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111. 发明申请

US20080290282A1 Concurrent DC-Coupled Anode and Dynode Readout Scheme For PET Block Detectors 有权
标题翻译：用于PET块检测器的并行DC耦合阳极和Dynode读出方案
公开(公告)号：US20080290282A1
公开(公告)日：2008-11-27
申请号：US11753067
申请日：2007-05-24
申请人： Nan Zhang , Matthias J. Schmand , Niraj K. Doshi , Michael D. Loope
发明人： Nan Zhang , Matthias J. Schmand , Niraj K. Doshi , Michael D. Loope
IPC分类号： G01T1/20
CPC分类号： G01T1/1642 , G01T1/208
摘要： A scintillation detector including one or more photomultiplier tubes, a scintillation block optically attached to the photomultiplier tubes, and a DC-coupled bleeder circuit combining outputs of dynodes of the photomultipliers to provide a DC-coupled dynode output together with a DC-coupled anode output of the photomultiplier tubes. The DC-coupled bleeder circuit includes a RF transformer. A positive high voltage supply also can be used together with a DC-coupled bleeder circuit for the anode outputs.
摘要翻译：闪烁检测器，包括一个或多个光电倍增管，与光电倍增管光学连接的闪烁块，以及组合光电倍增管的倍增电极输出的DC耦合泄放电路，以提供DC耦合的倍增电极输出以及直流耦合的阳极输出的光电倍增管。直流耦合放电电路包括RF变压器。阳极高压电源也可以与阳极输出的直流耦合泄放电路一起使用。

112. 发明授权

US07439509B1 Dual channel SiPM for optimal energy and fast timing 有权
标题翻译：双通道SiPM，实现最佳的能量和快速定时
公开(公告)号：US07439509B1
公开(公告)日：2008-10-21
申请号：US11752693
申请日：2007-05-23
申请人： Ronald Grazioso , Nan Zhang
发明人： Ronald Grazioso , Nan Zhang
IPC分类号： G01J5/20
CPC分类号： G01T1/2018 , G01T1/208
摘要： Dual channel silicon photomultipliers (SiPMs) can replace PMTs and APDs for use in PET and other radiation detectors. The devices are compact, have high gain, high QE and low noise. Due to their timing performance, these devices can be used in time-of-flight PET applications. By dividing the device into two separate channels, one for timing resolution and one for energy resolution, both can be optimized simultaneously.
摘要翻译：双通道硅光电倍增管（SiPM）可以替代用于PET和其他辐射探测器的PMT和APD。器件紧凑，增益高，QE高，噪音低。由于其时序性能，这些设备可用于飞行时间PET应用。通过将器件分成两个独立的通道，一个用于定时分辨率，一个用于能量分辨率，两者可以同时优化。

113. 发明申请

US20080209261A1 Data repair and synchronization method of dual flash read only memory 有权
标题翻译：双闪存数据修复和同步方式只读存储器
公开(公告)号：US20080209261A1
公开(公告)日：2008-08-28
申请号：US11710694
申请日：2007-02-26
申请人： Nan Zhang , Yan-Peng Yang , Tom Chen , Win-Harn Liu
发明人： Nan Zhang , Yan-Peng Yang , Tom Chen , Win-Harn Liu
IPC分类号： G06F11/14
CPC分类号： G06F11/1417 , G06F11/1658 , G06F11/1666 , G06F11/2056
摘要： A data repair and synchronization method of dual flash ROM is provided, which includes a first flash ROM and a second flash ROM that store the same system data, wherein one of the first flash ROM and the second flash ROM is used to perform a data repair on the other flash ROM with damaged data and perform a data synchronization between the two flash ROMs, thereby ensuring that once the data in one flash ROM is damaged during the system operation, the complete system data stored in the other flash ROM is used to recover the damaged operating system and the files in the system. Meanwhile, through performing the data synchronization periodically, important configuration files in the system stored in the two flash ROMs are kept to be updated and completed.
摘要翻译：提供了一种双闪存ROM的数据修复和同步方法，其包括存储相同系统数据的第一闪存ROM和第二闪存ROM，其中第一闪存ROM和第二闪存ROM中的一个用于执行数据修复在另一个具有损坏数据的闪存ROM中，并且在两个闪存ROM之间执行数据同步，从而确保一旦在系统操作期间一个闪存ROM中的数据被损坏，则存储在另一个闪存ROM中的完整系统数据被用于恢复受损的操作系统和系统中的文件。同时，通过周期性地执行数据同步，保存存储在两个闪存ROM中的系统中的重要配置文件被更新和完成。

114. 发明申请

US20080161513A1 Catalyst for Olefin Polymerization and Preparation Thereof and Polymerization Process 有权
标题翻译：烯烃聚合催化剂及其制备及聚合方法
公开(公告)号：US20080161513A1
公开(公告)日：2008-07-03
申请号：US11659621
申请日：2006-02-24
申请人： Licai Wang , Zhanxian Gao , Wei Li , Guotong Zheng , Qingxin Dong , Riping Liu , Xiaohuan Wang , Nan Zhang , Jingzhuang Wang , Shimian Cai
发明人： Licai Wang , Zhanxian Gao , Wei Li , Guotong Zheng , Qingxin Dong , Riping Liu , Xiaohuan Wang , Nan Zhang , Jingzhuang Wang , Shimian Cai
IPC分类号： C08F4/50
CPC分类号： C08F10/00 , B01J21/063 , B01J35/023 , B01J35/1019 , C08F110/06 , C08F4/6543 , C08F4/651 , C08F4/6545 , C08F2500/15 , C08F2500/18
摘要： The catalyst for olefin polymerization contains three components A, B and C. The component A is a solid catalyst containing titanium, magnesium, chlorine element and an internal electron donor, the internal electron donor consists of 1,4-diether [2,2′-dialkoxy-1,1′-biphenyl, 2,2′-dialkoxy-1,1′-binaphthalene, 10,10′-dialkoxy-9,9-biphenanthrene] and organic acid ester or 1,3-diether [9,9-bis(methoxymethyl)fluorine, 2,2-dialky 1-1,3-dimethoxypropane]; the component B is an organoaluminum compound; the component C is external electron donor-organic silicon compound or the 1,4 aromatic diether. The catalyst has high catalytic activity, and can be adjusted in the range from 40,000 to 150,000 gPP/gCat when used in propylene polymerization. The polymer made therefrom has isotactivity of 80 to 99 percent and the molecular weight distribution can be adjusted in a wide range. The invention provides a novel method for preparing the 1,4 aromatic diether.
摘要翻译：用于烯烃聚合的催化剂包含三种组分A，B和C.组分A是含有钛，镁，氯元素和内电子给体的固体催化剂，内电子给体由1,4-二醚[2,2' 二烷氧基-1,1'-联苯，2,2'-二烷氧基-1,1'-联萘，10,10'-二烷氧基-9,9-联苯]和有机酸酯或1,3-二醚[ 9-二（甲氧基甲基）氟，2,2-二烷基1-1,3-二甲氧基丙烷]; 组分B是有机铝化合物; 组分C是外电子给体 - 有机硅化合物或1,4-芳族二醚。该催化剂具有高催化活性，当用于丙烯聚合时可以将其调节至40,000至150,000gPP / gCat。由其制备的聚合物具有80-99％的等规度，并且可以在宽范围内调节分子量分布。本发明提供了一种制备1,4芳族二醚的新方法。

115. 发明授权

US07276519B2 Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors 失效
标题翻译：噻吩并[3,2-b]吡啶-6-羰腈和噻吩并[2,3-b]吡啶-5-腈作为蛋白激酶抑制剂
公开(公告)号：US07276519B2
公开(公告)日：2007-10-02
申请号：US10845710
申请日：2004-05-14
申请人： Diane Harris Boschelli , Nan Zhang , Ana Carolina Barrios Sosa , Haris Durutlic , Biqi Wu
发明人： Diane Harris Boschelli , Nan Zhang , Ana Carolina Barrios Sosa , Haris Durutlic , Biqi Wu
IPC分类号： A61K31/4365 , C07D495/06
CPC分类号： C07D495/04 , A61K31/44 , A61K31/497 , A61K31/535
摘要： This invention provides compounds of Formula (1a)–(1f), II wherein: X, m, n, q, R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Q, Z, Z′, Z′″, Z″ and J are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
摘要翻译：本发明提供式（1a） - （1f），II的化合物，其中：X，m，n，q，R 1，R 2，R 3 R 4，R 5，R 5，R 6，R 7，R 8，在本说明书中定义，R 9，Y，Q，Z，Z'，Z“'，Z”和J“可以用于治疗癌症，中风，心肌梗塞，神经性疼痛，骨质疏松症，多囊肾病，自身免疫性疾病，类风湿性关节炎和移植排斥反应以及用于制备所述化合物的方法。

116. 发明申请

US20050090508A1 6-[(Substituted)phenyl]triazolopyrimidines as anticancer agents 失效
标题翻译： 6 - [（取代的）苯基]三唑并嘧啶作为抗癌剂
公开(公告)号：US20050090508A1
公开(公告)日：2005-04-28
申请号：US10950543
申请日：2004-09-24
申请人： Nan Zhang , Semiramis Ayral-Kaloustian , Thai Nguyen , Yanzhong Wu , Wei Tong
发明人： Nan Zhang , Semiramis Ayral-Kaloustian , Thai Nguyen , Yanzhong Wu , Wei Tong
IPC分类号： A61P35/00 , A61P35/04 , C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. The present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及某些6 - [（取代的）苯基]三唑并嘧啶化合物或其药学上可接受的盐，以及含有所述化合物或其药学上可接受的盐的组合物，其中所述化合物是可用于治疗哺乳动物癌症的抗癌剂。本发明还涉及治疗或抑制哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，并进一步提供了治疗或预防表达多重耐药性（MDR）或耐多药耐药性的癌性肿瘤的方法在有需要的哺乳动物中，所述方法包括向所述哺乳动物施用有效量的所述化合物或其药学上可接受的盐。本发明涉及通过促进微管聚合来治疗或抑制有需要的哺乳动物中癌性肿瘤细胞和相关疾病的生长的方法，其包括对所述哺乳动物施用有效量的所述化合物及其药学上可接受的盐。

117. 发明授权

US06521618B2 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors 失效
标题翻译： 3-氰基喹啉，3-氰基-1,6-萘啶和3-氰基-1,7-萘啶作为蛋白激酶抑制剂
公开(公告)号：US06521618B2
公开(公告)日：2003-02-18
申请号：US09820070
申请日：2001-03-28
申请人： Diane Harris Boschelli , Yanong Wang , Frank Charles Boschelli , Dan Maarten Berger , Nan Zhang , Dennis William Powell , Fei Ye , Ayako Yamashita , Frenel Fils DeMorin , Biqi Wu , Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
发明人： Diane Harris Boschelli , Yanong Wang , Frank Charles Boschelli , Dan Maarten Berger , Nan Zhang , Dennis William Powell , Fei Ye , Ayako Yamashita , Frenel Fils DeMorin , Biqi Wu , Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
IPC分类号： A61K315377
CPC分类号： C07D401/04 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14
摘要： This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
摘要翻译：本发明提供具有其中T，Z，X，A，R 1，R 2a，R 2b，R 2c，R 3，R 4和n如本文所定义的结构的式（I）化合物或其药学上可接受的盐，其可用作抗肿瘤剂药物和治疗骨质疏松症和多囊肾病。

118. 发明授权

US06459524B1 Apparatus and method for sensing switching positions of a MEMS optical switch 失效
标题翻译：用于感测MEMS光开关的切换位置的装置和方法
公开(公告)号：US06459524B1
公开(公告)日：2002-10-01
申请号：US09815170
申请日：2001-03-22
申请人： Nan Zhang , Hong Zhang , Arden L. Olson
发明人： Nan Zhang , Hong Zhang , Arden L. Olson
IPC分类号： G02B2600
CPC分类号： G02B6/359 , G02B6/3514 , G02B6/3546 , G02B6/357 , G02B6/358 , G02B26/0841
摘要： A position sensing apparatus, for sensing switching positions in a MEMS device that includes a suspension structure, an actuator, and a support structure, is provided. The apparatus includes a first contact disposed on the suspension structure, a second contact coupled to the support structure, and an indicator coupled to one of the first and second contacts. When the first and second contacts are in contact, the indicator provides a first signal, and when the first and second contacts are not in contact, the indicator provides a second signal.
摘要翻译：提供了一种位置检测装置，用于感测包括悬架结构的MEMS装置中的开关位置，致动器和支撑结构。该装置包括设置在悬挂结构上的第一触点，耦合到支撑结构的第二触点和耦合到第一和第二触点之一的指示器。当第一和第二触点接触时，指示器提供第一信号，并且当第一和第二触点不接触时，指示器提供第二信号。

119. 发明授权

US5430150A Retroviral protease inhibitors 失效
标题翻译：逆转录病毒蛋白酶抑制剂
公开(公告)号：US5430150A
公开(公告)日：1995-07-04
申请号：US991876
申请日：1992-12-16
申请人： Michael P. Trova , Robert E. Babine , Nan Zhang , Steven R. Schow , Allan Wissner
发明人： Michael P. Trova , Robert E. Babine , Nan Zhang , Steven R. Schow , Allan Wissner
IPC分类号： C12N9/99 , A61K31/395 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4402 , A61K31/47 , A61K31/472 , A61K38/00 , A61P31/12 , C07D205/04 , C07D207/16 , C07D209/02 , C07D211/60 , C07D213/40 , C07D213/81 , C07D215/48 , C07D217/26 , C07D223/06 , C07D225/00 , C07D235/14 , C07D263/22 , C07D401/12 , C07D413/06 , C07D413/12 , C07K5/02 , C07K5/078 , C07K5/097 , C07D217/18 , C07D217/12 , C07D217/14
CPC分类号： C07D213/40 , C07D215/48 , C07D217/26 , C07D235/14 , C07D263/22 , C07D401/12 , C07D413/10 , C07K5/022 , C07K5/06139 , C07K5/0821 , A61K38/00
摘要： Compounds of the formula I: ##STR1## wherein X, Y, Z, a, b, c, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined in the specification are provided. The compounds are useful as inhibitors of retroviral protease enzymes.
摘要翻译：提供式I化合物：其中X，Y，Z，a，b，c，R1，R2，R3，R4和R5在说明书中定义。这些化合物可用作逆转录病毒蛋白酶的抑制剂。

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