS系统的产物产生的脂肪酸产物。还公开了包含由该系统生产的这种油的油籽，油和产品，以及用于生产这种植物的方法。

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