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121. 发明授权

US07734341B2 Method and apparatus for gastrointestinal stimulation via the lymphatic system 有权
标题翻译：通过淋巴系统进行胃肠道刺激的方法和装置
公开(公告)号：US07734341B2
公开(公告)日：2010-06-08
申请号：US11422418
申请日：2006-06-06
申请人： Allan C. Shuros
发明人： Allan C. Shuros
IPC分类号： A61N1/36
CPC分类号： A61N1/36007
摘要： An implantable gastrointestinal (GI) stimulation system includes an implantable medical device and at least one stimulus delivery device configured to be placed in one or more lymphatic vessels of a patient, such as the patient's thoracic duct and/or vessels branching from the thoracic duct. In one embodiment, the implantable medical device includes a GI stimulation circuit to deliver electrical stimulation pulses to one or more target regions adjacent to a lymphatic vessel through the stimulus delivery device. In one embodiment, to control obesity, the electrical stimulation pulses are delivered to the organs and/or nerves of the GI tract to create a sensation of satiety and/or to expedite food movement through the GI tract.
摘要翻译：植入式胃肠（GI）刺激系统包括可植入医疗装置和至少一个刺激递送装置，其被配置为放置在患者的一个或多个淋巴管中，例如患者的胸导管和/或从胸导管分支的血管。在一个实施例中，可植入医疗装置包括GI刺激电路，以通过刺激输送装置将电刺激脉冲输送到与淋巴管相邻的一个或多个目标区域。在一个实施方案中，为了控制肥胖，将电刺激脉冲输送到胃肠道的器官和/或神经以产生饱腹感和/或加速通过胃肠道的食物运动。

122. 发明申请

US20100076279A1 METHOD AND APPARATUS FOR ORGAN SPECIFIC INFLAMMATION MONITORING 有权
标题翻译：用于组织特异性暴露监测的方法和装置
公开(公告)号：US20100076279A1
公开(公告)日：2010-03-25
申请号：US12565233
申请日：2009-09-23
申请人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Craig Stolen
发明人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Craig Stolen
IPC分类号： A61B5/02 , A61B5/00 , A61B5/053 , A61B5/01 , A61B5/107
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/01 , A61B5/036 , A61B5/053 , A61B5/1076 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4205 , A61B5/4878 , A61B5/7275 , A61B8/488 , A61N1/36521
摘要： An apparatus comprises an implantable sensor and a detection circuit. The implantable sensor provides a physiologic sensor signal and is to be positioned at a lymph node of a subject. The detection circuit detects a change in a physiologic parameter of the lymph node that exceeds a threshold change, and deems that the change in the physiologic parameter indicates a change in inflammation of an organ associated with the lymph node.
摘要翻译：一种装置包括可植入传感器和检测电路。植入式传感器提供生理传感器信号并且被定位在受试者的淋巴结处。检测电路检测超过阈值变化的淋巴结生理参数的变化，认为生理参数的变化表示与淋巴结相关的器官的炎症变化。

123. 发明申请

US20100069989A1 PRESSURE-DRIVEN INTERMITTENT PACING THERAPY 失效
标题翻译：压力驱动间歇性治疗
公开(公告)号：US20100069989A1
公开(公告)日：2010-03-18
申请号：US12537165
申请日：2009-08-06
申请人： Robert Shipley , Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jason J. Hamann
发明人： Robert Shipley , Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jason J. Hamann
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/3684 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing but may also be hazardous. Described herein is a method and system that uses measures of a patient's physiological response to ventricular dyssynchrony to control the duty cycles of intermittent pre-excitation pacing.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的所需心脏保护作用，但也可能是危险的。本文描述了一种方法和系统，其使用患者对心室不同步的生理反应的测量来控制间歇性预激励起搏的占空比。

124. 发明申请

US20090281591A1 SMART DELAY FOR INTERMITTENT STRESS THERAPY 有权
标题翻译：智能延迟用于间歇性压力治疗
公开(公告)号：US20090281591A1
公开(公告)日：2009-11-12
申请号：US12436497
申请日：2009-05-06
申请人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Robert Shipley
发明人： Allan C. Shuros , Shantha Arcot-Krishnamurthy , Robert Shipley
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A pacing system delivers cardiac protection pacing to protect the heart from injuries. The pacing system receives a set of inputs and calculates parameters for delivering optimized cardiac protection pacing tailored for different stress levels. The system automatically adjusts heart rate to optimize cardiac protection pacing in a closed-loop system. In one embodiment, a method for delivering pacing pulses for cardiac protection is provided. Intrinsic atrioventricular (AV) intervals are sensed. The intrinsic AV interval and a predetermined equation relating the AV interval to an optimal AV delay are used to provide a maximum positive rate of left ventricular pressure change during systole. An AV delay is calculated using a predetermined percentage of the optimal AV delay to deliver ventricular pacing pulses to provide a desired level of stress for cardiac protective pacing therapy (CPPT) to provide a cardiac conditioning therapy to improve autonomic balance.
摘要翻译：起搏系统提供心脏保护起搏，以保护心脏免受伤害。起搏系统接收一组输入，并计算用于提供针对不同应力水平定制的优化心脏保护起搏的参数。系统自动调节心率以优化闭环系统中的心脏保护起搏。在一个实施例中，提供了一种用于输送用于心脏保护的起搏脉冲的方法。感测房室内（AV）间隔。使用本征AV间隔和将AV间隔与最佳AV延迟相关联的预定方程用于在收缩期间提供左心室压力变化的最大正率。使用预定百分比的最佳AV延迟来计算AV延迟以递送心室起搏脉冲以提供用于心脏保护起搏治疗（CPPT）的期望水平的应力以提供心脏调节疗法以改善自主神经平衡。

125. 发明申请

US20090234416A1 INTERMITTENT PACING THERAPY DELIVERY STATISTICS 有权
标题翻译：间歇性治疗传播统计
公开(公告)号：US20090234416A1
公开(公告)日：2009-09-17
申请号：US12401194
申请日：2009-03-10
申请人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
发明人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3688
摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode and stores a statistic related to the stress augmentation mode in a stress augmentation cycle memory area.
摘要翻译：本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替，并将与应力增加模式相关的统计量存储在应力增加周期存储区域中。

126. 发明申请

US20090149766A1 CORONARY VEIN HEMODYNAMIC SENSOR 审中-公开
标题翻译：冠状动脉血液动力传感器
公开(公告)号：US20090149766A1
公开(公告)日：2009-06-11
申请号：US12256203
申请日：2008-10-22
申请人： Allan C. Shuros , Lili Liu
发明人： Allan C. Shuros , Lili Liu
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/053 , A61B5/0538 , A61B5/1076 , A61B5/6846
摘要： A system and method for estimating a hemodynamic performance parameter value of a patient's heart. The system includes a pulse generator and a medical electrical lead implanted partially within a coronary vein of heart. The lead includes at least one sensor located within the coronary vein configured to generate a signal indicative of at least one dimensional parameter of the coronary vein. Changes in the dimensional parameter during one or more cardiac cycles are measured. The hemodynamic performance parameter is estimated based on the change in the dimensional parameter of the coronary vein.
摘要翻译：一种用于估计患者心脏的血液动力学性能参数值的系统和方法。该系统包括部分地植入在心脏冠状静脉内的脉冲发生器和医用电线。引线包括位于冠状静脉内的至少一个传感器，其构造成产生指示冠状静脉的至少一维参数的信号。测量一个或多个心动周期内尺寸参数的变化。基于冠状静脉尺寸参数的变化估计血流动力学性能参数。

127. 发明申请

US20090082823A1 Variable shortening of AV delay for treatment of cardiac disease 有权
标题翻译： AV延迟可变缩短治疗心脏病
公开(公告)号：US20090082823A1
公开(公告)日：2009-03-26
申请号：US11903758
申请日：2007-09-25
申请人： Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/365
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/36514 , A61N1/36535 , A61N1/36585 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently and variably reduce the AV delay interval used in an atrial triggered pacing mode in a manner that simulates exercise. The device may be programmed to intermittently switch to and from a variably shortened AV delay mode according to defined entry and exit conditions.
摘要翻译：用于递送心室起搏的可植入起搏装置可以被配置为以模拟运动的方式间歇地和可变地减小在心房触发起搏模式中使用的AV延迟间隔。该设备可以被编程为根据定义的进入和退出条件间歇地切换到可变地缩短的AV延迟模式。

128. 发明申请

US20080294228A1 METHOD AND DEVICE FOR CONTROLLED STIMULATION OF LYMPHATIC FLOW 审中-公开
标题翻译：用于控制淋巴流动刺激的方法和装置
公开(公告)号：US20080294228A1
公开(公告)日：2008-11-27
申请号：US11752377
申请日：2007-05-23
申请人： M. Jason Brooke , Allan C. Shuros , Robert J. Sweeney , Alok S. Sathaye
发明人： M. Jason Brooke , Allan C. Shuros , Robert J. Sweeney , Alok S. Sathaye
IPC分类号： A61N1/05
CPC分类号： A61N1/326 , A61N1/08
摘要： A device and method for controllably augmenting the flow of lymphatic fluid through one or more lymphatic vessels. The device may utilize various means of modulating the flow of lymph, including neural, mechanical and/or chemical stimulation and could be a stand-alone device or be incorporated into any cardiac, neuromodulation and/or drug delivery device.
摘要翻译：一种用于可控地增加通过一个或多个淋巴管的淋巴液流动的装置和方法。该装置可以利用调节淋巴液流动的各种手段，包括神经，机械和/或化学刺激，并且可以是独立装置，或并入任何心脏，神经调节和/或药物输送装置中。

129. 发明申请

US20080234556A1 METHOD AND APPARATUS FOR SENSING RESPIRATORY ACTIVITIES USING SENSOR IN LYMPHATIC SYSTEM 审中-公开
标题翻译：传感器在淋巴系统中感染呼吸活动的方法和装置
公开(公告)号：US20080234556A1
公开(公告)日：2008-09-25
申请号：US11688380
申请日：2007-03-20
申请人： M. Jason Brooke , Yachuan Pu , Allan C. Shuros
发明人： M. Jason Brooke , Yachuan Pu , Allan C. Shuros
IPC分类号： A61B5/08 , A61N1/36 , A61N1/362
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/113 , A61B5/415 , A61B5/418 , A61N1/3601 , A61N1/36114 , A61N1/3627
摘要： A respiratory monitoring system includes an implantable lymphatic sensor configured to be placed in a lymphatic vessel, such as the thoracic duct or a vessel branching from the thoracic duct, near the diaphragm. The implantable lymphatic sensor senses a signal indicative of respiratory activities. Examples of the signal include a diaphragmatic activity signal indicative of movement of the diaphragm and a transthoracic impedance signal indicative of pulmonary volume. In one embodiment, the respiratory monitoring system is incorporated into a cardiac rhythm management system that controls cardiac therapy delivery using the signal sensed by the implantable lymphatic sensor.
摘要翻译：呼吸监测系统包括植入式淋巴传感器，该植入式淋巴传感器被配置为放置在淋巴管中，例如胸膜导管或在隔膜附近从胸导管分支的血管。可植入淋巴传感器感测到指示呼吸活动的信号。信号的示例包括指示振膜的移动的膈肌活动信号和指示肺容积的经胸阻抗信号。在一个实施例中，将呼吸监测系统并入心脏节律管理系统，其使用由可植入淋巴传感器感测到的信号来控制心脏治疗递送。

130. 发明申请

US20080140000A1 DEVICE AND METHOD FOR MODULATING RENAL FUNCTION 有权
标题翻译：用于调节肾功能的装置和方法
公开(公告)号：US20080140000A1
公开(公告)日：2008-06-12
申请号：US11567907
申请日：2006-12-07
申请人： Allan C. Shuros , M. Jason Brooke , Tasneem Poonawala
发明人： Allan C. Shuros , M. Jason Brooke , Tasneem Poonawala
IPC分类号： A61M29/00 , A61N1/00
CPC分类号： A61N1/3606 , A61M25/00 , A61N1/05 , A61N1/36007 , A61N1/36135
摘要： Renal function may be modulated by an implantable device having one or more leads or catheters disposed near the kidney via the lymphatic system. In one embodiment, lymphatic drainage from the kidney is modulated to increase or decrease tubular reabsorption of salt and water. The renal function modulation therapy may be delivered in an open-loop or closed-loop fashion, with the latter dependent upon a physiological variable such as blood pressure or cardiac output.
摘要翻译：肾功能可以由具有通过淋巴系统设置在肾附近的一个或多个引线或导管的可植入装置调节。在一个实施方案中，来自肾脏的淋巴引流被调节以增加或减少盐和水的管状再吸收。肾功能调节治疗可以以开环或闭环方式递送，后者取决于诸如血压或心输出量的生理变量。

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