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111. 发明授权

US07173051B2 Inhibitors of cathepsin S 失效
公开(公告)号：US07173051B2
公开(公告)日：2007-02-06
申请号：US10868459
申请日：2004-06-10
申请人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号： A61K31/423 , A61K31/403 , A61K31/428 , C07D263/58 , C07D227/04 , C07D417/02 , C07D498/02
CPC分类号： C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

112. 发明申请

US20060183850A1 Solvent free aqueous polyurethane dispersions and shaped articles therefrom 审中-公开
公开(公告)号：US20060183850A1
公开(公告)日：2006-08-17
申请号：US11300229
申请日：2005-12-13
申请人： Hong Liu , Carmen Covelli , Douglas Farmer
发明人： Hong Liu , Carmen Covelli , Douglas Farmer
IPC分类号： C08G18/08
CPC分类号： C08G18/0895 , A41B2500/54 , A41C3/0014 , A41D27/245 , B32B5/26 , B32B7/12 , B32B27/12 , B32B27/40 , B32B2255/02 , B32B2255/10 , B32B2255/26 , B32B2307/306 , B32B2307/51 , B32B2307/554 , B32B2437/00 , C08G18/0823 , C08G18/12 , C08G18/4808 , C08G18/4854 , C08G18/6692 , C08G18/7671 , C08G2170/80 , C08J3/05 , C08J2375/04 , D06M15/564 , D06M15/568 , D06M15/572 , D06M17/10 , D06N3/14 , C08G18/302
摘要： An article comprising an adhesive, a stretch member and a substrate wherein the adhesive is used to attach the stretch member to the fabric in a folded hem arrangement. The adhesive can be a tape made from an aqueous polyurethane dispersion and the stretch member can be a spandex fiber.

113. 发明申请

US20060142383A1 3D-Structure model of SARS coronavirus 3CL protease and anti-SARS drugs 失效
标题翻译： SARS冠状病毒3CL蛋白酶和抗SARS药物的3D结构模型
公开(公告)号：US20060142383A1
公开(公告)日：2006-06-29
申请号：US11293847
申请日：2005-12-02
申请人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
发明人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
IPC分类号： C12Q1/70 , G06F19/00 , C12N9/48 , A61K31/21 , A61K31/235 , A61K31/165
CPC分类号： C12N9/506 , A61K31/167
摘要： The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.
摘要翻译：本发明公开了通过分子模拟获得的SARS-CoV病毒3CL蛋白酶的三维结构。使用3D结构作为筛选现有医学数据库CMC（Comprehensive Medicinal Chemistry，MDL Information System，Inc。）的药物靶点，并发现一组具有抑制SARS-CoV病毒3CL蛋白酶活性的化合物。在分子和病毒水平测试了Cinanserin，发现能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒。合成Cinanserin类似物并在分子和病毒水平进行测试，发现它们能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒，可用于治疗和/或预防SARS-CoV病毒感染。

114. 发明申请

US20060074853A1 Canonicalization of terms in a keyword-based presentation system 有权
标题翻译：基于关键词的演示系统中术语的规范化
公开(公告)号：US20060074853A1
公开(公告)日：2006-04-06
申请号：US11282435
申请日：2005-11-17
申请人： Hong Liu , Ravi Narasimhan Raj
发明人： Hong Liu , Ravi Narasimhan Raj
IPC分类号： G06F17/30
CPC分类号： G06Q30/02 , G06F17/30864 , G06Q30/0641 , G06Q50/12 , Y10S707/99933 , Y10S707/99945
摘要： A presentation system accepts presentations or references to presentations from prospective presenters. Some or all of the presentations or references are stored in a database and referenced by keywords such that presentations to be presented in response to particular searches can be identified. A presentation manager handles accepting bids and settling terms between prospective presenters. The results of such processes might be stored in a presentation details database. A presentation server handles retrieving presentations from the presentation details database for presentation to users along with requests such as search results. Both the presentation manager and the presentation server can operate on a keywords-basis, wherein presentation terms specify keywords to be associated with particular presentations and the presentation server serves particular presentations based on keywords in a search query for which the presentations are to be returned. The association of keywords can be done using canonicalization so that, under certain conditions, different keywords are treated as the same keyword. Canonicalizations might include plural/singular forms, gender forms, stem word forms, suffix forms, prefix forms, typographical error forms, word order, pattern ignoring, acronyms, stop word elimination, etc. Conditions might include aspects of the search query state, such as the user's demographics, the page from which the search query was initiated, etc.
摘要翻译：演示系统接受来自潜在主持人的演示或参考。一些或全部演示文稿或参考资料存储在数据库中，并由关键字引用，以便能够识别出响应特定搜索而呈现的演示文稿。演示经理处理接受投标并在潜在主持人之间确定条款。这些过程的结果可能存储在演示详细信息数据库中。呈现服务器处理从呈现详细数据库检索演示文稿，以呈现给用户以及诸如搜索结果的请求。呈现管理器和呈现服务器都可以基于关键字操作，其中呈现术语指定要与特定演示文稿相关联的关键字，并且呈现服务器基于要对其进行演示的搜索查询中的关键字进行特定演示。可以使用规范化来完成关键字的关联，使得在某些条件下，不同的关键字被视为相同的关键字。规范化可能包括复数/单数形式，性别形式，词干形式，后缀形式，前缀形式，排版错误形式，字序，模式忽略，首字母缩略词，停止词消除等。条件可能包括搜索查询状态的方面，作为用户的人口统计，搜索查询的起始页面等。

115. 发明申请

US20050265316A1 Audio distribution 审中-公开
标题翻译：音频分配
公开(公告)号：US20050265316A1
公开(公告)日：2005-12-01
申请号：US11123957
申请日：2005-05-06
申请人： Hong Liu , Adam Carvalho , Steve Mooney , Joel McNamee , Christopher Yafrate
发明人： Hong Liu , Adam Carvalho , Steve Mooney , Joel McNamee , Christopher Yafrate
IPC分类号： H04L12/28 , H04L29/06
CPC分类号： H04L29/06027 , H04L65/608
摘要： Methods and apparatus, including computer program products, for audio distribution. In one aspect, a system includes a client, the client uploading a set of audio files to a server, and the server capable of maintaining multiple sets of audio files and generating multiple unique streams of the audio files to one or more audio receivers over a wireless interface using a streaming protocol.
摘要翻译：方法和设备，包括计算机程序产品，用于音频分配。在一个方面，系统包括客户机，客户端将一组音频文件上载到服务器，以及能够维护多组音频文件并且通过一个或多个音频文件生成音频文件的多个独特流的一个或多个音频接收器的服务器无线接口使用流协议。

116. 发明授权

US06960576B2 Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production 有权
标题翻译：羟基烷酰氨基内酰胺和相关结构作为Abeta蛋白质生产的抑制剂
公开(公告)号：US06960576B2
公开(公告)日：2005-11-01
申请号：US10287117
申请日：2002-11-04
申请人： Richard E. Olson , Hong Liu , Lorin A. Thompson
发明人： Richard E. Olson , Hong Liu , Lorin A. Thompson
IPC分类号： C07D223/18 , C07D243/08 , C07D243/14 , C07D243/24 , C07D401/04 , C07D243/00 , A61K31/55 , C07D223/12 , C07D487/00
CPC分类号： C07D223/18 , C07D223/10 , C07D223/12 , C07D223/16 , C07D243/08 , C07D243/14 , C07D243/24 , C07D243/26 , C07D401/04
摘要： This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
摘要翻译：本发明涉及具有式（I）的新型内酰胺：其药物组合物及其使用方法。这些新化合物抑制淀粉样蛋白前体蛋白的加工，更具体地，抑制Aβ肽的产生，从而起到防止淀粉样蛋白质神经沉积的形成的作用。更具体地，本发明涉及治疗与β-淀粉样蛋白产生相关的神经系统疾病，例如阿尔茨海默病和唐氏综合征。

117. 发明申请

US20050239795A1 Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists 有权
标题翻译：吡唑并[4,3-e] -1,2,4-三唑并 - [1,5-c] - 嘧啶腺苷A2a受体拮抗剂
公开(公告)号：US20050239795A1
公开(公告)日：2005-10-27
申请号：US11108916
申请日：2005-04-19
申请人： Bernard Neustadt , Jinsong Hao , Hong Liu , Craig Boyle , Samuel Chackalamannil , Unmesh Shah , Andrew Stamford , Joel Harris
发明人： Bernard Neustadt , Jinsong Hao , Hong Liu , Craig Boyle , Samuel Chackalamannil , Unmesh Shah , Andrew Stamford , Joel Harris
IPC分类号： A61K31/519 , C07D487/14
CPC分类号： C07D487/14
摘要： Compounds having the structural formula I or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, furanyl, thienyl, pyridyl, pyridyl N-oxide, oxazolyl or pyrrolyl, or cycloalkenyl R1, R2, R3, R4 and R5 are H, alkyl or alkoxyalkyl; and Z is optionally substituted aryl or heteroaryl are disclosed. Also disclosed is the use of compounds of formula I in the treatment of central nervous system diseases, in particular Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, and pharmaceutical compositions comprising them.
摘要翻译：具有结构式I的化合物或其药学上可接受的盐，其中R是任选取代的苯基，呋喃基，噻吩基，吡啶基，吡啶基N-氧化物，恶唑基或吡咯基，或环烯基R 1， R 3，R 3，R 4和R 5是H，烷基或烷氧基烷基; 和Z是任选取代的芳基或杂芳基。还公开了式I化合物在治疗中枢神经系统疾病，特别是帕金森病中单独使用或与用于治疗帕金森病的其它药物组合的用途，以及包含它们的药物组合物的用途。

118. 发明申请

US20050234039A1 Substituted lactams as inhibitors of Abeta protein production 有权
公开(公告)号：US20050234039A1
公开(公告)日：2005-10-20
申请号：US11005573
申请日：2004-12-06
申请人： Qi Han , Hong Liu , Richard Olson , Michael Yang
发明人： Qi Han , Hong Liu , Richard Olson , Michael Yang
IPC分类号： C07D243/26 , A61K31/55 , A61K31/5513 , A61P25/28 , A61P43/00 , C07D223/12 , C07D223/18 , C07D243/12 , C07D243/24 , C07D401/04 , C07D43/02
CPC分类号： C07D401/04 , C07D223/12 , C07D223/18 , C07D243/12 , C07D243/24 , C07D403/02
摘要： This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.

119. 发明申请

US20050130959A1 Inhibitors of cathepsin S 失效
公开(公告)号：US20050130959A1
公开(公告)日：2005-06-16
申请号：US10970344
申请日：2004-10-20
申请人： Hong Liu , Phillip Alper , Daniel Mutnick , Donald Karanewsky
发明人： Hong Liu , Phillip Alper , Daniel Mutnick , Donald Karanewsky
IPC分类号： A61K20060101 , A61K31/34 , A61K31/4025 , A61K31/452 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/541 , C07D307/04 , C07D307/33 , C07D405/12 , C07D407/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D45/02
CPC分类号： C07D407/12 , C07C311/29 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D235/08 , C07D295/215 , C07D307/33 , C07D307/68 , C07D405/12
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

120. 发明申请

US20050113356A1 Inhibitors of cathepsin S 失效
公开(公告)号：US20050113356A1
公开(公告)日：2005-05-26
申请号：US10922515
申请日：2004-08-18
申请人： Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
发明人： Hong Liu , Arnab Chatterjee , David Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David Woodmansee , Daniel Mutnick , Donald Karanewsky , Yun He
IPC分类号： A61K20060101 , A61K31/397 , A61K31/401 , A61K31/404 , A61K31/423 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/537 , A61K31/5375 , A61K31/54 , C07D209/04 , C07D209/08 , C07D261/14 , C07D265/30 , C07D295/13 , C07D295/18 , C07D295/20 , C07D411/12 , C07D413/12 , C07D417/12
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

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