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111. 发明授权

US4554380A Process for the manufacture of o-toluidine and/or m-toluidine and/or p-toluidine 失效
标题翻译：邻甲苯胺和/或间甲苯胺和/或对甲苯胺的制备方法
公开(公告)号：US4554380A
公开(公告)日：1985-11-19
申请号：US644866
申请日：1984-08-27
申请人： Hans-Jurgen Arpe , Heinz Litterer
发明人： Hans-Jurgen Arpe , Heinz Litterer
IPC分类号： C07B61/00 , B01J21/00 , B01J29/40 , C07C67/00 , C07C209/00 , C07C209/64 , C07C209/68 , C07C209/86 , C07C211/47 , C07C85/00
CPC分类号： C07C209/68
摘要： The invention provides a process for the manufacture of o-toluidine and/or m-toluidine and/or p-toluidine, which comprises the two following steps (a) and (b):(a) treatment of a toluidine isomer mixture or of the not intended toluidine isomer or of one of the not intended toluidine isomers with an isomerization catalyst selected from the group of synthetic zeolites of the pentasil type,(b) isolation of the intended isomer or one of the intended isomers from the isomer mixture formed in step (a) by selective adsorption to a medium-pore or large-pore zeolite and subsequent desorption, furthermore discharge of the isolated isomer and recycling of the remaining isomer mixture to step (a).
摘要翻译：本发明提供了制备邻甲苯胺和/或间甲苯胺和/或对甲苯胺的方法，其包括以下两个步骤（a）和（b）：（a）处理甲苯胺异构体混合物或不需要的甲苯胺异构体或一种不需要的甲苯胺异构体，其中异构化催化剂选自pentasil类型的合成沸石，（b）从所形成的异构体混合物中分离出所需异构体或其中一种异构体步骤（a）通过选择性吸附到中孔或大孔沸石并随后解吸，此外排出分离的异构体并将剩余的异构体混合物再循环到步骤（a）。

112. 发明授权

US4521627A Method of preparing alkali metal salts of organic diamines 失效
标题翻译：制备有机二胺碱金属盐的方法
公开(公告)号：US4521627A
公开(公告)日：1985-06-04
申请号：US577514
申请日：1984-02-06
申请人： Peter W. D. Mitchell
发明人： Peter W. D. Mitchell
IPC分类号： C07B61/00 , B01J20060101 , B01J23/00 , B01J23/56 , B01J23/74 , B01J27/00 , B01J27/122 , B01J27/128 , B01J27/138 , B01J31/04 , B01J31/20 , B01J31/22 , C07C20060101 , C07C67/00 , C07C209/00 , C07C209/66 , C07C211/09 , C07F1/00 , C22B20060101 , C07C87/14
CPC分类号： C07C209/68
摘要： The disclosure is of a method of preparing alkaline metal salts of organic diamines. The method comprises, in brief, reacting the alkaline metal with a molar excess of the diamine in the presence of a catalytic proportion of a transition metal compound, at a temperature of from about 20.degree. C. to reflux temperature for the reaction mixture.
摘要翻译：本公开是制备有机二胺的碱金属盐的方法。该方法简单地包括在催化剂比例的过渡金属化合物的存在下，在约20℃至反应混合物的回流温度下使碱金属与摩尔过量的二胺反应。

113. 发明授权

US4493931A Process for the preparation of .beta.-cyclo-substituted ethylamines 失效
标题翻译：制备β-环取代的乙胺的方法
公开(公告)号：US4493931A
公开(公告)日：1985-01-15
申请号：US393383
申请日：1982-06-29
申请人： Isaac Chekroun , Alain Heymes
发明人： Isaac Chekroun , Alain Heymes
IPC分类号： C07C67/00 , C07C209/00 , C07C209/62 , C07C209/68 , C07C211/27 , C07C213/00 , C07C217/60 , C07D213/38 , C07D307/52 , C07D307/54 , C07D333/20 , C07D333/28 , C07F9/24 , C07F9/40 , C07F9/58 , C07F9/655 , C07F9/6553 , C07D213/18 , C07C85/24 , C07C87/28
CPC分类号： C07F9/655345 , C07C209/68 , C07D213/38 , C07D307/52 , C07D333/20 , C07D333/28 , C07F9/2462 , C07F9/2475 , C07F9/4006 , C07F9/588 , C07F9/65515
摘要： The present invention provides a multistep process for the preparation of .beta.-cyclo-substituted ethylamines of the general formula:-Ar--CH.sub.2 --CH.sub.2 --NH.sub.2 (I)in which AR is a heterocyclic or non-heterocyclic aromatic radical, which is optionally mono- or poly- substituted, wherein said compounds represent a class of intermediates which can be converted to 4,5,6,7-tetrahydro[3,2-C] or [2,3-C]pyridines wherein the latter are useful for anti-inflammatory, vasodilator or blood platelet aggregation inhibition activities.
摘要翻译：本发明提供了用于制备通式如下的β-环取代的乙胺的多步骤方法：其中AR是杂环或非杂环芳族基团，其中Ar-CH 2 -CH 2 -NH 2 + 任选地被单取代或多取代，其中所述化合物代表一类中间体，其可转化为4,5,6,7-四氢[3,2-C]或[2,3-C]吡啶，其中后者可用于抗炎，血管扩张或血小板聚集抑制活性。

114. 发明授权

US4462933A Process for preparing 4-phenyl-1,3-benzodiazepines 失效
公开(公告)号：US4462933A
公开(公告)日：1984-07-31
申请号：US300015
申请日：1981-09-08
申请人： Lawrence L. Martin , Manfred Worm , Charles A. Crichlow
发明人： Lawrence L. Martin , Manfred Worm , Charles A. Crichlow
IPC分类号： C07D243/04
CPC分类号： C07D243/04 , C07C201/12 , C07C209/36 , C07C209/50 , C07C209/52 , C07C209/68 , C07C213/02 , C07C231/02 , C07C231/12 , C07C233/13 , C07C233/18 , C07C233/59 , C07C233/60 , C07C249/08 , C07C249/12 , C07C251/48 , C07C251/60 , C07C2101/14
摘要： Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.

115. 发明授权

US4409145A Process for preparing 4-phenyl-1,3-benzodiazepines 失效
标题翻译：制备4-苯基-1,3-苯并二氮杂卓的方法
公开(公告)号：US4409145A
公开(公告)日：1983-10-11
申请号：US299867
申请日：1981-09-08
申请人： Lawrence L. Martin , Manfred Worm , Charles A. Crichlow
发明人： Lawrence L. Martin , Manfred Worm , Charles A. Crichlow
IPC分类号： C07D243/04
CPC分类号： C07C201/12 , C07C209/36 , C07C209/50 , C07C209/52 , C07C209/60 , C07C209/68 , C07C213/02 , C07C231/02 , C07C231/12 , C07C249/08 , C07C249/12 , C07D243/04 , C07C2102/14
摘要： Novel 4-phenyl-1,3-benzodiazepines, novel intermediates thereof, and methods of preparing same are described. These benzodiazepines are useful as antidepressants, analgetics and anticonvulsants.
摘要翻译：描述了新的4-苯基-1,3-苯并二氮杂，其新颖的中间体及其制备方法。这些苯二氮卓类可用作抗抑郁药，止痛药和抗惊厥药。

116. 发明授权

US4375561A Process for the preparation of aromatic amines 失效
标题翻译：芳香胺的制备方法
公开(公告)号：US4375561A
公开(公告)日：1983-03-01
申请号：US318117
申请日：1981-11-04
申请人： Rudiger Berthold , Werner H. Muller
发明人： Rudiger Berthold , Werner H. Muller
IPC分类号： C07B61/00 , B01J23/00 , C07C67/00 , C07C209/00 , C07C209/40 , C07C209/68 , C07C211/45 , C07C211/55 , C07C85/11
CPC分类号： C07C209/68
摘要： Aromatic amines are obtained from the corresponding cycloaliphatic oximes by heating the oxime to a temperature of from 150.degree. to 350.degree. C. in an ether group containing solvent in the presence of a catalyst containing a noble metal of the 8th auxiliary group of the Periodic Table of Elements. The solvent is preferably an aliphatic ether, especially a lower dialkyl ether of a polyethyleneglycol.
摘要翻译：在含有第8族元素周期表的贵金属的催化剂存在下，通过将肟在含有醚基的溶剂中加热至150℃至350℃的温度，从相应的脂环族肟得到芳族胺的元素。溶剂优选为脂族醚，特别是聚乙二醇的低级二烷基醚。

117. 发明授权

US4326989A Catalyst of nickel compound and ligand in presence of a reducing metal 失效
标题翻译：在还原金属存在下镍化合物和配体的催化剂
公开(公告)号：US4326989A
公开(公告)日：1982-04-27
申请号：US206147
申请日：1980-11-12
申请人： Ismael Colon , Louis M. Maresca , George T. Kwiatkowski
发明人： Ismael Colon , Louis M. Maresca , George T. Kwiatkowski
IPC分类号： B01J31/24 , C07C41/26 , C07C43/205 , C07C45/72 , C07C209/68 , C07D213/22 , B01J31/02
CPC分类号： C07D213/22 , B01J31/181 , B01J31/1815 , B01J31/2404 , B01J31/26 , C07C209/68 , C07C41/30 , C07C45/72 , B01J2231/4205 , B01J23/02 , B01J23/06 , B01J23/34 , B01J2531/847 , C07C2527/08 , C07C2527/10 , C07C2527/128 , C07C2531/24 , C07C2531/26 , C07C2531/30
摘要： Aryl and heteroaryl mono chlorides are coupled in an aprotic solvent under an inert atmosphere by a catalyst mixture of a nickel compound and a ligand in the presence of a reducing metal.
摘要翻译：芳基和杂芳基一氯化物在非活性溶剂中，在惰性气氛下，在还原金属存在下，通过镍化合物和配体的催化剂混合物偶合。

118. 发明授权

US4326082A Use of aqueous triethylamine/phosphoric acid salt solutions to extract water and triethylamine from solutions thereof in organic solvents 失效
标题翻译：使用三乙胺/磷酸盐水溶液从有机溶剂中的溶液中提取水和三乙胺
公开(公告)号：US4326082A
公开(公告)日：1982-04-20
申请号：US137653
申请日：1980-04-07
申请人： Patrick H. Martin , Stephen L. Michaels
发明人： Patrick H. Martin , Stephen L. Michaels
IPC分类号： C07C85/26
CPC分类号： C07C209/68 , C07C209/86
摘要： Triethylamine and water are simultaneously removed from solutions in organic solvents, by liquid/liquid extraction with concentrated aqueous solutions of (C.sub.2 H.sub.5).sub.3 N.H.sub.3 PO.sub.4 which preferably contain free phosphoric acid as well. Upon heating of the resulting extract, the water and amine taken up are boiled off and the extractant regenerated. The method is of particular value in the preparation of aqueous coating compositions comprising reaction products of polyether epoxides and H.sub.3 PO.sub.4 in organic media. The reaction product is salified with triethylamine in excess, in the presence of added water. The organic solvent is boiled off, together with the excess amine and some of the water, to form an aqueous dispersion of the salified product and a distillate which can be processed by the method of the invention. The recovered solvent, water and amine may be recycled.
摘要翻译：通过液体/液体萃取（C2H5）3N.H3PO4的浓度水溶液（其优选含有游离磷酸）同时从有机溶剂溶液中除去三乙胺和水。在加热得到的提取物时，将所吸收的水和胺煮沸并且萃取剂再生。该方法在包含聚醚环氧化物和H 3 PO 4在有机介质中的反应产物的水性涂料组合物的制备中是特别有价值的。在加入水的存在下，将反应产物用三乙胺过量盐化。将有机溶剂与过量的胺和一些水一起煮沸，以形成可以通过本发明的方法处理的成盐产物和馏出物的水分散体。回收的溶剂，水和胺可以再循环。

119. 发明授权

US4289906A Chemical process for preparing methylene bis-anilines 失效
标题翻译：制备亚甲基双苯胺的化学方法
公开(公告)号：US4289906A
公开(公告)日：1981-09-15
申请号：US101544
申请日：1979-12-10
申请人： Kju H. Shin
发明人： Kju H. Shin
IPC分类号： C07C209/68 , C07C85/02
CPC分类号： C07C209/68
摘要： Aromatic amine hydrochloride having an unsubstituted ortho or para position reacts with dimethylsulfoxide forming methylenebis aromatic amine.
摘要翻译：具有未取代的邻位或对位的芳族胺盐酸盐与形成亚甲基双芳族胺的二甲基亚砜反应。

120. 发明授权

US4219502A Aromatic amine alkylation process 失效
标题翻译：芳香胺烷基化方法
公开(公告)号：US4219502A
公开(公告)日：1980-08-26
申请号：US44671
申请日：1979-06-01
申请人： Kryn G. Ihrman , Manuel Brandt
发明人： Kryn G. Ihrman , Manuel Brandt
IPC分类号： C07C209/68 , C07C85/24
CPC分类号： C07C209/68
摘要： An improvement in the process for alkylating the nucleus of an aromatic amine which contains small amounts of a nickel compound by reaction with an olefin in the presence of an aluminum anilide-type catalyst whereby hydrogen sulfide or a sulfide generating compound (e.g. thioacetamide) is added to the aromatic amine to reduce the rate inhibiting effect of the nickel compound.
摘要翻译：通过在铝酰苯胺型催化剂的存在下与烯烃反应而含有少量镍化合物的芳族胺核的方法的改进，由此加入硫化氢或硫化物产生化合物（例如硫代乙酰胺）与芳族胺反应以降低镍化合物的抑制率。

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