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    • 102. 发明申请
    • Conserved and specific streptococcal genomes
    • 保守和特异性链球菌基因组
    • US20070053924A1
    • 2007-03-08
    • US10525536
    • 2003-08-26
    • Herve TettelinVega Masignani
    • Herve TettelinVega Masignani
    • A61K39/09C07H21/04
    • A61K39/092C07K14/315
    • The invention relates to polynucleotides which are conserved or specific to one or more species of Streptococcus, Streptococcus species serotypes, and/or serotype isolates. In particular, the invention relates to polynucleotides from Streptococcus which are conserved or specific to one or more of the species of S. pneumoniae (“pneumococcus” or “S. pn.”), S. pyogenes (“group A streptococcus” or “GAS”), and S. agalactiae (“group B streptococcus” or “GBS”). The invention further relates to polynucleotides which are conserved or specific to one or more Streptococcal species serotypes, such as GBS serotypes Ia, Ib, II, III, IV, V, VI, VII, and VIII. The invention still further relates to polynucleotides which are conserved or specific to one or more clinical isolates of a Streptococcus species.
    • 本发明涉及对一种或多种链球菌,链球菌血清型和/或血清型分离物保守或特异性的多核苷酸。 特别地,本发明涉及来自链球菌的多核苷酸,其对肺炎链球菌(“肺炎球菌”或“S.pn。”),化脓性链球菌(“A组链球菌”或“A型链球菌”)的一种或多种物种是保守的或特异性的, GAS“)和无乳糖乳杆菌(”B组链球菌“或”GBS“)。 本发明还涉及对一种或多种链球菌属血清型保守或特异性的多核苷酸,例如GBS血清型Ia,Ib,II,III,IV,V,VI,VII和VIII。 本发明还涉及对链球菌属物种的一种或多种临床分离物保守或特异性的多核苷酸。