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121. 发明申请

US20110229414A1 Contrast Agents For Detecting Protease Activity By Means Of Hyperpolarization And For Stratifying Patients 审中-公开
标题翻译：用于通过超极化和分层患者检测蛋白酶活性的对比剂
公开(公告)号：US20110229414A1
公开(公告)日：2011-09-22
申请号：US13013127
申请日：2011-01-25
申请人： Christian Geppert , Arne Hengerer , Sven Meyburg , Sebastian Schmidt , Susanne Schmolke , Ralph Markus Wirtz
发明人： Christian Geppert , Arne Hengerer , Sven Meyburg , Sebastian Schmidt , Susanne Schmolke , Ralph Markus Wirtz
IPC分类号： A61K49/08 , C07K2/00 , A61K49/00 , C07K7/06 , A61P43/00
CPC分类号： A61K49/06
摘要： A contrast agent is disclosed for imaging methods. In at least one embodiment the contrast agent includes a construct including i) at least two copies of a substrate for at least one tumor-specific protease, and ii) at least one linker having at least one recognition site for at least one tumor-specific protease, wherein a hyperpolarization site is located at the N and/or C terminus of the substrate, and wherein the linker is configured such that the hydrophobic ends of the substrate interact and form a central core by means of noncovalent interactions with the lipophilic residues, and the contrast agent together with a parahydrogen metal template for use in an imaging method for diagnosing a tumor. At least one embodiment of the invention further relates to a method for imaging a tumor tissue, wherein the above-described contrast agent accumulated in a tumor tissue is imaged using a suitable imaging method after hyperpolarization by way of contact with a parahydrogen metal template, and also to a method for imaging a tumor tissue in a patient, wherein a) a contrast agent as described above is administered to a patient, b) a parahydrogen metal template is administered to the patient, and c) the presence of a tumor is depicted using an imaging method.
摘要翻译：公开了用于成像方法的造影剂。在至少一个实施方案中，造影剂包括构建体，其包括i）用于至少一种肿瘤特异性蛋白酶的底物的至少两个拷贝，和ii）至少一个具有至少一个肿瘤特异性的识别位点的接头蛋白酶，其中超极化位点位于底物的N和/或C末端，并且其中接头被配置为使得底物的疏水末端通过与亲脂性残基的非共价相互作用相互作用并形成中心核心，和造影剂以及用于诊断肿瘤的成像方法中的副氢金属模板。本发明的至少一个实施方案还涉及一种用于对肿瘤组织进行成像的方法，其中通过与超临界金属模板的接触在超极化之后，使用合适的成像方法将累积在肿瘤组织中的上述造影剂成像，并且还涉及对患者的肿瘤组织进行成像的方法，其中a）对患者施用如上所述的造影剂，b）向患者施用副氢金属模板，和c）描绘肿瘤的存在使用成像方法。

122. 发明申请

US20110150758A1 TRACKING OF BONE MARROW CELLS FOR METASTASIS SCREENING 失效
标题翻译：跟踪用于METASTASIS筛选的骨髓细胞
公开(公告)号：US20110150758A1
公开(公告)日：2011-06-23
申请号：US12974214
申请日：2010-12-21
申请人： Christian Geppert , Arne Hengerer , Sven Meyburg , Sebastian Schmidt , Susanne Schmolke , Ralph Markus Wirtz
发明人： Christian Geppert , Arne Hengerer , Sven Meyburg , Sebastian Schmidt , Susanne Schmolke , Ralph Markus Wirtz
IPC分类号： A61K51/02 , C12N5/071 , A61K49/08 , C12Q1/02 , B82Y15/00
CPC分类号： G01N33/574 , A61K49/1896 , A61K51/1203 , C12N5/0669 , C12N2503/00
摘要： At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method. At least one embodiment also relates a method for imaging a metastasizing tumor tissue, wherein a suitable imaging method is used to image bone marrow precursor cells and/or bone marrow cells that are accumulated in a metastasizing tumor tissue and labeled with at least one contrast agent suitable for an imaging method.
摘要翻译：本发明的至少一个实施方案涉及患者的骨髓前体细胞或骨髓细胞，所述细胞用适于成像方法的至少一种造影剂标记，用于诊断转移性癌症的成像方法，其中标记的前体细胞或骨髓细胞的局部积累表明存在转移性肿瘤生长。至少一个实施方案还涉及用于对患者的转移性肿瘤组织进行成像的方法，其中a）从患者中提取骨髓前体细胞或骨髓细胞，b）至少标记这些前体细胞或骨髓细胞一种适用于成像方法的造影剂，c）将如此标记的前体细胞或骨髓细胞重新移植或重新注入患者体内，d）用成像方法描绘转移肿瘤细胞的存在。至少一个实施方案还涉及用于成像转移肿瘤组织的方法，其中使用合适的成像方法来成像骨髓前体细胞和/或骨髓细胞，所述骨髓前体细胞和/或骨髓细胞积聚在转移肿瘤组织中并用至少一种造影剂适合成像方法。

123. 发明申请

US20110092787A1 ENDOCAPSULE 有权
公开(公告)号：US20110092787A1
公开(公告)日：2011-04-21
申请号：US12988422
申请日：2009-04-02
申请人： Clemens Bulitta , Stefan Förtsch , Norbert Gläsel , Rainer Kuth , Bernhard Roas , Sebastian Schmidt , Rainer Graumann , Arne Hengerer , Ludwig Herbst
发明人： Clemens Bulitta , Stefan Förtsch , Norbert Gläsel , Rainer Kuth , Bernhard Roas , Sebastian Schmidt , Rainer Graumann , Arne Hengerer , Ludwig Herbst
IPC分类号： A61B5/145 , A61B5/08
CPC分类号： A61B5/073 , A61B1/00016 , A61B1/00158 , A61B1/041 , A61B1/05 , A61B5/14539 , A61B5/14542 , A61B5/14546 , A61B5/1459 , A61B5/42 , A61B5/6861
摘要： An endocapsule has a measurement chamber therein containing a sensor that detects at least one metabolic product of a specific bacterium in a hollow organ of a human or animal gastrointestinal tract. The endocapsule is introduced into the hollow organ wherein detection of the at least one metabolic product takes place.
摘要翻译：内囊具有其中包含测量室的测量室，所述传感器检测人或动物胃肠道的中空器官中特定细菌的至少一种代谢产物。将内囊引入中空器官中，其中发生至少一种代谢产物的检测。

124. 发明申请

US20100331833A1 IN-VITRO DEVICE MONITORING DURING MINIMALLY INVASIVE ABLATION THERAPY 审中-公开
标题翻译：在最小的入侵治疗期间的体内装置监测
公开(公告)号：US20100331833A1
公开(公告)日：2010-12-30
申请号：US12492315
申请日：2009-06-26
申请人： Michael Maschke , Gudrun Zahlmann , Sebastian Schmidt , Karsten Hiltawsky
发明人： Michael Maschke , Gudrun Zahlmann , Sebastian Schmidt , Karsten Hiltawsky
IPC分类号： A61B18/02 , A61B18/14 , A61N7/00 , C12Q1/00 , C40B30/00
CPC分类号： G01N33/50 , A61B18/02 , A61B18/14 , A61B18/20 , A61B34/20 , A61B2090/376 , G06F19/3481
摘要： A method and apparatus for monitoring and controlling interventional therapy is described, where the interventional therapy results in the destruction of tissue and the release of chemical markers. When interventional therapy results in destruction of a patient tissue, such as cancerous tissue, a variety of chemical markers may be released into the bloodstream. An in-vitro diagnostic (IVD) device may be used to measure the concentration of an analyte representing a marker and compare the measured concentration with a predetermined set point so as to monitor or control the procedure. The blood for the analysis may be obtained either inter-procedurally or intra-procedurally depending on the promptness of the effect being measured and the speed of measurement.
摘要翻译：描述了用于监测和控制介入治疗的方法和装置，其中介入治疗导致组织的破坏和化学标记的释放。当介入治疗导致患者组织（例如癌组织）的破坏时，各种化学标记物可被释放到血流中。可以使用体外诊断（IVD）装置来测量表示标记物的分析物的浓度，并将测量的浓度与预定设定点进行比较，以便监测或控制程序。用于分析的血液可以通过程序间或程序内获得，这取决于所测量的效果的快速性和测量速度。

125. 发明授权

US07724931B2 Method and apparatus for evaluating a 3D image of a laterally-symmetric organ system 有权
标题翻译：用于评估横向对称的器官系统的3D图像的方法和装置
公开(公告)号：US07724931B2
公开(公告)日：2010-05-25
申请号：US11593884
申请日：2006-11-07
申请人： Rainer Kuth , Sebastian Schmidt
发明人： Rainer Kuth , Sebastian Schmidt
IPC分类号： G06K9/00 , G06K9/46 , A61B5/05
CPC分类号： G06T7/0012 , G06K9/6206 , G06T2207/30008
摘要： In a method for automated evaluation of a three-dimensional map of a laterally-symmetric organ system as well as medical image acquisition system and a computer program for this purpose, a three-dimensional image of the organ system is segmented, and the segmented organ system is deformed such that the deformed organ system has two mirror-symmetric halves with regard to its external shape. The differences between both mirror-symmetrical halves of the deformed organ system are determined by a comparison of one half with the other half. Alternatively, instead of the deformation of the segmented organ system a mirror-symmetric normal model of the organ system can be deformed, relative to the organ system, or vice versa, such that differences of corresponding regions of both halves of the organ system can be determined using the normal model. The determined differences are presented to a user.
摘要翻译：在用于自动评估横向对称的器官系统的三维图的方法以及用于此目的的医学图像采集系统和计算机程序中，分割器官系统的三维图像，并且分割的器官系统变形使得变形的器官系统相对于其外部形状具有两个镜像对称的两半。通过将一半与另一半的比较来确定变形的器官系统的两个镜对称半部之间的差异。或者，代替分段器官系统的变形，器官系统的镜像对称正常模型可以相对于器官系统变形，反之亦然，使得器官系统的两半的对应区域的差异可以是使用正常模型确定。所确定的差异被呈现给用户。

126. 发明申请

US20100049743A1 USER INTERFACE IN AN INFORMATION TECHNOLOGY (IT) SYSTEM 有权
标题翻译：信息技术（IT）系统中的用户界面
公开(公告)号：US20100049743A1
公开(公告)日：2010-02-25
申请号：US12541537
申请日：2009-08-14
申请人： Sebastian Schmidt , Katharina Socher
发明人： Sebastian Schmidt , Katharina Socher
IPC分类号： G06F3/01 , G06F17/30 , G06F3/048
CPC分类号： G06F11/2294
摘要： A method and system for improving user interfaces in IT systems is provided. In one embodiment, the method includes using a remote maintenance function by a user of a user interface in order to allow a technician to take control of a data transmission connection during operation, recording interactions implemented during the use of the remote maintenance function in a database of the manufacturer of the IT system and evaluating the recorded interactions by the manufacturer in order to derive therefrom indications of an improvement in the user interface.
摘要翻译：提供了一种改进IT系统中用户界面的方法和系统。在一个实施例中，该方法包括由用户界面的用户使用远程维护功能，以便技术人员在操作期间控制数据传输连接，记录在数据库中使用远程维护功能期间实现的交互的IT制造商的制造商，并评估制造商记录的交互作用，从而得出用户界面改进的指示。

127. 发明申请

US20100010757A1 Method for determining an attenuation map 有权
标题翻译：确定衰减图的方法
公开(公告)号：US20100010757A1
公开(公告)日：2010-01-14
申请号：US12458431
申请日：2009-07-13
申请人： Sebastian Schmidt
发明人： Sebastian Schmidt
IPC分类号： G01R29/00 , G06N3/02 , G06F19/00
CPC分类号： G01R33/481 , A61B5/055 , A61B6/037 , A61B6/5235 , A61B6/5247 , G01T1/1603
摘要： A method is disclosed for defining an attenuation map. In at least one embodiment, the method includes creating at least two data sets from which attenuation values are able to be determined; evaluating the data sets and determining attenuation values; weighting the attenuation values determined and creating the attenuation map by inserting the weighted attenuation values.
摘要翻译：公开了一种用于定义衰减图的方法。在至少一个实施例中，该方法包括创建能够确定衰减值的至少两个数据集; 评估数据集和确定衰减值; 通过插入加权衰减值对所确定的衰减值进行加权并创建衰减图。

128. 发明申请

US20090307010A1 METHOD AND SYSTEM FOR AUTOMATICALLY ASSOCIATING AN ASSESSOR WITH A MEDICAL ASSESSMENT TASK 有权
标题翻译：具有医疗评估任务的评估者自动关联的方法和系统
公开(公告)号：US20090307010A1
公开(公告)日：2009-12-10
申请号：US12480817
申请日：2009-06-09
申请人： Sonja Boehmer-Lasthaus , Rainer Kuth , Sebastian Schmidt
发明人： Sonja Boehmer-Lasthaus , Rainer Kuth , Sebastian Schmidt
IPC分类号： G06N5/02 , G06Q30/00 , G06Q10/00 , G06Q50/00
CPC分类号： G06Q50/22 , G06F19/00 , G06Q10/06 , G06Q10/06398 , G06Q20/102 , G06Q30/0283
摘要： In a method and system for automated association of an assessor with an assessment task (in particular an evaluation of an image data set) an assessor database is used that contains assessors as well as selection information associated with assessors and task information associated with assessment tasks. A medical assessment is automatically associated with an assessor using at least one decision rule, starting from the task information and with consideration of the relevant selection information.
摘要翻译：在用于评估者与评估任务（特别是图像数据集的评估）的自动关联的方法和系统中，使用包含评估者的评估者数据库以及与评估者相关联的选择信息和与评估任务相关联的任务信息。使用至少一个决策规则，从任务信息开始并考虑相关的选择信息，自动与评估者相关联的医学评估。

129. 发明申请

US20090180933A1 REACTOR 失效
标题翻译：反应堆
公开(公告)号：US20090180933A1
公开(公告)日：2009-07-16
申请号：US12297987
申请日：2007-04-23
申请人： Jörg Kauling , Helmut Brod , Sebastian Schmidt , Martin Poggel , Björn Frahm , Reinhold Rose
发明人： Jörg Kauling , Helmut Brod , Sebastian Schmidt , Martin Poggel , Björn Frahm , Reinhold Rose
IPC分类号： G01N21/64 , B01J19/00 , C12M1/00 , B01J19/12
CPC分类号： B01J19/28 , B01F3/04269 , B01F11/0002 , B01F11/0008 , B01F13/0018 , B01F13/0032 , B01F15/00733 , B01F15/0085 , B01F15/00915 , B01F15/065 , B01F15/066 , B01F2003/04361 , B01J19/123 , B01J19/285 , B01J2219/0025 , B01J2219/00761 , B01J2219/185 , B01J2219/192 , C12M23/14 , C12M23/28 , C12M27/02 , C12M27/10
摘要： The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.
摘要翻译：本发明涉及一种围绕其固定的，优选垂直的轴以振荡旋转方式驱动的反应器，优选用于生物技术和制药应用。通过其混合，悬浮，气态物质运输，传热，照射和颗粒保留的工艺增强性能，确保了工业规模的适用性。没有轴封成功的反应器相对于无菌技术可以特别稳定的生产，避免了当反应器被构造为一次性反应器时所需的清洁和清洁验证。

130. 发明申请

US20090156927A1 ANGIOGRAPHIC METHOD AND APPARATUS ALLOWING IDENTIFICATION OF CONTRAST AGENT PROPAGATION 有权
标题翻译：有助于识别对比剂传播的摄像方法和装置
公开(公告)号：US20090156927A1
公开(公告)日：2009-06-18
申请号：US12335627
申请日：2008-12-16
申请人： Sebastian Schmidt
发明人： Sebastian Schmidt
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/7289 , G01R33/5601 , G01R33/5635 , G01R33/56509
摘要： In a method and apparatus for acquisition of angiographic data sets of a region of an examination subject, into whose bloodstream a contrast agent has been introduced, a data set of the region to be examined is acquired during a first propagation phase of the contrast agent in the bloodstream as a reference data set to determine reference data, additional data sets of the region to be examined are then acquired, and based on the reference data, variations that are caused in at least some of the additional data sets due to the arrival of a second propagation phase of the contrast agent are determined, and the arrival of the second propagation phase of the contrast agent in the bloodstream is identified based on the determined variations.
摘要翻译：在用于获取检查对象的区域的血管造影数据集的方法和装置中，其引入了造影剂的血流中，在造影剂的第一传播阶段期间获取待检查区域的数据集，作为用于确定参考数据的参考数据集的血流，然后获取待检查区域的附加数据集，并且基于参考数据，由于至少一些附加数据集在由于到达确定造影剂的第二传播阶段，并且基于确定的变化来识别造影剂在血流中的第二传播期的到达。

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