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101. 发明授权

US08680034B2 Automatic dishwashing detergent composition 有权
标题翻译：自动餐具洗涤剂组合物
公开(公告)号：US08680034B2
公开(公告)日：2014-03-25
申请号：US13189610
申请日：2011-07-25
申请人： Philip Frank Souter
发明人： Philip Frank Souter
IPC分类号： C11D3/386 , C12N9/54 , C12N9/28
CPC分类号： C11D3/386 , C11D3/0036 , C11D3/378 , C11D3/38609 , C11D3/38618 , C11D3/38627 , C11D17/042 , C11D17/045 , C12N9/2414 , C12N9/54 , C12Y301/01003 , C12Y302/01001 , C12Y304/00 , C12Y304/21062
摘要： An automatic dishwashing detergent composition comprising: a. at least 0.1 mg of active protease per gram of composition, wherein the protease is a variant of a protease that has at least 70% identity with the amino acid sequence of SEQ ID NO:1. wherein said variant comprise variations in one or more of the following positions: 32, 33, 48-54, 58-62, 94-107, 116, 123-133, 150, 152-156, 158-161, 164, 169, 175-186, 197, 198, 203-216 as compared with the protease in SEQ ID NO:1; and b. at least 0.05 mg of an active low temperature amylase per gram of composition.
摘要翻译：一种自动餐具洗涤剂组合物，其包含：a。每克组合物至少0.1mg活性蛋白酶，其中所述蛋白酶是与SEQ ID NO：1的氨基酸序列具有至少70％同一性的蛋白酶的变体。其中所述变体包含一个或多个以下位置的变体：32,33,48-54,58-62,94-107,116,123-133,150,152-156,158-161,164,169， 175-186,197,198,203-216与SEQ ID NO：1中的蛋白酶相比; 和b。每克组合物至少0.05mg活性低温淀粉酶。

102. 发明申请

US20140073552A1 Subtilase Vairants 审中-公开
标题翻译：附件Vairants
公开(公告)号：US20140073552A1
公开(公告)日：2014-03-13
申请号：US13632349
申请日：2012-10-01
申请人： Unilever PLC , NOVOZYMES A/S
发明人： Laurens Nicolaas Sierkstra , Jan Klugkist , Peter Markvardsen , Claus Von Der Osten , Peter Bauditz
IPC分类号： C12N9/54
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38681
摘要： The present invention relates to enzymes produced by mutating the genes for a number of subtilases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved stability and/or improved wash performance in any detergent in comparison to their wild type parent enzymes. The enzymes are well-suited for use in any detergent and for some in especially liquid or solid shaped detergent compositions.
摘要翻译：本发明涉及通过突变多个枯草芽孢杆菌基因并在合适的宿主中表达突变的基因而产生的酶。与其野生型亲本酶相比，酶在任何洗涤剂中表现出改进的稳定性和/或改善的洗涤性能。这些酶非常适合用于任何洗涤剂和一些特别是液体或固体形式的洗涤剂组合物中。

103. 发明申请

US20140018283A1 Subtilase Variants 审中-公开
标题翻译：脱铁酶变体
公开(公告)号：US20140018283A1
公开(公告)日：2014-01-16
申请号：US14035241
申请日：2013-09-24
申请人： Novozymes A/S
发明人： Tina Sejersgard Fano , Claus Von Der Osten , Malene Kappen Kruger , Mads Norregaard-Madsen
IPC分类号： C12N9/54
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38609 , C11D3/38618 , C11D3/38627 , C11D3/38636 , C11D3/38645 , C11D3/38654 , C11D11/0017 , C11D11/0023 , C12N9/50 , C12N9/52 , C12Y304/21062
摘要： The present invention relates to novel subtilase variants exhibiting alterations relative to the parent subtilase in one or more properties including: Wash performance, thermal stability, storage stability or catalytic activity. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dishwash compositions, including automatic dishwash compositions.
摘要翻译：本发明涉及在一种或多种性质中显示相对于亲本脱羧酶的改变的新型脱羧酶变体，包括：洗涤性能，热稳定性，储存稳定性或催化活性。本发明的变体适用于例如，清洁剂或洗涤剂组合物，例如衣物洗涤剂组合物和洗碟组合物，包括自动洗碗组合物。

104. 发明申请

US20140011234A1 ENHANCED PROTEIN EXPRESSION IN BACILLUS 有权
标题翻译：增强蛋白质表达在BACILLUS
公开(公告)号：US20140011234A1
公开(公告)日：2014-01-09
申请号：US13745630
申请日：2013-01-18
申请人： DANISCO US INC.
发明人： Eugenio Ferrari , Carole Harbison , M. Harunur Rashid , Walter Weyler
IPC分类号： C12N15/75 , C12N9/54
CPC分类号： C12N15/75 , C07K14/32 , C12N9/54 , C12P21/02 , C12R1/125 , C12Y304/00
摘要： The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
摘要翻译：本发明提供已被遗传操作以具有改变产生表达蛋白质的能力的细胞。特别地，本发明涉及革兰氏阳性微生物，例如具有增强的感兴趣蛋白表达的芽孢杆菌属物种，其中一个或多个染色体基因已被灭活，并且优选其中一个或多个染色体基因已经从芽孢杆菌中缺失染色体。在一些另外的实施方案中，一个或多个本征染色体区已经从相应的野生型芽孢杆菌宿主染色体中缺失。

105. 发明申请

US20130344055A1 ANTIMICROBIAL AGENTS 审中-公开
标题翻译：抗菌药物
公开(公告)号：US20130344055A1
公开(公告)日：2013-12-26
申请号：US13997058
申请日：2011-12-23
申请人： Yves Briers , Rob Lavigne , Maarten Walmagh , Stefan Miller
发明人： Yves Briers , Rob Lavigne , Maarten Walmagh , Stefan Miller
IPC分类号： A01N37/46 , C12Q1/37 , C12N9/54 , C12N9/52
CPC分类号： A01N37/46 , A61K38/00 , C07K2319/00 , C12N9/2462 , C12N9/52 , C12N9/54 , C12Q1/37 , Y02A50/469 , Y02A50/475 , Y02A50/478
摘要： The present invention relates to a fusion protein composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and/or Gram-positive bacteria and at least two peptide stretches fused to the enzyme at the N- or C-terminus, wherein the peptide stretches are distinct and selected from the group of synthetic amphiphatic peptide, synthetic cationic peptide, synthetic polycationic peptide, synthetic hydrophobic peptide, or naturally occurring antimicrobial peptide, like sushi peptide and defensin. Moreover, the present invention relates to nucleic acid molecules encoding said fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to said fusion protein for use as a medicament, diagnostic means, cosmetic substance, a disinfectant or a food additive. The present invention also relates to the treatment or prevention of Gram-positive and/or Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.
摘要翻译：本发明涉及由具有降解革兰氏阴性细菌和/或革兰氏阳性细菌的细胞壁的活性的酶组成的融合蛋白，以及在N-或C-末端与酶融合的至少两个肽段其中肽延伸是不同的，并且选自合成的两性肽，合成阳离子肽，合成聚阳离子肽，合成疏水性肽或天然存在的抗微生物肽，如寿司肽和防御素。此外，本发明涉及编码所述融合蛋白的核酸分子，包含所述核酸分子的载体和包含所述核酸分子或所述载体的宿主细胞。此外，本发明涉及用作药物，诊断方法，化妆品，消毒剂或食品添加剂的所述融合蛋白。本发明还涉及治疗或预防食品加工设备，食品加工厂，与食品接触的表面，医疗器械的表面的革兰氏阳性和/或革兰氏阴性细菌污染医院和手术。

106. 发明授权

US08597884B2 Process controls for molecular assay 有权
公开(公告)号：US08597884B2
公开(公告)日：2013-12-03
申请号：US13417025
申请日：2012-03-09
申请人： Benoit Dore , Christian Menard , Tobin Hellyer
发明人： Benoit Dore , Christian Menard , Tobin Hellyer
IPC分类号： C12Q1/68 , C12Q1/00 , C12Q1/70 , C12Q1/34 , C12Q1/37 , G01N33/53 , C12N9/36 , C12N9/54 , C12N1/20 , C12M1/34
CPC分类号： C12Q1/689 , C12N1/06 , C12Q1/6806
摘要： A full process control for use with a molecular assay and a method of determine the efficacy of the molecular assay. A full process control can include a fixed cell, and specifically can include a fixed vegetative cell. A method of determining the efficacy of a molecular assay can include providing an internal control, mixing the internal control with a sample, lysing the internal control and the sample, and detecting the lysis product. The full process control and/or the internal control can be Bacillus subtilis cells.

107. 发明授权

US08574884B2 Thermostable neutral metalloproteases 有权
标题翻译：耐热中性金属蛋白酶
公开(公告)号：US08574884B2
公开(公告)日：2013-11-05
申请号：US13345547
申请日：2012-01-06
申请人： Andrew Shaw , Louise Wallace , David A. Estell , Ronaldus W. J. Hommes , Sang-Kyu Lee , Hiroshi Oh , Eugene S. Sadlowski
发明人： Andrew Shaw , Louise Wallace , David A. Estell , Ronaldus W. J. Hommes , Sang-Kyu Lee , Hiroshi Oh , Eugene S. Sadlowski
IPC分类号： C12N9/54 , C12N9/50 , C12N1/20 , C12N15/00 , C12P21/06 , D06M16/00 , C02F3/34 , C14C1/00 , C12P1/00 , C07H21/04 , C11D3/00 , C07K1/00
CPC分类号： C12N9/54 , C11D1/02 , C11D3/386 , C11D3/38663 , C12Y304/24
摘要： The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus sp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from B. amyloliquefaciens. In still further preferred embodiments, the neutral metalloprotease is a variant of the B. amyloliquefaciens neutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the B. amyloliquefaciens neutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.
摘要翻译：本发明提供包含至少一种具有改善的储存稳定性的中性金属蛋白酶的方法和组合物。在一些实施方案中，中性金属蛋白酶可用于清洁和其它应用。在一些特别优选的实施方案中，本发明提供了包含从芽孢杆菌属芽孢杆菌获得的中性金属蛋白酶的方法和组合物。在一些更特别优选的实施方案中，中性金属蛋白酶从解淀粉芽孢杆菌获得。在另外的优选实施方案中，中性金属蛋白酶是解淀粉芽孢杆菌中性金属蛋白酶的变体。在另外的实施方案中，中性金属蛋白酶是解淀粉芽孢杆菌中性金属蛋白酶的同系物。本发明特别用于包括但不限于清洁，漂白和消毒的应用。

108. 发明授权

US08530218B2 Proteases with modified pro regions 有权
公开(公告)号：US08530218B2
公开(公告)日：2013-09-10
申请号：US12761275
申请日：2010-04-15
申请人： Eugenio Ferrari , Carol Fioresi , Anita van Kimmenade
发明人： Eugenio Ferrari , Carol Fioresi , Anita van Kimmenade
IPC分类号： C12N9/00 , C12N9/54 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/54 , C12N15/75
摘要： The present invention provides methods and compositions for the production of mature proteases in bacterial host cells. The compositions include modified polynucleotides that encode modified proteases, which have at least one mutation in the pro region; the modified serine proteases encoded by the modified polynucleotides; expression cassettes, DNA constructs, and vectors comprising the modified polynucleotides that encode the modified proteases; and the bacterial host cells transformed with the vectors of the invention. The methods include methods for enhancing the production of mature proteases in bacterial host cells e.g. Bacillus sp. host cells. The produced proteases find use in the industrial production of enzymes, suitable for use in various industries, including but not limited to the cleaning, animal feed and textile processing industry.

109. 发明申请

US20130216519A1 PROTEASES PRODUCING AN ALTERED IMMUNOGENIC RESPONSE AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：US20130216519A1
公开(公告)日：2013-08-22
申请号：US13757222
申请日：2013-02-01
申请人： DANISCO US INC.
发明人： David A. Estell , Fiona A. Harding
IPC分类号： C12N9/54
CPC分类号： C12N9/54 , C11D3/386
摘要： The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.

110. 发明申请

US20130029402A1 BACILLUS STRAIN FOR INCREASED PROTEIN PRODUCTION 有权
标题翻译：用于增加蛋白质生产的微生物菌株
公开(公告)号：US20130029402A1
公开(公告)日：2013-01-31
申请号：US13622968
申请日：2012-09-19
申请人： Danisco US Inc.
发明人： Cristina Bongiorni , Eugenio Ferrari
IPC分类号： C12N9/54 , C12N9/56 , C12N1/21
CPC分类号： C12N9/16 , C07K14/32 , C12N9/1205
摘要： The present invention provides host cells that have been genetically manipulated to have an enhanced capacity to produce proteins of interest. In particular, the invention relates to modified Bacillus sp. Host cells that have at least one inactivated phr gene. The enhanced production of proteins of interest by the modified Bacillus sp. Host cells is further increased in modified Bacillus sp. Host cells that overexpress YmaH. Methods for producing proteins of interest in the modified host cells are also provided
摘要翻译：本发明提供已被遗传操作以具有增强的产生感兴趣蛋白质的能力的宿主细胞。特别地，本发明涉及改良的芽孢杆菌属具有至少一个失活的phr基因的宿主细胞。通过改良的芽孢杆菌菌种增强生产的目的蛋白质宿主细胞在改良的芽孢杆菌中进一步增加。宿主细胞过度表达YmaH。还提供了在修饰的宿主细胞中产生目标蛋白质的方法

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