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101. 发明授权

US4941093A Surface erosion using lasers 失效
标题翻译：使用激光表面侵蚀
公开(公告)号：US4941093A
公开(公告)日：1990-07-10
申请号：US905156
申请日：1986-09-09
申请人： John Marshall , Anthony L. Raven , Walter T. Welford , Karen M. M. Ness
发明人： John Marshall , Anthony L. Raven , Walter T. Welford , Karen M. M. Ness
IPC分类号： A61B18/20 , A61B17/00 , A61B17/30 , A61F9/00 , A61F9/007 , A61F9/008 , A61F9/01 , B23K26/00 , B23K26/06 , B23K26/073 , G02B5/00
CPC分类号： B23K26/0652 , A61F9/00804 , A61F9/00817 , B23K26/0622 , B23K26/0648 , G02B5/001 , A61B2017/00119 , A61B2017/306 , A61F2009/00844 , A61F2009/00872 , A61F2009/00882
摘要： Laser apparatus for eroding a surface comprises means to select and control the shape and size of the area irradiated by each pulse of laser energy without varying the energy density of the beam. By varying the size of the irradiated area between pulses, some regions of the surface may be eroded more than others and so the surface may be reprofiled. The method and apparatus are suitable, inter alia, for removing corneal ulcers and reprofiling the cornea to remove refractive errors and also for reprofiling optical elements. In one embodiment the beam from the laser enters an optical system housed in an articulated arm and terminating in an eyepiece having a suction cup for attachment to an eye. The optical system includes a beam forming arrangement to correct an asymmetric beam cross-section, a first relay telescope, a beam dimensional control system and a second relay telescope. The beam dimension control system has a stop with a shaped window or a shaped stop portion and movable axially along a converging or diverging beam portion. An alternative beam dimension control system has a stop with a shaped window and positioned between coupled zoom systems. Mirrors, adjustable slits and refractive systems may also be used. The laser is preferably an ArF Excimer laser. The apparatus may include a measurement device to measure the surface profile, and a feedback control system to control the laser operation in accordance with the measured and desired profiles.
摘要翻译：用于侵蚀表面的激光装置包括用于选择和控制由激光能量的每个脉冲照射的区域的形状和尺寸的装置，而不改变光束的能量密度。通过改变脉冲之间的照射区域的尺寸，表面的某些区域可能比其他区域更多地腐蚀，因此表面可能被重新构造。所述方法和装置特别适用于去除角膜溃疡并重新植入角膜以消除屈光不正以及重新生成光学元件。在一个实施例中，来自激光器的光束进入容纳在铰接臂中的光学系统，并终止于具有用于附接到眼睛的吸盘的目镜中。光学系统包括用于校正不对称光束横截面的光束形成装置，第一中继望远镜，光束尺寸控制系统和第二中继望远镜。光束尺寸控制系统具有带有成形窗口或成形止挡部分的止动件，并且沿着会聚或发散的光束部分轴向移动。一个替代的光束尺寸控制系统具有一个具有成形窗口并且位于耦合变焦系统之间的停止。还可以使用镜子，可调缝和折射系统。激光器优选为ArF准分子激光器。该装置可以包括用于测量表面轮廓的测量装置，以及反馈控制系统，以根据所测量的和期望的轮廓来控制激光器的操作。

102. 发明公开

US20240076879A1 ARTICLE AND METHOD FOR ENCLOSING APERTURE IN HOUSE SIDING TO PREVENT OR DISCOURAGE ENTRY BY SMALL ANIMALS AND INSECTS 审中-公开
公开(公告)号：US20240076879A1
公开(公告)日：2024-03-07
申请号：US18150844
申请日：2023-01-06
申请人： John Marshall
发明人： John Marshall
IPC分类号： E04F13/073 , A01M29/30
CPC分类号： E04F13/0733 , A01M29/30 , E04F2290/00
摘要： This invention relates to an apparatus for obstructing the open end of vertical corner channel pieces of siding often used in residential building applications. Siding terminates at the corners of buildings into a vertical corner channel piece that is typically open on its top and bottom ends. This opening provides opportunity for small animals to enter and damage the building. This invention comprises an enclosing cap with a bottom surface to obstruct the opening of the vertical corner channel piece and two exterior surfaces along with two interior pinching surfaces that secure the apparatus onto the siding piece. This enclosing cap provides an attractive and inexpensive solution to the problem of small animals entering spaces located underneath siding.

103. 发明授权

US08935243B2 Method and system for dynamic web display 有权
标题翻译：动态网页显示的方法和系统
公开(公告)号：US08935243B2
公开(公告)日：2015-01-13
申请号：US12758255
申请日：2010-04-12
申请人： John Marshall
发明人： John Marshall
IPC分类号： G06F17/30 , G06Q30/02 , H04L29/08
CPC分类号： G06Q50/16 , G06F3/0481 , G06F17/2247 , G06F17/30867 , G06F17/3089 , G06Q30/02 , G06Q30/0251 , G06Q30/0255 , G06Q30/0277 , H04L67/02 , H04L67/20 , Y10S707/913 , Y10S707/915
摘要： A system and method for transacting retrieval of inventory data, such as real estate property listing(s), over an information network and dynamically transmitting the listing(s), in near or real time, to one or more subwindows of a web browser window. The listings contain customized rendering instructions that are encoded into an inventory data string and sent to an ad server that renders the listings in the subwindow according to the customized rendering instructions.
摘要翻译：一种系统和方法，用于通过信息网络来处理库存数据的检索，例如房地产属性列表，并且近似或实时地将列表动态地发送到web浏览器窗口的一个或多个子窗口。列表包含编码为库存数据字符串并定制到广告服务器的定制渲染指令，该服务器根据自定义渲染指令在子窗口中呈现列表。

104. 发明申请

US20140157354A1 Securing Access to Resources on a Network 审中-公开
标题翻译：保护对网络资源的访问
公开(公告)号：US20140157354A1
公开(公告)日：2014-06-05
申请号：US13922665
申请日：2013-06-20
申请人： John Marshall , Erich Stuntebeck
发明人： John Marshall , Erich Stuntebeck
IPC分类号： H04L29/06
CPC分类号： H04L63/20 , G06F21/6218
摘要： Secure access to resources on a network may be provided. Upon receiving a request for at least one resource, a determination may be made as to whether the at least one resource comprises a secure resource. In response to determining that the at least one resource comprises a secure resource, the at least one resource may be retrieved; and at least one security policy may be applied to the at least one resource.
摘要翻译：可以提供对网络上的资源的安全访问。在接收到对至少一个资源的请求后，可以确定至少一个资源是否包括安全资源。响应于确定所述至少一个资源包括安全资源，可以检索所述至少一个资源; 并且至少一个安全策略可以被应用于所述至少一个资源。

105. 发明授权

US08673857B2 Long term potentiation with cyclic-GluR6 analogs 有权
标题翻译：长期增强与环状GluR6类似物
公开(公告)号：US08673857B2
公开(公告)日：2014-03-18
申请号：US13389047
申请日：2010-08-27
申请人： John Marshall , Andrew Mallon
发明人： John Marshall , Andrew Mallon
IPC分类号： A61K38/00 , A61K38/10
CPC分类号： A61K38/12 , A61K47/645
摘要： This invention discloses CN2097-like compositions that facilitate the induction of long-term potentiation (LTP). In one embodiment the method comprises inducing long-term potentiation in a subject by the method of administering a therapeutically effective dose of a CN2097-like compound.
摘要翻译：本发明公开了促进长期增强（LTP）诱导的CN2097样组合物。在一个实施方案中，该方法包括通过施用治疗有效剂量的CN2097样化合物的方法在受试者中诱导长期增强作用。

106. 发明授权

US08552056B2 Biologically active taxane analogs and methods of treatment by oral administration 有权
标题翻译：生物活性紫杉烷类似物和口服治疗方法
公开(公告)号：US08552056B2
公开(公告)日：2013-10-08
申请号：US13620852
申请日：2012-09-15
申请人： James D. McChesney , Gilles Tapolsky , David E. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
发明人： James D. McChesney , Gilles Tapolsky , David E. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
IPC分类号： A61K31/335 , A61K31/44 , C07D407/00 , C07D309/00
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound of formula S-(1): for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译：本发明涉及式S-（1）的新型化合物：用于治疗癌症的组合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。

107. 发明申请

US20130137743A1 AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE 审中-公开
标题翻译：作为葡萄糖酸合成酶抑制剂的非晶形态和晶体结构112638 HEMITARTRATE
公开(公告)号：US20130137743A1
公开(公告)日：2013-05-30
申请号：US13511768
申请日：2010-11-24
申请人： Hanlan Liu , Chris Willis , Renu Bhardwaj , Diane P. Copeland , Abizer Harianawala , Jeffrey Skell , John Marshall , Jianmei Kochling , Gerard Palace , Judith Peterschmitt , Craig Siegel , Seng Cheng
发明人： Hanlan Liu , Chris Willis , Renu Bhardwaj , Diane P. Copeland , Abizer Harianawala , Jeffrey Skell , John Marshall , Jianmei Kochling , Gerard Palace , Judith Peterschmitt , Craig Siegel , Seng Cheng
IPC分类号： C07D319/16 , A61K45/06 , A61K31/4025
CPC分类号： A61K31/4025 , A61K45/06 , C07D319/16 , C07D405/06
摘要： The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.
摘要翻译：公开了由以下结构式表示的化合物的盐酸盐：（式I Hemitartrate），其可用于药物应用。式（I）的特殊单晶形式酒石酸盐的特征在于多种性质和物理测量。此外，还讨论了生产结晶式（I）酒石酸盐并使用其抑制葡萄糖神经酰胺合成酶或降低受试者中的糖鞘醇浓度以治疗许多疾病的方法。还描述了药物组合物。

108. 发明授权

US08273789B2 Biologically active taxane analogs and methods of treatment by oral administration 有权
标题翻译：生物活性紫杉烷类似物和口服治疗方法
公开(公告)号：US08273789B2
公开(公告)日：2012-09-25
申请号：US12873477
申请日：2010-09-01
申请人： James D. McChesney , Gilles Tapolsky , David L. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
发明人： James D. McChesney , Gilles Tapolsky , David L. Emerson , John Marshall , Tauseef Ahmed , Allen Cohn , Michael Kurman , Manuel Modiano
IPC分类号： A61K31/35 , A61K31/335 , C07D309/00 , C07D407/00
CPC分类号： C07D493/06 , A61K31/357 , A61K31/495 , A61K39/3955 , A61K45/06
摘要： The present invention relates to a novel chemical compound of formula S-(1): for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agents.
摘要翻译：本发明涉及式S-（1）的新型化合物：用于治疗癌症的组合物，含有所述化合物的组合物，制备方法和与其它治疗剂的组合。

109. 外观设计

USD652298S1 Smile creases for a container 有权
标题翻译：微笑的容器褶皱
公开(公告)号：USD652298S1
公开(公告)日：2012-01-17
申请号：US29364515
申请日：2010-06-24
申请人： Craig Caldwell , John Marshall , William Rasile
设计人： Craig Caldwell , John Marshall , William Rasile

110. 发明申请

US20110288466A1 SYSTEMS AND METHODS FOR ACTIVATING CROSS-LINKING IN AN EYE 审中-公开
标题翻译：用于在眼睛中进行交叉连接的系统和方法
公开(公告)号：US20110288466A1
公开(公告)日：2011-11-24
申请号：US13086019
申请日：2011-04-13
申请人： David Muller , John Marshall , Stephen L. Trokel , Peter Hersh , Pavel Kamaev
发明人： David Muller , John Marshall , Stephen L. Trokel , Peter Hersh , Pavel Kamaev
IPC分类号： A61M37/00
CPC分类号： A61K31/525 , A61F9/008 , A61F2009/00844 , A61F2009/00857 , A61F2009/00872 , A61N5/062
摘要： Devices and approaches for activating cross-linking within at least one eye component of an eye to stabilize and strengthen corneal tissue or other tissues of the eye. Cross-linking is activated within the at least one eye component by conveying a cross-linking agent to regions of the at least one eye component and then activating the cross-linking agent by delivering an initiating element to the at least one eye component. Approaches disclosed herein allow for precisely controlling the three dimensional region of strengthened tissue by conveying the cross-linking agent to regions of the at least one eye component. Approaches allow for conveying the cross-linking agent to a depth below the corneal surface such that cross-linking is activated below the corneal surface.
摘要翻译：激活眼睛的至少一个眼睛部件内的交联的装置和方法，以稳定和加强眼睛的角膜组织或其他组织。通过将交联剂输送到至少一种眼睛部件的区域，然后通过将起始元件递送至至少一种眼睛部件来激活交联剂，在至少一种眼睛部件内激活交联。本文公开的方法允许通过将交联剂输送到至少一种眼睛部件的区域来精确地控制强化组织的三维区域。方法允许将交联剂输送到角膜表面下方的深度，使得交联在角膜表面下被激活。

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