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121. 发明授权

US5726312A Methods for preparing antiproliferative 5-substituted pyrimidone compounds 失效
标题翻译：制备抗增殖性5-取代嘧啶酮化合物的方法
公开(公告)号：US5726312A
公开(公告)日：1998-03-10
申请号：US449602
申请日：1995-05-24
申请人： Michael D. Varney , William H. Romines , Cynthia L. Palmer , Judith G. Deal
发明人： Michael D. Varney , William H. Romines , Cynthia L. Palmer , Judith G. Deal
IPC分类号： C07D239/60 , A61K31/505 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P33/02 , A61P33/10 , A61P37/06 , C07C67/343 , C07C69/78 , C07C323/56 , C07D239/49 , C07D239/56 , C07D409/12 , C07D239/48
CPC分类号： C07D239/56 , C07D409/12
摘要： Intermediates for preparing derivatives of 5-thia- and 5-selenopyrimidinone, ##STR1## which are useful as inhibitors of the enzymes glycinamide ribonucleotide formyl transferase (GARFT) and amino imidazole carboxamide ribonucleotide formyl transferase (AICARFT). The present invention is also directed to methods of preparing these intermediates.
摘要翻译：用于制备5-硫杂和5-硒代嘧啶酮衍生物的中间体，其可用作甘氨酰胺核糖核苷酸甲酰基转移酶（GARFT）和氨基咪唑甲酰胺核糖核苷酸甲酰转移酶（AICARFT）的抑制剂。本发明还涉及制备这些中间体的方法。

122. 发明授权

US5618839A Retinoid-like compounds 失效
标题翻译：类视黄醇样化合物
公开(公告)号：US5618839A
公开(公告)日：1997-04-08
申请号：US643142
申请日：1996-05-02
申请人： John E. Starrett, Jr. , Kuo-Long Yu , Muzammil M. Mansuri , David R. Tortolani , Peter R. Reczek
发明人： John E. Starrett, Jr. , Kuo-Long Yu , Muzammil M. Mansuri , David R. Tortolani , Peter R. Reczek
IPC分类号： A61K31/695 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/235 , A61K31/24 , A61K31/245 , A61K31/255 , A61P17/00 , A61P35/00 , A61P43/00 , C07C17/16 , C07C45/41 , C07C45/45 , C07C45/59 , C07C45/63 , C07C45/64 , C07C45/67 , C07C47/548 , C07C49/67 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/798 , C07C51/09 , C07C63/331 , C07C63/49 , C07C63/66 , C07C63/74 , C07C65/26 , C07C65/28 , C07C65/36 , C07C67/14 , C07C67/317 , C07C67/333 , C07C67/343 , C07C69/00 , C07C69/618 , C07C69/76 , C07C69/773 , C07C69/78 , C07C69/82 , C07C69/83 , C07C69/90 , C07C69/92 , C07C69/94 , C07C205/06 , C07C205/45 , C07C205/58 , C07C227/18 , C07C229/38 , C07C229/60 , C07C231/02 , C07C231/12 , C07C233/15 , C07C233/54 , C07C233/65 , C07C233/66 , C07C233/76 , C07C233/81 , C07C233/87 , C07C309/71 , C07C309/75 , C07C319/14 , C07C323/56 , C07C323/62 , C07C327/26 , C07C327/28 , C07C327/32 , C07C327/48 , C07F7/10 , A61K31/21 , A61K31/185 , C07C229/34
CPC分类号： C07C69/00 , C07C17/16 , C07C205/06 , C07C205/45 , C07C205/58 , C07C229/38 , C07C229/60 , C07C233/65 , C07C233/76 , C07C233/81 , C07C323/56 , C07C323/62 , C07C327/26 , C07C327/28 , C07C327/32 , C07C327/48 , C07C45/41 , C07C45/45 , C07C45/59 , C07C45/63 , C07C45/64 , C07C45/673 , C07C47/548 , C07C49/67 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/798 , C07C63/49 , C07C63/66 , C07C63/74 , C07C65/26 , C07C65/36 , C07C69/618 , C07C69/76 , C07C69/82 , C07C69/90 , C07C69/92 , C07C2102/08 , C07C2102/10 , C07C2103/00 , C07C2103/24 , Y10S514/825
摘要： The present invention relates to a compound of formula I ##STR1## or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in whichX is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --C.tbd.C--, --CH.sub.2 --NH--, --COCH.sub.2 --, --NHCS--, --CH.sub.2 S--, --CH.sub.2 O--, --OCH.sub.2 --, --NHCH.sub.2 -- or --CR.sup.5 .dbd.CR.sup.6 --;R.sup.m and R.sup.k are independently hydrogen, halogen, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkyloxy or nitro;n is zero or one;R.sup.4 is --(CH.sub.2).sub.t --Y, C.sub.1-6 alkyl, or C.sub.3-6 cycloalkyl;R.sup.1 is --CO.sub.2 Z, C.sub.1-6 alkyl, CH.sub.2 OH, --CONHR.sup.y, or CHO;R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1-6 alkyl;R.sup.a and R.sup.b are independently hydrogen or C.sub.1-6 alkyl; but when n is one, R.sup.a and R.sup.b together can form a radical of the formula ##STR2## Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C.sub.1-6 alkyl or halogen;Z is hydrogen or C.sub.1-6 alkyl;R.sup.5, R.sup.6 and R.sup.y are independently hydrogen or C.sub.1-6 alkyl; andt is zero to six.
摘要翻译：本发明涉及式I的化合物或其无毒的药学上可接受的盐，生理上可水解的酯或其溶剂合物，其中X是-O-CO-，-NH-CO-，-CS-NH-， -CO-O-，-CO-NH-，-COS-，-SCO-，-SCH 2 - ， - CH 2 -CH 2 - ， - C 3BOND C - ， - CH 2 -NH-，-COCH 2 - ， - NHCS-， -CH 2 S - ， - CH 2 O - ， - OCH 2 - ， - NHCH 2 - 或-CR 5 = CR 6 - ; R m和R k独立地是氢，卤素，C 1-6烷基，羟基，C 1-6烷氧基或硝基; n为零或一; R4是 - （CH2）t-Y，C1-6烷基或C3-6环烷基; R1是-CO2Z，C1-6烷基，CH2OH，-CONHRy或CHO; R2和R3独立地是氢或C1-6烷基; R a和R b独立地是氢或C 1-6烷基; 但是当n为1时，R a和R b可以一起形成下式的基团：Y是萘基或苯基，两个基团可任选地被一至三个相同或不同的C 1-6烷基或卤素取代; Z是氢或C 1-6烷基; R5，R6和Ry独立地是氢或C1-6烷基; t为0〜6。

123. 发明授权

US5550149A MDR reversal agents 失效
公开(公告)号：US5550149A
公开(公告)日：1996-08-27
申请号：US328643
申请日：1994-10-25
申请人： Dennis Powell , Rolf Paul , William A. Hallett , Dan M. Berger , Minu D. Dutia
发明人： Dennis Powell , Rolf Paul , William A. Hallett , Dan M. Berger , Minu D. Dutia
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/47 , A61K31/472 , A61K45/00 , A61P35/00 , A61P43/00 , C07C323/07 , C07C323/16 , C07C323/56 , C07C323/60 , C07D209/44 , C07D209/48 , C07D215/20 , C07D217/02 , C07D217/04 , C07D217/06 , C07D217/20 , C07D217/24 , C07D401/12 , C07D405/06 , C07D491/04 , C07D491/056 , C07D521/00 , C07F7/10 , C07F7/18
CPC分类号： C07D209/48 , C07C323/07 , C07C323/16 , C07C323/56 , C07C323/60 , C07D209/44 , C07D217/02 , C07D217/04 , C07D217/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D405/06 , C07D491/04 , C07F7/1856 , C07C2101/14
摘要： Compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are herein described, A is a straight or branched (C.sub.2 -C.sub.12)alkyl or a phenyl moiety and B is a moiety of the formula: ##STR2## The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.

124. 发明授权

US5473066A Process for preparing benzothiazepine derivatives 失效
标题翻译：制备苯并硫氮杂衍生物的方法
公开(公告)号：US5473066A
公开(公告)日：1995-12-05
申请号：US182828
申请日：1994-01-19
申请人： Teruo Yamamori , Hiroshi Harada , Eiichi Oosugi , Katsunori Sakai
发明人： Teruo Yamamori , Hiroshi Harada , Eiichi Oosugi , Katsunori Sakai
IPC分类号： B01J23/745 , B01J23/74 , C07B53/00 , C07B61/00 , C07C319/14 , C07C323/56 , C07D281/10 , C07D295/13 , C07B45/00 , C07D295/14
CPC分类号： C07D295/13 , C07C319/14 , C07C323/56 , C07D281/10
摘要： Process for stereoselectivity preparing a cis-form of 5-(aminoalkylamino)-1,5-benzothiazepine derivative represented by formula (VI): ##STR1## is provided, said process comprising carrying out a stereoselective addition reaction of an o-(aminoalkylamino) thiophenyl derivative with a trans-substituted glycidic ester at an elevated temperature in a nonpolar solvent in the presence of a divalent or trivalent iron ion to prepare a threo-form intermediate, hydrolyzing the ester group of said intermediate, acetylating the hydroxyl group of said hydrolyzed compound, and subjecting said acetylated compound to a ring closure reaction to obtain the objective compound (VI).
摘要翻译：（VI）表示的5-（氨基烷基氨基）-1,5-苯并硫氮杂衍生物的顺式形式的立体选择性方法：所述方法包括进行邻位反应的立体选择性加成反应，（氨基烷基氨基）噻吩基衍生物与反式取代的缩水甘油酯在升高的温度下在非极性溶剂中在二价或三价铁离子存在下反应以制备苏式中间体，水解所述中间体的酯基，乙酰化羟基的所述水解化合物，并使所述乙酰化合物进行闭环反应以获得目标化合物（VI）。

125. 发明授权

US5310746A Alpha-methylene-6-styryl-acrylic acid derivatives 失效
标题翻译： α-亚甲基-6-苯乙烯基 - 丙烯酸衍生物
公开(公告)号：US5310746A
公开(公告)日：1994-05-10
申请号：US981071
申请日：1992-11-24
申请人： Jean-Louis Brayer , Jean-Pierre Demoute , Yannick Le Stanc , Nicole Reinier
发明人： Jean-Louis Brayer , Jean-Pierre Demoute , Yannick Le Stanc , Nicole Reinier
IPC分类号： C07B61/00 , A01N37/36 , A01N43/78 , A01N43/82 , A01N43/836 , C07C67/343 , C07C69/734 , C07C69/738 , C07C317/44 , C07C323/56 , C07D271/06 , C07D277/22 , C07D277/30 , C07D417/04 , C07F9/40 , C07F9/653 , C07F9/6539 , C07F9/6558 , C07C69/618 , A01N37/10
CPC分类号： C07D271/06 , A01N37/36 , A01N43/78 , A01N43/82 , C07C69/734 , C07C69/738 , C07D277/30 , C07D417/04 , C07F9/4056 , C07F9/65318 , C07F9/6539 , C07F9/65583
摘要： All possible stereoisomer forms and mixtures of a compound of the formula ##STR1## wherein X is a halogen, R.sub.2 and R.sub.3 are individually selected from the group consisting of alkyl and cycloalkyl of up to 8 carbon atoms optionally substituted with at least one halogen, R.sub.1 is selected from the group consisting of alkyl, alkenyl, alkynyl and cycloalkyl of up to 12 carbon atoms optionally substituted with at least one halogen, aryl and heteroaryl of 5 to 6 ring members optionally substituted with at least one member of the group consisting of halogen, alkyl, alkenyl, alkynyl and cycloalkyl of up to 8 carbon atoms optionally substituted with at least one member of the group consisting of --NO.sub.2, --NH.sub.2, --CN, --OR', --SR", --SOR", --SO.sub.2 R", --NR"'.sub.2, --Ar, OAr.sub.1 and SAr.sub.2, R', R" and R"' are individually selected from the group consisting of alkyl, alkenyl, alkynyl and cycloalkyl of up to 12 carbon atoms optionally substituted by at least one halogen, Ar, Ar.sub.1 and Ar.sub.2 are aryl or heteroaryl of up to 14 carbon atoms optionally substituted with at least one member of the group consisting of halogen and alkyl, alkenyl, alkynyl and cycloalkyl of up to 8 carbon atoms optionally substituted by at least one member of the group consisting of halogen, --NO.sub.2, --NH.sub.2, --CN, --OR', --SR", --SOR", --SO.sub.2 R" and --NR"'.sub.2 and R', R" and R"' have the above definitions and their preparations and novel intermediates useful as pesticides.
摘要翻译：所有可能的立体异构体形式和式I化合物的混合物，其中X是卤素，R 2和R 3分别选自任选被至少一个卤素取代的至多8个碳原子的烷基和环烷基， R 1选自由至多12个碳原子的烷基，烯基，炔基和环烷基组成的组，其任选被至少一个5至6个环成员的卤素，芳基和杂芳基取代，任选被至少一个成员卤素，烷基，烯基，炔基和至多8个碳原子的环烷基，任选被至少一个由-NO 2，-NH 2，-CN，-OR'，-SR“，-SOR”， -SO 2 R“，-NR”'2，-Ar，OAr 1和SAr 2，R'，R“和R”'分别选自至多12个碳的烷基，烯基，炔基和环烷基任选被至少一个卤素取代的原子，Ar，Ar 1和Ar 2是至多1个的芳基或杂芳基 4个碳原子，任选被至少一个由卤素和至多8个碳原子的烷基，烯基，炔基和环烷基组成的组取代，任选被至少一个卤素，-NO 2，-NH 2， -CN，-OR'，-SR“，-SOR”，-SO 2 R“和-NR”'2和R'，R“和R”'具有上述定义及其制备和新型中间体作为农药有用

126. 发明授权

US5221760A Alkenoic acid derivatives 失效
标题翻译：烯酸衍生物
公开(公告)号：US5221760A
公开(公告)日：1993-06-22
申请号：US891629
申请日：1992-06-01
申请人： Ulrich Rosentreter , Harold C. Kluender , Trevor S. Abram , Peter Norman , Steven R. Tudhope
发明人： Ulrich Rosentreter , Harold C. Kluender , Trevor S. Abram , Peter Norman , Steven R. Tudhope
IPC分类号： C07C43/225 , C07C43/23 , C07C63/14 , C07C65/24 , C07C309/73 , C07C323/56 , C07F7/18 , C07F9/54
CPC分类号： C07F9/5456 , C07C309/73 , C07C323/56 , C07C43/225 , C07C43/23 , C07C63/14 , C07C65/24 , C07F7/1852 , C07F9/5407
摘要： An alkenoic acid derivative of the formula ##STR1## in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH.sub.2 --, or oxygen or a direct bond,W represents --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --,o represents a number 1 to 5,A and B are identical or different and represent carboxyl, carboxymethylene, tetrazolyl or tetrazolylmethylene, or --CO.sub.2 R.sup.9 or --CH.sub.2 CO.sub.2 R.sup.9 or --CONR.sup.10 R.sup.11 or nitrilen represents a number 1 to 10,m represents a number 0 to 7,T and Z are identical or different and represent oxygen or a direct bond andR.sup.2, R.sup.3, R.sup.8 are identical or different and represent hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano or nitro andR.sup.9 is lower alkyl and R.sup.10 and R.sup.11 are hydrogen, lower alkyl, alkylsulfonyl or arylsulfonyl or together are an alkylene chain to form a ringand pharmaceutically acceptable salts thereof. Such alkenoic acid derivatives are useful as leucotriene disease antagonists.
摘要翻译：其中X和Y相同或不同并表示硫，亚砜，砜，亚烷基链，-SCH 2 - 或氧或直接键的式（I）的链烯酸衍生物，W表示-CH = CH-或-CH 2 -CH 2 - ，o表示数1至5，A和B相同或不同，表示羧基，羧基亚甲基，四唑基或四唑基亚甲基，或-CO 2 R 9或-CH 2 CO 2 R 9或-CONR 10 R 11或腈n表示1 至10，m表示0至7的数，T和Z相同或不同，表示氧或直接键，R2，R3，R8相同或不同，表示氢，烷基，烷氧基，卤素，三氟甲基，三氟甲氧基，氰基或硝基，R 9为低级烷基，R 10和R 11为氢，低级烷基，烷基磺酰基或芳基磺酰基，或一起为形成环的亚烷基链及其药学上可接受的盐。这样的链烯酸衍生物可用作白三烯类疾病拮抗剂。

127. 发明授权

US5219886A Mercapto-acylamino acids 失效
标题翻译：巯基 - 酰氨基酸
公开(公告)号：US5219886A
公开(公告)日：1993-06-15
申请号：US768647
申请日：1991-10-01
申请人： Elizabeth M. Smith , Philip M. DeCapite , Bernard R. Neustadt
发明人： Elizabeth M. Smith , Philip M. DeCapite , Bernard R. Neustadt
IPC分类号： A61K38/22 , A61K31/16 , A61K31/195 , A61K31/215 , A61K31/265 , A61K31/38 , A61K31/40 , A61K31/47 , A61K31/55 , A61K31/675 , A61K38/55 , A61K45/06 , A61P3/00 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P43/00 , C07C319/12 , C07C323/00 , C07C323/56 , C07C323/60 , C07C327/06 , C07C327/32
CPC分类号： C07C327/32 , A61K38/2242 , A61K38/556 , C07C323/60
摘要： Novel mercapto-acylamino acids of the formula ##STR1## wherein Q is hydrogen or R.sup.7 CO--;R.sup.1 is lower alkyl, cyclolower alkyl, aryl or heteroaryl;R.sup.2 is hydrogen; lower alkyl; cyclolower alkyl; lower alkyl substituted with hydroxy, lower alkoxy, mercapto, lower alkylthio, aryl or heteroaryl; aryl; or heteroaryl;R.sup.3 is --OR.sup.5 or --NR.sup.5 R.sup.6 ;R.sup.4 and R.sup.9 are independently --(CH.sub.2).sub.q R.sup.8, provided that when R.sup.4 and R.sup.9 are both hydrogen, R.sup.2 is biphenylyl, phenoxyphenyl, phenylthiophenyl, naphthyl, heteroaryl, or lower alkyl substituted with hydroxy, lower alkoxy, mercapto or lower alkylthio;R.sup.5 and R.sup.6 are independently selected from the group consisting of hydrogen, lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl and aryl lower alkyl, or R.sup.5 and R.sup.6 together with the nitrogen to which they are attached form a 5-7 membered ring;R.sup.7 is hydrogen, lower alkyl or aryl;R.sup.8 is hydrogen, hydroxy, lower alkoxy, mercapto, lower alkylthio, aryl or heteroaryl;n is 1 or 2;p is 0 or 1;q is 0, 1 or 2; andt is 0 or 1; and the pharmaceutically acceptable salts thereof useful in the treatment of cardiovascular disorders and pain conditions and combinations of mercapto-acrylamino acids and atrial natriuretic factors or angiotensin converting enzyme inhibitors useful for treating cardiovascular disorders are disclosed.
摘要翻译： PCT No.PCT / US90 / 01787 Sec。 371日期1991年10月1日 102（e）1991年10月1日授权PCT 1990年4月6日提交。式IMA的新型巯基酰基氨基酸其中Q为氢或R7CO-; R 1是低级烷基，环己烷基，芳基或杂芳基; R2是氢; 低级烷基环状烷基; 被羟基，低级烷氧基，巯基，低级烷硫基，芳基或杂芳基取代的低级烷基; 芳基; 或杂芳基; R3为-OR5或-NR5R6; R 4和R 9独立地为 - （CH 2）q R 8，条件是当R 4和R 9均为氢时，R 2为联苯基，苯氧基苯基，苯硫基苯基，萘基，杂芳基或被羟基，低级烷氧基，巯基或低级烷硫基取代的低级烷基; R 5和R 6独立地选自氢，低级烷基，羟基低级烷基，低级烷氧基低级烷基和芳基低级烷基，或者R 5和R 6与它们所连接的氮一起形成5-7元环; R7是氢，低级烷基或芳基; R8是氢，羟基，低级烷氧基，巯基，低级烷硫基，芳基或杂芳基; n为1或2; p为0或1; q是0,1或2; t为0或1; 和其可用于治疗心血管疾病和疼痛病症的药学上可接受的盐，以及用于治疗心血管疾病的巯基丙烯酰胺酸和心房利钠因子或血管紧张素转换酶抑制剂的组合。

128. 发明授权

US5189063A Pesticidal substituted acrylic esters 失效
标题翻译：杀虫剂替代丙烯酸酯
公开(公告)号：US5189063A
公开(公告)日：1993-02-23
申请号：US570099
申请日：1990-08-17
申请人： Alexander Klausener , Herbert Gayer , Wolfgang Kramer , Dieter Berg , Wilhelm Brandes , Gerd Hanssler , Ulrike Wachendorff-Neumann
发明人： Alexander Klausener , Herbert Gayer , Wolfgang Kramer , Dieter Berg , Wilhelm Brandes , Gerd Hanssler , Ulrike Wachendorff-Neumann
IPC分类号： C07D317/60 , A01N37/06 , A01N37/36 , A01N37/38 , A01N37/44 , A01N37/48 , A01N43/16 , A01N43/18 , A01N43/30 , A01N43/40 , A01N43/74 , A01N43/80 , C07C67/31 , C07C69/73 , C07C69/732 , C07C69/734 , C07C229/32 , C07C229/44 , C07C251/42 , C07C251/52 , C07C251/60 , C07C323/55 , C07C323/56 , C07C323/57 , C07D211/70 , C07D213/55 , C07D213/61 , C07D213/64 , C07D261/08 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/30 , C07D307/54 , C07D309/20 , C07D309/22 , C07D317/54 , C07D333/24 , C07D335/02 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D521/00
CPC分类号： A01N43/74 , A01N37/36 , A01N37/38 , A01N37/44 , A01N37/48 , A01N43/30 , A01N43/40 , A01N43/80 , C07C229/44 , C07C323/56 , C07C69/734 , C07D213/61 , C07D261/08 , C07D263/32 , C07D277/24 , C07D309/22 , C07D317/54 , C07D335/02
摘要： Pesticidal substituted acrylic esters of the formula ##STR1## in which R.sup.1 represents alkyl, or represents unsubstituted or substituted aralkyl,R.sup.2 represents dialkylamino, or represents a radical --Z--R.sup.3,R.sup.3 represents alkyl, or represents unsubstituted or substituted aralkyl,Z represents oxygen or sulphur,A represents ##STR2## where n represents a number from 0 to 6,R.sup.4 and R.sup.5 in each case independently of one another represent alkyl, or together represent an alkylene chain having 2 to 7 carbon atoms, andR.sup.6 represents alkyl, or represents a radical ##STR3## where R.sup.7 represents alkyl, alkoxy or dialkylamino,B represents the group CH--R.sup.8 or, whereR.sup.9 represents unsubstituted or substituted alkyl, alkenyl, alkynyl, aralkyl, aryl or hetaryl, and R and Q independently of one another represent hydrogen, alkyl, halogenoalkyl or alkoxy.
摘要翻译：式（I）的杀虫取代的丙烯酸酯，其中R 1表示烷基，或表示未取代或取代的芳烷基，R 2表示二烷基氨基，或表示基团-Z-R 3，R 3表示烷基，或表示未取代或取代的芳烷基， Z表示氧或硫，A表示其中n表示0至6的数，R4和R5各自独立地表示烷基，或一起表示具有2至7个碳原子的亚烷基链，R6表示烷基，或表示基团，其中R 7表示烷基，烷氧基或二烷基氨基，B表示基团CH-R 8，或其中R 9表示未取代或取代的烷基，烯基，炔基，芳烷基，芳基或杂芳基，R和Q独立地彼此表示氢，烷基，卤代烷基或烷氧基。

129. 发明授权

US5159097A Alkenoic acid derivatives 失效
标题翻译：烯酸衍生物
公开(公告)号：US5159097A
公开(公告)日：1992-10-27
申请号：US618184
申请日：1990-11-26
申请人： Ulrich Rosentreter , Harold C. Kluender , Trevor S. Abram , Peter Norman , Steven R. Tudhope
发明人： Ulrich Rosentreter , Harold C. Kluender , Trevor S. Abram , Peter Norman , Steven R. Tudhope
IPC分类号： A61K31/19 , A61K31/215 , A61K31/235 , A61K31/275 , A61K31/41 , A61P11/08 , A61P43/00 , C07C43/225 , C07C43/23 , C07C51/353 , C07C63/14 , C07C63/66 , C07C65/24 , C07C65/28 , C07C67/343 , C07C69/76 , C07C69/94 , C07C309/73 , C07C317/44 , C07C317/46 , C07C319/20 , C07C323/52 , C07C323/56 , C07C323/62 , C07C323/65 , C07D257/06 , C07F7/18 , C07F9/54
CPC分类号： C07F9/5456 , C07C309/73 , C07C323/56 , C07C43/225 , C07C43/23 , C07C63/14 , C07C65/24 , C07F7/1852 , C07F9/5407
摘要： An alkenoic acid derivative of the formula ##STR1## in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH.sub.2 --, or oxygen or a direct bond,W represents --CH.dbd.CH--or --CH.sub.2 --CH.sub.2 --,o represents a number 1 to 5,A and B are identical or different and represent carboxyl, carboxymethylene, tetrazolyl or tetrazolylmethylene, or --CO.sub.2 R.sup.9 or --CH.sub.2 CO.sub.2 R.sup.9 or --CONR.sup.10 R.sup.11 or nitrilen represents a number 1 to 10,m represents a number 0 to 7,T and Z are identical or different and represent oxygen or a direct bond andR.sup.2, R.sup.3, R.sup.8 are identical or different and represent hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano or nitro andR.sup.9 is lower alkyl and R.sup.10 and R.sup.11 are hydrogen, lower alkyl, alkylsulfonyl or arylsulfonyl or together are an alkylene chain to form a ringand pharmaceutically acceptable salts thereof. Such alkenoic acid derivatives are useful as leucotriene disease antagonists.
摘要翻译：其中X和Y相同或不同并表示硫，亚砜，砜，亚烷基链，-SCH 2 - 或氧或直接键的式（I）的链烯酸衍生物，W表示-CH = CH-或-CH 2 -CH 2 - ，o表示数1至5，A和B相同或不同，表示羧基，羧基亚甲基，四唑基或四唑基亚甲基，或-CO 2 R 9或-CH 2 CO 2 R 9或-CONR 10 R 11或腈n表示1 至10，m表示0至7的数，T和Z相同或不同，表示氧或直接键，R2，R3，R8相同或不同，表示氢，烷基，烷氧基，卤素，三氟甲基，三氟甲氧基，氰基或硝基，R 9为低级烷基，R 10和R 11为氢，低级烷基，烷基磺酰基或芳基磺酰基，或一起为形成环的亚烷基链及其药学上可接受的盐。这样的链烯酸衍生物可用作白三烯类疾病拮抗剂。

130. 发明授权

US5149737A Carboxy containing monomers and polymers and latices prepared from same 失效
标题翻译：含羧基的单体和聚合物以及由其制备的胶乳
公开(公告)号：US5149737A
公开(公告)日：1992-09-22
申请号：US654112
申请日：1991-02-12
申请人： Ignazio S. Ponticello , Richard C. Sutton
发明人： Ignazio S. Ponticello , Richard C. Sutton
IPC分类号： C07C69/40 , C07C69/007 , C07C69/42 , C07C233/05 , C07C233/49 , C07C251/24 , C07C275/38 , C07C323/12 , C07C323/41 , C07C323/50 , C07C323/52 , C07C323/56 , C08F12/00 , C08F12/04 , C08F12/14 , C08F20/02 , C08F20/64 , C12Q1/68 , G01N33/53 , G01N33/543
CPC分类号： C07C69/007 , C07C323/12 , C07C323/52 , C07C323/56 , C08F12/14 , G01N33/54313
摘要： Certain ethylenically unsaturated polymerizable monomers having a reactive carboxy group are useful for preparing homo- and copolymers for a variety of uses, including diagnostic assays. The polymers can be supplied as latex particles in aqueous compositions. The monomers are represented by the structure: ##STR1## wherein: R is hydrogen, halo or alkyl or 1 to 3 carbon atoms,M is hydrogen, an alkali metal ion or an ammonium ion, andL is a linking group having from 8 to 50 atoms in its linking chain, and comprises two or more divalent hydrocarbon groups connected or terminated with one or more nitrogen, oxygen or sulfur atoms, or with one or more groups containing such atoms in the linking chain, provided L has at least one arylene which is not directly connected to the terminal ##STR2## and further provided that none of the hydrocarbon groups has non-aromatic unsaturation.

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