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121. 发明授权

US5882660A Personal care composition 失效
标题翻译：个人护理构成
公开(公告)号：US5882660A
公开(公告)日：1999-03-16
申请号：US794719
申请日：1997-02-03
申请人： John George Chambers , Graham Andrew Turner
发明人： John George Chambers , Graham Andrew Turner
IPC分类号： A61K8/00 , A61K8/31 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/44 , A61K8/63 , A61K8/67 , A61K8/72 , A61K8/73 , A61K8/86 , A61K8/92 , A61K8/97 , A61K8/98 , A61Q5/00 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C11D3/18 , C11D3/20 , C11D3/38 , A61K7/48
CPC分类号： A61K8/31 , A61K8/342 , A61K8/361 , A61K8/63 , A61K8/671 , A61K8/731 , A61K8/737 , A61K8/86 , A61K8/97 , A61K8/985 , A61Q19/00 , A61Q19/10 , A61K2800/5426 , Y10S514/844 , Y10S514/845 , Y10S514/846
摘要： A personal care composition in the form of an aqueous liquid comprises:i) a lipid composition comprising two components D and E, where D is a molecule having one long hydrocarbon chain and a hydrophillic head group and E is a material which comprises at least one of a compound selected from 3.beta.-sterol; squalane; squalane; saponins or sapogenins of the plant steroid or triterpenoid type; di and tri terpenes such as phytol, retinol and amyrin; and mixtures thereof, wherein D and E are respectively present at levels within the range 0.1 to 10 wt % and 0.2 a to 12 wt % based on the total composition;ii) a surface active agent selected from anionic, nonionic, cationic, zwitterionic, amphoteric surface active agents, soap and mixtures thereof; andiii) a deposition aid; andthe composition is substantially free of a molecule having at least two hydrocarbon chains and a polar head group which satisfies the relationship ##EQU1## where V is the volume of the hydrocarbon chainsI.sub.c is the critical length of the hydrocarbon chains anda.sub.o is the optimum area of the polar head group.The composition may in the form of for example a shower gel or facial cleanser which is temporarily applied to the skin before being removed such as wiping or rinsing it from the skin.
摘要翻译：水性液体形式的个人护理组合物包括：i）包含两种组分D和E的脂质组合物，其中D是具有一个长烃链和亲水性头基的分子，E是包含至少一种的选自3β-甾醇的化合物; 角鲨烷角鲨烷植物类固醇或三萜类皂甙或皂甙元; 二萜和三萜，如植醇，视黄醇和氨in; 和其混合物，其中D和E分别以基于总组合物的0.1至10重量％和0.2重量至12重量％的范围内的水平存在; ii）选自阴离子，非离子，阳离子，两性离子，两性表面活性剂，皂及其混合物的表面活性剂; 和iii）沉积助剂; 并且所述组合物基本上不含具有至少两个烃链和极性头基团的分子，其满足关系式（I）其中V是烃链的体积Ic是烃链的临界长度，ao 是极地头组的最佳面积。组合物可以是例如沐浴露或面部清洁剂的形式，其在被去除之前临时施用于皮肤，例如从皮肤擦拭或冲洗皮肤。

122. 发明授权

US5869068A Compositions and methods for treating wrinkles and/or fine lines of the skin 失效
公开(公告)号：US5869068A
公开(公告)日：1999-02-09
申请号：US538119
申请日：1995-10-02
申请人： Olivier De Lacharriere , Lionel Breton
发明人： Olivier De Lacharriere , Lionel Breton
IPC分类号： A61K8/30 , A61K8/00 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/63 , A61K8/67 , A61K8/72 , A61K8/92 , A61K31/195 , A61K31/515 , A61K31/55 , A61Q19/00 , A61Q19/08 , A61K7/48
CPC分类号： A61K8/63 , A61K8/44 , A61K8/466 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4953 , A61Q19/08 , A61K2800/70 , Y10S514/844 , Y10S514/846 , Y10S514/944
摘要： Compositions which contain an agonist substance of one or a number of receptors associated with a chlorine channel are useful for slackening and/or relaxing cutaneous tissue, and in particular for the purpose of treating wrinkles and fine lines of the skin. Such compositions can be administered topically or by injection. Preferred agonists include glycine, serine, taurine, .beta.-alanine, N-(benzyloxycarbonyl)glycine (Z-glycine), gamma-aminobutyric acid (GABA), isoguvacine, isonipecotic acid, 4,5,6,7-tetrahydroisoxazolo�5,4-c!pyrid-3(2H)-one, benzodiazepines, steroids, and barbiturates. The composition can additionally contain a retinoid and/or a hydroxy acid.

123. 发明授权

US5843476A Slimming composition for topical treatment, containing two types of liposomes, and use thereof 失效
标题翻译：用于局部治疗的减肥组合物，含有两种类型的脂质体及其用途
公开(公告)号：US5843476A
公开(公告)日：1998-12-01
申请号：US803146
申请日：1997-02-19
申请人： Alain Ribier , Jean-Thierry Simonnet , Chantal Fanchon , Evelyne Segot , Herve Cantin
发明人： Alain Ribier , Jean-Thierry Simonnet , Chantal Fanchon , Evelyne Segot , Herve Cantin
IPC分类号： A61K9/127 , A61K8/00 , A61K8/14 , A61K8/19 , A61K8/25 , A61K8/30 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/44 , A61K8/49 , A61K8/63 , A61K8/64 , A61K8/66 , A61K8/68 , A61K8/72 , A61K8/73 , A61K8/81 , A61K8/92 , A61K8/96 , A61K8/97 , A61P3/04 , A61Q19/06 , A61Q90/00
CPC分类号： A61K8/14 , A61K8/368 , A61K8/4953 , A61K8/63 , A61Q19/06 , Y10S514/869 , Y10S514/909
摘要： Compositions containing a first dispersion of lipid vesicles which are capable of penetrating into the deep layers of the skin and which contain at least one active agent chosen from lipolytic agents, draining agents and firming agents, for treating these deep layers, and a second dispersion of lipid vesicles which are capable of penetrating into the surface layers of the skin and which contain at least one active agent chosen from cutaneous surface treatment agents, exfoliation agents, smoothing agents and softening agents for the skin, for treating these surface layers, are effective as slimming agents for combating plumpness.
摘要翻译：含有脂质囊泡的第一分散体的组合物能够渗入皮肤的深层并且含有至少一种选自脂肪分解剂，排液剂和紧肤剂的活性剂，用于处理这些深层，以及第二分散体能够渗透到皮肤表层中并且含有选自皮肤表面处理剂，脱皮剂，平滑剂和皮肤软化剂中的至少一种活性剂用于处理这些表面层的脂质囊泡是有效的减肥剂，以抵抗丰满度。

124. 发明授权

US5834513A Oxa diacids and related compounds for treating skin conditions 失效
标题翻译：用于治疗皮肤病的Oxa二酸和相关化合物
公开(公告)号：US5834513A
公开(公告)日：1998-11-10
申请号：US636540
申请日：1996-04-25
申请人： Dmitri Ptchelintsev , Neil Scancarella , Robert Kalafsky
发明人： Dmitri Ptchelintsev , Neil Scancarella , Robert Kalafsky
IPC分类号： A61K8/30 , A61K8/00 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/60 , A61K8/63 , A61K8/67 , A61K8/68 , A61K8/73 , A61K8/88 , A61K8/89 , A61K8/891 , A61K8/92 , A61K8/98 , A61K31/195 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C59/245 , C07C59/305 , C07C69/708 , A61K31/19
CPC分类号： C07C69/708 , A61K8/35 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/63 , A61K8/671 , A61K8/68 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , C07C59/305 , A61K2800/244 , A61K2800/522
摘要： Described are the use of compounds of Formula (I), depicted below, as active principals for treating skin conditions, compositions containing these compounds, and methods of treating skin conditions using these compounds and compositions. ##STR1## wherein, R.sub.4 is (CR.sub.5 R.sub.6 --CR.sub.7 R.sub.8 --X.sub.1).sub.n --CR.sub.9 R.sub.10 --C(.dbd.X.sub.2)X.sub.3 R.sub.11, with n being an integer from 1 to 18; R.sub.1, R.sub.2, R.sub.3, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 are independently, hydrogen or non-hydrogen substituents; and X, X.sub.1, X.sub.2, X.sub.3, Y and Z are independently, O, NH or S.
摘要翻译：描述了下面描述的式（I）化合物作为治疗皮肤病症的活性成分，含有这些化合物的组合物和使用这些化合物和组合物治疗皮肤病症的方法的用途。（I）其中，R4为（CR5R6-CR7R8-X1）n-CR9R10-C（= X2）X3R11，n为1至18的整数; R 1，R 2，R 3，R 5，R 6，R 7，R 8，R 9，R 10和R 11独立地为氢或非氢取代基; X，X 1，X 2，X 3，Y和Z独立地为O，NH或S.

125. 发明授权

US5817299A Non-chemical sunscreen composition 失效
标题翻译：非化学防晒组合物
公开(公告)号：US5817299A
公开(公告)日：1998-10-06
申请号：US742300
申请日：1996-11-01
申请人： Abul M. Manirazman
发明人： Abul M. Manirazman
IPC分类号： A61K8/29 , A61K8/36 , A61K8/49 , A61K8/63 , A61K8/97 , A61K36/539 , A61Q17/04 , A61K7/42 , A61K7/00 , A61K35/78
CPC分类号： A61Q17/04 , A61K8/29 , A61K8/365 , A61K8/498 , A61K8/63 , A61K8/97
摘要： The present invention relates to nonchemical sunscreen composition comprising as its active components, in synergistically effective amounts, a plant extract containing at least about 50% by weight of proanthocyanidins, .gamma.-oryzanol, ferulic acid and/or an ester thereof, titanium dioxide and optionally, Scutellaria extract.
摘要翻译：本发明涉及非化学防晒组合物，其包含协同有效量的作为其活性成分的植物提取物，其含有至少约50重量％的原花色素，γ-木萨醇，阿魏酸和/或其酯，二氧化钛和任选的黄芩提取物。

126. 发明授权

US5798347A Therapeutic methods and delivery systems utilizing sex steroid precursors 失效
公开(公告)号：US5798347A
公开(公告)日：1998-08-25
申请号：US477170
申请日：1995-06-07
申请人： Fernand Labrie
发明人： Fernand Labrie
IPC分类号： A61K8/63 , A61K9/00 , A61K9/70 , A61K31/565 , A61K31/57 , A61K31/58 , A61P5/00 , A61P15/00 , A61P15/02 , A61P17/00 , A61P25/00 , A61Q19/00 , C07J1/00 , C07J17/00 , C07J43/00 , A61K31/56
CPC分类号： C07J43/006 , A61K31/565 , A61K31/566 , A61K31/5685 , A61K31/57 , A61K31/58 , C07J1/0011 , C07J43/003
摘要： Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment and/or prevention of vaginal atrophy, hypogonadism, diminished libido, osteoporosis, urinary incontinence, ovarian cancer, uterine cancer, skin atrophy, for contraception, and, in combination with an estrogen and/or progestin, for the treatment of menopause. The precursors may be formulated for percutaneous or transmucosal administration. Gels, solutions, lotions, creams, ointments and transdermal patches for the administration of these precursors are provided, as are certain pharmaceutical compositions and kits which can be used for the prevention and treatment of a wide variety of conditions related to decreased secretion of sex steroid precursors by the adrenals.

127. 发明授权

US5753713A Method for promoting hair growth 失效
标题翻译：促进头发生长的方法
公开(公告)号：US5753713A
公开(公告)日：1998-05-19
申请号：US823463
申请日：1997-03-24
申请人： James S. Bass
发明人： James S. Bass
IPC分类号： A61K8/41 , A61K8/42 , A61K8/49 , A61K8/60 , A61K8/63 , A61K8/64 , A61K31/13 , A61K31/57 , A61K31/65 , A61K31/70 , A61K38/12 , A61K45/06 , A61Q7/00 , A61Q19/00 , A61K31/56
CPC分类号： A61Q19/00 , A61K31/57 , A61K31/65 , A61K38/12 , A61K45/06 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/60 , A61K8/63 , A61K8/64 , A61Q7/00 , A61K2800/59 , A61K2800/70 , A61Q5/006
摘要： Disclosed is a pharmaceutical composition intended for the topical application to human skin, comprising (A) as an effective ingredient, a mixture comprising (1) an antibiotic medication; (2) an antihistamine; and (B) a physiologically acceptable carrier. Also disclosed is a method for treatment using this composition.
摘要翻译：公开了用于局部施用于人皮肤的药物组合物，其包含（A）作为有效成分的混合物，所述混合物包含（1）抗生素药物; （2）抗组胺药; 和（B）生理上可接受的载体。还公开了使用该组合物的治疗方法。

128. 发明授权

US5753242A External skin treatment composition 失效
标题翻译：外用皮肤护理组合物
公开(公告)号：US5753242A
公开(公告)日：1998-05-19
申请号：US712293
申请日：1996-09-11
申请人： Fumiaki Nakamura , Yoshimaru Kumano , Kenzo Ito
发明人： Fumiaki Nakamura , Yoshimaru Kumano , Kenzo Ito
IPC分类号： A61K8/30 , A61K8/00 , A61K8/34 , A61K8/55 , A61K8/58 , A61K8/63 , A61K8/72 , A61K31/765 , A61P17/16 , A61Q19/00 , A61K7/00
CPC分类号： A61K8/0212 , A61K31/685 , A61K31/765 , A61K8/345 , A61K8/553 , A61K8/63 , A61Q19/00 , Y10S514/844
摘要： An external skin treatment composition comprising erythritol, hydrogenated lecithin, and a polyoxyethylene-added cholesterol derivative, which is superior in prevention and improvement of skin roughness, with little sticky feeling, with quick absorption into the skin, and superior in the softening effect on the corneum.
摘要翻译：包含赤藓糖醇，氢化卵磷脂和聚氧乙烯添加的胆固醇衍生物的外用皮肤处理组合物，其具有优异的防止和改善皮肤粗糙度，具有很少的粘性感，并快速吸收到皮肤中，并且对角质层

129. 发明授权

US5714169A Method for wound healing after surgery by applying a composition comprising LYCD and one or more cytokine protein growth factors 失效
标题翻译：通过应用包含LYCD和一种或多种细胞因子蛋白生长因子的组合物，手术后伤口愈合的方法
公开(公告)号：US5714169A
公开(公告)日：1998-02-03
申请号：US640559
申请日：1996-05-01
申请人： Robert H. Levin
发明人： Robert H. Levin
IPC分类号： A61K8/38 , A61K8/49 , A61K8/60 , A61K8/63 , A61K8/64 , A61K8/67 , A61K8/99 , A61K31/19 , A61K31/56 , A61K33/40 , A61K36/00 , A61K38/00 , A61K38/18 , A61K38/19 , A61K38/21 , A61K38/39 , A61Q7/00 , A61Q19/00 , A61Q19/08 , G01N33/15 , A61K35/78
CPC分类号： A61Q7/00 , A61K36/06 , A61K36/064 , A61K38/1808 , A61K38/1858 , A61K38/30 , A61K8/38 , A61K8/4953 , A61K8/602 , A61K8/63 , A61K8/64 , A61K8/671 , A61K8/99 , A61Q19/00 , A61Q19/08
摘要： A topical composition comprising LYCD together with known topically active useful medicinal agents such as anti-wrinkling, antibiotic, anticancer, antifungal, antiinflammatory such as anti-acne, antiviral, wound healing, and hair-growing agents. The LYCD works together with the other active agents to achieve a synergistic result more effective than can be obtained from the topical agents individually, and more effective than could be predicted from the mere addition of the known efficacies of the individual ingredients.
摘要翻译：一种局部组合物，其包含LYCD以及已知的局部活性的有用药物如抗皱，抗生素，抗癌，抗真菌剂，抗炎剂如抗痤疮，抗病毒，伤口愈合和发育剂。 LYCD与其他活性剂一起使用，以达到比单独从局部药物获得的更有效的协同效果，并且比仅仅添加各种成分的已知功效可以预测的更有效。

130. 发明授权

US5702688A Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use 失效
标题翻译：两性组合物和α-羟基酸的聚合形式及其治疗用途
公开(公告)号：US5702688A
公开(公告)日：1997-12-30
申请号：US135841
申请日：1993-10-07
申请人： Ruey J. Yu , Eugene J. Van Scott
发明人： Ruey J. Yu , Eugene J. Van Scott
IPC分类号： A61K8/26 , A61K8/27 , A61K8/34 , A61K8/362 , A61K8/365 , A61K8/37 , A61K8/42 , A61K8/43 , A61K8/49 , A61K8/55 , A61K8/58 , A61K8/60 , A61K8/63 , A61K8/67 , A61K8/81 , A61K8/85 , A61K31/19 , A61K31/191 , A61K31/192 , A61K31/194 , A61K31/195 , A61K31/20 , A61K31/202 , A61K31/365 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/415 , A61K31/445 , A61K31/66 , A61K31/70 , A61K31/715 , A61K45/06 , A61K47/12 , A61K47/18 , A61K47/24 , A61K47/26 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q15/00 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , A61K23/30 , A61K7/42
CPC分类号： A61Q19/008 , A61K31/19 , A61K31/191 , A61K31/192 , A61K31/194 , A61K31/195 , A61K31/20 , A61K31/202 , A61K31/365 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/415 , A61K31/445 , A61K31/66 , A61K31/70 , A61K31/7048 , A61K31/715 , A61K45/06 , A61K47/12 , A61K47/183 , A61K47/24 , A61K47/26 , A61K8/26 , A61K8/27 , A61K8/347 , A61K8/362 , A61K8/365 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/43 , A61K8/494 , A61K8/4953 , A61K8/4973 , A61K8/553 , A61K8/585 , A61K8/60 , A61K8/63 , A61K8/671 , A61K8/675 , A61K8/678 , A61K8/8152 , A61K8/85 , A61K9/0014 , A61Q15/00 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08 , A61Q19/10 , A61Q5/006 , A61Q5/02 , A61Q7/00 , Y10S514/844 , Y10S514/847 , Y10S514/941
摘要： Preventive as well as therapeutic treatment to alleviate cosmetic conditions and symptoms of dermatologic disorders with amphoteric compositions containing alpha hydroxyacids, alpha ketoacids, related compounds or polymeric forms of hydroxyacids is disclosed. The cosmetic conditions and the dermatologic disorders in which the amphoteric compositions and the polymeric compounds may be useful include dry skin, dandruff, ache, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, kyperkeratotic skin, inflammatory dermatoses, skin changes associated with aging, and skin requiring cleansers.
摘要翻译：公开了用含有α-羟基酸，α-酮酸，相关化合物或聚合形式的羟基酸的两性组合物来减轻化妆品状况和皮肤病症状的预防和治疗。两性组合物和聚合物可能有用的美容条件和皮肤病学障碍包括干性皮肤，头皮屑，疼痛，角化病，牛皮癣，湿疹，瘙痒，老年斑，斑点，黑斑病，皱纹，疣，瑕疵皮肤，色素沉着皮肤，皮肤过敏皮肤，炎性皮肤病，与老化有关的皮肤变化，以及需要清洁剂的皮肤。

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