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101. 发明申请

US20120130343A1 Tissue penetration device 有权
标题翻译：组织穿透装置
公开(公告)号：US20120130343A1
公开(公告)日：2012-05-24
申请号：US13184644
申请日：2011-07-18
申请人： Dominique Freeman , Dirk Boecker , Don Alden , Barry Dean Briggs , Jon Hewitt Leonard , Ray Freeman , George Gogue
发明人： Dominique Freeman , Dirk Boecker , Don Alden , Barry Dean Briggs , Jon Hewitt Leonard , Ray Freeman , George Gogue
IPC分类号： A61M5/31
CPC分类号： A61M5/46 , A61B5/14532 , A61B5/150022 , A61B5/150061 , A61B5/150068 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/15019 , A61B5/150213 , A61B5/150221 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15176 , A61B5/15178 , A61B5/15184 , A61B5/15186 , A61B5/157 , A61B17/32093 , A61M5/158 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905 , G01N33/557 , G06F19/00
摘要： An agent injection device is provided that is capable of injecting an agent to a known predetermined tissue depth. An injection member has an elongate injection shaft with an outlet port configured to dispense an agent at a controllable time. A controllable driver is coupled to the elongate injection shaft and is configured to drive the injection member into target tissue. A velocity control system is in communication with the controllable driver and is configured to control the velocity of the elongate injection shaft.
摘要翻译：提供了能够将药剂注射到已知的预定组织深度的药剂注射装置。注射构件具有细长注射轴，其具有配置成在可控制时间分配药剂的出口端口。可控制的驱动器联接到细长注射轴并被构造成将注射构件驱动到靶组织中。速度控制系统与可控驱动器连通，并被配置成控制细长注射轴的速度。

102. 发明申请

US20120040337A1 Conformational Epitope Initiated Signal Amplification 审中-公开
标题翻译：构象表位启动信号放大
公开(公告)号：US20120040337A1
公开(公告)日：2012-02-16
申请号：US13263367
申请日：2010-04-09
申请人： John T. Unger , Rolf Hilfiker
发明人： John T. Unger , Rolf Hilfiker
IPC分类号： G01N21/64 , C12Q1/70 , G01N21/75
CPC分类号： G01N33/557 , C12Q1/6804 , C12Q2565/101 , C12Q2525/205
摘要： This invention relates to a method to generate a signal used to detect the presence or quantity of a biomarker in a sample. The signal generating reaction is initiated when the biomarker under assay interacts with a specific binding partner. The interaction produces a structural change in the binding partner that is recognized by additional binding partners capable of generating a signal. The reaction produces a localized cluster of signaling molecules that can be detected above background. The signaling cluster is detectable within minutes when interrogated in a chamber of specific dimensions. The presence of the signaling clusters is a qualitative indication of the presence of the analyte, while the number of signaling clusters detected is a direct quantification of the number of biomarker molecules in the sample. The reaction can be formatted to detect proteins, nucleic acids, cells or other informative biomarkers.
摘要翻译：本发明涉及生成用于检测样品中生物标志物的存在或数量的信号的方法。当测定中的生物标志物与特异性结合配偶体相互作用时，起始信号产生反应。相互作用产生由能够产生信号的另外的结合配偶体识别的结合配偶体的结构变化。该反应产生可以在背景以上检测到的信号分子的局部簇。当在特定尺寸的室中询问时，信号簇在几分钟内可被检测。信号簇的存在是分析物存在的定性指示，而检测到的信号簇的数量是对样品中生物标记分子数量的直接定量。该反应可被格式化以检测蛋白质，核酸，细胞或其他信息生物标志物。

103. 发明授权

US08079960B2 Methods and apparatus for lancet actuation 有权
标题翻译：刺血针致动方法和装置
公开(公告)号：US08079960B2
公开(公告)日：2011-12-20
申请号：US11539945
申请日：2006-10-10
申请人： Barry Dean Briggs , Dominique M. Freeman , Don Alden , Jon Hewitt Leonard , Dirk Boecker
发明人： Barry Dean Briggs , Dominique M. Freeman , Don Alden , Jon Hewitt Leonard , Dirk Boecker
IPC分类号： A61B5/00
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150068 , A61B5/150083 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/15019 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150412 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/150809 , A61B5/150824 , A61B5/150832 , A61B5/15087 , A61B5/150916 , A61B5/150954 , A61B5/151 , A61B5/15111 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15146 , A61B5/15151 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15174 , A61B5/15176 , A61B5/15184 , A61B5/15186 , A61B5/1519 , A61B5/15194 , A61B17/32093 , B01L3/5027 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver of includes a drive force generator for advancing the lancet along a path into the tissue site, and a sensor configured to detect lancet position along said path during the lancing cycle.
摘要翻译：提供了一种刺血针驱动器，其中驾驶员在穿刺周期期间在柳叶刀上施加驱动力并且在组织部位上使用。驱动器包括驱动力发生器，用于将刺血针沿着路径推进到组织部位;以及传感器，被配置为在穿刺周期期间沿着所述路径检测刺血针位置。

104. 发明申请

US20110274692A1 Screening Methods 有权
标题翻译：筛选方法
公开(公告)号：US20110274692A1
公开(公告)日：2011-11-10
申请号：US12890590
申请日：2010-09-24
申请人： Mark L. White , Marina Roell , John Corbin , Robert Bauer , Daniel Bedinger
发明人： Mark L. White , Marina Roell , John Corbin , Robert Bauer , Daniel Bedinger
IPC分类号： A61K39/395 , G01N33/577 , G01N33/566 , C12Q1/48 , C12P21/00 , C12N1/21 , C12N1/15 , C07K16/22 , C07K16/28 , C12N1/19 , C12N5/10 , C07K16/24 , C07K16/18 , C07H21/04 , G01N33/53
CPC分类号： G01N33/557 , G01N33/6854 , G01N2500/02 , G01N2500/20
摘要： The present invention provides polypeptide binding agents, e.g. antibodies, that exhibit the ability to kinetically modulate the binding and signaling of biological signaling complexes, e.g., receptor-ligand complexes; methods of identifying such polypeptide binding agents, methods of making such polypeptide binding agents, compositions comprising such polypeptide binding agents, and methods of using such polypeptide binding agents.
摘要翻译：本发明提供了多肽结合剂，例如，抗体，其表现出动力调节生物信号传导复合物例如受体 - 配体复合物的结合和信号传导的能力; 识别这种多肽结合剂的方法，制备这种多肽结合剂的方法，包含这种多肽结合剂的组合物，以及使用这种多肽结合剂的方法。

105. 发明申请

US20110171668A1 Determination Of Equilibrium Constants In Solution By Multi-Step Kinetics 审中-公开
标题翻译：通过多步动力学测定溶液中的平衡常数
公开(公告)号：US20110171668A1
公开(公告)日：2011-07-14
申请号：US12954647
申请日：2010-11-25
申请人： Hans-Heinrich Trutnau
发明人： Hans-Heinrich Trutnau
IPC分类号： G01N33/53 , G01N33/00 , G06F19/00
CPC分类号： G01N33/557 , G01N33/54373
摘要： The invention relates to a method for determining a first equilibrium constant of a first equilibrium reaction via MSK analysis of a second equilibrium reaction, whereby the first and the second equilibrium reaction share at least one reactant.
摘要翻译：本发明涉及通过第二平衡反应的MSK分析确定第一平衡反应的第一平衡常数的方法，其中第一和第二平衡反应共享至少一种反应物。

106. 发明申请

US20110091904A1 METHOD FOR DETERMINATION OF AFFINITY AND KINETIC CONSTANTS 审中-公开
标题翻译：确定亲和性和动力学常数的方法
公开(公告)号：US20110091904A1
公开(公告)日：2011-04-21
申请号：US12920735
申请日：2009-03-05
申请人： Mats Inganas , Josefin Bolik , Johan Engstroem , Karolina Osterlund
发明人： Mats Inganas , Josefin Bolik , Johan Engstroem , Karolina Osterlund
IPC分类号： G01N33/53 , G01N33/00
CPC分类号： G01N33/557
摘要： The invention is related to a method for quantification of a first dissociation equilibrium constant Kd1 for a complex AB between interactants A and B relative to a second dissociation equilibrium constant Kd2 for a complex CD between interactants C and D.
摘要翻译：本发明涉及一种用于定量相互作用剂A和B之间的复合物AB的第一解离平衡常数Kd1相对于相互作用剂C和D之间的复合物CD的第二解离平衡常数Kd2的方法。

107. 发明授权

US07914465B2 Method and apparatus for penetrating tissue 有权
标题翻译：渗透组织的方法和装置
公开(公告)号：US07914465B2
公开(公告)日：2011-03-29
申请号：US11672746
申请日：2007-02-08
申请人： Dominique M. Freeman , Dirk Boecker , Don Alden
发明人： Dominique M. Freeman , Dirk Boecker , Don Alden
IPC分类号： A61B5/00
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150213 , A61B5/150251 , A61B5/150358 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/15087 , A61B5/15107 , A61B5/15123 , A61B5/15151 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15178 , A61B5/157 , A61B17/32093 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： A skin penetrating system has a housing member and a plurality of penetrating members positioned in the housing member. A tissue stabilizing device is coupled to the housing member. A user interface is configured to relay at least one of, skin penetrating performance or a skin penetrating setting.
摘要翻译：皮肤穿透系统具有壳体构件和定位在壳体构件中的多个穿透构件。组织稳定装置联接到壳体构件。用户界面被配置为中继皮肤穿透性能或皮肤穿透设置中的至少一种。

108. 发明授权

US07909774B2 Method and apparatus for penetrating tissue 有权
公开(公告)号：US07909774B2
公开(公告)日：2011-03-22
申请号：US11674203
申请日：2007-02-13
申请人： Dominique Freeman , Dirk Boecker , Don Alden
发明人： Dominique Freeman , Dirk Boecker , Don Alden
IPC分类号： A61B5/00
CPC分类号： G01N33/557 , A61B5/14532 , A61B5/14546 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150213 , A61B5/150251 , A61B5/150358 , A61B5/150435 , A61B5/150503 , A61B5/150572 , A61B5/150809 , A61B5/150816 , A61B5/150824 , A61B5/15087 , A61B5/15107 , A61B5/15123 , A61B5/15151 , A61B5/15153 , A61B5/15163 , A61B5/15169 , A61B5/15171 , A61B5/15178 , A61B5/157 , A61B17/32093 , A61M2005/004 , B01L3/5027 , B01L3/502715 , B01L2200/10 , B01L2300/0663 , B01L2300/18 , G01N33/4905
摘要： These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A cartridge houses the penetrating member. The cartridge has first and second seals coupled to the penetrating member to maintain a sterile environment around a portion of the penetration member prior to penetrating member actuation. A user interface is configured to relay at least one of, penetrating member performance or a penetrating member setting.

109. 发明授权

US07824924B2 Analytical measuring and evaluation method for molecular interactions 有权
标题翻译：分子相互作用的分析测量和评估方法
公开(公告)号：US07824924B2
公开(公告)日：2010-11-02
申请号：US10203169
申请日：2001-02-07
申请人： Hans-Heinrich Trutnau
发明人： Hans-Heinrich Trutnau
IPC分类号： G01N33/557
CPC分类号： G01N33/557
摘要： The invention relates to an analytical measuring and evaluation method for determining the interaction parameters between an analyte and a ligand, preferably in a biosensor. According to the inventive method, the concentration of the analyte is gradually changed at defined intervals ti and the initial association or dissociation rates or association and dissociation rate constants are determined. The invention further relates to a device for carrying out the inventive method.
摘要翻译：本发明涉及用于确定分析物和配体之间的相互作用参数的分析测量和评价方法，优选在生物传感器中。根据本发明的方法，分析物的浓度以确定的间隔ti逐渐变化，并且确定初始缔合或解离速率或缔合和解离速率常数。本发明还涉及一种用于实施本发明的方法的装置。

110. 发明申请

US20100011842A1 BIOCHEMICAL ASSAY METHODS 审中-公开
标题翻译：生物化学测定方法
公开(公告)号：US20100011842A1
公开(公告)日：2010-01-21
申请号：US11719533
申请日：2006-08-10
申请人： Christopher Kevin Hoyle , Theresa Jane Pell , Stephanie Yuk Fan Wong Hawkes , Brian Herbert Warrington
发明人： Christopher Kevin Hoyle , Theresa Jane Pell , Stephanie Yuk Fan Wong Hawkes , Brian Herbert Warrington
IPC分类号： G01N33/00
CPC分类号： G01N33/557
摘要： Biochemical Assay Methods. There is described a method for determining a value that allows the effect that a compound has on a target to be compared with the effect that another compound has on the target, which method comprises adding the compound, at a concentration which continuously varies with time, to a flow of the target. The method can be carried out using a microfluidic system.
摘要翻译：生化测定方法。描述了一种用于确定化合物对靶标的影响与另一化合物对靶标的影响进行比较的值的方法，该方法包括以随时间连续变化的浓度添加化合物，到目标的流动。该方法可以使用微流体系统进行。

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