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101. 发明授权

US07014816B2 Food quality indicator device 失效
公开(公告)号：US07014816B2
公开(公告)日：2006-03-21
申请号：US10005004
申请日：2001-12-04
申请人： Dwight W. Miller , Jon G. Wilkes , Eric D. Conte
发明人： Dwight W. Miller , Jon G. Wilkes , Eric D. Conte
IPC分类号： G01N31/22 , G01N21/17 , G01N33/02
CPC分类号： G01N33/02 , G01N31/22 , Y10T436/15 , Y10T436/173845
摘要： A food quality indicator device an indicator compound provided on a substrate. The indicator compound changes color due to the presence of volatile compounds, such as volatile bases, in spoiled food, even when the food is frozen. Alternatively, the indicator compound detects the presence of an unwanted amine-producing biological agent, such as bacteria or fungi. The indicator compound is typically contained within a polymeric matrix disposed on the substrate. Examples of suitable indicator compounds include halogenated azo dyes, sulfonated xanthene dyes, and sulfonated hydroxy-functional triphenylmethane dyes.

102. 发明授权

US06982146B1 High speed parallel molecular nucleic acid sequencing 失效
标题翻译：高速平行分子核酸测序
公开(公告)号：US06982146B1
公开(公告)日：2006-01-03
申请号：US10070053
申请日：2000-08-29
申请人： Thomas D. Schneider , Denise Rubens
发明人： Thomas D. Schneider , Denise Rubens
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6869 , C12Q1/6818 , C12Q2563/107 , C12Q2537/143
摘要： A method and device is disclosed for high speed, automated sequencing of nucleic acid molecules. A nucleic acid molecule to be sequenced is exposed to a polymerase in the presence of nucleotides which are to be incorporated into a complementary nucleic acid strand. The polymerase carries a donor fluorophore, and each type of nucleotide (e.g. A, T/U, C and G) carries a distinguishable acceptor fluorophore characteristic of the particular type of nucleotide. As the polymerase incorporates individual nucleic acid molecules into a complementary strand, a laser continuously irradiates the donor fluorophore, at a wavelength that causes it to emit an emission signal (but the laser wavelength does not stimulate the acceptor fluorophore). In particular embodiments, no laser is needed if the donor fluorophore is a luminescent molecule or is stimulated by one. The emission signal from the polymerase is capable of stimulating any of the donor fluorophores (but not acceptor fluorophores), so that as a nucleotide is added by the polymerase, the acceptor fluorophore emits a signal associated with the type of nucleotide added to the complementary strand. The series of emission signals from the acceptor fluorophores is detected, and correlated with a sequence of nucleotides that correspond to the sequence of emission signals.
摘要翻译：公开了用于核酸分子的高速，自动测序的方法和装置。待测序的核酸分子在待并入互补核酸链的核苷酸的存在下暴露于聚合酶。聚合酶携带供体荧光团，并且每种类型的核苷酸（例如A，T / U，C和G）携带特定类型核苷酸特征的可区别的受体荧光团。当聚合酶将单个核酸分子结合到互补链中时，激光以使得其发射发射信号（但激光波长不刺激受体荧光团）的波长连续照射供体荧光团。在具体实施方案中，如果供体荧光团是发光分子或被一个激发的，则不需要激光。来自聚合酶的发射信号能够刺激任何供体荧光团（但不是受体荧光团），使得当通过聚合酶加入核苷酸时，受体荧光团发射与添加到互补链的核苷酸类型相关联的信号。检测来自受体荧光团的一系列发射信号，并与与发射信号序列相对应的核苷酸序列相关。

103. 发明授权

US06932814B2 Radiofrequency probes for tissue treatment and methods of use 失效
标题翻译：用于组织治疗的射频探针和使用方法
公开(公告)号：US06932814B2
公开(公告)日：2005-08-23
申请号：US10332297
申请日：2001-06-28
申请人： Bradford J. Wood
发明人： Bradford J. Wood
IPC分类号： A61B18/14 , A61B19/00 , A61B18/18
CPC分类号： A61B18/1477 , A61B2018/143 , A61B2018/1432 , A61B2018/1475 , A61B2090/3925
摘要： A device and method for radiofrequency treatment of tissue is disclosed. The device includes an introducer, a plurality of RF electrodes positionable in a nondeployed state within the introducer, and an electrode advancement element. In the nondeployed state, the RF electrodes are contained within the introducer, and separated from the subject's tissue by a plug which substantially occludes the distal end of the introducer. In the method for RF tissue treatment, the introducer is introduced into the tissue of a subject. The RF electrodes are then positioned in the deployed state when the electrode advancement element advances the RF electrodes through the distal end of the introducer, thereby displacing the plug. The electrode advancement element may be a spring-loaded element, and may be actuated by a triggering device on the introducer. The introducer and the RF electrodes may be scored to enhance their visibility in medical imaging studies such as ultrasound, thereby helping to ensure optimal placement of the introducer and the RF electrodes.
摘要翻译：公开了一种用于组织射频治疗的装置和方法。该装置包括导引器，可在导引器内以非部署状态定位的多个RF电极和电极前进元件。在非部署状态下，RF电极被包含在导引器内，并且通过基本上封闭导引器的远端的插塞与被检者的组织分离。在用于RF组织处理的方法中，引入器被引入到受试者的组织中。然后当电极前进元件使RF电极通过引导器的远端前进时，RF电极被定位在展开状态，从而移位插头。电极推进元件可以是弹簧加载元件，并且可以由导引器上的触发装置来致动。可以对导引器和RF电极进行刻痕以增强其在诸如超声的医学成像研究中的可见性，从而有助于确保导引器和RF电极的最佳放置。

104. 发明授权

US06916843B1 Anti-inflammatory actions of cytochrome P450 expoxygenase-derived eicosanoids 失效
标题翻译：细胞色素P450环氧化酶衍生的类花生酸的抗炎作用
公开(公告)号：US06916843B1
公开(公告)日：2005-07-12
申请号：US09634369
申请日：2000-08-09
申请人： James K. Liao , Darryl Zeldin
发明人： James K. Liao , Darryl Zeldin
IPC分类号： A61K31/16 , A61K31/17 , A61K31/202 , A61K31/325 , A61K31/557 , A61K31/558 , A61K38/44 , A61K45/06 , A61K48/00 , C12Q1/26 , A61K31/335
CPC分类号： A61K31/559 , A61K31/16 , A61K31/17 , A61K31/202 , A61K31/325 , A61K31/557 , A61K31/558 , A61K38/44 , A61K45/06 , A61K48/00 , C12Q1/26 , C12Y114/14001 , G01N2500/04 , A61K2300/00
摘要： Epoxyeicosatrienoic acids (EETs) are products of cytocrome P450 epoxygenases that have vasodilatory properties similar to endotheilum-derived hyperpolarizing factor (EDHF). The cytochrome P450 isoform CYP2J2 was cloned and identified as a source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytolcine-induced endothelial cell adhesion molecule expression and prevented subsequent leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-κB and IκB kinase (IKK). The inhibitory effects of EETs were independent of their membrane hyporpolarizing effects suggesting that these molecules play an important non-vasodilatory role in vascular inflammation.
摘要翻译：环氧二十碳三烯酸（EETs）是具有类似于内皮衍生的超极化因子（EDHF）的血管扩张性质的细胞色素P450环氧化酶的产物。克隆细胞色素P450同种型CYP2J2，并将其鉴定为人内皮细胞中EET的来源。 EETs的生理浓度或CYP2J2的过表达降低细胞因子诱导的内皮细胞粘附分子表达，并通过涉及抑制转录因子NF-κB和IkappaB激酶（IKK）的机制阻止随后的白细胞与血管壁的粘附。 EETs的抑制作用与其膜下极化作用无关，表明这些分子在血管炎症中发挥重要的非血管扩张作用。

105. 发明授权

US06890917B2 Geldanamycin derivative and method of treating cancer using same 有权
标题翻译：格尔德霉素衍生物和使用其治疗癌症的方法
公开(公告)号：US06890917B2
公开(公告)日：2005-05-10
申请号：US10432581
申请日：2002-03-28
申请人： Kenneth M. Snader , B. Rao Vishnuvajjala , Melinda G. Hollingshead , Edward A. Sausville
发明人： Kenneth M. Snader , B. Rao Vishnuvajjala , Melinda G. Hollingshead , Edward A. Sausville
IPC分类号： A61K31/395 , A61P35/00 , A61P43/00 , C07D225/06
CPC分类号： C07D225/06
摘要： A geldanamycin derivative exhibiting significant preliminary in vivo activity, particularly significant oral in vivo activity, and a method of treating or preventing cancer in a host comprising administering a geldanamycin derivative to a host in an amount sufficient to treat or prevent cancer.
摘要翻译：表现出明显的体内活性，特别是口服体内活性的格尔德霉素衍生物，以及治疗或预防宿主中的癌症的方法，包括以足以治疗或预防癌症的量向宿主施用格尔德霉素衍生物。

106. 发明授权

US06861415B2 21-substituted progesterone derivatives as new antiprogestational agents 有权
标题翻译： 21位替代孕酮衍生物作为新的抗孕剂
公开(公告)号：US06861415B2
公开(公告)日：2005-03-01
申请号：US09180132
申请日：1997-04-30
申请人： Hyun K. Kim , Richard P. Blye , Pemmaraju N. Rao , James W. Cessac , Carmie K. Acosta
发明人： Hyun K. Kim , Richard P. Blye , Pemmaraju N. Rao , James W. Cessac , Carmie K. Acosta
IPC分类号： A61K31/57 , A61K31/00 , A61P5/24 , C07J5/00 , C07J7/00 , C07J9/00 , C07J21/00 , C07J41/00 , C07J51/00 , C07J71/00 , A61K31/56
CPC分类号： C07J5/00 , C07J5/0053 , C07J7/00 , C07J7/0085 , C07J9/00 , C07J21/006 , C07J41/00 , C07J41/0016 , C07J41/0083 , C07J41/0094 , C07J51/00 , C07J71/001 , Y10S514/841
摘要： A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, —COCH3 and —CHOHCH3; R2 is a member selected from the group consisting of halogen, alkyl, acyl, hydroxy, alkoxy, acyloxy, alkyl carbonate, cypionyloxy, S-alkyl and S-acyl; R3 is a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; R4 is a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ═O and ═N—OR5, wherein R5 is a member selected from the group consisting of hydrogen and alkyl. In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce labor; and for contraception.
摘要翻译：具有以下通式的化合物：其中：R 1是选自-OCH 3，-SCH 3，-N（CH 3）2，-NHCH 3，-CHO，-COCH 3和-CHOHCH 3的成员; R 2是选自卤素，烷基，酰基，羟基，烷氧基，酰氧基，碳酸烷基酯，Cypion氧基，S-烷基和S-酰基的成员。 R 3是选自烷基，羟基，烷氧基和酰氧基的成员; R 4是选自氢和烷基的成员; 并且X是选自= O和= N-OR 5的成员，其中R 5是选自氢和烷基的成员。除了提供式I化合物外，本发明提供了其中式I化合物有利地用于拮抗内源性孕酮的方法; 诱发月经; 治疗子宫内膜异位症; 治疗痛经; 治疗内分泌激素依赖性肿瘤; 治疗子宫肌瘤; 抑制子宫内膜增生; 诱导劳动; 和避孕。

107. 发明授权

US06858712B1 Cloning and expression of HTLV-III DNA 失效
标题翻译： HTLV-III DNA的克隆和表达
公开(公告)号：US06858712B1
公开(公告)日：2005-02-22
申请号：US08463209
申请日：1995-06-05
申请人： Nancy T. Chang , Robert C. Gallo , Flossie Wong-Staal
发明人： Nancy T. Chang , Robert C. Gallo , Flossie Wong-Staal
IPC分类号： A61K38/00 , C07K14/16 , C07K16/10 , C12N5/24 , C12P21/08 , C12Q1/70 , C07H21/02 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/702 , A61K38/00 , C07K14/005 , C07K16/1054 , C07K16/1063 , C07K2319/00 , C12N2740/14022 , C12N2740/16122 , C12Q1/703
摘要： The determination of the nucleotide sequence of HTLV-III DNA; identification, isolation and expression of HTLV-III sequences which encode immunoreactive polypeptides by recombinant DNA methods and production of viral RNA are disclosed. Such polypeptides can be employed in immunoassays to detect HTLV-III.
摘要翻译：测定HTLV-III DNA的核苷酸序列; 公开了通过重组DNA方法编码免疫反应性多肽的HTLV-III序列的鉴定，分离和表达以及病毒RNA的产生。这些多肽可用于免疫测定以检测HTLV-III。

108. 发明授权

US06849417B1 Mammalian selenoprotein differentially expressed in tumor cells 失效
公开(公告)号：US06849417B1
公开(公告)日：2005-02-01
申请号：US09676718
申请日：2000-09-28
申请人： Vadim N. Gladyshev , Dolph L. Hatfield , Kuan-Teh Jeang , Alan Diamond , John C. Wootton
发明人： Vadim N. Gladyshev , Dolph L. Hatfield , Kuan-Teh Jeang , Alan Diamond , John C. Wootton
IPC分类号： A61K38/00 , C07K14/47 , G01N33/574 , C07K16/00
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00
摘要： A 15 kDa selenium-containing protein (“selenoprotein”) is disclosed. The protein is shown to be differentially expressed in cancer cells, such as prostate cancer cells. There is a correlation between the presence of a polymorphism at nucleotide positions 811 and 1125 of the 15 kDa selenoprotein gene, and the presence of cancer. This polymorphism is more prevalent in the African American population. The determination of an individual's genotype may be used as an indicator of the need for dietary selenium supplementation to inhibit tumor development. Compositions including the isolated protein, specific binding agents that recognize the protein, as well as underlying nucleic acid sequences are presented, as are methods of using such compositions.

109. 发明授权

US06846911B2 Methods and compositions for inhibiting inflammation and angiogenesis comprising a mammalian CD97 α subunit 失效
标题翻译：用于抑制炎症和血管生成的方法和组合物，其包含哺乳动物CD97α亚基
公开(公告)号：US06846911B2
公开(公告)日：2005-01-25
申请号：US10059506
申请日：2002-01-29
申请人： Kathleen Kelly
发明人： Kathleen Kelly
IPC分类号： G01N33/53 , A61K31/711 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , C07K14/705 , C07K14/725 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , C07K16/00 , A61K35/14 , C07K1/00 , C12P21/08
CPC分类号： C07K16/2896 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/70596 , C07K2317/34
摘要： Isolated proteins comprising the T-cell surface antigen CD97 α are provided. Compositions and methods for making and detecting CD97 α are also provided. Further, the invention provides diagnostic and therapeutic methods and compositions for medical conditions involving CD97. The inventions also provides antibody compositions that bind specifically to CD97 α subunits.
摘要翻译：提供了包含T细胞表面抗原CD97α的分离的蛋白质。还提供了用于制作和检测CD97 alpha的组合物和方法。此外，本发明提供了涉及CD97的医学病症的诊断和治疗方法和组合物。本发明还提供了与CD97α亚基特异性结合的抗体组合物。

110. 发明授权

US6143494A Poliovirus specific primers and methods of detection utilizing the same 失效
标题翻译：脊髓灰质炎病毒特异性引物及其检测方法
公开(公告)号：US6143494A
公开(公告)日：2000-11-07
申请号：US935100
申请日：1997-09-25
申请人： David R. Kilpatrick
发明人： David R. Kilpatrick
IPC分类号： C12N15/09 , C07H21/04 , C12Q1/68 , C12Q1/70 , C07H21/02
CPC分类号： C12Q1/701
摘要： The ability to rapidly detect wild polioviruses in clinical specimens is a major concern for the world-wide eradication of polioviruses. Provided is a method of detecting polioviruses of all three serotypes from viral isolates of clinical specimens using a pair of degenerate PCR primers. This primer set, which uses deoxyinosine residues to compensate for third position mismatches at specific positions, recognizes nucleotide sequences near the receptor binding site of polioviruses. These sequences are unique to polioviruses and are absolutely conserved at the amino acid level. As a result, these PCR primers do not recognize nonpoliovirus enteroviruses. All poliovirus serotypes (40 poliovaccine related genotypes and 120 wild poliovirus genotypes from around the world) tested positive. All 14 prototype strains of nonpoliovirus enteroviruses tested negative. Also provided is a series of degenerate PCR primers that differentiates between the three wild poliovirus serotypes and a method of detecting the presence of the three serotypes utilizing a nucleic acid amplification technique.
摘要翻译：在临床标本中快速检测野生型脊髓灰质炎病毒的能力是全世界根除脊髓灰质炎病毒的主要关切。提供了使用一对简并PCR引物来检测来自临床标本病毒分离株的所有三种血清型的脊髓灰质炎病毒的方法。该引物组使用脱氧肌苷残基补偿特定位置的第三位错配，识别脊髓灰质炎病毒受体结合位点附近的核苷酸序列。这些序列对于脊髓灰质炎病毒是独一无二的，并且在氨基酸水平上是绝对保守的。因此，这些PCR引物不识别非脊髓灰质炎病毒肠道病毒。所有脊髓灰质炎病毒血清型（来自世界各地的40种脊髓灰质炎疫苗相关基因型和120种野生型脊髓灰质炎病毒基因型）检测为阳性。所有14种非卵巢病毒肠道病毒的原型菌株均为阴性。还提供了一系列简并PCR引物，其区分三种野生型脊髓灰质炎病毒血清型和利用核酸扩增技术检测三种血清型的存在的方法。

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