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101. 发明申请

US20110236426A1 PHARMACEUTICAL PRODUCT FOR UP-DOSING OF ALLERGY VACCINE 失效
标题翻译：用于过敏疫苗上药的药物产品
公开(公告)号：US20110236426A1
公开(公告)日：2011-09-29
申请号：US13123476
申请日：2009-10-15
申请人： Henrik Hugo Jacobi , Eike Gunther Wüstenberg , Lise Lund Maerkedahl
发明人： Henrik Hugo Jacobi , Eike Gunther Wüstenberg , Lise Lund Maerkedahl
IPC分类号： A61K39/35 , A61K39/36 , A61P37/04 , A61P37/08
CPC分类号： A61K39/35 , A61K39/39
摘要： This invention relates to the use of a pharmaceutical product comprising allergen and optionally an adjuvant for fast up-dosing in connection with allergy vaccination wherein a reduced number of injections are used. The invention also relates to the pharmaceutical product as such.
摘要翻译：本发明涉及包含变应原和任选的佐剂的药物产品在与过敏疫苗接种相关的快速给药中的用途，其中使用减少数量的注射剂。本发明还涉及药物产品。

102. 发明授权

US07994288B2 Allergenic proteins of natural rubber latex, their production and use in assays 失效
标题翻译：天然橡胶胶乳的过敏蛋白，其生产和用于测定
公开(公告)号：US07994288B2
公开(公告)日：2011-08-09
申请号：US12458538
申请日：2009-07-15
申请人： Mary Jane Cardosa , Hamid Sharifah , Shirley Samuel-Verghese , Elumalai Sunderasan , Hoong Yeet Yeang , Hamzah Samsidar
发明人： Mary Jane Cardosa , Hamid Sharifah , Shirley Samuel-Verghese , Elumalai Sunderasan , Hoong Yeet Yeang , Hamzah Samsidar
IPC分类号： C12P21/06
CPC分类号： C08C3/02 , A61K38/00 , A61K39/35 , C07K14/415 , C07K16/16 , C08C1/04 , Y10S530/868
摘要： This invention relates to allergenic proteins of natural rubber latex in substantially purified form, their production and their use, together with monoclonal antibodies developed against those allergenic proteins, in assays for the qualitative and quantitative determination of the levels of the allergenic proteins in natural rubber latex or in products made from latex. Assays for identifying and/or quantitating antibodies in blood or blood products that mediate the occurrence of an allergic reaction induced by natural rubber latex are also provided, together with in vivo and in vitro diagnostic tests for detecting hypersensitivity to natural rubber latex and which involve use of the aforesaid allergenic proteins. The invention also provides for the use of the aforesaid allergens as de-sensitising agents in the treatment of latex protein allergy. There is still further provided a method for removing allergenic proteins from latex products.
摘要翻译：本发明涉及基本纯化形式的天然橡胶胶乳的过敏原蛋白，其生产及其用途，以及针对这些过敏原蛋白的单克隆抗体，用于定性和定量测定天然橡胶胶乳中过敏原蛋白水平的测定或由乳胶制成的产品。还提供用于鉴定和/或定量介导由天然橡胶胶乳引起的过敏反应发生的血液或血液制品中的抗体的测定，以及用于检测对天然橡胶胶乳的超敏反应的体内和体外诊断测试，其涉及使用的上述变应原蛋白。本发明还提供了上述变应原作为去敏化剂在治疗胶乳蛋白过敏中的用途。还提供了从乳胶产品中除去过敏原蛋白的方法。

103. 发明申请

US20110159042A1 PYTHIUM IMMUNOTHERAPY 有权
公开(公告)号：US20110159042A1
公开(公告)日：2011-06-30
申请号：US12647971
申请日：2009-12-28
申请人： ALBERTO L. MENDOZA , ROBERT L. GLASS , RICHARD D. HANSEN
发明人： ALBERTO L. MENDOZA , ROBERT L. GLASS , RICHARD D. HANSEN
IPC分类号： A61K39/00 , A61P31/00
CPC分类号： A61K39/0002 , A61K36/07 , A61K39/35 , A61K39/39 , A61K2039/545 , C12N2710/20011
摘要： A method and vaccine for modulating the immune system of animals with diseases other than caused by P. insidiosum, comprising administering to the animal immune modulating effective amount of the P. insidiosum, Strain MTPI-04. The vaccine uses an immune response that effectively treats and manages a variety of human and animal diseases.
摘要翻译：一种调节动物免疫系统的方法和疫苗，其除了由隐球菌引起的疾病以外，还包括对所述动物进行免疫调节有效量的小鼠隐球菌属菌株MTPI-04。疫苗使用有效治疗和管理各种人类和动物疾病的免疫应答。

104. 发明申请

US20110150987A1 MUCOADHESIVE PARTICULATE FORMULATION FOR INDUCING ANTIGEN-SPECIFIC IMMUNE TOLERANCE 审中-公开
标题翻译：用于诱导抗原特异性免疫耐受的MUCOADHESIVE颗粒剂配方
公开(公告)号：US20110150987A1
公开(公告)日：2011-06-23
申请号：US12993563
申请日：2009-05-20
申请人： Nathalie Saint-Lu , Alain Razafindratsita , Sophia Tourdot , Philippe Moingeon , Laurence Van Overtvelt
发明人： Nathalie Saint-Lu , Alain Razafindratsita , Sophia Tourdot , Philippe Moingeon , Laurence Van Overtvelt
IPC分类号： A61K39/35 , A61K9/14 , A61K39/00 , A61K39/36 , A61K9/20 , A61K9/48 , A61P37/08 , A61P37/02 , A61P37/04 , A61P37/06 , B82Y5/00
CPC分类号： A61K47/36 , A61K9/006 , A61K9/146 , A61K9/1652 , A61K9/5161 , A61K39/35 , A61K2039/542 , A61K2039/55583
摘要： The present invention relates to a mucoadhesive composition, adapted for preventing and/or treating a pathological reaction of the immune system of an individual, by inducing a specific tolerance towards at least one antigen involved in said pathological reaction, comprising chitosan particles loaded with said at least one antigen involved in the pathological reaction, wherein the size of the loaded chitosan particles is of more than 800 nm.
摘要翻译：本发明涉及一种粘膜粘附性组合物，其适用于通过对参与所述病理反应的至少一种抗原诱导特异性耐受性来预防和/或治疗个体的免疫系统的病理反应，所述组合物包含装载有所述at 涉及病理反应的至少一种抗原，其中负载的壳聚糖颗粒的尺寸大于800nm。

105. 发明申请

US20110123558A1 Peptide with Reduced Dimer Formation 有权
标题翻译：具有减少二聚体形成的肽
公开(公告)号：US20110123558A1
公开(公告)日：2011-05-26
申请号：US12673334
申请日：2008-08-15
申请人： Roderick Peter Hafner , Paul Laidler
发明人： Roderick Peter Hafner , Paul Laidler
IPC分类号： A61K39/00 , A61K38/08 , A61K38/10 , G01N33/53 , C40B30/00 , C07K16/18 , A61P37/06 , A61P37/02
CPC分类号： A61K39/0003 , A61K38/00 , A61K39/0002 , A61K39/0005 , A61K39/0008 , A61K39/35 , A61K39/36 , A61K39/39 , C07K7/06 , C07K7/08 , C07K14/415 , C07K14/435 , C07K14/43531 , C07K16/16 , C07K16/18 , C07K2319/00 , G01N33/56977
摘要： The present invention relates to peptides which are formulated or engineered to prevent or reduce the formation of dimers.
摘要翻译：本发明涉及配制或工程化以防止或减少二聚体形成的肽。

106. 发明授权

US07927600B2 Anti-allergic pharmaceutical composition containing at least one allergen and at least one antihistamine compound 有权
标题翻译：含有至少一种变应原和至少一种抗组胺剂化合物的抗过敏药物组合物
公开(公告)号：US07927600B2
公开(公告)日：2011-04-19
申请号：US11413489
申请日：2006-04-28
申请人： Emile Loria , Gaetan Terrasse , Yves Trehin
发明人： Emile Loria , Gaetan Terrasse , Yves Trehin
IPC分类号： A61K39/36 , A61K38/03 , A61K38/43 , C07K4/10 , C07K14/415 , C12N15/29
CPC分类号： A61K31/4172 , A61K31/473 , A61K31/495 , A61K39/35 , A61K39/36 , A61K45/06
摘要： The present invention relates to an anti-allergic pharmaceutical composition containing at least two active agents chosen from: (i) one allergen, (ii) one antihistamine compound, and (iii) one inhibitor of histamine synthesis, said active agents being associated in said composition with a pharmaceutically acceptable vehicle.
摘要翻译：本发明涉及含有至少两种活性剂的抗过敏药物组合物，所述活性剂选自：（i）一种变应原，（ii）一种抗组胺剂化合物和（iii）一种组胺合成抑制剂，所述活性剂与所述具有药学上可接受的载体的组合物。

107. 发明授权

US07923209B2 Allergen peptide fragments and use thereof 有权
标题翻译：过敏原肽片段及其用途
公开(公告)号：US07923209B2
公开(公告)日：2011-04-12
申请号：US10799514
申请日：2004-03-12
申请人： Francois Spertini , Blaise Corthesy
发明人： Francois Spertini , Blaise Corthesy
IPC分类号： G01N33/53
CPC分类号： A61K38/168 , A61K39/35 , C07K14/415 , C07K14/43531 , C07K14/43563 , C07K14/43572
摘要： The present invention relates generally to in vivo methods and compositions designed for allergen specific immunotherapy. The compositions include contiguous overlapping peptide fragments which together form an entire amino acid sequence of an allergen.
摘要翻译：本发明一般涉及设计用于变应原特异性免疫治疗的体内方法和组合物。组合物包括连续重叠的肽片段，其一起形成变应原的完整氨基酸序列。

108. 发明申请

US20110027298A1 MICROBIAL DELIVERY SYSTEM 审中-公开
标题翻译：微波传送系统
公开(公告)号：US20110027298A1
公开(公告)日：2011-02-03
申请号：US12843739
申请日：2010-07-26
申请人： Michael J. Caplan , Hugh A. Sampson , A. Wesley Burks , H. Kim Bottomly , Howard B. Sosin
发明人： Michael J. Caplan , Hugh A. Sampson , A. Wesley Burks , H. Kim Bottomly , Howard B. Sosin
IPC分类号： A61K39/35 , A61P37/08
CPC分类号： A61K39/35 , A61K2039/5156 , A61K2039/523 , A61K2039/5256
摘要： The present invention provides methods and compositions for treating or preventing allergic responses, particularly anaphylactic allergic responses, in subjects who are allergic to allergens or susceptible to allergies. Methods of the present invention utilize administration of microorganisms to subjects, where the microorganisms produce allergens and protect the subjects from exposure to the allergens until phagocytosed by antigen-presenting cells. Particularly preferred microorganisms are gram-negative bacteria, gram-positive bacteria, and yeast. Particularly preferred allergens are proteins found in foods, venoms, drugs and latex that elicit allergic reactions and anaphylactic allergic reactions in individuals who are allergic to the proteins or are susceptible to allergies to the proteins. The proteins may also be modified to reduce the ability of the proteins to bind and crosslink IgE antibodies and thereby reduce the risk of eliciting anaphylaxis without affecting T-cell mediated Th1-type immunity.
摘要翻译：本发明提供了用于治疗或预防对过敏原过敏或容易过敏的受试者的过敏反应，特别是过敏性过敏反应的方法和组合物。本发明的方法利用对微生物施用微生物，其中微生物产生变应原并保护受试者不被暴露于变应原，直到被抗原呈递细胞吞噬。特别优选的微生物是革兰氏阴性细菌，革兰氏阳性菌和酵母。特别优选的过敏原是在食物，毒液，药物和胶乳中发现的蛋白质，其对于对蛋白质过敏或易受蛋白质过敏的个体引起过敏反应和过敏性过敏反应。也可以修饰蛋白质以降低蛋白质结合和交联IgE抗体的能力，从而降低引发过敏反应的风险，而不影响T细胞介导的Th1型免疫。

109. 发明申请

US20110014238A1 IMMUNOGENIC PROTEIN PAS N 1 FROM BAHIA GRASS POLLEN 审中-公开
标题翻译：免疫蛋白质蛋白N 1来自巴戟草
公开(公告)号：US20110014238A1
公开(公告)日：2011-01-20
申请号：US12738618
申请日：2008-10-21
申请人： Robyn O'Hehir , Janet Davies , Jennifer Rolland
发明人： Robyn O'Hehir , Janet Davies , Jennifer Rolland
IPC分类号： A61K39/35 , C07H21/04 , C07K14/415 , C07K16/16 , A61P37/08
CPC分类号： A61K39/35 , C07K14/415 , C07K16/16 , G01N33/577
摘要： The present invention relates generally to novel recombinant polypeptides of Bahia grass pollen and to genetic sequences encoding same. More particularly, the present invention is directed to Pas n 1 polypeptides and derivatives, and fragments thereof and genetic sequences encoding same. The molecules of the present invention are useful in a range of therapeutic, prophylactic and diagnostic applications including, but not limited to, applications in the context of conditions characterised by an aberrant, inappropriate or otherwise unwanted immune response to the Bahia grass pollen.
摘要翻译：本发明一般涉及巴伊亚草花粉的新型重组多肽和编码它的遗传序列。更具体地说，本发明涉及Pas n 1多肽及其衍生物及其片段和编码其的遗传序列。本发明的分子可用于一系列治疗，预防和诊断应用，包括但不限于在特征在于对巴伊亚草花粉异常，不适当或其他不期望的免疫应答的病症的应用中。

110. 发明授权

US07846449B2 Modified mite allergen and pharmaceutical uses thereof 有权
公开(公告)号：US07846449B2
公开(公告)日：2010-12-07
申请号：US11778946
申请日：2007-07-17
申请人： Ching-Hsiang Hsu , Wei-Chih Su
发明人： Ching-Hsiang Hsu , Wei-Chih Su
IPC分类号： A61K39/00 , C07K14/00 , C07K17/00
CPC分类号： A61K39/35 , C07H21/04 , C07K14/43531 , Y10S530/868
摘要： The present invention provides a modified Dermatophagoides pteronyssinus allergen Der p 5 protein which has ability to inhibit IgE binding when exposed against to the antigen. A method for treating allergy comprising administrating a therapeutically effective dose of the modified D. pteronyssinus allergen Der p 5 protein to a subject suffering from allergy Der p 5 is also provided.

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