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101. 发明申请

US20140328788A1 Curing Accelerator and Method of Making 审中-公开
标题翻译：固化促进剂及其制备方法
公开(公告)号：US20140328788A1
公开(公告)日：2014-11-06
申请号：US14230351
申请日：2014-03-31
申请人： Adhezion Biomedical, LLC
发明人： Sheng Zhang , Rafael Ruiz, SR. , Max Azevedo
IPC分类号： A61L24/06 , A61L24/00
CPC分类号： A61L24/06 , A61L24/0015 , A61L26/0014 , A61L26/0066 , A61L2300/602 , A61L2300/624 , C08L35/06
摘要： A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein the sterilized cyanoacrylate adhesive composition does not cure upon sterilization. A kit for applying the sterilized cyanoacrylate adhesive composition, including the cyanoacrylate adhesive composition and an applicator. A method of making the sterilized cyanoacrylate adhesive composition, by adding a cure speed enhancer to a cyanoacrylate adhesive composition and sterilizing the composition. A method of applying the sterilized cyanoacrylate adhesive composition to tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid, and quickly curing the sterilized cyanoacrylate adhesive composition. A method of sealing tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid to tissue to be sealed, quickly curing the sterilized cyanoacrylate adhesive composition, and sealing the tissue.
摘要翻译：一种灭菌的氰基丙烯酸酯粘合剂组合物，其包含氰基丙烯酸酯组合物和固化速度增强剂，其中灭菌的氰基丙烯酸酯粘合剂组合物在灭菌时不固化。一种用于施用灭菌的氰基丙烯酸酯粘合剂组合物的试剂盒，包括氰基丙烯酸酯粘合剂组合物和涂布器。通过向氰基丙烯酸酯粘合剂组合物中加入固化速度增强剂并对组合物进行灭菌来制备灭菌的氰基丙烯酸酯粘合剂组合物的方法。通过将灭菌的氰基丙烯酸酯粘合剂组合物作为液体施用灭菌的氰基丙烯酸酯粘合剂组合物并快速固化灭菌的氰基丙烯酸酯粘合剂组合物的方法。通过将灭菌的氰基丙烯酸酯粘合剂组合物作为液体施加到待密封的组织上，快速固化灭菌的氰基丙烯酸酯粘合剂组合物并密封组织来密封组织的方法。

102. 发明授权

US08878146B2 Medical implants 有权
标题翻译：医疗植入物
公开(公告)号：US08878146B2
公开(公告)日：2014-11-04
申请号：US11885474
申请日：2006-03-03
申请人： Takahiro Ogawa
发明人： Takahiro Ogawa
IPC分类号： B82Y40/00 , A61F2/28 , A61F2/30 , A61B17/86 , A61L24/02 , A61L24/04 , A61L24/06 , A61L27/50 , A61L31/14 , B23K26/00 , A61B17/68 , A61B17/80 , A61C8/02 , A61F2/00 , A61F2/18 , A61F2/32 , A61F2/36 , A61F2/38 , A61F2/42 , A61F2/44
CPC分类号： A61F2/30767 , A61B17/68 , A61B17/80 , A61B17/866 , A61C8/0006 , A61F2/0077 , A61F2/186 , A61F2/2803 , A61F2/3094 , A61F2/32 , A61F2/36 , A61F2/38 , A61F2/4261 , A61F2/44 , A61F2002/183 , A61F2002/30031 , A61F2002/30062 , A61F2002/3084 , A61F2002/30906 , A61F2002/30925 , A61F2002/3097 , A61F2002/3625 , A61F2210/0004 , A61F2250/0056 , A61F2310/00011 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00041 , A61F2310/00047 , A61F2310/00059 , A61F2310/00071 , A61F2310/00089 , A61F2310/00095 , A61F2310/00107 , A61F2310/00131 , A61F2310/00149 , A61F2310/00155 , A61F2310/00179 , A61F2310/00293 , A61F2310/00329 , A61F2310/00353 , A61L24/02 , A61L24/046 , A61L24/06 , A61L27/50 , A61L31/14 , A61L2400/12 , A61L2400/18 , B23K26/355 , B82Y40/00 , Y10S977/901 , Y10S977/904 , C08L67/04 , C08L33/12
摘要： Provided herein is methods of treating a medical implant and methods of using the same.
摘要翻译：本文提供了治疗医疗植入物的方法及其使用方法。

103. 发明申请

US20140323662A1 SYSTEM FOR USE IN BONE CEMENT PREPARATION AND DELIVERY 有权
标题翻译：用于骨水泥制备和输送的系统
公开(公告)号：US20140323662A1
公开(公告)日：2014-10-30
申请号：US14329335
申请日：2014-07-11
申请人： DFINE, Inc.
发明人： Harry Kwan , Andrew Kohm , Csaba Truckai
IPC分类号： A61L24/00 , B29B7/94 , A61L24/06
CPC分类号： A61L24/001 , A61B17/8827 , A61B17/8833 , A61F2002/3008 , A61F2250/0098 , A61L24/06 , B01F3/1228 , B01F13/002 , B01F13/0022 , B01F13/0023 , B01F15/0203 , B01F15/0258 , B01F15/0279 , B01F2215/0029 , B29B7/94
摘要： A system for use in bone cement preparation can include a chamber for intermixing a liquid monomer and solid polymer components, a container, a vacuum channel, and a filter. The mixing chamber can be configured to hold a non-liquid, polymer powder component of a bone cement. The container can be configured to hold a liquid component of the bone cement. The system can have a first interface disposed between the mixing chamber and the container and a second interface disposed between the mixing chamber and the vacuum channel. The second interface can to receive and position the filter between the mixing chamber and the vacuum channel. The vacuum channel can direct a partial vacuum to draw the liquid component from the container into the non-liquid component in the mixing chamber to intermix the components and to thereby provide a settable bone cement
摘要翻译：用于骨水泥制剂的系统可以包括用于混合液体单体和固体聚合物组分的腔室，容器，真空通道和过滤器。混合室可以构造成容纳骨水泥的非液体聚合物粉末组分。容器可以构造成容纳骨粘固剂的液体组分。系统可以具有设置在混合室和容器之间的第一界面和设置在混合室和真空通道之间的第二界面。第二接口可以在混合室和真空通道之间接收和定位过滤器。真空通道可以引导部分真空将液体组分从容器中抽出到混合室中的非液体组分中以混合组分，从而提供可固化骨粘固剂

104. 发明授权

US08864493B2 Dental appliance, dental appliance adhesive and related methods and uses 有权
标题翻译：牙科器具，牙科用具胶及相关方法及用途
公开(公告)号：US08864493B2
公开(公告)日：2014-10-21
申请号：US13674714
申请日：2012-11-12
申请人： Symdent, Inc.
发明人： Laurel Rae Leslie-Martin , Neil Brian Cramer , Charles Couch , Michael Cole
IPC分类号： A61C7/08 , A61K6/00 , A61L24/06 , A61C13/15
CPC分类号： A61C7/08 , A61C19/003 , A61K6/0023 , A61L24/06 , C08L33/06 , C08L33/08
摘要： A dental appliance has an auxiliary feature bonded to a polymeric surface of a shell body with a compartment for receiving teeth. The auxiliary feature is bonded with a light-curable acrylic adhesive comprising acrylate base material and photoinitiator. Auxiliary features include colored layers and, decals, reinforcing features and auxiliary dental devices. A light-curable acrylic adhesive may include a thiol monomer and/or a pigment. A dental appliance may have a shell body with a bonding surface adapted for attachment of an auxiliary feature, such as prepared by a pretreatment to mar the surface of to impregnate the surface with a reactive adhesion promoter.
摘要翻译：牙科器具具有结合到壳体的聚合物表面的辅助特征，具有用于接收牙齿的隔室。辅助特征与包含丙烯酸酯基材和光引发剂的光固化丙烯酸粘合剂粘合。辅助功能包括彩色层和贴花，增强功能和辅助牙科设备。可光固化的丙烯酸粘合剂可以包括硫醇单体和/或颜料。牙科器具可以具有壳体，其具有适于附接辅助特征的接合表面，例如通过预处理制成的表面以用反应性粘合促进剂浸渍表面。

105. 发明授权

US08834845B2 Bioactive bone cement and method for its production 有权
标题翻译：生物活性骨水泥及其生产方法
公开(公告)号：US08834845B2
公开(公告)日：2014-09-16
申请号：US12750782
申请日：2010-03-31
申请人： Berthold Nies , Werner Siol
发明人： Berthold Nies , Werner Siol
IPC分类号： A61F2/02 , A61L24/06
CPC分类号： A61L24/06 , A61L2430/02 , Y10S977/904 , Y10S977/908 , C08L33/12
摘要： A bioactive PMMA (polymethylmethacrylate) bone cement contains a powder component and a reactive monomer liquid, wherein the powder component and the reactive monomer liquid when mixed with one another react with one another and form a polymer-based solid material. The powder component contains particulate polymer powder of polymethylmethacrylates; a radical starter; and anionic copolymer nanoparticles. The anionic copolymer nanoparticles are distributed in nano-particulate form within the particulate powder component or coated as a film on particles of the particulate polymer powder.
摘要翻译：生物活性PMMA（聚甲基丙烯酸甲酯）骨水泥含有粉末成分和反应性单体液体，其中当彼此混合时，粉末组分和反应性单体液体彼此反应并形成基于聚合物的固体材料。粉末成分含有聚甲基丙烯酸甲酯的微粒聚合物粉末; 激进的启动者和阴离子共聚物纳米粒子。阴离子共聚物纳米颗粒以纳米颗粒形式分布在颗粒状粉末组分内，或者作为薄膜涂覆在颗粒状聚合物粉末颗粒上。

106. 发明授权

US08791172B2 Three-component bone cement 有权
标题翻译：三组分骨水泥
公开(公告)号：US08791172B2
公开(公告)日：2014-07-29
申请号：US13012909
申请日：2011-01-25
申请人： Sebastian Vogt , Hubert Büchner
发明人： Sebastian Vogt , Hubert Büchner
IPC分类号： A61F2/28 , A61L24/06 , A61L24/02 , A61L24/00
CPC分类号： A61L24/0073 , A61L24/0015 , A61L24/06 , A61L27/44 , A61L2300/00 , A61L2430/02 , A61L2430/24 , C08L33/10
摘要： A paste is provided from which bone cement can be formed, which is to the largest extent possible bubble-free and has a high impact strength. The paste includes (i) 15-50 weight percent of at least one mono-functional, hydrophobic methacrylic acid ester, (ii) 40-85 weight percent of at least one filler, (iii) 0.01-4 weight percent of at least one radical initiator soluble in the methacrylic acid ester (i) and having at least one peroxide group, (iv) 0.01-4 weight percent of at least one radical initiator soluble in the methacrylic acid ester (i) and having no peroxide groups, (v) 0.000001-3 weight percent of at least one accelerator soluble in the methacrylic acid ester (i) and capable of forming radicals from the radical initiators according to (iii) and (iv), (vi) 0.001-5 weight percent of at least one halide salt, and (vii) 0.2-3 weight percent of at least one cross-linking agent.
摘要翻译：提供了可以形成骨粘固剂的浆料，其最大程度上可能是无气泡的并且具有高冲击强度。该糊状物包括（i）15-50重量％的至少一种单官能疏水性甲基丙烯酸酯，（ii）40-85重量％的至少一种填料，（iii）0.01-4重量％的至少一种可溶于甲基丙烯酸酯（i）中并且具有至少一个过氧化物基团的自由基引发剂，（iv）0.01-4重量％的可溶于甲基丙烯酸酯（i）中并且不含过氧化物基团的至少一种自由基引发剂（v ）0.000001-3重量％的可溶于甲基丙烯酸酯（i）中的至少一种促进剂，并能够根据（ⅲ）和（ⅳ），（vi）的自由基引发剂形成自由基，至少0.001-5重量％一种卤化物盐，和（vii）0.2-3％重量的至少一种交联剂。

107. 发明申请

US20140135720A1 Collecting device for body fluids 有权
标题翻译：体液收集装置
公开(公告)号：US20140135720A1
公开(公告)日：2014-05-15
申请号：US14157543
申请日：2014-01-17
申请人： Coloplast A/S
发明人： Esben Stroebech , Anders Bach , Hasse Buus
IPC分类号： A61L24/00 , A61L24/06
CPC分类号： A61L24/0021 , A61F5/443 , A61F5/445 , A61L24/001 , A61L24/0031 , A61L24/043 , A61L24/046 , A61L24/06 , A61L28/0034 , C08L71/02
摘要： A body waste collecting device includes a collecting pouch and an adhesive wafer for attachment to the body. The adhesive wafer includes a backing layer, a first adhesive and a second adhesive. The second adhesive includes a polar plasticising oil or a combination of polar plasticising oils in the content of above 10% (w/w) of the second adhesive, and at least one polar polyethylene copolymer, where the content of the polyethylene copolymer is 10-50% (w/w) of the second adhesive, and the polyethylene copolymer has a melt flow index below 2 g/10 min (190° C./21.1N).
摘要翻译：身体废物收集装置包括收集袋和用于附接到身体的粘合剂晶片。粘合剂晶片包括背衬层，第一粘合剂和第二粘合剂。第二粘合剂包括极性增塑油或极性增塑油的组合，其含量在第二粘合剂的10％（w / w）以上，以及至少一种极性聚乙烯共聚物，其中聚乙烯共聚物的含量为10- 第二粘合剂的50％（w / w），聚乙烯共聚物的熔体流动指数低于2g / 10min（190℃/ 21.1N）。

108. 发明申请

US20140073743A1 POLY(OCTYLCYANOACRYLATE)-POLYISOBUTYLENE POLYMER CONETWORK, METHOD FOR THE PRODUCTION THEREOF AND USES THEREOF 审中-公开
标题翻译：聚（甲基丙烯酸甲酯） - 聚异丁烯聚合物体系，其生产方法及其用途
公开(公告)号：US20140073743A1
公开(公告)日：2014-03-13
申请号：US13984367
申请日：2012-02-07
申请人： Joseph Kennedy , Gabor Erdodi , Ryan Gasser , Juay Seng Tang
发明人： Joseph Kennedy , Gabor Erdodi , Ryan Gasser , Juay Seng Tang
IPC分类号： A61L24/06
CPC分类号： A61L24/06 , A61L2430/36 , C08F22/32 , C08F290/042 , C08F220/34 , C08L35/04
摘要： A polymer conetwork formed from the polymerization reaction of octyl-cyanoacrylate and a tri-telechelic star polymer comprising polyisobutylene terminated with cyanoacrylate groups (Ø(PIB-CA)3), wherein the ratio of octyl cyanoacrylate to Ø(PIB-CA)3 is from about 10:1 to about 40:1.
摘要翻译：由氰基丙烯酸辛酯与包含用氰基丙烯酸酯基（（PIB-CA）3封端的聚异丁烯）的三 - 遥爪星形聚合物形成的聚合物网络，其中氰基丙烯酸辛酯与（PIB-CA）3的比例为约10:1至约40:1。

109. 发明授权

US08598251B2 Paste-like bone cement 有权
标题翻译：糊状骨水泥
公开(公告)号：US08598251B2
公开(公告)日：2013-12-03
申请号：US13162735
申请日：2011-06-17
申请人： Sebastian Vogt , Hubert Büchner
发明人： Sebastian Vogt , Hubert Büchner
IPC分类号： A61L24/06
CPC分类号： A61L24/001 , A61L24/0094 , A61L24/06 , A61L27/50 , A61L2400/06 , A61L2430/02
摘要： A kit is provided based on two pastes designed to produce bone cement with high initial stability and therefore low post-cure. The kit includes a paste A and a paste B, wherein paste A contains (a1) a polymerizable monomer having a pH in water in the range of 5-9, (a2) a filling agent insoluble in (a1), and (a3) a barbituric acid derivative selected from the group consisting of 1,5-disubstituted barbiturates, 1,3,5-trisubstituted barbiturates, and 1,3,5-tetrasubstituted barbiturates, and paste B contains (b1) a polymerizable monomer having a pH in water in the range of 5-9, (b2) a filling agent insoluble in (b1), (b3) a peroxide soluble in (b1), (b4) a heavy metal compound insoluble in (b1) and selected from the group consisting of heavy metal salts and heavy metal complexes, and wherein at least one of the pastes A and B contains a halide salt.
摘要翻译：提供了一种基于两种浆料的试剂盒，其设计用于生产具有高初始稳定性和因此低固化后的骨水泥。试剂盒包括糊剂A和糊剂B，其中糊剂A含有（a1）水中pH值在5-9范围内的可聚合单体，（a2）不溶于（a1）的填充剂和（a3）选自1,5-二取代巴比妥酸盐，1,3,5-三取代巴比妥酸盐和1,3,5-四取代巴比妥酸盐的巴比土酸衍生物，糊剂B含有（b1）具有pH值的可聚合单体（b2）不溶于（b1）的填充剂，（b3）可溶于（b1）的过氧化物，（b4）不溶于（b1）的重金属化合物，并且选自的重金属盐和重金属络合物，并且其中至少一种糊状物A和B含有卤化物盐。

110. 发明申请

US20120195848A1 STRONTIUM-CONTAINING BIOACTIVE BONE CEMENT 审中-公开
标题翻译：含锶生物骨水泥
公开(公告)号：US20120195848A1
公开(公告)日：2012-08-02
申请号：US13326760
申请日：2011-12-15
申请人： William Weijia Lu , Raymond Wing Moon Lam , Keith Dip-Kei Luk , Zhao Yang Li
发明人： William Weijia Lu , Raymond Wing Moon Lam , Keith Dip-Kei Luk , Zhao Yang Li
IPC分类号： A61L24/04 , A61L24/06
CPC分类号： A61L24/0089 , A61L27/446 , A61L2430/02
摘要： The present invention provides bioactive bone cements that not only have sufficient radiopacity, low physiological toxicity, and requisite mechanism strength, but also promote local bone in-growth. The bone cement utilizes strontium salts as radiopacifiers, and comprises a powder component and a liquid component. In an embodiment, the powder component comprises a strontium salt, poly(methyl methacrylate) (PMMA), and a polymerization initiator; and the liquid component comprises methyl methacrylate (MMA) as reactive monomers and a polymerization accelerator.
摘要翻译：本发明提供生物活性骨水泥，其不仅具有足够的射线不透性，低生理毒性和必要的机制强度，而且还促进局部骨生长。骨水泥利用锶盐作为放射性填充剂，并且包含粉末组分和液体组分。在一个实施方案中，粉末组分包括锶盐，聚（甲基丙烯酸甲酯）（PMMA）和聚合引发剂; 并且液体组分包含作为反应性单体的甲基丙烯酸甲酯（MMA）和聚合促进剂。

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