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111. 发明申请

US20080014178A1 Method for Stimulating Mammalian Cells and Mammalian Cell 审中-公开
标题翻译：刺激哺乳动物细胞和哺乳动物细胞的方法
公开(公告)号：US20080014178A1
公开(公告)日：2008-01-17
申请号：US11631323
申请日：2005-06-17
申请人： Jari Koistinaho , Milla Koistinaho
发明人： Jari Koistinaho , Milla Koistinaho
IPC分类号： A61K35/12 , A61P25/16 , A61P25/28 , A61P3/10 , A61P31/12 , C12N5/00 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0647 , A61K2035/124 , C12N2501/052 , C12N2501/22
摘要： The current invention relates to methods for stimulating mammalian cells to enhance their ability to cross the blood-brain-barrier and to phagocytose and degrade beta-amyloid plaques in the brain. The current invention also relates to cells obtained by the method of the invention. The current invention also relates to methods for prevention and treatment of amyloid-accumulating disorders.
摘要翻译：本发明涉及用于刺激哺乳动物细胞增强其跨血脑屏障和吞噬并降解脑中β-淀粉样蛋白斑的能力的方法。本发明还涉及通过本发明的方法获得的细胞。本发明还涉及用于预防和治疗淀粉样蛋白积聚障碍的方法。

112. 发明申请

US20070269885A1 Method for producing dendritic cells 有权
公开(公告)号：US20070269885A1
公开(公告)日：2007-11-22
申请号：US11789669
申请日：2007-04-24
申请人： Herman Waldmann , Paul Fairchild , Richard Gardner , Frances Brook
发明人： Herman Waldmann , Paul Fairchild , Richard Gardner , Frances Brook
IPC分类号： C12N5/06
CPC分类号： C12N5/0639 , A61K2039/5154 , A61K2039/5156 , C12N5/0603 , C12N5/064 , C12N2501/052 , C12N2501/22 , C12N2501/23 , C12N2503/02 , C12N2506/02 , C12N2510/00
摘要： Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of providing a population of embryonic stem cells; culturing the embryonic stem cells in the presence of a cytokine or combination of cytokines which brings about differentiation of the embryonic stem cells into dendritic cells; and recovering the dendritic cells from the culture. In a further embodiment, the cells may be genetically modified.

113. 发明授权

US07247480B2 Method for producing dendritic cells 有权
标题翻译：树突状细胞的制备方法
公开(公告)号：US07247480B2
公开(公告)日：2007-07-24
申请号：US09849499
申请日：2001-05-04
申请人： Herman Waldmann , Paul J. Fairchild , Richard Gardner , Frances Brook
发明人： Herman Waldmann , Paul J. Fairchild , Richard Gardner , Frances Brook
IPC分类号： C12N5/00 , C12N5/02 , C12N5/06 , C12N5/08 , A01N63/00 , A61K48/00 , C12N15/00
CPC分类号： C12N5/0639 , A61K2039/5154 , A61K2039/5156 , C12N5/0603 , C12N5/064 , C12N2501/052 , C12N2501/22 , C12N2501/23 , C12N2503/02 , C12N2506/02 , C12N2510/00
摘要： Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of providing a population of embryonic stem cells; culturing the embryonic stem cells in the presence of a cytokine or combination of cytokines which brings about differentiation of the embryonic stem cells into dendritic cells; and recovering the dendritic cells from the culture. In a further embodiment, the cells may be genetically modified.
摘要翻译：公开了胚胎干细胞衍生的树突状细胞，能够成熟的遗传修饰的未成熟树突状细胞，以及用于产生这种细胞的方法。在一个实施方案中，制备的细胞通过包括以下步骤的方法产生：提供一群胚胎干细胞; 在细胞因子或细胞因子的组合存在下培养胚胎干细胞，其导致胚胎干细胞分化成树突状细胞; 并从培养物中回收树突状细胞。在另一个实施方案中，细胞可以被遗传修饰。

114. 发明申请

US20040259790A1 Methods for identifying and administering agents that bias the immune response via dendritic cells 审中-公开
标题翻译：用于鉴定和施用通过树突状细胞偏置免疫应答的药剂的方法
公开(公告)号：US20040259790A1
公开(公告)日：2004-12-23
申请号：US10769635
申请日：2004-01-30
发明人： Bali Pulendran , Sudhanshu Agrawal , Stephanie Maree Dillon
IPC分类号： A61K038/17
CPC分类号： C12N5/0639 , A61K2035/122 , A61K2039/57 , C12N5/0636 , C12N2501/052 , C12N2501/998
摘要： The invention provides a method of regulating a Th2 immune response which comprises contacting a cell with an amount of a molecule effective to modulate an ERK null pathway and/or a c-FOS pathway in the cell so as a to regulate the TH2 immune response, which molecule is any of (a) an agonist of a TLR2 or a TLR2 variant; (b) an agonist of an intracellular pathway that is initiated by activation of a TLR2; (c) an agonist of an intracellular pathway that is initiated by activation of a receptor activated by SEA; (d) an antagonist of an intracellular pathway that opposes TLR2 signaling or activation; (e) an agonist of an ERK null pathway; (f) an antagonist of a p38 pathway; (g) an antagonist of a JNK null pathway; or (h) an agonist of the c-FOS pathway, or a molecule that induces c-Fos gene expression, c-Fos messenger RNA stability, c-Fos protein induction, c-Fos protein stability, or c-Fos protein phosphorylation.
摘要翻译：本发明提供了一种调节Th2免疫应答的方法，其包括使细胞与一定量的有效调节细胞中ERK 1/2途径和/或c-FOS途径的分子接触，以调节TH2免疫应答，该分子是（a）TLR2或TLR2变体的激动剂中的任一种; （b）通过激活TLR2引发的细胞内途径的激动剂; （c）由SEA激活的受体的活化引发的细胞内途径的激动剂; （d）抗TLR2信号传导或激活的细胞内途径的拮抗剂; （e）ERK 1/2途径的激动剂; （f）p38途径的拮抗剂; （g）JNK 1/2途径的拮抗剂; 或（h）c-FOS途径的激动剂，或诱导c-Fos基因表达的分子，c-Fos信使RNA稳定性，c-Fos蛋白诱导，c-Fos蛋白稳定性或c-Fos蛋白磷酸化。

115. 发明申请

US20030108527A1 Maturation-promoting agent for immature dendrtic cells 审中-公开
标题翻译：未成熟树突细胞成熟促进剂
公开(公告)号：US20030108527A1
公开(公告)日：2003-06-12
申请号：US10169203
申请日：2002-10-29
发明人： Tsukasa Seya , Shoutaro Tsuji , Misako Matsumoto , Akira Hayashi , Ichiro Azuma
IPC分类号： A61K045/00 , A61K031/739 , C12N005/08
CPC分类号： C12N5/0639 , A61K2035/124 , A61K2039/5154 , A61K2039/55594 , C12N2501/052
摘要： This invention relates to dendritic cells that are matured by utilizing a cell wall skeleton of a Gram positive bacteria-CWS and a process for maturing said cells, as well as a composition for accelerating the maturation of immature dendritic cells comprising a Gram positive bacteria-CWS as an essential component.
摘要翻译：本发明涉及通过利用革兰氏阳性细菌CWS的细胞壁骨架和成熟所述细胞的方法成熟的树突状细胞，以及用于加速未成熟树突状细胞成熟的组合物，其包含革兰氏阳性细菌CWS 作为必不可少的组成部分。

116. 发明申请

US20020131962A1 Method of producing dendritic cells 审中-公开
标题翻译：树突状细胞的制备方法
公开(公告)号：US20020131962A1
公开(公告)日：2002-09-19
申请号：US10135593
申请日：2002-04-30
申请人： ISIS INNOVATION LIMITED
发明人： Herman Waldmann , Paul J. Fairchild , Richard Gardner , Frances Brook
IPC分类号： A61K048/00 , C12N005/08
CPC分类号： C12N5/0639 , A61K2039/5154 , A61K2039/5156 , C12N5/0603 , C12N5/064 , C12N2501/052 , C12N2501/22 , C12N2501/23 , C12N2503/02 , C12N2506/02 , C12N2510/00
摘要： Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells may be produced by a method comprising the steps of providing a population of embryonic stem cells; culturing the embryonic stem cells in the presence of a cytokine or combination of cytokines which brings about differentiation of the embryonic stem cells into dendritic cells; and recovering the dendritic cells from the culture. In a further embodiment, the cells may be genetically modified.
摘要翻译：公开了胚胎干细胞衍生的树突状细胞，能够成熟的遗传修饰的未成熟树突状细胞，以及用于产生这种细胞的方法。在一个实施方案中，细胞可以通过包括以下步骤的方法产生：提供一群胚胎干细胞; 在细胞因子或细胞因子的组合存在下培养胚胎干细胞，其导致胚胎干细胞分化成树突状细胞; 并从培养物中回收树突状细胞。在另一个实施方案中，细胞可以被遗传修饰。

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