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    • 111. 发明申请
    • Fungicidal mixtures II
    • 杀菌混合物II
    • US20100267555A1
    • 2010-10-21
    • US12742756
    • 2008-11-14
    • Jens RennerSarah UlmschhneiderJochen DietzEgon Haden
    • Jens RennerSarah UlmschhneiderJochen DietzEgon Haden
    • A01C1/06A01N43/40A01N43/54A01N43/88A01P3/00A01P7/04
    • A01N43/40A01N37/34A01N43/50A01N43/54A01N43/653A01N43/88A01N47/12A01N47/18A01N47/38A01N2300/00
    • The present invention relates to mixtures of fungicidally active compounds comprising at least one substituted 3-hydroxyl-3-(3-pyridyl)propanoate compound of the formula I wherein: X1 and X2 are hydrogen or X1 together with X2 form a covalent bond; R1 is H, CN, C1-C6-alkyl, C2-C6-alkynyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkylthio-C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, aryl-C1-C4-alkyl, aryloxy-C1-C4-alkyl, arylthio-C1-C4-alkyl, aryl, hetaryl-C1-C4-alkyl, hetaryloxy-C1-C4-alkyl, hetarylthio-C1-C4-alkyl or heteroaryl, wherein the cyclic moieties of the last eight radicals are unsubstituted or substituted with 1, 2 or 3 radicals selected from halogen, C1-C4-alkyl, C2-C4-alkynyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulfinyl, C1-C4-alkylsulfonyl, C1-C4-haloalkoxy, C1-C4-haloalkylthio, cyano and nitro; A is a covalent bond or C1-C4-alkylen, which is unsubstituted or which may carry a substitutent selected from C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and cyano; Ar is aryl or heteroaryl, wherein the cyclic moieties of the aromatic radicals are unsubstituted or substituted with 1, 2 or 3 radicals Ra, where the radicals Ra are identical or different and selected from halogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-haloalkoxy, C1-C4-haloalkylthio, cyano, nitro, aryl, hetaryl, aryloxy, hetaryloxy, aryloxy-C1-C4-alkyl and hetaryloxy-C1-C4-alkyl, wherein the cyclic moieties of the six last mentioned radicals are unsubstituted or substituted with 1, 2 or 3 radicals selected from halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-haloalkoxy, cyano and nitro; or a tautomer or a salt thereof. and at least one further fungicidally active compound II.
    • 本发明涉及杀真菌活性化合物的混合物,其包含至少一种式I的取代的3-羟基-3-(3-吡啶基)丙酸酯化合物,其中:X 1和X 2是氢或X 1与X 2一起形成共价键; R 1是H,CN,C 1 -C 6烷基,C 2 -C 6炔基,C 1 -C 6烷氧基-C 1 -C 6烷基,C 1 -C 6烷硫基-C 1 -C 6烷基,C 1 -C 6卤代烷基, C 1 -C 4烷基,芳氧基-C 1 -C 4 - 烷基,芳硫基-C 1 -C 4 - 烷基,芳基,杂芳基-C 1 -C 4烷基,芳氧基-C 1 -C 4 - 烷基,杂芳硫基-C 1 -C 4 - C4-烷基或杂芳基,其中最后八个基团的环状部分是未取代的或被1,2或3个选自卤素,C 1 -C 4 - 烷基,C 2 -C 4 - 炔基,C 1 -C 4 - 卤代烷基,C 1 -C 4 - C 1 -C 4 - 烷氧基,C 1 -C 4 - 烷硫基,C 1 -C 4烷基亚磺酰基,C 1 -C 4烷基磺酰基,C 1 -C 4卤代烷氧基,C 1 -C 4卤代烷硫基,氰基和硝基; A是共价键或C1-C4-亚烷基,其是未取代的或可以携带选自C 1 -C 4 - 烷基,C 1 -C 4 - 卤代烷基,C 1 -C 4 - 烷氧基和氰基的取代基; Ar是芳基或杂芳基,其中芳族基团的环状部分是未取代的或被1,2或3个基团R a取代,其中基团R a相同或不同并且选自卤素,C 1 -C 4烷基,C 2 -C 4 - 烯基,C 2 -C 4 - 炔基,C 1 -C 4卤代烷基,C 1 -C 4 - 烷氧基,C 1 -C 4 - 烷硫基,C 1 -C 4卤代烷氧基,C 1 -C 4卤代烷硫基,氰基,硝基,芳基,杂芳基,芳氧基, 芳氧基-C 1 -C 4烷基和芳基氧基-C 1 -C 4烷基,其中六个最后提到的基团的环状部分是未取代的或被1,2或3个选自卤素,C 1 -C 4 - 烷基,C 1 -C 4 卤代烷基,C 1 -C 4 - 烷氧基,C 1 -C 4 - 烷硫基,C 1 -C 4卤代烷氧基,氰基和硝基; 或其互变异构体或其盐。 和至少一种其它杀真菌活性化合物II。
    • 114. 发明申请
    • PROCESS FOR PREPARING SUBSTITUTED BIPHENYLS
    • 制备替代BIPHENYLS的方法
    • US20100256418A1
    • 2010-10-07
    • US12726196
    • 2010-03-17
    • Sebastian Peer SMIDTJochen DietzMichael KeilThomas Grote
    • Sebastian Peer SMIDTJochen DietzMichael KeilThomas Grote
    • C07C205/04
    • C07C201/12C07C209/68C07C211/52C07C205/12
    • A process for preparing substituted biphenyls of the formula I in which the substituents are defined as follows: X is fluorine or chlorine; R1 is nitro, amino or NHR3; R2 is cyano, nitro, halogen, C1-C6-alkyl, C1-C-6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-alkylcarbonyl or phenyl; R3 is C1-C4-alkyl, C1-C4-alkenyl or C1-C4-alkynyl; n is 1, 2 or 3, where in case that n is 2 or 3, the R.sup.2 radicals may also be different, which comprises reacting the compound of the formula II in which Hal is halogen and X and R1 are as defined above, in the presence of a base and of a palladium catalyst selected from the group of:3 a) palladium-triarylphosphine or -trialkylphosphine complex with palladium in the zero oxidation state, b) salt of palladium in the presence of triarylphospine or trialkylphosphine as a complex ligand or c) metallic palladium, optionally applied to support, in the presence of triarylphosphine or trialkylphosphine, in a solvent, with a diphenylborinic acid (III) in which R2 and n are as defined above, where the triarylphosphines or trialkylphosphines used may be substituted.
    • 制备式I取代的联苯的方法,其中取代基定义如下:X是氟或氯; R1是硝基,氨基或NHR3; R2是氰基,硝基,卤素,C1-C6-烷基,C1-C6-6烯基,C1-C6-炔基,C1-C6-烷氧基,C1-C6-卤代烷基,C1-C6烷基羰基或苯基; R3是C1-C4-烷基,C1-C4-烯基或C1-C4-炔基; n为1,2或3,其中在n为2或3的情况下,R 2基团也可以不同,其包括使其中Hal为卤素且X和R 1的式II化合物与 在碱存在下和选自以下组中的钯催化剂存在下:a)钯 - 三芳基膦或三烷基膦配合物与钯在零氧化状态,b)钯在三芳基膦或三烷基膦存在下的盐 作为络合配体或c)金属钯,任选地在三芳基膦或三烷基膦存在下,在溶剂中与二苯基硼酸(III)反应,其中R 2和n如上所定义,其中使用三芳基膦或三烷基膦 可以被替代。
    • 115. 发明申请
    • Fungicidal 5-Hydroxypyrazolines, Method for Producing the Same and Agents Comprising the Same
    • 杀真菌剂5-羟基吡唑啉,其制备方法及其制剂
    • US20080194405A1
    • 2008-08-14
    • US11915989
    • 2006-05-24
    • Markus GewehrJochen DietzThomas GroteAndreas GypserMatthias Niedenbruck
    • Markus GewehrJochen DietzThomas GroteAndreas GypserMatthias Niedenbruck
    • A01N43/56C07D231/08A01P3/00
    • A01N43/56
    • The present invention relates to novel 5-hydroxypyrazolines of the formula I in which the substituents are as defined below: B is phenyl, naphthyl or 5- or 6-membered hetaryl which contains one to four heteroatoms from the group consisting of O, N and S; A is C═O, C═S or SO2; R1 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, phenyl, 5- or 6-membered heterocyclyl or hetaryl which contains one to four heteroatoms from the group consisting of O, N and S; R2 is alkyl, haloalkyl, alkenyl, haloalkyl, alkynyl, haloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, phenyl, 5- or 6-membered hetaryl or heterocyclyl which contains one to four heteroatoms from the group consisting of O, N and S; R3 is hydrogen, nitro, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl or NR′2, where R′ independently of one another are hydrogen or alkyl; R4 is hydrogen, halogen, nitro, cyano, NR′2, alkyl, haloalkyl, COOR′ or 5- or 6-membered hetaryl or heterocyclyl; where the variables mentioned above may be substituted according to the description; processes for their preparation, their use for controlling harmful fungi and compositions comprising them.
    • 本发明涉及式I的新的5-羟基吡唑啉,其中取代基如下所定义:B是苯基,萘基或5-或6-元杂芳基,其含有一至四个由O,N和 S; A是C-O,C-S或SO 2。 R 1是烷基,卤代烷基,烯基,卤代烯基,炔基或卤代炔基,环烷基,环烯基,环炔基,苯基,5-或6-元杂环基或杂芳基,其含有一至四个 O,N和S; R 2是烷基,卤代烷基,烯基,卤代烷基,炔基,卤代炔基,环烷基,环烯基,环炔基,苯基,5-或6-元杂芳基或杂环基,其含有一至四个 O,N和S; R 3是氢,硝基,氰基,烷基,卤代烷基,烷氧基,卤代烷氧基,烯基,卤代烯基,炔基,卤代炔基或NR'2,其中R'彼此独立地 是氢或烷基; R 4是氢,卤素,硝基,氰基,NR'2,烷基,卤代烷基,COOR'或5-或6-元杂芳基或杂环基; 其中上述变量可以根据描述被替代; 其制备方法,它们用于控制有害真菌的用途和包含它们的组合物。
    • 117. 发明申请
    • Process for Preparing Substituted Biphenyls
    • 制备取代联苯的方法
    • US20090005597A1
    • 2009-01-01
    • US12087345
    • 2007-05-31
    • Sebastian Peer SmidtJochen DietzMichael KeilThomas Grote
    • Sebastian Peer SmidtJochen DietzMichael KeilThomas Grote
    • C07C201/12C07C209/68
    • C07C201/12C07C209/68C07C211/52C07C205/12
    • A process for preparing substituted biphenyls of the formula I in which the substituents are defined as follows: X is fluorine or chlorine; R1 is nitro, amino or NHR3; R2 is cyano, nitro, halogen, C1-C6-alkyl, C1-C6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-alkylcarbonyl or phenyl; R3 is C1-C4-alkyl, C1-C4-alkenyl or C1-C4-alkynyl; n is 1, 2 or 3, where in case that n is 2 or 3, the R2 radicals may also be different, which comprises reacting the compound of the formula II in which Hal is halogen and X and R1 are as defined above, in the presence of a base and of a palladium catalyst selected from the group of: a) palladium-triarylphosphine or -trialkylphosphine complex with palladium in the zero oxidation state, b) salt of palladium in the presence of triarylphospine or trialkylphosphine as a complex ligand or c) metallic palladium, optionally applied to support, in the presence of triarylphosphine or trialkylphosphine, in a solvent, with a diphenylborinic acid (III) in which R2 and n are as defined above, where the triarylphosphines or trialkylphosphines used may be substituted.
    • 制备式I取代的联苯的方法,其中取代基定义如下:X是氟或氯; R1是硝基,氨基或NHR3; R2是氰基,硝基,卤素,C1-C6-烷基,C1-C6-烯基,C1-C6-炔基,C1-C6-烷氧基,C1-C6-卤代烷基,C1-C6-烷基羰基或苯基; R3是C1-C4-烷基,C1-C4-烯基或C1-C4-炔基; n为1,2或3,其中在n为2或3的情况下,R2基团也可以不同,其包括使Hal为卤素的化合物与X和R 1如上所定义的化合物反应在 存在碱和钯催化剂,其选自:a)钯 - 三芳基膦或三烷基膦配合物与钯在零氧化状态,b)钯在三芳基膦或三烷基膦作为络合配体的存在下的盐,或 c)金属钯,任选地在三芳基膦或三烷基膦存在下,在溶剂中与其中R 2和n如上定义的二苯基硼酸(III)反应,其中所用的三芳基膦或三烷基膦可以被取代。
    • 118. 发明申请
    • Bicyclic 5-Hydroxypyrazolines, Method For Producing the Same and Agents Comprising the Same
    • 双环5-羟基吡唑啉,其制备方法和包含其的试剂
    • US20080227840A1
    • 2008-09-18
    • US11916201
    • 2006-05-24
    • Markus GewehrJochen DietzThomas GroteAndreas GypserMatthias Niedenbruck
    • Markus GewehrJochen DietzThomas GroteAndreas GypserMatthias Niedenbruck
    • A01N43/56C07D231/54A01N25/26A01P3/00
    • C07D401/12A01N43/56C07D231/56
    • Bicyclic 5-hydroxypyrazolines of the formula I in which the substituents are as defined below: B is phenyl, naphthyl or 5- or 6-membered hetaryl which contains one to four heteroatoms from the group consisting of O, N and S; A is C═O, C═S or SO2; R1 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, phenyl, 5- or 6-membered heterocyclyl or hetaryl which contains one to four heteroatoms from the group consisting of O, N and S; R2 together with R1 or R4 is C3-C4-alkylene or C3-C4-alkenylene, which groups may be defined according to the description, R3 is hydrogen, nitro, cyano, NR″2, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl or haloalkynyl, where R″ independently of one another are hydrogen or alkyl; R4 is hydrogen, halogen, nitro, cyano, NR″2, alkyl, haloalkyl, COOR″, hetaryl or heterocyclyl; where the variables mentioned above may be substituted according to the description; processes for their preparation, their use for controlling harmful fungi and compositions comprising them.
    • 其中取代基如下定义的式I的双环5-羟基吡唑啉:B是含有一至四个由O,N和S组成的组的杂原子的苯基,萘基或5-或6-元杂芳基; A是C-O,C-S或SO 2。 R 1是烷基,卤代烷基,烯基,卤代烯基,炔基或卤代炔基,环烷基,环烯基,环炔基,苯基,5-或6-元杂环基或杂芳基,其含有一至四个 O,N和S; R 2与R 1或R 4一起是C 3 -C 4烷基, - 亚烷基或C 3 -C 4 - 亚烯基,这些基团可以根据描述定义,R 3是氢,硝基,氰基 ,NR“2,烷基,卤代烷基,烷氧基,卤代烷氧基,烯基,卤代烯基,炔基或卤代炔基,其中R”彼此独立地是氢或烷基; R 4是氢,卤素,硝基,氰基,NR“2,烷基,卤代烷基,COOR”,杂芳基或杂环基; 其中上述变量可以根据描述被替代; 其制备方法,它们用于控制有害真菌的用途和包含它们的组合物。
    • 119. 发明申请
    • Fungicidal N-Benzyl-5-Hydroxy-5-Phenylpryrazolines, Processes For Their Preparation and Compositions Comprising Them
    • 杀真菌剂N-苄基-5-羟基-5-苯基吡唑啉,其制备方法及其组合
    • US20080214642A1
    • 2008-09-04
    • US11916233
    • 2006-05-24
    • Markus GewehrJochen DietzThomas GroteAndreas GypserMatthias Niedenbruck
    • Markus GewehrJochen DietzThomas GroteAndreas GypserMatthias Niedenbruck
    • A01N43/56C07D231/08A01P3/00
    • C07D231/08A01N43/56
    • N-benzoyl-5-hydroxy-5-phenylpyrazolines of the formula I in which the substituents are as defined below: L1, L2 are hydrogen, halogen, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl; L3, L4, L5 are alkyl or one of the groups mentioned under L1 and L2; X is oxygen or sulfur; R1 is halogen, nitro, cyano, NR′2, alkyl, haloalkyl, alkoxy, alkenyl, haloalkyl, alkynyl, haloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, phenyl, 5- or 6-membered heterocyclyl or hetaryl which contains one to four heteroatoms from the group consisting of O, N and S; R′ independently of one another are hydrogen or alkyl; m is 1, 2, 3, 4 or 5; R2 is hydrogen or alkyl; R3 is hydrogen, nitro, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl or NR′2, where R4 is hydrogen, halogen, nitro, cyano, NR′2, alkyl, haloalkyl, COOR′ or 5- or 6-membered heterocyclyl or hetaryl which contains one to four heteroatoms from the group consisting of O, N and S; where the variables mentioned above may be substituted according to the description; processes for their preparation, their use for controlling harmful fungi and compositions comprising them.
    • 其中取代基如下定义的式I的N-苯甲酰基-5-羟基-5-苯基吡唑:L 1,L 2是氢,卤素,卤代烷基, 烯基,卤代烯基,炔基或卤代炔基; L 3,L 4,L 5是烷基或在L 1和L 2之间提及的基团之一, SUP> 2 ; X是氧或硫; R 1是卤素,硝基,氰基,NR'2,烷基,卤代烷基,烷氧基,烯基,卤代烷基,炔基,卤代炔基,环烷基,环烯基,环炔基,苯基,5 - 或6元杂环基或杂芳基,其含有一至四个由O,N和S组成的组的杂原子; R'彼此独立地是氢或烷基; m为1,2,3,4或5; R 2是氢或烷基; R 3是氢,硝基,氰基,烷基,卤代烷基,烷氧基,卤代烷氧基,烯基,卤代烯基,炔基,卤代炔基或NR'2,其中R 4, / SUP>是氢,卤素,硝基,氰基,NR'2,烷基,卤代烷基,COOR'或5-或6-元杂环基或杂芳基,其含有一至四个由以下组成的组的杂原子: O,N和S; 其中上述变量可以根据描述被替代; 其制备方法,它们用于控制有害真菌的用途和包含它们的组合物。
    • 120. 发明申请
    • Fungicidal 5-Hydroxypyrazolines, Processes for their Preparation and Comprising Them
    • 杀真菌剂5-羟基吡唑啉,其制备方法及其组成
    • US20080182886A1
    • 2008-07-31
    • US11915779
    • 2006-05-24
    • Markus GewehrJochen DietzThomas GroteAndreas GypserMatthias Niedenbruck
    • Markus GewehrJochen DietzThomas GroteAndreas GypserMatthias Niedenbruck
    • A01N43/56C07D231/06A01P3/00A01N25/26
    • A01N43/56C07D231/06
    • Novel 5-hydroxypyrazolines of the formula I in which the substituents are as defined below: B is phenyl, naphthyl or 5- or 6-membered hetaryl which contains one to four heteroatoms from the group consisting of O, N and S; A is C═O, C═S or SO2; W is CX1X2; X1, X2 are hydrogen, fluorine, chlorine or bromine; R1 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, phenyl, 5- or 6-membered heterocyclyl or hetaryl which contains one to four heteroatoms from the group consisting of O, N and S; R2 is hydrogen or alkyl; R3 is hydrogen, nitro, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl or NR′2, where R′ independently of one another are hydrogen or alkyl; R4 is hydrogen, halogen, nitro, cyano, NR′2, alkyl, haloalkyl, COOR′ or 5- or 6-membered hetaryl or heterocyclyl; where the variables mentioned above may be substituted according to the description; processes for their preparation, their use for controlling harmful fungi and compositions comprising them.
    • 式I的新型5-羟基吡唑啉,其中取代基如下所定义:B是苯基,萘基或含有一至四个由O,N和S组成的组的杂原子的5-或6-元杂芳基; A是C-O,C-S或SO 2。 W是CX 1,X 2, X 1,X 2是氢,氟,氯或溴; R 1是烷基,卤代烷基,烯基,卤代烯基,炔基或卤代炔基,环烷基,环烯基,环炔基,苯基,5-或6-元杂环基或杂芳基,其含有一至四个 O,N和S; R 2是氢或烷基; R 3是氢,硝基,氰基,烷基,卤代烷基,烷氧基,卤代烷氧基,烯基,卤代烯基,炔基,卤代炔基或NR'2,其中R'彼此独立地 是氢或烷基; R 4是氢,卤素,硝基,氰基,NR'2,烷基,卤代烷基,COOR'或5-或6-元杂芳基或杂环基; 其中上述变量可以根据描述被替代; 其制备方法,它们用于控制有害真菌的用途和包含它们的组合物。