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111. 发明授权

US07705121B2 Chimeric human T1R3 taste receptor polypeptides and compositions containing same 有权
标题翻译：嵌合人类T1R3味觉受体多肽和含有它们的组合物
公开(公告)号：US07705121B2
公开(公告)日：2010-04-27
申请号：US11797155
申请日：2007-05-01
申请人： Jon Elliott Adler , Sergey Zozulya , Xiadong Li , Shawn O'Connell , Lena Staszewski
发明人： Jon Elliott Adler , Sergey Zozulya , Xiadong Li , Shawn O'Connell , Lena Staszewski
IPC分类号： C07K14/705 , C07K19/00 , C12N15/62
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

112. 发明申请

US20080038741A1 T1R taste receptors and genes encoding same 有权
标题翻译： T1R味觉受体和编码相同的基因
公开(公告)号：US20080038741A1
公开(公告)日：2008-02-14
申请号：US11797156
申请日：2007-05-01
申请人： Jon Adler , Sergey Zozulya , Xiadong Li , Shawn O'Connell , Lena Staszewski
发明人： Jon Adler , Sergey Zozulya , Xiadong Li , Shawn O'Connell , Lena Staszewski
IPC分类号： C12N15/12 , C07H21/00 , C07K14/705 , C12Q1/68 , G01N33/566 , G01N33/53 , C12N15/63 , C07K16/28
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

113. 发明申请

US20080026404A1 Chimeric human T1R3 taste receptor polyptides and compositions containing same 有权
标题翻译：嵌合人类T1R3味道受体多肽及其组合物
公开(公告)号：US20080026404A1
公开(公告)日：2008-01-31
申请号：US11797155
申请日：2007-05-01
申请人： Jon Adler , Sergey Zozulya , Xiadong Li , Shawn O'Connell , Lena Staszewski
发明人： Jon Adler , Sergey Zozulya , Xiadong Li , Shawn O'Connell , Lena Staszewski
IPC分类号： G01N33/53 , C07K14/00 , G01N33/68
CPC分类号： C07K14/723 , C07K14/705 , C07K2319/00
摘要： Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors. Methods for representing taste perception of a particular tastant in a mammal are also described, as are methods for generating novel molecules or combinations of molecules that elicit a predetermined taste perception in a mammal, and methods for simulating one or more tastes. Further, methods for stimulating or blocking taste perception in a mammal are also disclosed.
摘要翻译：描述了新鉴定的哺乳动物味细胞特异性G蛋白偶联受体，以及编码所述受体的基因和cDNA。具体地说，描述了活跃于味觉信号传导中的T1R G蛋白偶联受体以及编码相同基因的cDNA，以及用于分离这些基因并用于分离和表达此类受体的方法。还描述了用于表示哺乳动物中特定促味剂的味觉的方法，以及用于产生在哺乳动物中引发预定味觉的新颖分子或分子组合的方法，以及用于模拟一种或多种口味的方法。此外，还公开了哺乳动物刺激或阻止味觉的方法。

114. 发明申请

US20080268471A1 USE OF SPECIFIC T2R RECEPTORS TO IDENTIFY COMPOUNDS THAT BLOCK BITTER TASTE 有权
标题翻译：使用特异性T2R受体鉴别化合物
公开(公告)号：US20080268471A1
公开(公告)日：2008-10-30
申请号：US12041956
申请日：2008-03-04
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparationshaving a bitter taste.
摘要翻译：提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。这些化合物是具有苦味的食品，饮料或药用制剂的有用添加剂。

115. 发明申请

US20100317035A1 USE OF SPECIFIC T2R TASTE RECEPTORS TO IDENTIFY COMPOUNDS THAT BLOCK BITTER TASTE 有权
标题翻译：特异性T2R受体受体的鉴别鉴定化合物
公开(公告)号：US20100317035A1
公开(公告)日：2010-12-16
申请号：US12854570
申请日：2010-08-11
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
摘要翻译：提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。这些化合物是具有苦味的食品，饮料或药物制剂的有用添加剂。

116. 发明授权

US08071320B2 Use of specific T2R taste receptors to identify compounds that block bitter taste 有权
标题翻译：使用特定的T2R味觉受体来鉴别抑制苦味的化合物
公开(公告)号：US08071320B2
公开(公告)日：2011-12-06
申请号：US12854570
申请日：2010-08-11
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
摘要翻译：提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。这些化合物是具有苦味的食品，饮料或药物制剂的有用添加剂。

117. 发明授权

US07776561B2 Use of specific T2R receptors to identify compounds that block bitter taste 有权
标题翻译：使用特定的T2R受体来鉴定阻止苦味的化合物
公开(公告)号：US07776561B2
公开(公告)日：2010-08-17
申请号：US12041956
申请日：2008-03-04
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparationshaving a bitter taste.
摘要翻译：提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。这些化合物是具有苦味的食品，饮料或药用制剂的有用添加剂。

118. 发明授权

US07338771B2 Use of specific T2R taste receptors to identify compounds that block bitter taste 有权
标题翻译：使用特定的T2R味觉受体来鉴别抑制苦味的化合物
公开(公告)号：US07338771B2
公开(公告)日：2008-03-04
申请号：US10191058
申请日：2002-07-10
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
摘要翻译：提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。这些化合物是具有苦味的食品，饮料或药物制剂的有用添加剂。

119. 发明申请

US20060220322A1 Replenishment pockets on piston rings for the prevention of microwelding 审中-公开
标题翻译：活塞环上的补充口袋用于防止微焊接
公开(公告)号：US20060220322A1
公开(公告)日：2006-10-05
申请号：US11098364
申请日：2005-04-04
申请人： Harold McCormick , Shawn O'Connell
发明人： Harold McCormick , Shawn O'Connell
IPC分类号： F16J9/26
CPC分类号： F16J9/22
摘要： A method is provided for replenishing lubricant to a piston ring groove to prevent microwelding between a piston and a piston ring from an engine. The method includes forming a plurality replenishment pockets on at least one surface of the ring; and disposing a lubricant (such as a dry-film) on the at least one side of the ring so that the plurality of replenishment pockets are substantially filled with lubricant and such that a layer of lubricant is applied to the at least one surface of the ring. During operation of the engine, the lubricant disposed in the plurality of replenishment pockets migrates onto the at least one surface of the ring and is deposited thereto to inhibit microwelding between the at least one surface of the ring and at least one of the upper and lower groove surfaces of the respective piston ring groove. The lubricant is preferred to be a dry-film lubricant.
摘要翻译：提供了一种用于将润滑剂补充到活塞环槽的方法，以防止来自发动机的活塞和活塞环之间的微焊接。该方法包括在环的至少一个表面上形成多个补充袋; 以及在所述环的至少一个侧面上设置润滑剂（例如干膜），使得所述多个补充袋基本上充满润滑剂，并且使润滑剂层施加到所述至少一个表面上环。在发动机操作期间，设置在多个补充口袋中的润滑剂移动到环的至少一个表面上并沉积到其上以阻止环的至少一个表面与上下两个中的至少一个之间的微焊接相应的活塞环槽的槽表面。润滑剂优选为干膜润滑剂。

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