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101. 发明授权

US08366712B2 Multiple pathways for spinal nerve root decompression from a single access point 有权
公开(公告)号：US08366712B2
公开(公告)日：2013-02-05
申请号：US13312272
申请日：2011-12-06
申请人： Jeffery L. Bleich , Michael Sheinberg , Michael P. Wallace
发明人： Jeffery L. Bleich , Michael Sheinberg , Michael P. Wallace
IPC分类号： A61B17/00
CPC分类号： A61B17/0218 , A61B17/025 , A61B17/1671 , A61B17/32 , A61B17/320016 , A61B17/32002 , A61B17/32053 , A61B17/320758 , A61B17/3401 , A61B17/3403 , A61B17/3421 , A61B17/3496 , A61B18/1477 , A61B18/1487 , A61B90/04 , A61B2017/00261 , A61B2017/00287 , A61B2017/003 , A61B2017/00867 , A61B2017/0225 , A61B2017/0256 , A61B2017/320004 , A61B2017/320044 , A61B2017/32006 , A61B2018/1407 , A61B2018/1425 , A61B2090/061 , A61B2090/08021 , A61N1/0551
摘要： A method of accessing target tissue adjacent to a spinal nerve of a patient includes the steps of accessing a spine location of the patient by entering the patient through the skin at an access location, inserting a flexible tissue modification device through the access location to the spine location, advancing a distal portion of the first flexible tissue modification device from the spine location to a first exit location, passing through the first exit location and out of the patient, advancing the first or a second flexible tissue modification device through the same access location to the spine location and to a second exit location, and passing through the second exit location and out of the patient.

102. 发明授权

US08192436B2 Tissue modification devices 有权
标题翻译：组织修饰装置
公开(公告)号：US08192436B2
公开(公告)日：2012-06-05
申请号：US12324147
申请日：2008-11-26
申请人： Gregory P. Schmitz , Michael P. Wallace , Ronald Leguidleguid , Nestor C. Cantorna , James Shapiro , Jeffery L. Bleich
发明人： Gregory P. Schmitz , Michael P. Wallace , Ronald Leguidleguid , Nestor C. Cantorna , James Shapiro , Jeffery L. Bleich
IPC分类号： A61B17/00 , A61B17/32
CPC分类号： A61B17/1631 , A61B17/149 , A61B17/1659 , A61B17/1671 , A61B17/1735 , A61B17/320016 , A61B17/32002 , A61B17/3207 , A61B2017/00261 , A61B2017/320004 , A61B2017/320008 , A61B2017/32006
摘要： Described herein are elongate device for modifying tissue having a plurality of flexibly connected rungs or links, and methods of using them, including methods of using them to decompress stenotic spinal tissue. These devices may be included as part of a system for modifying tissue. In general, these devices include a plurality of blades positioned on (or formed from) rungs that are flexibly connected. The rungs are typically rigid, somewhat flat and wider than they are long (e.g., rectangular). The rungs may be arranged, ladder like, and may be connected by a flexible connector substrate or between two or more cables. Different sized rungs may be used. The blades (on the rungs) may be arranged in a staggered arrangement. A tissue-collection or tissue capture element (e.g., chamber, bag, or the like) may be used to collect the cut or modified tissue. In some variations the tissue modification devices may have a non-linear axial shape, or may be converted from a first axial shape to a second axial shape.
摘要翻译：本文描述的是用于修改具有多个柔性连接的梯级或链节的组织的细长装置，以及使用它们的方法，包括使用它们来减压狭窄的脊髓组织的方法。可以将这些装置作为用于修改组织的系统的一部分。通常，这些装置包括位于柔性连接的（或由）梯级形成的多个叶片。梯级通常是刚性的，稍微平坦并且比它们长（例如矩形）更宽。梯级可以布置成梯子，并且可以通过柔性连接器基板或两根或更多根电缆连接。可以使用不同尺寸的梯级。刀片（在梯级上）可以以交错排列布置。可以使用组织收集或组织捕获元件（例如，室，袋等）来收集切割或修饰的组织。在一些变型中，组织改变装置可以具有非线性轴向形状，或者可以从第一轴向形状转换成第二轴向形状。

103. 发明授权

US08185208B2 Modular stimulation lead network 失效
标题翻译：模块化刺激引线网络
公开(公告)号：US08185208B2
公开(公告)日：2012-05-22
申请号：US12549223
申请日：2009-08-27
申请人： Robert J. Garabedian , Michael P. Wallace
发明人： Robert J. Garabedian , Michael P. Wallace
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021
摘要： A medical kit and method for treating an ailment, such as chronic pain is provided. The kit comprises first and second medical leads, e.g., stimulation leads. Each lead comprises an elongated body and at least one operative element. The first medical lead comprises a coupling mechanism, such as a slot, and the second medical lead comprises a complementary mechanism, such as a rail, that slidably engages the coupling mechanism of the first medical lead. The method may comprise delivering the first medical lead into a patient's body, e.g., into the epidural space of the patient, and delivering the second medical lead into the patient's body by sliding the complementary coupling mechanism of the second medical lead along the coupling mechanism of the first medical lead.
摘要翻译：提供了用于治疗诸如慢性疼痛之类的疾病的医疗用具和方法。该试剂盒包括第一和第二医疗引线，例如刺激引线。每个引线包括细长主体和至少一个操作元件。第一医疗引线包括诸如槽的联接机构，并且第二医疗引线包括可滑动地接合第一医疗引线的联接机构的互补机构，例如轨道。该方法可以包括将第一医疗引线输送到患者体内，例如进入患者的硬膜外腔，并且通过沿第二医疗引线的联接机构滑动第二医疗引线的互补联接机构，将第二医疗引线输送到患者体内第一个医疗领导。

104. 发明申请

US20120078255A1 MULTIPLE PATHWAYS FOR SPINAL NERVE ROOT DECOMPRESSION FROM A SINGLE ACCESS POINT 有权
标题翻译：从单个接入点进行脊髓神经根分解的多路径
公开(公告)号：US20120078255A1
公开(公告)日：2012-03-29
申请号：US13312272
申请日：2011-12-06
申请人： Jeffery L. Bleich , Michael Sheinberg , Michael P. Wallace
发明人： Jeffery L. Bleich , Michael Sheinberg , Michael P. Wallace
IPC分类号： A61B17/16
CPC分类号： A61B17/0218 , A61B17/025 , A61B17/1671 , A61B17/32 , A61B17/320016 , A61B17/32002 , A61B17/32053 , A61B17/320758 , A61B17/3401 , A61B17/3403 , A61B17/3421 , A61B17/3496 , A61B18/1477 , A61B18/1487 , A61B90/04 , A61B2017/00261 , A61B2017/00287 , A61B2017/003 , A61B2017/00867 , A61B2017/0225 , A61B2017/0256 , A61B2017/320004 , A61B2017/320044 , A61B2017/32006 , A61B2018/1407 , A61B2018/1425 , A61B2090/061 , A61B2090/08021 , A61N1/0551
摘要： A method of accessing target tissue adjacent to a spinal nerve of a patient includes the steps of accessing a spine location of the patient by entering the patient through the skin at an access location, inserting a flexible tissue modification device through the access location to the spine location, advancing a distal portion of the first flexible tissue modification device from the spine location to a first exit location, passing through the first exit location and out of the patient, advancing the first or a second flexible tissue modification device through the same access location to the spine location and to a second exit location, and passing through the second exit location and out of the patient.
摘要翻译：一种接近患者脊髓神经附近的目标组织的方法包括以下步骤：通过进入患者的皮肤进入患者的脊柱位置，将柔性组织修饰装置穿过入口位置插入脊柱位置，将第一柔性组织修改装置的远端部分从脊柱位置推进到第一出口位置，穿过第一出口位置并离开患者，使第一或第二柔性组织修改装置通过相同的存取位置到达脊柱位置并且到达第二出口位置，并且穿过第二出口位置并离开患者。

105. 发明申请

US20120059446A1 COLLAPSIBLE/EXPANDABLE TUBULAR ELECTRODE LEADS 审中-公开
标题翻译：可拆卸/可扩展的管状电极引线
公开(公告)号：US20120059446A1
公开(公告)日：2012-03-08
申请号：US13230410
申请日：2011-09-12
申请人： Michael P. Wallace , Robert J. Garabedian
发明人： Michael P. Wallace , Robert J. Garabedian
IPC分类号： A61N1/375 , A61N1/36
CPC分类号： A61N1/0553
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force.
摘要翻译：提供医疗用铅和治疗患者的方法。医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态压缩力。

106. 发明申请

US20110282378A1 DETACHABLE ANEURYSM NECK BRIDGE 有权
标题翻译：可拆卸的ANEURYSM NECK BRIDGE
公开(公告)号：US20110282378A1
公开(公告)日：2011-11-17
申请号：US13194730
申请日：2011-07-29
申请人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
发明人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
IPC分类号： A61M29/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/1214 , A61B17/12168 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12063
摘要： A device for bridging a neck of an aneurysm, comprises a junction region, one or more radially extending array elements secured to the junction region, each array element having an unfolded shape and a delivery shape; and a cover attached to the junction region, and extending over the delivery shape of the array elements, wherein each array element is attached at one end to the junction region and the array elements are constructed and arranged to unfold the cover when assuming their unfolded shape, and wherein the device further comprises a tip, and each array element is attached at another end to the tip, the tip comprising an opening through which a vaso-occlusive device or occlusion fluid may be delivered.
摘要翻译：用于桥接动脉瘤颈部的装置包括接合区域，固定到接合区域的一个或多个径向延伸的阵列元件，每个阵列元件具有展开形状和递送形状; 以及附接到接合区域并且延伸在阵列元件的输送形状上的盖子，其中每个阵列元件在一端附接到接合区域，并且阵列元件被构造和布置成在假设其展开形状时展开盖子并且其中所述装置还包括尖端，并且每个阵列元件在另一端附接到所述尖端，所述尖端包括可以输送血管闭塞装置或闭塞液的开口。

107. 发明申请

US20110082534A1 Ultrasound-enhanced stenosis therapy 审中-公开
标题翻译：超声增强狭窄治疗
公开(公告)号：US20110082534A1
公开(公告)日：2011-04-07
申请号：US12807129
申请日：2010-08-27
申请人： Michael P. Wallace
发明人： Michael P. Wallace
IPC分类号： A61N7/00 , A61M31/00 , A61F2/84 , A61B18/20 , A61B18/02
CPC分类号： A61M37/0092 , A61B17/22004 , A61B17/22012 , A61B18/02 , A61B2018/00029 , A61B2018/0212 , A61M25/00 , A61N2007/0043
摘要： Apparatus and methods are disclosed for vascular stenosis therapy, including enhancing permeability of the vessel wall using ultrasound energy and delivering a therapeutic agent into the arterial wall. Ultrasound energy may also be delivered using transcutaneous techniques and endovascular methods. In some embodiments, ultrasound energy and therapeutic agent application may be combined with angioplasty techniques and with blood flow protection devices to prevent dissipation of the therapeutic agent from the treatment site.
摘要翻译：公开了用于血管狭窄治疗的装置和方法，包括使用超声能量增强血管壁的渗透性并将治疗剂递送到动脉壁中。超声能量也可以使用经皮技术和血管内方法进行。在一些实施例中，超声能量和治疗剂应用可以与血管成形术技术和血液流动保护装置组合以防止治疗剂从治疗部位的耗散。

108. 发明申请

US20110082396A1 Ultrasound-enhanced stenosis therapy 审中-公开
标题翻译：超声增强狭窄治疗
公开(公告)号：US20110082396A1
公开(公告)日：2011-04-07
申请号：US12925495
申请日：2010-10-22
申请人： Michael P. Wallace
发明人： Michael P. Wallace
IPC分类号： A61N7/00
CPC分类号： A61B17/22012 , A61B17/22004
摘要： Apparatus and methods are disclosed for vascular stenosis and vulnerable plaque therapies, including enhancing permeability of the vessel wall using ultrasound energy and delivering a therapeutic agent into the arterial wall. Ultrasound energy may also be delivered at frequencies less than 10 MHz and power less than 20 watts using transcutaneous techniques and endovascular methods. Therapeutic agents may be delivered to the treatment area via intravenous and endovascular methods. In some embodiments, ultrasound energy and therapeutic agent application may be combined with angioplasty techniques and with blood flow protection devices.
摘要翻译：公开了用于血管狭窄和易损斑块治疗的装置和方法，包括使用超声能量增强血管壁的渗透性并将治疗剂递送到动脉壁中。超声能量也可以使用经皮技术和血管内方法在小于10MHz的频率和功率小于20瓦的情况下递送。治疗剂可通过静脉内和血管内途径递送至治疗区域。在一些实施例中，超声能量和治疗剂应用可以与血管成形术技术和血液流动保护装置组合。

109. 发明授权

US07818063B2 Method of intravascularly delivering stimulation leads into brain to stimulate the SPG 有权
标题翻译：血管内传递刺激的方法导致大脑刺激SPG
公开(公告)号：US07818063B2
公开(公告)日：2010-10-19
申请号：US11627359
申请日：2007-01-25
申请人： Michael P. Wallace , Robert J. Garabedian , Robert M. Abrams
发明人： Michael P. Wallace , Robert J. Garabedian , Robert M. Abrams
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a neurological disorder in a patient is provided. The method comprises intravascularly delivering a stimulation lead within the head of the patient, and placing the stimulation lead adjacent brain tissue (e.g., cortical brain tissue or deep brain tissue), the stimulation of which will treat the neurological disorder. The stimulation lead can be placed into indirect contact with the brain tissue (e.g., through a blood vessel) or indirect contact with the brain tissue (e.g., when placed within the ventricular cavity or by being introduced through an exit point within a vessel wall). Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead, which conveniently extends from the access point within the circulatory system, to the implanted stimulation source. Using the stimulation lead, the brain tissue can then be stimulated in order to treat the neurological disorder.
摘要翻译：提供了治疗患者神经障碍的方法。该方法包括血管内递送患者头部内的刺激引线，并将刺激引导线邻近脑组织（例如皮质脑组织或深部脑组织）放置，其刺激将治疗神经障碍。刺激引线可以与脑组织（例如，通过血管）间接接触或与脑组织间接接触（例如当放置在心室内或通过血管壁内的出口点引入时）。可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电连接，其方便地从循环系统内的接入点延伸到植入的刺激源。使用刺激引线，可以刺激脑组织以治疗神经系统疾病。

110. 发明申请

US20100222803A1 SYSTEMS AND METHODS OF DE-ENDOTHELIALIZATION 审中-公开
标题翻译： DE-ENDOTHELIZIZATION的系统和方法
公开(公告)号：US20100222803A1
公开(公告)日：2010-09-02
申请号：US12780638
申请日：2010-05-14
申请人： Paul S. Seifert , Elaine Lee , Michael P. Wallace , Stephen C. Porter
发明人： Paul S. Seifert , Elaine Lee , Michael P. Wallace , Stephen C. Porter
IPC分类号： A61M29/00
CPC分类号： A61M29/02 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12113 , A61B17/12118 , A61B17/12136 , A61B17/12145 , A61B17/1215 , A61B17/12159 , A61B17/12186 , A61B17/1219 , A61B2017/1205 , A61B2017/12063 , A61B2017/22068 , A61B2017/22069 , A61F2/82
摘要： Apparatus and methods for treating a wall of an aneurysm formed in a vessel includes introducing a tubular member into the body lumen until a distal end of the tubular member is located within the aneurysm. A fluid is delivered via a lumen of the tubular member into the aneurysm to at least partially de-endothelialize the wall of the aneurysm, thereby causing an endothelium of the wall to generate fibrous tissue to strengthen the wall of the aneurysm.
摘要翻译：用于治疗在血管中形成的动脉瘤壁的装置和方法包括将管状构件引入体腔，直到管状构件的远端位于动脉瘤内。流体通过管状构件的内腔被输送到动脉瘤中以至少部分地去动脉瘤内壁，从而导致壁的内皮产生纤维组织以加强动脉瘤壁。

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