专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

101. 发明申请

US20110142920A1 TREATMENT OF LENGTH DEPENDENT NEUROPATHY 有权
标题翻译：治疗长期依赖性神经病变
公开(公告)号：US20110142920A1
公开(公告)日：2011-06-16
申请号：US13031393
申请日：2011-02-21
申请人： James N. Campbell
发明人： James N. Campbell
IPC分类号： A61K31/4168 , A61K9/127 , A61P3/10 , A61P29/00
CPC分类号： A61K31/4168 , A61K31/506 , A61K31/517 , A61K45/06
摘要： Compositions, and methods of use thereof, are provided for the treatment of painful neuropathy by local or topical delivery of compounds that interact with α-adrenergic receptors, especially an alpha2 adrenergic agonist such as clonidine, to the entire painful area such that the need for systemic dosing is minimized. The compounds are delivered to or adjacent to painful areas in patients with painful length dependent neuropathy, and other neuropathies that affect the pain signaling fibers in the skin. A preferred compound for the treatment of patients with length dependent neuropathy is clonidine applied in a transdermal patch, gel, ointment, lotion, liposomal formulation, cream, or emulsion, wherein the concentration is sufficient to provide an effective dose in the painful area or immediately adjacent areas.
摘要翻译：提供组合物及其使用方法，用于通过局部或局部递送与α-肾上腺素能受体（特别是α2肾上腺素能激动剂如可乐定）相互作用的化合物在整个疼痛区域治疗疼痛性神经病变，使得需要全身给药最小化。化合物在疼痛长度依赖性神经病变的患者中被传递到或邻近疼痛区域，以及影响皮肤疼痛信号纤维的其它神经病变。用于治疗长度依赖性神经病变的患者的优选化合物是可乐定应用于透皮贴剂，凝胶，软膏，洗剂，脂质体制剂，乳膏或乳液中，其中所述浓度足以在疼痛区域或立即提供有效剂量相邻区域。

102. 发明授权

US07956076B2 Ribonucleotide reductase inhibitors and methods of use 有权
标题翻译：核糖核苷酸还原酶抑制剂及其使用方法
公开(公告)号：US07956076B2
公开(公告)日：2011-06-07
申请号：US12420713
申请日：2009-04-08
申请人： Yun Yen , David Horne , Yate-Ching Yuan , Bing-Sen Zhou , Angela L Perkins Harki , Leila Su
发明人： Yun Yen , David Horne , Yate-Ching Yuan , Bing-Sen Zhou , Angela L Perkins Harki , Leila Su
IPC分类号： A61K31/426 , A61K31/4168 , C07D277/46 , C07D233/88
CPC分类号： C12N9/99 , C07D277/46 , C07D417/12
摘要： Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme. These inhibitors may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
摘要翻译：本文提供通过结合RRM2并干扰RRM1 / RRM2全酶的活性来抑制核糖核苷酸还原酶（RR）的新型化合物。这些抑制剂可用于抑制RR活性并治疗与RRM2表达相关的各种病症，例如某些癌症类型，线粒体疾病或退行性疾病。

103. 发明申请

US20110104155A1 DRUG DELIVERY TO THE ANTERIOR AND POSTERIOR SEGMENTS OF THE EYE USING EYE DROPS 审中-公开
标题翻译：使用眼睛运动的眼药水输送给前列腺和前列腺部分
公开(公告)号：US20110104155A1
公开(公告)日：2011-05-05
申请号：US12921958
申请日：2008-05-05
申请人： Raouf Rekik
发明人： Raouf Rekik
IPC分类号： A61K39/395 , A61K31/56 , A61K31/498 , A61K31/4168 , A61K31/5377 , A61P9/10 , A61P27/02 , A61P27/10
CPC分类号： A61K31/5377 , A61K9/0048 , A61K31/137 , A61K31/403 , A61K31/415 , A61K31/4168 , A61K31/498 , A61K31/502 , A61K39/3955 , A61K45/06 , C07K16/22 , A61K2300/00
摘要： A method and means for delivery of drugs to the chorio-retina and the optic nerve head which comprises contacting the surface of the eye with an effective amount of drug for treatment of chorio-retina and optic nerve head and a physiologically acceptable adrenergic agent for enhancing delivery of the drug to these tissues in an ophtalmologically acceptable carrier, said adrenergic agent being selected from the group consisting of alpha adrenergic agonist agents, derivatives of the alpha adrenergic agonist agents, beta-blocking agents, derivatives of the beta-blocking agents and mixtures thereof.
摘要翻译：一种用于将药物递送到视网膜和视神经头的方法和装置，其包括使眼表面与有效量的用于治疗视网膜和视神经头的药物和用于增强的视觉神经头和生理上可接受的肾上腺素能试剂接触所述肾上腺素能药剂选自α-肾上腺素能激动剂，α-肾上腺素能激动剂衍生物，β-阻断剂，β-阻断剂的衍生物和混合物其中。

104. 发明申请

US20110091511A1 TRANSDERMAL DELIVERY OF DRUGS BASED ON CRYSTAL SIZE 有权
标题翻译：基于晶体尺寸的药物转运
公开(公告)号：US20110091511A1
公开(公告)日：2011-04-21
申请号：US12979978
申请日：2010-12-28
申请人： Viet Nguyen
发明人： Viet Nguyen
IPC分类号： A61K31/4168 , A61K31/404 , A61K9/00 , A61P9/12 , A61P25/06 , A61P25/22 , A61P25/30 , A61P25/32 , A61P15/12 , A61P25/00
CPC分类号： A61K9/7061 , A61K9/7069
摘要： A blend of at least two polymers in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. According to the invention, providing drug having differing crystal sizes as well as drug which is solublized in the pressure-sensitive adhesive composition controls the rate of drug delivery from the pressure-sensitive adhesive composition.
摘要翻译：与药物组合的至少两种聚合物的共混物提供了用于透皮药物递送系统的压敏粘合剂组合物，其中当压敏粘合剂组合物在压敏粘合剂组合物中时，药物从压敏粘合剂组合物递送，并通过真皮递送与人体接触。根据本发明，提供具有不同晶体尺寸的药物以及在压敏粘合剂组合物中被溶解的药物控制从压敏粘合剂组合物的药物递送速率。

105. 发明申请

US20110015243A2 CO-SOLVENT COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF DANTROLENE THERAPUTIC AGENTS 有权
标题翻译：用于改进递送治疗药物的共溶剂组合物和方法
公开(公告)号：US20110015243A2
公开(公告)日：2011-01-20
申请号：US12205303
申请日：2008-09-05
申请人： Ahmad Malkawi , Abeer Al-Ghananeem , Patrick DeLuca , George Digenis
发明人： Ahmad Malkawi , Abeer Al-Ghananeem , Patrick DeLuca , George Digenis
IPC分类号： A61K31/4168 , A61K31/4166 , C07D405/12
CPC分类号： A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/4166 , A61K31/4168
摘要： The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery.
摘要翻译：本发明提供了使用叔丁醇（TBA）共溶剂体系制备和生产低溶解度的药剂的方法。本发明还提供了使用新型共溶剂体系制备的药物组合物。在一个实施方案中，本发明提供了制备用于静脉内使用的丹曲林钠（DS）制剂的方法（DS-IV）。 DS-IV产品的这种即时重建对于在手术期间接受恶性高热的患者的药物治疗是一个显着的改善。

106. 发明申请

US20100239523A1 TLR MODULATORS AND METHODS FOR USING THE SAME 审中-公开
标题翻译： TLR调节器及其使用方法
公开(公告)号：US20100239523A1
公开(公告)日：2010-09-23
申请号：US12740690
申请日：2008-10-30
申请人： Linda May Rothblum Watkins , Mark Rowland Hutchinson
发明人： Linda May Rothblum Watkins , Mark Rowland Hutchinson
IPC分类号： A61K38/20 , A61P3/10 , A61P1/00 , A61P9/00 , A61P25/04 , A61P37/00 , A61P25/28 , A61P15/04 , A61P29/00 , A61P25/06 , A61P25/08 , A61P25/36 , A61K31/485 , A61K31/437 , A61K31/138 , A61K31/366 , A61K31/167 , A61K31/522 , A61K31/19 , A61K31/46 , A61K31/4168 , A61K31/65
CPC分类号： A61K31/485 , A61K2300/00
摘要： The invention provides Toll-like receptor (TLR) modulators, compositions comprising the same, and methods for using the same.
摘要翻译：本发明提供了Toll样受体（TLR）调节剂，包含其的组合物及其使用方法。

107. 发明申请

US20100150840A1 Small-molecule agonists for type-2 orexin receptor 有权
标题翻译： 2型食欲素受体的小分子激动剂
公开(公告)号：US20100150840A1
公开(公告)日：2010-06-17
申请号：US12478753
申请日：2009-06-04
申请人： Masashi Yanagisawa
发明人： Masashi Yanagisawa
IPC分类号： A61K31/5377 , A61K31/4168 , A61K31/506 , A61K31/496 , A61P3/04 , A61K49/00 , C12Q1/02
CPC分类号： A61K31/4168 , A61K31/496 , A61K31/506 , A61K31/5377
摘要： Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.
摘要翻译：包括通常的方法（a）向受试者施用环状胍基OX2R激动剂和（b）检测所得到的增强的觉醒性的方法和组合物，所述方法和组合物用于激活确定为需要的细胞中的2型食欲蛋白受体（OX2R）或增加对饮食诱导的身体脂肪积累的抵抗力，或缩小从全身麻醉或射精滞后的恢复。

108. 发明申请

US20100125076A1 SUBSTITUTED SULPHONAMIDES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF AND THEIR USE 有权
标题翻译：替代磺酰胺，其制备方法，包含其的药物组合物及其用途
公开(公告)号：US20100125076A1
公开(公告)日：2010-05-20
申请号：US12596820
申请日：2008-04-20
申请人： Fridrich Gregan , Milan Remko , Elena Sluciakova , Jarmila Knapikova
发明人： Fridrich Gregan , Milan Remko , Elena Sluciakova , Jarmila Knapikova
IPC分类号： A61K31/18 , A61K31/5377 , A61K31/5375 , A61K31/498 , A61K31/445 , A61K31/4168 , A61K31/40 , C07D295/12 , C07D211/30 , C07D207/06 , C07C311/18 , A61P27/00
CPC分类号： C07D295/096 , C07C311/16 , C07C311/17 , C07C311/18 , C07D295/125 , C07D295/13
摘要： Substituted sulphonamides having the general formula (I) and salts, hydrates and solvates thereof were prepared and described, wherein R1 is CO or SO2 and R2 is NH or O and where R represents linear or cyclic aliphatic chain and n represents number of linking aliphatic chain carbons (n can be 0, 1, 2 or 3), which are useful in the manufacture of the medicaments due to the carboanhydrase inhibition. These compounds are prepared by nucleophilic reaction of an amine with 4-sulfamoylbenzenesulphonyl chloride in the presence of triethylamine excess in tetrahydrofurane or in ether at temperature 0 to 20° C. The compounds show an antiglaucomatic activity.
摘要翻译：制备并描述了具有通式（I）的取代磺酰胺及其盐，水合物和溶剂化物，其中R1是CO或SO2，R2是NH或O，其中R表示直链或环状脂族链，n表示连接脂肪链的数目碳（n可以是0,1,2或3），其可用于由于糖酐酶抑制而制备药物。这些化合物通过胺与4-氨磺酰基苯磺酰氯在三乙胺过量的四氢呋喃或乙醚存在下在0至20℃的温度下进行亲核反应来制备。化合物显示出防静电活性。

109. 发明申请

US20090263450A1 ALPHA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF INFLAMMATORY DISEASES 有权
标题翻译：治疗炎症性疾病的ALPHA ADRENERGIC RECEPTOR AGONISTS
公开(公告)号：US20090263450A1
公开(公告)日：2009-10-22
申请号：US12422624
申请日：2009-04-13
申请人： John Myers ZANELLA , William F. McKay , Vanja Margareta King , Christopher M. Hobot , Keith R. Hildebrand
发明人： John Myers ZANELLA , William F. McKay , Vanja Margareta King , Christopher M. Hobot , Keith R. Hildebrand
IPC分类号： A61K31/4168 , A61F2/00 , A61P25/00 , A61P29/00
CPC分类号： A61K31/137 , A61K9/0024 , A61K9/14 , A61K31/415 , A61K31/4162
摘要： Effective treatments of pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a target site, one can reduce, prevent or treat pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease.
摘要翻译：提供了对肌腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或口腔面部疾病的疼痛和/或炎症的有效治疗。通过在目标部位处或附近施用有效量的至少一种α肾上腺素能激动剂，可以减少，预防或治疗由腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或口腔疾病。

110. 发明申请

US20090263441A1 DRUG DEPOTS HAVING DIFFREENT RELEASE PROFILES FOR REDUCING, PREVENTING OR TREATING PAIN AND INFLAMMATION 有权
标题翻译：具有用于减少，预防或治疗疼痛和炎症的不同释放特征的药物组合物
公开(公告)号：US20090263441A1
公开(公告)日：2009-10-22
申请号：US12105994
申请日：2008-04-18
申请人： William McKay
发明人： William McKay
IPC分类号： A61F2/00 , A61K31/4402 , A61K31/192 , A61K31/4168 , A61K31/585 , A61K31/56 , A61K31/366 , A61K31/485 , A61K31/353
CPC分类号： A61K9/7007 , A61K9/0002 , A61K9/0024 , A61K31/135 , A61K31/192 , A61K31/366 , A61K31/4168 , A61K31/485 , A61K31/573 , A61K31/58 , A61K31/655
摘要： Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a target site, one can reduce, prevent or treat inflammation and pain.
摘要翻译：提供有效的疼痛和/或炎症治疗。通过在目标部位或其附近施用有效量的至少止痛剂和/或至少一种抗炎剂，可以减少，预防或治疗炎症和疼痛。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式