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111. 发明授权

US06999815B2 Automatic selection of stimulation chamber for ventricular resynchronization therapy 有权
公开(公告)号：US06999815B2
公开(公告)日：2006-02-14
申请号：US10655569
申请日：2003-09-04
申请人： Jiang Ding , Julio C. Spinelli , Yinghong Yu , Andrew P. Kramer
发明人： Jiang Ding , Julio C. Spinelli , Yinghong Yu , Andrew P. Kramer
IPC分类号： A61N1/362
CPC分类号： A61N1/36592 , A61B5/0472 , A61N1/3627 , A61N1/3684
摘要： A method and apparatus for selection of one or more ventricular chambers to stimulate for ventricular resynchronization therapy. Intrinsic intracardia electrograms that include QRS complexes, are recorded from a left and right ventricle. A timing relationship between the intrinsic intracardia electrograms recorded from the left and right ventricle is then determined. In one embodiment, the timing relationship is determined using a delay between a left ventricular and a right ventricular sensed intrinsic ventricular depolarizations and a duration interval of one or more QRS complexes. In one embodiment, the duration of QRS complexes is determined from either intracardiac electrograms or from surface ECG recordings. One or more ventricular chambers in which to provide pacing pulses are then selected based on the timing relationship between intrinsic intracardia electrograms recorded from the right and left ventricle, and the duration of one or more QRS complexes.

112. 发明申请

US20050131472A1 Cardiac pacing using adjustable atrio-ventricular delays 有权
标题翻译：心脏起搏使用可调节的心房延迟
公开(公告)号：US20050131472A1
公开(公告)日：2005-06-16
申请号：US11049181
申请日：2005-02-02
申请人： Jiang Ding , Yinghong Yu , Andrew Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew Kramer , Julio Spinelli
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

113. 发明授权

US06768924B2 Method and apparatus for capture verification based on propagated electrical activity 有权
标题翻译：基于传播电活动的捕获验证方法和装置
公开(公告)号：US06768924B2
公开(公告)日：2004-07-27
申请号：US10038225
申请日：2002-01-03
申请人： Jiang Ding , Yinghong Yu , Julio C. Spinelli , Qingsheng Zhu
发明人： Jiang Ding , Yinghong Yu , Julio C. Spinelli , Qingsheng Zhu
IPC分类号： A61N1362
CPC分类号： A61N1/3712 , A61N1/3684 , A61N1/3714
摘要： An implantable cardiac rhythm/function management device that automatically determines whether or not a pacing stimulus to the ventricles results in capture by detecting propagated depolarizations at stimulating and non-stimulating electrodes. The device of the present invention is suitable for use in either a single or multiple electrode pacing/sensing configuration and may be utilized to verify either atrial or ventricular capture of a heart having either normal or abnormal intrinsic AV conduction.
摘要翻译：一种植入式心律/功能管理装置，其自动确定对心室的起搏刺激是否通过检测刺激和非刺激电极处的传播去极化而导致捕获。本发明的装置适用于单电极或多电极起搏/感测配置，并且可用于验证具有正常或异常固有AV传导的心脏的心房或心室捕获。

114. 发明授权

US06684103B2 Cardiac pacing using adjustable atrio-ventricular delays 有权
标题翻译：心脏起搏使用可调节的心房延迟
公开(公告)号：US06684103B2
公开(公告)日：2004-01-27
申请号：US10243811
申请日：2002-09-13
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.
摘要翻译：一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机心室起搏脉搏。该系统为多个血液动力学参数的近似最佳起搏提供了选择。该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

115. 发明授权

US06453192B1 Detection of ventricular ectopic beats using ventricular electrogram 失效
标题翻译：使用心室电图检测心室异位搏动
公开(公告)号：US06453192B1
公开(公告)日：2002-09-17
申请号：US09523616
申请日：2000-03-13
申请人： Jiang Ding , Julio C. Spinelli , Yinghong Yu
发明人： Jiang Ding , Julio C. Spinelli , Yinghong Yu
IPC分类号： A61B50452
CPC分类号： A61B5/0468 , A61N1/3622
摘要： A method of accurately determining if ectopic beats are occurring in the heart by detecting the time interval, T, between a point Q* defined is the onset of the QRS complex and the peak value of R (T=Q*R) during a heart beat cycle and comparing that time with a running mean value calculated from normal heartbeats. A beat is identified as an ectopic beat if the Q*R time interval for a current beat is at least four standard deviations from the mean Q*R time interval of normal preceding beats. The electrodes for detecting the ectopic beats may be inside the patient's heart or on the patient's skin. If more than one electrode is used for monitoring the depolarization of the heart, then by combining the Q*R intervals (e.g. using a triangulation method) calculated from different electrodes, the location of the ectopic excitation can be determined and identified. The method of determining and localizing ectopic beats may be used in a pacing device to initiate ectopic beat handling procedures and to analyze the nature and possible trend of ectopic activities. This method of using the Q*R interval is independent of the PR or RR intervals normally measured and used to detect early ectopic beats and is therefore a more accurate method, since ectopic beats may occur at any time independent of PR or RR intervals.
摘要翻译：通过检测定义的点Q *之间的时间间隔T来确定心脏中是否发生异位搏动的方法是QRS复合物的开始和心脏中的R（T = Q * R）的峰值比较该时间与从正常心跳计算的运行平均值。如果当前节拍的Q * R时间间隔与正常以前节拍的平均Q * R时间间隔至少有四个标准偏差，则拍子被识别为异位拍子。用于检测异位搏动的电极可以在患者的心脏内或病人的皮肤上。如果使用多于一个电极来监测心脏的去极化，则通过组合由不同电极计算的Q * R间隔（例如使用三角测量方法），可以确定和鉴定异位激发的位置。确定和定位异位搏动的方法可以用于起搏装置中以启动异位搏动处理程序并分析异位活动的性质和可能的趋势。使用Q * R间隔的这种方法与通常测量的PR或RR间隔无关，用于检测早期异位搏动，因此是更准确的方法，因为异位搏动可以随时独立于PR或RR间期发生。

116. 发明授权

US08538519B2 Method and system for treatment of mechanical cardiac asynchrony 有权
标题翻译：用于治疗机械心脏不同步的方法和系统
公开(公告)号：US08538519B2
公开(公告)日：2013-09-17
申请号：US11113827
申请日：2005-04-25
申请人： Jiang Ding , Yinghong Yu , Milton M. Morris
发明人： Jiang Ding , Yinghong Yu , Milton M. Morris
IPC分类号： A61N1/365
CPC分类号： A61N1/36528 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A system and method for identifying patients with asynchronous ventricular contractions due to abnormal electro-mechanical coupling and computing optimal pacing parameters for restoring synchronous contractions is disclosed. Such patients may have normal intra-ventricular and inter-ventricular conduction and cannot be identified from intrinsic conduction data alone such as QRS width. Techniques for computing optimal resynchronization pacing in order to compensate for abnormal electro-mechanical coupling are also described.
摘要翻译：公开了一种用于识别异常心电耦合异常心室收缩患者的系统和方法，并且计算用于恢复同步收缩的最佳起搏参数。这样的患者可能具有正常的心室内和心室间传导，并且不能从内在传导数据单独识别，如QRS宽度。还描述了用于计算最佳再同步起搏以补偿异常机电耦合的技术。

117. 发明授权

US08478390B2 Method and apparatus for determing the coronary sinus vein branch accessed by a coronary sinus lead 有权
标题翻译：用于确定冠状静脉窦导管接近的冠状静脉窦静脉分支的方法和装置
公开(公告)号：US08478390B2
公开(公告)日：2013-07-02
申请号：US13488085
申请日：2012-06-04
申请人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio C. Spinelli
发明人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio C. Spinelli
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0456 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/3682
摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
摘要翻译：公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。电极位置的确定可用于自动调整VRT器件的工作参数。此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

118. 发明申请

US20120277607A1 METHOD AND APPARATUS FOR IDENTIFICATION OF ISCHEMIC/INFARCTED REGIONS AND THERAPY OPTIMIZATION 有权
标题翻译：用于鉴别化学/感染性地区和治疗优化的方法和装置
公开(公告)号：US20120277607A1
公开(公告)日：2012-11-01
申请号：US13544007
申请日：2012-07-09
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
IPC分类号： A61B5/0452 , A61N1/365
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译：描述了用于检测和定位心肌梗死或缺血区域的方法和装置。通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑刺激。

119. 发明申请

US20120238889A1 METHOD AND APPARATUS FOR DETERMING THE CORONARY SINUS VEIN BRANCH ACCESSED BY A CORONARY SINUS LEAD 有权
标题翻译：用于确定冠状动脉导管接收的冠状动脉支架的方法和装置
公开(公告)号：US20120238889A1
公开(公告)日：2012-09-20
申请号：US13488085
申请日：2012-06-04
申请人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio Spinelli
发明人： Yinghong Yu , Jiang Ding , Jeng Mah , Julio Spinelli
IPC分类号： A61B5/042 , A61N1/365
CPC分类号： A61B5/0452 , A61B5/0456 , A61B34/20 , A61B2034/2072 , A61N1/3627 , A61N1/3682
摘要： Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.
摘要翻译：公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。电极位置的确定可用于自动调整VRT器件的工作参数。此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

120. 发明授权

US08219210B2 Method and apparatus for identification of ischemic/infarcted regions and therapy optimization 有权
标题翻译：用于鉴别缺血/梗死区域的方法和装置以及治疗优化
公开(公告)号：US08219210B2
公开(公告)日：2012-07-10
申请号：US11541837
申请日：2006-10-02
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译：描述了用于检测和定位心肌梗死或缺血区域的方法和装置。通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑的刺激。

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