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121. 发明授权

US08435682B2 Biological fuel cell and methods 有权
公开(公告)号：US08435682B2
公开(公告)日：2013-05-07
申请号：US13567903
申请日：2012-08-06
申请人： Adam Heller
发明人： Adam Heller
IPC分类号： H01M8/16
CPC分类号： H01M8/16 , H01M4/9008 , H01M2250/30 , Y02B90/18 , Y02E60/527
摘要： A fuel cell has an anode and a cathode with anode enzyme disposed on the anode and cathode enzyme is disposed on the cathode. The anode is configured and arranged to electrooxidize an anode reductant in the presence of the anode enzyme. Likewise, the cathode is configured and arranged to electroreduce a cathode oxidant in the presence of the cathode enzyme. In addition, anode redox hydrogel may be disposed on the anode to transduce a current between the anode and the anode enzyme and cathode redox hydrogel may be disposed on the cathode to transduce a current between the cathode and the cathode enzyme.

122. 发明申请

US20130066178A1 Lyotropic Liquid Crystal Coated Analyte Monitoring Device and Methods of Use 有权
标题翻译：溶致液体涂层分析物监测装置及其使用方法
公开(公告)号：US20130066178A1
公开(公告)日：2013-03-14
申请号：US13568799
申请日：2012-08-07
申请人： Adam Heller , Pawel Rowinski , Benjamin Feldman
发明人： Adam Heller , Pawel Rowinski , Benjamin Feldman
IPC分类号： A61B5/1473
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1468 , C12Q1/006 , Y10T29/49117
摘要： The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.
摘要翻译：本发明涉及具有连续水通道的液晶的膜，例如包含立方相溶致液晶的溶致液晶，以及配备有这种膜的电化学传感器。该膜可用于限制分析物在电化学传感器中的工作电极的扩散，使得传感器在大范围的分析物浓度下不饱和和/或保持线性响应。配备有本发明的膜的电化学传感器在各种条件下表现出相当大的灵敏度和稳定性以及较大的信噪比。

123. 发明授权

US08372005B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08372005B2
公开(公告)日：2013-02-12
申请号：US12643982
申请日：2009-12-21
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

124. 发明授权

US08357091B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08357091B2
公开(公告)日：2013-01-22
申请号：US12643986
申请日：2009-12-21
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

125. 发明授权

US08353829B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08353829B2
公开(公告)日：2013-01-15
申请号：US12643975
申请日：2009-12-21
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

126. 发明申请

US20130006079A1 Analyte Sensor, and Associated System and Method Employing a Catalytic Agent 有权
标题翻译：分析物传感器，以及使用催化剂的相关系统和方法
公开(公告)号：US20130006079A1
公开(公告)日：2013-01-03
申请号：US13437692
申请日：2012-04-02
申请人： Benjamin J. Feldman , Zenghe Liu , David C. Cohen , Adam Heller
发明人： Benjamin J. Feldman , Zenghe Liu , David C. Cohen , Adam Heller
IPC分类号： A61B5/1486 , A61B5/145
CPC分类号： A61B5/686 , A61B5/14514 , A61B5/14528 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/004 , C12Q1/005 , C12Q1/006
摘要： An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and/or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.
摘要翻译：描述了与生物流体结合使用的分析物传感器。分析物传感器可以包括生物流体和生物流体的衍生物之间的任何合适的界面以及关于分析物的任何合适的信息传感器。在界面的区域或附近提供至少一种催化剂。催化剂，例如蛋白质剂或非蛋白质的有机金属剂，足以催化可能存在于界面附近的活性氧和/或氮物质的降解。还描述了分析物感测套件和感测分析物的方法。

127. 发明申请

US20120316412A1 Analyte Monitoring Device and Methods of Use 有权
标题翻译：分析物监测装置及使用方法
公开(公告)号：US20120316412A1
公开(公告)日：2012-12-13
申请号：US13555057
申请日：2012-07-20
申请人： Adam Heller , Steven H. Drucker , Robert Y. Jin , Jeffery V. Funderburk
发明人： Adam Heller , Steven H. Drucker , Robert Y. Jin , Jeffery V. Funderburk
IPC分类号： A61B5/1473
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/0022 , A61B5/0031 , A61B5/076 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B5/6832 , A61B5/6833 , A61B5/6849 , A61B5/7405 , A61B5/742 , A61B5/743 , A61B5/7445 , A61B2560/0252 , A61B2560/0412 , A61B2560/063 , A61N1/08 , H04B1/707 , H04L1/0071
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
摘要翻译：分析物监测器包括传感器，传感器控制单元和显示单元。传感器具有例如基板，形成在基板中的凹陷通道，以及设置在凹陷通道中以形成工作电极的导电材料。传感器控制单元通常具有适于放置在皮肤上并适于接收电化学传感器的一部分的壳体。传感器控制单元还包括设置在壳体上并被配置为耦合到传感器上的两个或更多个接触垫的两个或更多个导电触头。发射器设置在壳体中并且耦合到多个导电接触件，用于传送使用传感器获得的数据。显示单元具有用于接收由传感器控制单元的发送器发送的数据的接收器和耦合到接收器的显示器，用于显示分析物水平的指示。分析物监测器还可以是药物递送系统的一部分，以基于使用传感器获得的数据来改变分析物的水平。

128. 发明申请

US20120305395A1 Device for the Determination of Glycated Hemoglobin 有权
标题翻译：测定糖化血红蛋白的装置
公开(公告)号：US20120305395A1
公开(公告)日：2012-12-06
申请号：US13476625
申请日：2012-05-21
申请人： Adam Heller
发明人： Adam Heller
IPC分类号： G01N27/327
CPC分类号： C12Q1/26 , F01B1/12 , F01L9/04 , F02B75/20 , G01N33/723 , G01N2333/805 , H01M8/16 , Y02E60/527
摘要： An electrochemical device for determining the percentage of glycated hemoglobin in a blood sample is provided. The device includes a cathode and anode and one or more cells. The device may include an enzyme capable of reducing oxygen to water for determining the total amount of hemoglobin in a sample by electrochemically measuring, in an oxygen electroreduction reaction at a cathode, the amount of oxygen in the sample. The device may also be used to determine the amount of glycated hemoglobin in the sample (e.g., spectrometrically or electrochemically). Also provided are devices that include glycated hemoglobin hydrolysis agents or glycated hemoglobin separating agents.
摘要翻译：提供了用于测定血液样品中糖化血红蛋白百分比的电化学装置。该装置包括阴极和阳极以及一个或多个电池。该装置可以包括能够将氧还原成水的酶，以通过在阴极的氧电还原反应中电化学测量样品中的氧量来测定样品中血红蛋白的总量。该装置还可以用于确定样品中糖化血红蛋白的量（例如，光谱法或电化学方法）。还提供了包括糖化血红蛋白水解剂或糖化血红蛋白分离剂的装置。

129. 发明授权

US08265726B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08265726B2
公开(公告)日：2012-09-11
申请号：US12614990
申请日：2009-11-09
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

130. 发明授权

US08255034B2 Lyotropic liquid crystal coated analyte monitoring device and methods of use 有权
标题翻译：溶致液晶涂层分析物监测装置及使用方法
公开(公告)号：US08255034B2
公开(公告)日：2012-08-28
申请号：US11948915
申请日：2007-11-30
申请人： Adam Heller , Pawel Rowinski , Benjamin J. Feldman
发明人： Adam Heller , Pawel Rowinski , Benjamin J. Feldman
IPC分类号： A61B5/1468 , C25B9/10
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1468 , C12Q1/006 , Y10T29/49117
摘要： The present invention is directed to membranes composed liquid crystals having continuous aqueous channels, such as a lyotropic liquid crystal, including a cubic phase lyotropic liquid crystal, and to electrochemical sensors equipped with such membranes. The membranes are useful in limiting the diffusion of an analyte to a working electrode in an electrochemical sensor so that the sensor does not saturate and/or remains linearly responsive over a large range of analyte concentrations. Electrochemical sensors equipped with membranes of the present invention demonstrate considerable sensitivity and stability, and a large signal-to-noise ratio, in a variety of conditions.
摘要翻译：本发明涉及具有连续水通道的液晶的膜，例如包含立方相溶致液晶的溶致液晶，以及配备有这种膜的电化学传感器。该膜可用于限制分析物在电化学传感器中的工作电极的扩散，使得传感器在大范围的分析物浓度下不饱和和/或保持线性响应。配备有本发明的膜的电化学传感器在各种条件下表现出相当大的灵敏度和稳定性以及较大的信噪比。

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