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121. 发明授权

US4686987A Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiologic demand 失效
标题翻译：生物医学方法和装置，用于响应于生理需求的变化来控制对患者的治疗施用
公开(公告)号：US4686987A
公开(公告)日：1987-08-18
申请号：US362903
申请日：1982-03-29
申请人： Rodney W. Salo , Brian D. Pederson
发明人： Rodney W. Salo , Brian D. Pederson
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36521
摘要： A biomedical apparatus capable of sensing changes in the heart's ventricular volume or stroke volume and then changing the operating performance of the device in a fashion as a function of stroke volume. A relatively low frequency signal (under 5 KHz) is applied between spaced electrodes disposed in the heart and the beating action of the heart serves to modulate this signal due to changes in impedance being sensed between these or other electrodes within the heart. The modulated carrier signal is then processed to remove R-wave and other electrical artifacts and then demodulated to remove the carrier frequency component leaving the envelope which is proportional to instantaneous ventricular volume. This envelope signal then contains stroke volume and ventricular volume information which can be used by the biomedical apparatus to vary its operating parameters. For example, a current proportional to changes in stroke volume may be injected into the timing circuit of a demand-type cardiac pacer pulse generator whereby the interpulse interval of the pulse generator is varied as a function of stroke volume.
摘要翻译：一种生物医学装置，其能够感测心脏体积或冲程体积的变化，然后以作为行程体积的函数的方式改变装置的操作性能。相对较低的频率信号（低于5KHz）被施加在设置在心脏中的间隔电极之间，并且心脏的跳动作用是由于在心脏内的这些或其它电极之间感测的阻抗的变化来调制该信号。然后处理调制载波信号以去除R波和其他电气伪影，然后解调以去除离开与瞬时心室容积成比例的包络的载波频率分量。然后，该包络信号包含可由生物医学装置用于改变其操作参数的搏动体积和心室容积信息。例如，与笔画体积变化成比例的电流可以被注入到需求型心脏起搏器脉冲发生器的定时电路中，由此脉冲发生器的脉冲间隔作为行程体积的函数而变化。

122. 发明授权

US08255052B2 Temperature based systems and methods for tachycardia discrimination and therapy 有权
标题翻译：用于心动过速鉴别和治疗的基于温度的系统和方法
公开(公告)号：US08255052B2
公开(公告)日：2012-08-28
申请号：US12411157
申请日：2009-03-25
申请人： Rodney W. Salo , Allan Charles Shuros , Dan Li
发明人： Rodney W. Salo , Allan Charles Shuros , Dan Li
IPC分类号： A61N1/36
CPC分类号： A61N1/3622 , A61N1/3962
摘要： Embodiments of the invention are related to an implantable medical system, amongst other things. In an embodiment, the invention includes a processor, an electrical sensor, and a temperature sensor. The processor is configured to monitor myocardial electrical activity with input from the electrical sensor; identify myocardial electrical activity indicative of an arrhythmia, measure temperature of blood in the coronary venous system with input from the temperature sensor; determine if the arrhythmia is hemodynamically stable or hemodynamically unstable based on the temperature of blood in the coronary venous system, and initiate high-voltage shock therapy if the arrhythmia is hemodynamically unstable. Other embodiments are also included herein.
摘要翻译：本发明的实施例涉及可植入医疗系统等。在一个实施例中，本发明包括处理器，电传感器和温度传感器。处理器被配置为通过来自电传感器的输入来监测心肌电活动; 识别指示心律失常的心肌电活动，用来自温度传感器的输入测量冠状静脉系统中血液的温度; 根据冠状静脉系统中的血液温度，确定心律失常是否为血液动力学稳定或血液动力学不稳定，如果心律失常是血液动力学不稳定的话，开始进行高压休克治疗。本文还包括其它实施例。

123. 发明申请

US20090062894A1 MEDICAL DEVICE ELECTRODES HAVING CELLS DISPOSED ON NANOSTRUCTURES 失效
标题翻译：具有纳米结构处理细胞的医疗器械电极
公开(公告)号：US20090062894A1
公开(公告)日：2009-03-05
申请号：US11846280
申请日：2007-08-28
申请人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
发明人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0565
摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.
摘要翻译：用于组织刺激和感测的电极可以包括具有设置在支撑体上的纳米结构的支撑体。电极对可以彼此靠近放置。当向电极提供电能时，可以在电极上的纳米结构之间建立电场（和可能的电流）。纳米结构可以具有设置在其上的细胞，例如心肌细胞，心肌祖细胞，神经细胞和/或干细胞。此外，电极可以排列成阵列。

124. 发明授权

US07499749B2 Method and apparatus for minimizing post-infarct ventricular remodeling 失效
标题翻译：用于最小化梗死后心室重塑的方法和装置
公开(公告)号：US07499749B2
公开(公告)日：2009-03-03
申请号：US11025847
申请日：2004-12-29
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/0587 , A61N1/3684
摘要： A cardiac rhythm management device for in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.
摘要翻译：一种心律管理装置，其中预激发起搏应用于心室心肌梗塞区域附近的一个或多个部位。这种起搏服务器可以预防或最小化梗死后重塑。

125. 发明授权

US07400931B2 Devices and methods to stimulate therapeutic angiogenesis for ischemia and heart failure 失效
标题翻译：用于刺激局部缺血和心力衰竭的治疗性血管发生的装置和方法
公开(公告)号：US07400931B2
公开(公告)日：2008-07-15
申请号：US10246249
申请日：2002-09-18
申请人： Evgenia Mandrusov , Paul Consigny , Rodney W. Salo
发明人： Evgenia Mandrusov , Paul Consigny , Rodney W. Salo
IPC分类号： A61N1/05 , A61N1/372 , A61M25/00
CPC分类号： A61N1/0568 , A61N1/056 , A61N1/306 , A61N1/326 , A61N2001/0585
摘要： A device that includes an electrical output channel adapted to deliver a sub-threshold voltage, a lead that includes a proximal end adapted to be electrically connected to the electrical output channel and a distal end adapted to be placed in the blood conduit where the distal end of the lead is adapted to deliver a treatment agent that stimulates therapeutic angiogenesis, and at least one electrode on the distal end of the first lead.
摘要翻译：一种包括适于递送亚阈值电压的电输出通道的装置，包括适于电连接到电输出通道的近端的引线和适于放置在血管中的远端，其中远端的铅适于递送刺激治疗性血管生成的治疗剂，以及至少一个电极在第一引线的远端。

126. 发明申请

US20080109043A1 PRE-EXCITATION PACING FOR TREATMENT OF HYPERTENSION 有权
标题翻译：用于治疗高血压的预激活剂
公开(公告)号：US20080109043A1
公开(公告)日：2008-05-08
申请号：US11557202
申请日：2006-11-07
申请人： Rodney W. Salo , Robert Shipley
发明人： Rodney W. Salo , Robert Shipley
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36564
摘要： Described herein are methods and apparatus for treating hypertension with electrical pre-excitation pacing therapy. Electrical pre-excitation of a hypertrophic region advances the timing of the regional contraction and reduces its contribution to the overall contraction. Such pre-excitation pacing therapy may be beneficial to hypertensive patients with an abnormal distribution of ventricular wall stress/strain.
摘要翻译：本文描述了用电预激发起步疗法治疗高血压的方法和装置。增生区域的电预激发促进了区域收缩的时机，并减少了其对整体收缩的贡献。这种预激励起搏治疗可能有益于心室壁应力/应变异常分布的高血压患者。

127. 发明授权

US07194305B1 Cardiac rhythm management system with optimization of cardiac performance using heart rate 有权
标题翻译：心脏节律管理系统使用心率优化心脏性能
公开(公告)号：US07194305B1
公开(公告)日：2007-03-20
申请号：US09545536
申请日：2000-04-07
申请人： Rodney W. Salo , Lawrence S. Baumann , Kenneth L. Baker
发明人： Rodney W. Salo , Lawrence S. Baumann , Kenneth L. Baker
IPC分类号： A61N1/00
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688
摘要： A cardiac rhythm management device includes a dual chamber pacemaker, especially designed for treating congestive heart failure by pacing a plurality of sites. The device incorporates a program microcontroller which is operative to adjust the pacing mode and inter-site delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode inter-site delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Performance is optimized when the patient is at rest and when the patient exercises so that a rate-adapted dynamic value of the optimum performance can be applied.
摘要翻译：心律管理装置包括双室起搏器，其特别设计用于通过起搏多个部位治疗充血性心力衰竭。该装置包括程序微控制器，其可操作以调节起搏器的起搏模式和位置间延迟，以实现最佳血液动力学性能。信号处理后的瞬时（即时）时间间隔内测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。当患者处于静止状态并且患者锻炼时优化性能，以便可以应用最佳性能的速率适应动态值。

128. 发明授权

US06909919B2 Cardiac lead incorporating strain gauge for assessing cardiac contractility 失效
标题翻译：用于评估心脏收缩力的心脏导联
公开(公告)号：US06909919B2
公开(公告)日：2005-06-21
申请号：US10236310
申请日：2002-09-06
申请人： Mudit Jain , Qingsheng Zhu , Rodney W. Salo
发明人： Mudit Jain , Qingsheng Zhu , Rodney W. Salo
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： For chronic monitoring of the effects of pacing and/or drug therapy in treating CHF, a strain gauge element is disposed at the distal end of a cardiac lead and is effective to produce a signal relating to the amount of flexure being induced into the lead by the beating action of the heart.
摘要翻译：为了慢性监测起搏和/或药物治疗在治疗CHF中的作用，应变计元件设置在心脏引线的远端，并且有效地产生与通过引导引入的弯曲量相关的信号心跳的动作。

129. 发明授权

US06708061B2 Cardiac rhythm management system with optimization of cardiac performance using heart rate 有权
标题翻译：心脏节律管理系统使用心率优化心脏性能
公开(公告)号：US06708061B2
公开(公告)日：2004-03-16
申请号：US09734282
申请日：2000-12-11
申请人： Rodney W. Salo , Kenneth L. Baker , Lawrence S. Baumann
发明人： Rodney W. Salo , Kenneth L. Baker , Lawrence S. Baumann
IPC分类号： A61N118
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3688 , A61N1/3702
摘要： A cardiac rhythm management device includes a dual chamber pacemaker, especially designed for treating congestive heart failure by pacing a plurality of sites. The device incorporates a program microcontroller which is operative to adjust the pacing mode and inter-site delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode inter-site delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Performance is optimized when the patient is at rest and when the patient exercises so that a rate-adapted dynamic value of the optimum performance can be applied.
摘要翻译：心律管理装置包括双室起搏器，其特别设计用于通过起搏多个部位治疗充血性心力衰竭。该装置包括程序微控制器，其可操作以调节起搏器的起搏模式和位置间延迟，以实现最佳血液动力学性能。信号处理后的瞬时（即时）时间间隔内测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。当患者处于静止状态并且患者锻炼时优化性能，以便可以应用最佳性能的速率适应动态值。

130. 发明授权

US5836987A Apparatus and method for optimizing cardiac performance by determining the optimal timing interval from an accelerometer signal 失效
标题翻译：通过从加速度计信号确定最佳定时间隔来优化心脏性能的装置和方法
公开(公告)号：US5836987A
公开(公告)日：1998-11-17
申请号：US815697
申请日：1997-03-12
申请人： Lawrence S. Baumann , Bruce A. Tockman , Rodney W. Salo , Emanuel H. Silvermint
发明人： Lawrence S. Baumann , Bruce A. Tockman , Rodney W. Salo , Emanuel H. Silvermint
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/36542 , A61N1/3627 , A61N1/3682
摘要： A cardiac stimulating apparatus and method which optimizes cardiac performance by determining, from a filtered waveform transmitted from an accelerometer contained within the cardiac pacer, an optimum timing interval between at least one of intrinsic and paced stimulations of pre-selected chambers of the heart. Digitized data of the accelerometer signal, corresponding with identified R--R intervals, are stored for a plurality of preselected timing intervals for analysis and comparison. The accelerometer signal is filtered to isolate features of the waveform associated with specific cardiac events including for example, the first heart sound, the second heart sound or an amplitude in the frequency domain thereof. Characteristic values of these features of the accelerometer signal are calculated over a plurality of complete R--R intervals for each of the preselected timing intervals. The characteristic values are analyzed and compared to determine which timing interval optimizes cardiac performance. The cardiac stimulating apparatus and method may be used in any of several pacing modes including A-V pacing, V--V pacing, or A--A pacing.
摘要翻译：一种心脏刺激装置和方法，其通过从包含在所述心脏起搏器内的加速度计传输的经过滤波的波形确定心脏预先选择的腔室的内在和起搏刺激中的至少一个之间来优化心脏性能。对应于识别的R-R间隔的加速度计信号的数字化数据被存储用于多个预选的定时间隔用于分析和比较。过滤加速度计信号以分离与特定心脏事件相关联的波形的特征，包括例如第一心音，第二心音或其频域中的振幅。对于每个预选的定时间隔，在多个完整的R-R间隔上计算加速度计信号的这些特征的特征值。对特征值进行分析和比较，以确定哪个时间间隔优化心脏性能。心脏刺激装置和方法可以以包括A-V起搏，V-V起搏或A-A起搏的多种起搏方式中的任何一种使用。

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