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101. 发明授权

US5162546A Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity 失效
标题翻译：与苯基和2-取代的CHROMANYL，噻喃酮或具有类似活性的1,2,3,4-四氢喹啉啉类分离的乙酰胺
公开(公告)号：US5162546A
公开(公告)日：1992-11-10
申请号：US749747
申请日：1991-08-26
申请人： Roshantha A. S. Chandraratna
发明人： Roshantha A. S. Chandraratna
IPC分类号： C07D311/14 , C07D311/16 , C07D311/58 , C07D335/06 , C07D311/20
CPC分类号： C07D335/06 , C07D311/14 , C07D311/16 , C07D311/58
摘要： Retinold-like activity is exhibited by compounds of the formula ##STR1## where X is S, O; R.sub.1, R.sub.2 and R.sub.3 are hydrogen or lower alkyl; R.sub.4 and R.sub.5 are hydrogen or lower alkyl with the proviso that R.sub.4 and R.sub.5 cannot both be hydrogen, R.sub.6 is hydrogen, lower alkyl, lower alkenyl, lower cycloalkyl or halogen; n is 0-5, and B is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR.sub.1 or a ketal derivative where R.sub.1 l is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4, or a pharmaceutically acceptable salt thereof.
摘要翻译：视黄醇样活性由下式化合物显示：其中X为S，O; R1，R2和R3是氢或低级烷基; R4和R5是氢或低级烷基，条件是R4和R5不能都是氢，R6是氢，低级烷基，低级烯基，低级环烷基或卤素; n为0-5，B为H，-COOH或其药学上可接受的盐，酯或酰胺，-CH 2 OH或醚或酯衍生物，或-CHO或缩醛衍生物，或-COR1或缩酮衍生物，其中R1 l是 - （CH 2）m CH 3，其中m是0-4，或其药学上可接受的盐。

102. 发明授权

US5145985A Process for the preparation of anti-hypertensive benzopyran derivative 失效
标题翻译：制备抗高血压苯并噻吩衍生物的方法
公开(公告)号：US5145985A
公开(公告)日：1992-09-08
申请号：US543142
申请日：1990-06-25
申请人： Tibor Timar , Tibor Eszenyi , Peter Sebok , Vilmos Galamb , Julia Fazekas nee Kozak , Terezia Istvan nee Katona , Eva Kovach nee Lakatos , Erika Nagy nee Csaki
发明人： Tibor Timar , Tibor Eszenyi , Peter Sebok , Vilmos Galamb , Julia Fazekas nee Kozak , Terezia Istvan nee Katona , Eva Kovach nee Lakatos , Erika Nagy nee Csaki
IPC分类号： A61K31/40 , A61P9/12 , C07B61/00 , C07D207/12 , C07D311/20 , C07D311/58 , C07D405/04 , C07D493/04
CPC分类号： C07D405/04 , C07D311/58
摘要： A process is disclosed for the preparation of (.+-.)-6-cyano-3,4-dihydro-2,2-dimethyl-trans-4-(2-oxo-1-pyrrol idino)-2H-1-benzopyran-3-ol of the Formula (VI) ##STR1## from 4-cyanophenol of the Formula (I) ##STR2## which comprises reacting 4-cyanophenol of the Formula (I) with isoprene, followed with bromination and dehydrobromination steps with formation of intermediates to react with 2-pyrrolidone resulting in obtaining the compound of the Formula (VI).

103. 发明授权

US4838924A Aromatic urea derivatives and their use as herbicide 失效
标题翻译：芳香族脲衍生物及其作为除草剂的用途
公开(公告)号：US4838924A
公开(公告)日：1989-06-13
申请号：US39457
申请日：1987-04-01
申请人： Tetsuo Takematsu , Daisuke Fukuoka , Katsuya Takahashi , Isao Hashimoto
发明人： Tetsuo Takematsu , Daisuke Fukuoka , Katsuya Takahashi , Isao Hashimoto
IPC分类号： A01N47/30 , A01N47/36 , C07D307/77 , C07D307/79 , C07D307/83 , C07D307/86 , C07D307/91 , C07D307/94 , C07D311/04 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/64 , C07D311/72 , C07D311/78 , C07D311/94 , C07D317/46 , C07D317/64 , C07D405/12 , C07D493/10
CPC分类号： C07D307/79 , A01N47/30 , A01N47/36 , C07D307/83 , C07D307/86 , C07D307/91 , C07D307/94 , C07D311/04 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/64 , C07D311/72 , C07D311/78 , C07D311/94 , C07D317/46 , C07D317/64 , C07D405/12 , C07D493/10
摘要： This invention relates to novel compounds of formula [I], a process for their production, and their use as a herbicide. ##STR1## wherein A represents the bond ##STR2## in which X is a hydrogen atom, a chlorine atom, a nitro group or a trifluoromethyl group;B represents a hydrogen atom, a methyl group or a methoxy group; andAr represents one member selected from the group consisting of ##STR3## in which R.sup.1 to R.sup.38, are as defined hereinafter.
摘要翻译： PCT No.PCT / JP86 / 00398 Sec。 371日期1987年4月1日 102（e）日期1987年4月1日PCT提交1986年8月4日PCT公布。第WO87 / 00840号公报日本公开1987年2月12日。本发明涉及式[I]的新化合物，其生产方法及其作为除草剂的用途。其中A表示其中X为氢原子，氯原子，硝基或三氟甲基的键。 B表示氢原子，甲基或甲氧基; 并且Ar表示从下列定义的从 + TR 中选择的一个成员。

104. 发明授权

US4665203A Substituted dihydrobenzopyrans useful as leukotriene D.sub.4 inhibitors 失效
标题翻译：取代的二氢苯并吡喃可用作白三烯D4抑制剂
公开(公告)号：US4665203A
公开(公告)日：1987-05-12
申请号：US764697
申请日：1985-08-12
申请人： Masateru Miyano , Robert L. Shone , Daniel D. Sohn
发明人： Masateru Miyano , Robert L. Shone , Daniel D. Sohn
IPC分类号： C07C45/71 , C07D311/20 , C07D311/22 , C07D311/24 , C07D311/58 , C07D311/66 , C07D405/06 , C07D407/12 , C07D413/04
CPC分类号： C07D405/06 , C07C45/71 , C07D311/20 , C07D311/22 , C07D311/24 , C07D311/58 , C07D311/66 , C07D407/12 , C07D413/04
摘要： The invention relates to compounds of the formula: ##STR1## which are useful as leukotriene D.sub.4 (LTD.sub.4) inhibitors and therefore useful in the treatment of allergies and inflammatory conditions.
摘要翻译：本发明涉及用作白三烯D4（LTD4）抑制剂的下式的化合物：因此可用于治疗过敏和炎性病症。

105. 发明授权

US4234726A Heterocyclic containing chromans 失效
标题翻译：含杂环的色带
公开(公告)号：US4234726A
公开(公告)日：1980-11-18
申请号：US37958
申请日：1979-05-09
申请人： Derek V. Gardner
发明人： Derek V. Gardner
IPC分类号： A61K31/135 , A61K31/215 , C07C217/38 , C07C219/04 , C07D311/16 , C07D311/20 , C07D311/58 , C07D413/12 , C07D405/12
CPC分类号： C07D311/16 , C07D311/20 , C07D311/58 , Y10S514/91
摘要： Compounds of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof wherein the NR.sub.1 R.sub.2 moiety is a 5-, 6-, or 7-membered saturated heterocyclic ring; R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms or acyl of 1 to 4 carbon atoms; R.sub.4 is naphthyl or phenyl unsubstituted or substituted by one or two substituents selected from the group consisting of fluorine, chlorine, bromine, methoxyl, benzyloxyl, trifluoromethyl, methyl, cyano, nitro, acetoxyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, acetamide, hydroxyl, methoxycarbonyl, ethoxycarbonyl, carboxamido, sulphonamido, carboxy, trifluoromethylthio, trifluoromethoxyl, methylsulphonyl, trifluomethylsulphonyl and methylthio; R.sub.5 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.6 is hydrogen or alkyl of 1 to 4 carbon atoms; X is oxygen and the dotted line represents a single or double bond.
摘要翻译：式（I）化合物：其中NR1R2部分是5-，6-或7-元饱和杂环; R3是氢，1至4个碳原子的烷基或1至4个碳原子的酰基; R4是萘基或未取代的或被一个或两个选自氟，氯，溴，甲氧基，苄氧基，三氟甲基，甲基，氰基，硝基，乙酰氧基，氨基，甲基氨基，乙基氨基，二甲基氨基，二乙基氨基，乙酰胺，羟基，甲氧基羰基，乙氧基羰基，甲酰氨基，磺酰氨基，羧基，三氟甲硫基，三氟甲氧基，甲基磺酰基，三氟甲磺酰基和甲硫基; R5是氢或1-4个碳原子的烷基; R6是氢或1-4个碳原子的烷基; X是氧，虚线表示单键或双键。

106. 发明授权

US4113744A Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxycoumarin (warfarin) and methods of making 失效
标题翻译：微晶3-（α-丙酰基苄基）-4-羟基香豆素（华法林）及其制备方法
公开(公告)号：US4113744A
公开(公告)日：1978-09-12
申请号：US496932
申请日：1974-08-13
申请人： Nasri W. Badran
发明人： Nasri W. Badran
IPC分类号： A01N43/14 , A61K31/37 , A61P7/02 , C07D311/46 , C07D311/56 , C07D311/20
CPC分类号： C07D311/46
摘要： Microcrystalline 3-(alpha-acetonylbenzyl)-4-hydroxy coumarin (warfarin), having a crystal size not greater than 4.0 microns, is stable for long periods of time, is advantageous in that it is rapidly absorbed from the gastrointestinal tract and thus provides a highly desirable level of bioavailability not previously possible. It is crystallized from a buffered alkaline solution of warfarin by acidification thereof. Compositions thereof are useful for anticoagulant and rodenticide purposes, and methods of making such compositions and of using the new microcrystalline form of warfarin for such purposes are disclosed.
摘要翻译：具有晶体尺寸不大于4.0微米的微晶3-（α-丙酰基苄基）-4-羟基香豆素（华法林）长时间稳定是有利的，因为其被快速地从胃肠道吸收，从而提供以前不可能达到的高度希望的生物利用度水平。通过其酸化从华法林的缓冲碱性溶液中结晶。其组合物可用于抗凝和灭鼠目的，并且公开了制备这种组合物和使用新的微晶形式的华法林用于此目的的方法。

107. 发明授权

US4093631A 7-Aminopropoxy chromane and chromenes 失效
标题翻译： 7-氨基丙氧基色烯和色烯
公开(公告)号：US4093631A
公开(公告)日：1978-06-06
申请号：US691865
申请日：1976-06-01
申请人： Derek Victor Gardner
发明人： Derek Victor Gardner
IPC分类号： A61K31/135 , A61K31/215 , C07C217/38 , C07C219/04 , C07D311/16 , C07D311/20 , C07D311/58 , C07D311/02 , A61K31/35
CPC分类号： C07D311/16 , C07D311/20 , C07D311/58 , Y10S514/91
摘要： Compounds of the formula (I): ##STR1## and salts thereof wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or benzyl; R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms or is joined to R.sub.1 so that the NR.sub.1 R.sub.2 moiety is a 5-, 6- or 7-membered saturated heterocyclic ring; R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms or acyl of 1 to 4 carbon atoms; R.sub.4 is an aromatic group; R.sub.5 is hydrogen or alkyl of 1 to 4 carbon atoms R.sub.6 is hydrogen or alkyl of 1 to 4 carbon atoms; X is --CH.sub.2 -- or an oxygen atom and the dotted line represents a single or double bond, are useful for inducing anorexia and for their mood-modifying effects.
摘要翻译：式（I）的化合物：其中R 1是氢，1至4个碳原子的烷基或苄基; R 2是氢或1至4个碳原子的烷基或连接到R 1，使得NR 1 R 2部分是5-，6-或7-元饱和杂环; R3是氢，1至4个碳原子的烷基或1至4个碳原子的酰基; R4是芳基; R5是氢或1-4个碳原子的烷基R6是氢或1-4个碳原子的烷基; X是-CH 2 - 或氧原子，虚线表示单键或双键，可用于诱导厌食和其心情修饰效果。

108. 发明授权

US4079066A 4-Naphthyl derivatives of 7-aminoalkylenoxy-2H-chromene 失效
标题翻译： 7-氨基亚烷基氧基-2H-色烯的4-萘基衍生物
公开(公告)号：US4079066A
公开(公告)日：1978-03-14
申请号：US652134
申请日：1976-01-26
申请人： Derek Victor Gardner
发明人： Derek Victor Gardner
IPC分类号： A61K31/135 , A61K31/215 , C07C217/24 , C07D311/06 , C07D311/16 , C07D311/20 , C07D311/58 , C07D311/02 , A61K31/35 , A61K31/40 , C07D207/04
CPC分类号： C07D311/16 , C07D311/58
摘要： Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein X is an alkylene group of 2 - 4 carbon atoms; Y is CH.sub.2 or 0; R.sub.1 is a hydrogen atom or a C.sub.1-6 alkyl group; R.sub.2 is a hydrogen atom or a C.sub.1-6 alkyl or benzyl group or is joined to R.sub.1 so that NR.sub.1 R.sub.1 is a 5-, 6- or 7- membered saturated ring; R.sub.3 is a naphthyl group or a naphthyl group substituted by a fluorine, chlorine or bromine atom or a methyl, methoxyl, trifluoromethyl, hydroxy or acetoxy group; R.sub.4 is a hydrogen atom or a C.sub.1-4 alkyl group; and R.sub.5 is a hydrogen atom or a C.sub.1-4 alkyl group; have been found to be mood modifying agents.
摘要翻译：式（I）的化合物：其中X是2-4个碳原子的亚烷基; Y为CH 2或O; R1是氢原子或C1-6烷基; R2是氢原子或C1-6烷基或苄基，或与R1结合，使NR1R1为5-，6-或7-元饱和环; R3是被氟，氯或溴原子或甲基，甲氧基，三氟甲基，羟基或乙酰氧基取代的萘基或萘基; R4是氢原子或C1-4烷基; R5为氢原子或C1-4烷基; 已被发现是情绪调节剂。

109. 发明授权

US4018799A Antioxidant chroman compounds 失效
标题翻译：抗氧化色满化合物
公开(公告)号：US4018799A
公开(公告)日：1977-04-19
申请号：US637611
申请日：1975-12-04
申请人： John William Scott , David Richard Parrish , Gabriel Saucy
发明人： John William Scott , David Richard Parrish , Gabriel Saucy
IPC分类号： C07D311/58 , C11B5/00 , C07D311/20
CPC分类号： C07C255/00 , C11B5/0035
摘要： The (6-hydroxy-chroman-2-yl) acetic or carboxylic acid derivatives useful as antioxidants and a method for preparing these derivatives from hydroquinones and intermediates in this synthesis as well as the use of these derivatives as intermediates in the preparation of optically active alpha-tocopherol.
摘要翻译：用作抗氧化剂的（6-羟基 - 苯并二氢吡喃-2-基）乙酸或羧酸衍生物以及在该合成中由氢醌和中间体制备这些衍生物的方法以及这些衍生物作为制备光学活性剂的中间体的用途 α-生育酚。

110. 发明授权

US3984440A Polyene compounds 失效
标题翻译：聚烯化合物
公开(公告)号：US3984440A
公开(公告)日：1976-10-05
申请号：US495368
申请日：1974-08-07
申请人： Werner Bollag , Rudolf Ruegg , Gottlieb Ryser
发明人： Werner Bollag , Rudolf Ruegg , Gottlieb Ryser
IPC分类号： C07C69/734 , C07C27/00 , C07C29/147 , C07C33/38 , C07C33/50 , C07C41/00 , C07C43/14 , C07C43/20 , C07C45/00 , C07C45/51 , C07C47/20 , C07C51/00 , C07C57/50 , C07C57/62 , C07C59/64 , C07C59/66 , C07C59/72 , C07C67/00 , C07C69/025 , C07C69/618 , C07C69/65 , C07C201/00 , C07C205/19 , C07C205/34 , C07C205/45 , C07C205/56 , C07C213/00 , C07C215/68 , C07C217/76 , C07C217/84 , C07C219/32 , C07C227/00 , C07C227/02 , C07C227/10 , C07C227/18 , C07C229/44 , C07C231/00 , C07C231/02 , C07C233/11 , C07C235/34 , C07C235/78 , C07C237/20 , C07D279/02 , C07D311/20 , C07D311/58 , C07F9/54 , C07D311/02 , C07D311/72
CPC分类号： C07F9/5428 , C07C33/38 , C07C45/515 , C07C59/64 , C07C59/66 , C07D311/58
摘要： Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid, -tetraenal or -tetraenol derivatives are described. The subject compounds are useful in the treatment of neoplasias, certain dermatoses and inflammatory and allergic dermatological conditions.
摘要翻译：描述了新的9-取代的苯基-3,7-二甲基 - 非 - 2,4,6,8-四烯酸， - 四烯或四烯酚衍生物。本发明化合物可用于治疗肿瘤，某些皮肤病和炎性和过敏性皮肤病学病症。

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