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111. 发明授权

US08206774B2 Diazonium salt modification of silk polymer 有权
标题翻译：丝绸聚合物的重氮盐改性
公开(公告)号：US08206774B2
公开(公告)日：2012-06-26
申请号：US12192588
申请日：2008-08-15
申请人： David L. Kaplan , Amanda Murphy
发明人： David L. Kaplan , Amanda Murphy
IPC分类号： A61L33/00 , B05D3/00 , B05D1/40 , C12N5/00 , C12N5/02 , A61K38/17
CPC分类号： C09D189/00 , C08H1/00 , C08L89/00
摘要： A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These methods are particularly useful when the introduction of cells to a mammal is desired, since modifications to the silk protein affect the physical properties and thus the adhesion, metabolic activity and cell morphology of the desired cells. The silk protein can be modified to produce, or modify, a structure that provides an optimal environment for the desired cells.
摘要翻译：本文描述了通过将化学部分偶联到丝聚合物的酪氨酸残基来修饰丝聚合物的方法，用于改变丝蛋白的物理性质。因此，可以通过本文所述的方法制备具有所需物理性质的丝蛋白。当需要向哺乳动物引入细胞时，这些方法特别有用，因为对丝蛋白的修饰会影响所需细胞的物理性质，因此影响粘附，代谢活性和细胞形态。可以修饰丝蛋白以产生或修饰为所需细胞提供最佳环境的结构。

112. 发明申请

US20120076771A1 SURFACE MODIFICATION OF SILK FIBROIN MATRICES WITH POLY(ETHYLENE GLYCOL) USEFUL AS ANTI-ADHESION BARRIERS AND ANTI-THROMBOTIC MATERIALS 有权
标题翻译：具有聚（乙二醇）的丝状纤维素基质的表面改性作为抗粘连剂和抗生素材料有用
公开(公告)号：US20120076771A1
公开(公告)日：2012-03-29
申请号：US13129738
申请日：2009-11-17
申请人： Charu P. Vepari , David L. Kaplan
发明人： Charu P. Vepari , David L. Kaplan
IPC分类号： A61K47/42 , A61K35/00 , A61K38/16 , A61K38/02 , A61K31/7088 , A61P17/02 , A61K39/395 , A61K38/19 , A61K38/43 , A61K35/76 , A61P7/02 , C07K14/78 , A61K31/7052
CPC分类号： A61L31/005 , A61L31/10 , A61L33/068 , C08L71/02
摘要： The present invention provides compositions and methods for the production of silk fibroin matrices surface-PEGylated on one or more surfaces. Such surface-PEGylated silk fibroin matrices can be used in biomedical applications, such as anti-adhesive and anti-thrombosis materials. Silk matrices may be surface-PEGylated, for example, by a reaction with a functional group-activated PEG. Controlling the degree of PEGylation on surface of silk fibroin matrix can regulate both the degradation rate of the silk matrix, and the differentiated adhesion of cells or differentiated adsorption of proteins on the surface of the silk matrix. The present invention also provides for silk fibroin matrices having one or more surfaces possessing differentiated adhesion properties, which allows for tissue integration on the adherent side and inhibition of tissue adhesion to the opposing tissues or organs. Embedding active agents in silk fibroin matrices provides more benefits, such as promoting tissue ingrowth on the adherent side of the matrix.
摘要翻译：本发明提供了用于生产在一个或多个表面上表面聚乙二醇化的丝素蛋白基质的组合物和方法。这种表面聚乙二醇化的丝素蛋白基质可用于生物医学应用，例如抗粘连和抗血栓形成的材料。丝质基质可以被表面聚乙二醇化，例如通过与官能团活化的PEG的反应。控制丝素蛋白基质表面聚乙二醇化程度可以调节蚕丝基质的降解速率，分化细胞粘附或蛋白质在丝质基质表面的分化吸附。本发明还提供具有一个或多个具有分化的粘附性质的表面的丝素蛋白基质，其允许组合物在粘附层上的整合并抑制组织对相对组织或器官的粘附。在丝素蛋白基质中包埋活性剂提供了更多的益处，例如促进组织向上生长在基质的粘着面上。

113. 发明申请

US20110152214A1 SILK POLYMER-BASED ADENOSINE RELEASE: THERAPEUTIC POTENTIAL FOR EPILEPSY 有权
标题翻译：基于SILK聚合物的腺苷释放酶：治疗潜能
公开(公告)号：US20110152214A1
公开(公告)日：2011-06-23
申请号：US12991973
申请日：2009-05-15
申请人： Detlev Boison , David L. Kaplan
发明人： Detlev Boison , David L. Kaplan
IPC分类号： A61K31/7076 , A61P25/08
CPC分类号： A61K9/0085 , A61K47/42
摘要： This invention relates to sustained release formulations comprising silk fibroin biopolymer and adenosine, that provide for sustained, focal release of adenosine at therapeutic levels for the treatment of epilepsy and/or the prevention of epileptogenesis. An embodiment provides for a silk-based, adeno sine-releasing implant that alleviates seizures or prevents epileptogenesis. Another embodiment provides for a method of treating epilepsy or preventing epileptogenesis comprising focally administering adenosine in a sustained-release, silk-based adenosine delivery system.
摘要翻译：本发明涉及包含丝素蛋白生物聚合物和腺苷的持续释放制剂，其提供用于治疗癫痫治疗水平的腺苷的持续和局部释放和/或预防癫痫发生。一个实施方案提供了一种减轻癫痫发作或预防癫痫发生的丝状，腺苷释放的植入物。另一个实施方案提供了治疗癫痫或预防癫痫发生的方法，其包括在持续释放的基于丝的腺苷递送系统中对腺苷进行聚焦。

114. 发明授权

US07842780B2 Silk fibroin materials and use thereof 有权
标题翻译：丝素蛋白材料及其用途
公开(公告)号：US07842780B2
公开(公告)日：2010-11-30
申请号：US10541182
申请日：2004-01-07
申请人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
发明人： David L. Kaplan , Rina Nazarov , Gordana Vunjak-Novakovic , Lorenz Meinel
IPC分类号： A23J7/00 , A61K38/08 , A61K38/39 , C07K7/06 , C07K7/08
CPC分类号： A61K38/1825 , A61K38/1841 , A61K47/42 , A61L27/227 , A61L27/26 , A61L27/3604 , A61L27/3847 , A61L27/3852 , A61L27/3895 , A61L27/56 , D01D5/00 , D01F4/02 , Y10T428/29 , C08L89/00
摘要： The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
摘要翻译：本发明提供生产多孔丝素蛋白支架材料的方法。多孔丝素蛋白支架可用于组织工程。可以调节本文所述的丝素蛋白支架的孔隙率以模拟在天然组织中发现的密度梯度。因此，用于三维组织工程的方法，例如，还提供使用丝素蛋白骨架材料的骨和软骨。

115. 发明申请

US20100203226A1 METHOD FOR FORMING INORGANIC COATINGS 有权
标题翻译：形成无机涂料的方法
公开(公告)号：US20100203226A1
公开(公告)日：2010-08-12
申请号：US12762515
申请日：2010-04-19
申请人： David L. Kaplan , Chunmei Li
发明人： David L. Kaplan , Chunmei Li
IPC分类号： B05D3/00
CPC分类号： A61L27/227 , A61L27/24 , A61L27/30 , A61L27/446 , A61L27/46 , Y10T428/24999 , Y10T428/2933 , Y10T428/31768 , Y10T442/10
摘要： The present invention is directed to a method for forming an inorganic coating on a protein template. The method comprises contacting the template with an anionic polymer interface followed by an inorganic material for a sufficient period of time to allow mineralization of the inorganic material thus forming an inorganic coating on the template. Preferably, the coating is aligned.
摘要翻译：本发明涉及一种在蛋白质模板上形成无机涂层的方法。该方法包括使模板与阴离子聚合物界面接触，然后使无机材料接触足够的时间以允许无机材料的矿化，从而在模板上形成无机涂层。优选地，将涂层对准。

116. 发明授权

US07747739B2 Connection locator in a power aggregation system for distributed electric resources 有权
标题翻译：用于分布式电力资源的电力聚合系统中的连接定位器
公开(公告)号：US07747739B2
公开(公告)日：2010-06-29
申请号：US11836747
申请日：2007-08-09
申请人： Seth W. Bridges , Seth B. Pollack , David L. Kaplan
发明人： Seth W. Bridges , Seth B. Pollack , David L. Kaplan
IPC分类号： G06F15/173 , E01H4/00 , G06F15/02 , H01R29/00 , G01S3/02
CPC分类号： B60L3/12 , B60L11/1816 , B60L11/184 , B60L11/1842 , B60L11/1844 , B60L11/1846 , B60L11/1848 , B60L2230/16 , B60L2240/622 , B60L2240/72 , B60L2240/80 , B60L2250/16 , B60L2260/52 , B60L2260/54 , B60L2260/58 , B60L2270/32 , G06Q30/04 , H02J3/008 , H02J3/38 , H04L41/12 , H04L67/12 , H04L67/18 , H04W4/02 , H04W4/023 , H04W4/043 , H04W64/00 , Y02D70/122 , Y02D70/1242 , Y02D70/142 , Y02D70/146 , Y02D70/164 , Y02D70/166 , Y02E60/721 , Y02T10/7005 , Y02T10/7088 , Y02T10/7291 , Y02T90/121 , Y02T90/128 , Y02T90/14 , Y02T90/16 , Y02T90/162 , Y02T90/163 , Y02T90/169 , Y04S10/126 , Y04S30/14 , Y04S50/00 , Y04S50/10 , Y04S50/12 , Y10T307/696
摘要： Systems and methods are described for a power aggregation system. In one implementation, a service establishes individual Internet connections to numerous electric resources intermittently connected to the power grid, such as electric vehicles. The Internet connection may be made over the same wire that connects the resource to the power grid. The service optimizes power flows to suit the needs of each resource and each resource owner, while aggregating flows across numerous resources to suit the needs of the power grid. The service can bring vast numbers of electric vehicle batteries online as a new, dynamically aggregated power resource for the power grid. Electric vehicle owners can participate in an electricity trading economy regardless of where they plug into the power grid.
摘要翻译：为功率聚合系统描述了系统和方法。在一个实现中，服务建立与间歇地连接到诸如电动车辆的电网的许多电力资源的单独的互联网连接。互联网连接可以通过将资源连接到电网的相同电线进行。该服务优化电力流量，以适应每个资源和每个资源所有者的需求，同时整合多个资源的流量以适应电网的需求。该服务可以将大量电动汽车电池作为电力网络的新的，动态聚合的电力资源在线。电动车辆所有者可以参与电力交易经济，无论他们在哪里插入电网。

117. 发明授权

US07727575B2 Method for forming inorganic coatings 有权
标题翻译：无机涂层形成方法
公开(公告)号：US07727575B2
公开(公告)日：2010-06-01
申请号：US11289039
申请日：2005-11-29
申请人： David L. Kaplan , Chunmei Li
发明人： David L. Kaplan , Chunmei Li
IPC分类号： A61F2/00 , A61L27/32 , B05D3/02
CPC分类号： A61L27/227 , A61L27/24 , A61L27/30 , A61L27/446 , A61L27/46 , Y10T428/24999 , Y10T428/2933 , Y10T428/31768 , Y10T442/10
摘要： The present invention is directed to a method for forming an inorganic coating on a protein template. The method comprises contacting the template with an anionic polymer interface followed by an inorganic material for a sufficient period of time to allow mineralization of the inorganic material thus forming an inorganic coating on the template. Preferably, the coating is aligned.
摘要翻译：本发明涉及一种在蛋白质模板上形成无机涂层的方法。该方法包括使模板与阴离子聚合物界面接触，然后使无机材料接触足够的时间以允许无机材料的矿化，从而在模板上形成无机涂层。优选地，将涂层对准。

118. 发明申请

US20100055438A1 CONCENTRATED AQUEOUS SILK FIBROIN SOLUTION AND USE THEREOF 有权
标题翻译：浓缩水性丝素纤维素溶液及其用途
公开(公告)号：US20100055438A1
公开(公告)日：2010-03-04
申请号：US12611256
申请日：2009-11-03
申请人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
发明人： David L. Kaplan , Ung-Jin Kim , Jaehyung Park , Hyoung-Joon Jin
IPC分类号： B32B3/26 , C07K14/78 , B28B11/22 , B29C47/00 , B28B11/00 , B29C55/04 , B29C55/12
CPC分类号： A61L27/227 , A61L27/3604 , A61L27/38 , A61L27/52 , A61L27/56 , A61L2430/02 , B29C39/003 , B29C39/203 , B29C55/005 , B29D7/01 , B29K2089/00 , B29L2007/00 , B29L2009/00 , C07K14/43536 , C07K14/43586 , C08J3/07 , C08J3/075 , C08J5/18 , C08J9/0061 , C08J9/26 , C08J9/28 , C08J2201/0444 , C08J2201/0504 , C08J2205/022 , C08J2389/00 , C08L89/00 , D01D5/0007 , D01F4/02 , Y10T428/249921 , Y10T442/10 , Y10T442/60
摘要： The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
摘要翻译：本发明提供浓缩的水性丝素蛋白溶液和用于制备浓缩的丝心蛋白溶液的全水模式，避免使用有机溶剂，直接添加剂或刺激性化学品。本发明进一步提供了这些溶液在生产例如纤维，薄膜，泡沫，网眼，支架和水凝胶的材料中的用途。

119. 发明申请

US20090200988A1 Power Aggregation System for Distributed Electric Resources 有权
标题翻译：分布式电力资源集聚系统
公开(公告)号：US20090200988A1
公开(公告)日：2009-08-13
申请号：US12427958
申请日：2009-04-22
申请人： Seth W. Bridges , Seth B. Pollack , David L. Kaplan
发明人： Seth W. Bridges , Seth B. Pollack , David L. Kaplan
IPC分类号： H02J7/00
CPC分类号： B60L11/1844 , B60L11/1809 , B60L11/184 , B60L11/1842 , B60L2240/80 , G05B13/026 , G06Q30/0202 , G06Q50/06 , H02J3/008 , H02J3/32 , H02J3/38 , H02J7/0021 , H02J7/007 , H02J7/04 , H02J7/34 , H02J13/0082 , Y02E60/721 , Y02E60/722 , Y02E60/7815 , Y02T10/7005 , Y02T10/7072 , Y02T90/121 , Y02T90/128 , Y02T90/14 , Y02T90/16 , Y02T90/163 , Y02T90/169 , Y04S10/126 , Y04S10/14 , Y04S10/60 , Y04S30/14 , Y04S40/121 , Y04S50/00 , Y04S50/10 , Y04S50/14
摘要： Systems and methods are described for a power aggregation system. In one implementation, a method includes a establishing a communication connection with each of multiple electric resources connected to a power grid, receiving an energy generation signal from a power grid operator, and controlling a number of the electric resources being charged by the power grid as a function of the energy generation signal.
摘要翻译：为功率聚合系统描述了系统和方法。在一个实现中，一种方法包括建立与连接到电网的多个电力资源中的每一个的通信连接，从电网运营商接收能量产生信号，以及控制由电网充电的电力资源的数量作为能量产生信号的功能。

120. 发明申请

US20090063680A1 Connection Locator in a Power Aggregation System for Distributed Electric Resources 有权
标题翻译：用于分布式电力资源的电力聚合系统中的连接定位器
公开(公告)号：US20090063680A1
公开(公告)日：2009-03-05
申请号：US12252803
申请日：2008-10-16
申请人： Seth W. Bridges , Seth B. Pollack , David L. Kaplan
发明人： Seth W. Bridges , Seth B. Pollack , David L. Kaplan
IPC分类号： G06F15/173
CPC分类号： H04W48/16 , B60L11/1811 , B60L11/1816 , B60L11/1824 , B60L11/1838 , B60L11/184 , B60L11/1842 , B60L11/1846 , B60L11/1848 , B60L2230/34 , B60L2270/34 , H02J5/00 , H02J7/02 , H02J13/0006 , H02J13/0079 , H02J13/0086 , Y02E60/721 , Y02T10/7005 , Y02T10/7088 , Y02T90/121 , Y02T90/128 , Y02T90/14 , Y02T90/163 , Y02T90/169 , Y04S10/126 , Y04S30/14
摘要： Systems and methods are described for a power aggregation system. In one implementation, a method includes charging an electric resource over a power connection to an electric network, obtaining a unique identifier of a device over the power connection, and determining an electric network location of the electric resource from the unique identifier.
摘要翻译：为功率聚合系统描述了系统和方法。在一个实现中，一种方法包括通过电力连接向电网充电电力资源，通过电力连接获得设备的唯一标识符，以及从该唯一标识符确定电力资源的电网位置。

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