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111. 发明授权

US10842590B2 Medical observation apparatus with a movable beam deflector and method for operating the same 有权
公开(公告)号：US10842590B2
公开(公告)日：2020-11-24
申请号：US16274310
申请日：2019-02-13
申请人： LEICA INSTRUMENTS (SINGAPORE) PTE. LTD.
发明人： George Themelis
IPC分类号： H04N5/247 , A61B90/00 , H04N5/232 , G02B26/08 , G06F3/01 , G02B21/00 , A61B90/25 , G02B21/36 , A61B90/20 , H04N13/204 , G02B21/24 , A61B34/30
CPC分类号： A61B90/37 , A61B90/00 , A61B90/20 , A61B90/25 , A61B90/361 , G02B21/0012 , G02B21/368 , G02B26/0816 , G06F3/013 , H04N5/23299 , H04N5/247 , A61B34/30 , A61B2090/368 , A61B2090/3618 , A61B2090/371 , A61B2090/373 , G02B21/24 , H04N13/204
摘要： Medical observation apparatus (1) and method for observing an object or patient (67) in an operation area (21). Solutions of the art (3, 5) do not allow displaying further information, are expensive, bulky and non-intuitive. The inventive apparatus (1) overcomes these problems by comprising: an image acquisition assembly (41) with a camera subassembly (43) comprising at least one viewing camera (9) with a field of view (85) and an optical camera axis (75) for acquiring interoperative image data (83); a deflector subassembly (47) for deflecting the optical camera axis (75) into an optical viewing axis (77) directed towards the operation area (21), the deflector subassembly (47) comprising at least one optical beam deflector (71) and being arranged between the viewing camera (9) and the operation area (21), wherein the viewing camera (9) and the at least one optical beam deflector (71) are movable with respect to one another; and an image display assembly (37) comprising at least one monitor arrangement (35) for displaying the interoperative image data (83), the monitor arrangement (35) being visible at least from a user's observation position (29).

112. 发明授权

US10750938B2 Method, image processor and device for observing an object containing a bolus of a fluorophore 有权
公开(公告)号：US10750938B2
公开(公告)日：2020-08-25
申请号：US15986001
申请日：2018-05-22
申请人： Leica Instruments (Singapore) Pte. Ltd.
发明人： George Themelis
IPC分类号： G06T7/00 , A61B1/04 , G06T11/00 , A61B1/00 , A61B17/00
摘要： The invention relates to a method, an image processor (26) and a medical observation device (1), such as a microscope or endoscope, for observing an object (4) containing a bolus of at least one fluorophore (12). The object (4) is preferably live tissue comprising several types (16, 18, 20) of tissue. According to the method, a set (34) of component signals (36) is provided. Each component signal (36) represents a fluorescence intensity development of the fluorophore (12) over time in a different type of tissue. A time series (8) of input frames (10) is accessed, one input frame (10) after the other. The input frames (10) represent electronically coded still images of the object (4) at subsequent time. Each input frame (10) contains at least one observation area (22) comprising at least one pixel (23). In the observation area (22) of the current input frame (10) of the time series (8), a fluorescent light intensity (I) is determined over at least one fluorescence emission wavelength (15) of the fluorophore (12). This fluorescent light intensity (I1) is joined with the fluorescence light intensities (In) of the observation area (22) of preceding input frames (10) of the time series (8) to generate a time sequence (40) of fluorescent light intensities (I1, In) of the observation area (22). This time sequence (40) is decomposed on in a preferably linear combination (72) of at least some of the component signals (36) of the set (34). A new set (34) of component signals (36) is provided which includes only those component signals (36) which are present in the combination (72). An output frame (46) is generated, in which the observation area (22) is assigned a color from a color space depending on the combination (72) of component signals (36).

113. 发明申请

US20200257104A1 CONTROLLER FOR A MICROSCOPE, A CORRESPONDING METHOD AND A MICROSCOPE SYSTEM 审中-公开
公开(公告)号：US20200257104A1
公开(公告)日：2020-08-13
申请号：US16785729
申请日：2020-02-10
申请人： Leica Instruments (Singapore) Pte. Ltd.
发明人： George Themelis , Tobias Wilken
IPC分类号： G02B21/36 , G06T7/70 , G06T7/62 , G06T17/00 , H04N13/204 , G02B21/00
摘要： A controller for a microscope is configured to receive image data representing a wound and to determine a line of sight to a bottom of the wound using the image data. The controller is further configured to output a control signal for the microscope, the control signal instructing the microscope to align its optical axis with the line of sight.

114. 发明申请

US20190265453A1 SURGICAL MICROSCOPE WITH MOVABLE BEAM DEFLECTOR, METHOD FOR OPERATING THE SAME AND RETROFIT-KIT 审中-公开
公开(公告)号：US20190265453A1
公开(公告)日：2019-08-29
申请号：US16274315
申请日：2019-02-13
申请人： LEICA INSTRUMENTS (SINGAPORE) PTE. LTD.
发明人： George THEMELIS
IPC分类号： G02B21/00 , A61B90/25 , A61B90/30
摘要： The invention relates to a surgical microscope (1) and a method for observing an object (3) in an observation area (5) during surgery and to a retrofit-kit (41) for a surgical microscope (1). Solutions of the art may have an inflexible observation direction, require preoperative planning, and may be expensive and bulky. The inventive surgical microscope (1) overcomes these disadvantages by at least one optical carrier (47) for variably deflecting an observation axis (33) of an optical observation assembly (7) into an optical viewing axis (53) directed towards the observation area (5), the optical carrier (47) comprises at least one optical beam deflector (49) and is arranged between the optical observation assembly (7) and the observation area (5). The inventive method comprises the steps of variably deflecting an observation axis (33) of an optical observation assembly (7) into an optical viewing axis (53) directed towards the observation area (5); and propagating light (81) stemming from the observation area (5) essentially along the optical viewing axis (53) and the observation axis (33) and imaging said light (81) via an optical observation assembly (7).

115. 发明申请

US20190250384A1 ARM ADAPTED TO BE ATTACHED TO A MICROSCOPE, AND MICROSCOPE 审中-公开
公开(公告)号：US20190250384A1
公开(公告)日：2019-08-15
申请号：US16269647
申请日：2019-02-07
申请人： LEICA INSTRUMENTS (SINGAPORE) PTE. LTD.
发明人： George THEMELIS
IPC分类号： G02B21/00 , G02B21/06 , A61B90/20 , A61B90/00
CPC分类号： G02B21/0012 , A61B90/20 , A61B90/50 , A61B2017/00123 , A61B2090/367 , A61B2090/371 , G02B21/22 , G02B21/362 , G02B26/105
摘要： The invention relates to an arm (1) adapted to be attached to a microscope (10), in particular a surgical microscope (10), wherein the arm (1) comprises at a distal end (21) a light beam deflection member (3) or a camera. An inventive microscope (10) comprises an arm (1).

116. 发明授权

US10371934B2 Microscope arrangement comprising a plurality of microscopes, and method for operating a plurality of microscopes, in particular in a learning environment 有权
公开(公告)号：US10371934B2
公开(公告)日：2019-08-06
申请号：US15351499
申请日：2016-11-15
申请人： Leica Instruments (Singapore) Pte. Ltd.
发明人： Qingsong Zou , Anthony Lim , Apria Laksono , Michelle Li , Andreas Klopfer , Vincent Vaccarelli
IPC分类号： G02B21/36 , H04N7/18 , G09B19/00 , G09B5/02
摘要： A microscope arrangement includes a plurality of microscopes arranged in a geometric pattern. A control device has a display screen and a data link. The data link connects the microscopes to the control device and is configured to transfer microscopy data at least from the microscopes to the control device. The display screen comprises display symbols. Each display symbol represents microscopy data received by the control device from a different one of the microscopes. The display symbols are, in at least one operational state of the control device, arranged moveable on the display screen and are adapted to be moved into the geometric pattern.

117. 发明申请

US20190223973A1 METHOD FOR AUTOMATEDLY ALIGNING A STAND FOR A MICROSCOPE, STAND FOR A MICROSCOPE AND MICROSCOPE ASSEMBLY 审中-公开
公开(公告)号：US20190223973A1
公开(公告)日：2019-07-25
申请号：US16250223
申请日：2019-01-17
申请人： LEICA INSTRUMENTS (SINGAPORE) PTE. LTD.
发明人： Jason HUANG , Chin Yi LIAW
IPC分类号： A61B90/25 , G05D3/12 , G02B21/00 , G02B21/24
摘要： The invention relates to a method for automatedly aligning a stand (12) for a microscope (14), wherein the stand (12) for the microscope (14) comprises controllable positioning means (16) for positioning the microscope (14) and controllable orienting means (18) for orienting the microscope (14). The method comprises defining a target point (24) to be observed by the microscope (14), wherein the target point (24) is located within a coordinate range accessible by the stand (12), stabilizing the microscope (14) at a user determined position in an automated manner by means of the controllable positioning means (16) of the stand, and adjusting an orientation of the microscope (14) at the user determined position to the target point (24) in an automated manner using the controllable orienting means (18) of the stand. The invention further relates to a stand, a microscope assembly (10), a control unit, a computer program and a computer-readable data storage.

118. 发明授权

US10269097B2 Microscope and method for generating a combined image from multiple individual images of an object 有权
公开(公告)号：US10269097B2
公开(公告)日：2019-04-23
申请号：US15213430
申请日：2016-07-19
申请人： Leica Instruments (Singapore) Pte. Ltd.
发明人： Harald Schnitzler , Robert Paulus , Guenter Grabher
IPC分类号： G06K9/40 , G06T5/00 , G02B21/06 , G02B21/08 , G02B21/36 , H04N5/225 , G06T7/00
摘要： A microscope (10) for generating a combined image (34; 54; 64) from multiple individual images (28a to 28d; 52a to 52d; 62a to 62d) of an object (30; 50; 60) encompasses at least one illumination device (22) for illuminating the object (30; 50; 60) from at least two different illumination directions (24a, 24b); an image acquisition unit (26) for acquiring multiple individual images (28a to 28d; 52a to 52d; 62a to 62d) of the object (30; 50; 60) illuminated from the at least two different illumination directions (24a, 24b); and an image combination unit (32) for combining the individual images (28a to 28d; 52a to 52d; 62a to 62d) in order to obtain the combined image (34; 54; 64). The image combination unit (32) is embodied to combine the individual images (28a to 28d; 52a to 52d; 62a to 62d) so that an information loss connected with an image artifact of one of the individual images (28a to 28d; 52a to 52d; 62a to 62d) is compensated for utilizing an image datum of at least one other of the individual images (28a to 28d; 52a to 52d; 62a to 62d) in the combined image (34; 54; 64).

119. 发明授权

US10149734B2 Pivotable optical assembly for a surgical microscope, in particular 0°-assistant's device, and a retaining system for said pivotable optical assembly of the surgical microscope 有权
公开(公告)号：US10149734B2
公开(公告)日：2018-12-11
申请号：US15206432
申请日：2016-07-11
申请人： Leica Instruments (Singapore) Pte. Ltd.
发明人： Michael Guentert , Curdin Schlumpf
IPC分类号： A61B90/20 , A61B90/25 , G02B21/00 , G02B21/18 , G02B21/24
摘要： The present invention provides a pivotable optical assembly for a surgical microscope, specifically a zero-degree assistant's device, the assembly comprising: a microscope body interface for mounting the assembly on a microscope body; an assistant's module including an interface for an assistant's tube, the assistant's module being pivotable about a pivot axis relative to the microscope body; and a retaining system that blocks pivoting the assistant's module about the pivot axis. The retaining system comprises: a retaining element being moveable from a locking position into a release position, a biasing member forcing the retaining element into the locking position, and a hand-operable control element acting on the retaining element for moving it from the locking position into the release position, as well as a pivotable optical assembly comprising said retaining system according to the invention, whose retaining element, in its blocking position, blocks pivoting the assistant's module about the pivot axis.

120. 发明申请

US20180344137A1 METHOD, IMAGE PROCESSOR AND DEVICE FOR OBSERVING AN OBJECT CONTAINING A BOLUS OF A FLUOROPHORE 审中-公开
公开(公告)号：US20180344137A1
公开(公告)日：2018-12-06
申请号：US15986001
申请日：2018-05-22
申请人： Leica Instruments (Singapore) Pte. Ltd.
发明人： George THEMELIS
IPC分类号： A61B1/04 , A61B1/00
摘要： The invention relates to a method, an image processor (26) and a medical observation device (1), such as a microscope or endoscope, for observing an object (4) containing a bolus of at least one fluorophore (12). The object (4) is preferably live tissue comprising several types (16, 18, 20) of tissue. According to the method, a set (34) of component signals (36) is provided. Each component signal (36) represents a fluorescence intensity development of the fluorophore (12) over time in a different type of tissue. A time series (8) of input frames (10) is accessed, one input frame (10) after the other. The input frames (10) represent electronically coded still images of the object (4) at subsequent time. Each input frame (10) contains at least one observation area (22) comprising at least one pixel (23). In the observation area (22) of the current input frame (10) of the time series (8), a fluorescent light intensity (I) is determined over at least one fluorescence emission wavelength (15) of the fluorophore (12). This fluorescent light intensity (I1) is joined with the fluorescence light intensities (In) of the observation area (22) of preceding input frames (10) of the time series (8) to generate a time sequence (40) of fluorescent light intensities (I1, In) of the observation area (22). This time sequence (40) is decomposed on in a preferably linear combination (72) of at least some of the component signals (36) of the set (34). A new set (34) of component signals (36) is provided which includes only those component signals (36) which are present in the combination (72). An output frame (46) is generated, in which the observation area (22) is assigned a color from a color space depending on the combination (72) of component signals (36).

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