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101. 发明授权

US08273734B1 5HT2C receptor modulators 有权
标题翻译： 5HT2C受体调节剂
公开(公告)号：US08273734B1
公开(公告)日：2012-09-25
申请号：US13523805
申请日：2012-06-14
申请人： Brian Smith , Jeffrey Smith
发明人： Brian Smith , Jeffrey Smith
IPC分类号： A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00
CPC分类号： A61K31/55 , A61K9/20 , C07D223/16 , C07D403/04 , C07D409/04 , C07D491/04
摘要： The present invention relates to novel compounds of Formula (I): which act as 5HT2C receptor modulators. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.
摘要翻译：本发明涉及新的式（I）化合物：其作为5HT 2C受体调节剂。这些化合物可用于药物组合物，其用途包括治疗肥胖症。

102. 发明授权

US08152762B2 Plunger activated vacuum release mechanism for a syringe 有权
标题翻译：柱塞活塞用于注射器的真空释放机构
公开(公告)号：US08152762B2
公开(公告)日：2012-04-10
申请号：US11784796
申请日：2007-04-10
申请人： Jeffrey Smith , Rex O. Bare , Daniel Thayer
发明人： Jeffrey Smith , Rex O. Bare , Daniel Thayer
IPC分类号： A61M5/00
CPC分类号： A61M5/3234 , A61M5/31513 , A61M2005/3121 , A61M2005/3224 , A61M2005/3242
摘要： A retractable safety syringe may comprise a needle, needle holder, syringe body, and a plunger. A proximal portion of the body and a piston of the plunger may define a variable vacuum compartment. A through hole pneumatically connecting ambient air and the variable vacuum compartment may be formed through a thumb platform and rigid shaft of the plunger for allowing air to escape out of the variable vacuum compartment when a piston of the plunger is traversed toward the retracted position and allow air to be introduced into the variable vacuum compartment when the piston is traversed toward the engaged position. A retraction force may be created by the variable vacuum compartment by covering an entrance of the through hole and traversing the piston to the engaged position. At the engaged position, the piston may engage the needle holder and the retraction force may retract the piston, needle holder and needle into the syringe body to prevent accidental needle pricking and needle reuse.
摘要翻译：可伸缩的安全注射器可以包括针，针保持器，注射器主体和柱塞。主体的近端部分和柱塞的活塞可以限定可变的真空室。气动连接环境空气和可变真空隔室的通孔可以通过拇指平台和柱塞的刚性轴形成，用于当柱塞的活塞朝向缩回位置移动时允许空气从可变真空室中逸出，并允许当活塞朝向接合位置移动时，被引入可变真空室的空气。通过覆盖通孔的入口并将活塞穿过接合位置，可以通过可变真空隔室产生回缩力。在接合位置，活塞可以接合针保持器，并且缩回力可以将活塞，针保持器和针缩回到注射器体中，以防止意外的针刺和针重复使用。

103. 发明申请

US20110305508A1 Two Layer Pavement Preservation System 审中-公开
标题翻译：双层路面保护系统
公开(公告)号：US20110305508A1
公开(公告)日：2011-12-15
申请号：US12905010
申请日：2010-10-14
申请人： Gregory Reed , Marc A. Bertsch , Jeffrey Smith
发明人： Gregory Reed , Marc A. Bertsch , Jeffrey Smith
IPC分类号： E01C7/32 , E01C7/22
CPC分类号： E01C7/358 , C08L19/003 , C08L95/00 , C08L2555/22 , C08L2555/34 , C08L2555/52 , C08L2555/84 , C08L2555/86 , E01C7/187 , E01C11/005 , C08L17/00 , C08L25/10
摘要： A pavement preservation system comprises two layers of specialized chip seal applications. The first layer is a Polymer Modified Asphalt Rubber chip seal application. This layer is composed of an application of Polymer Modified Asphalt Rubber binder followed by a hot pre-coated ⅜ or ½ inch aggregate placed at 28 to 34 pounds per square yard and rolled into the binder material. The second layer is a Rubberized Asphalt Binder chip seal application. This layer is composed of an application of Rubberized Asphalt Binder followed by a hot pre-coated ⅛ inch aggregate placed at 10 to 14 pounds per square yard and rolled into the binder material.
摘要翻译：路面保护系统包括两层专门的芯片密封应用。第一层是聚合物改性沥青橡胶芯片密封应用。该层由聚合物改性沥青橡胶粘合剂的应用组成，然后是以28至34磅/平方码放置的热预涂⅜或½英寸聚集体并卷成粘合剂材料。第二层是橡胶沥青粘合剂芯片密封应用。该层由橡胶沥青粘合剂的应用组成，随后是以10至14磅/平方码放置的热预涂⅛英寸聚集体并且卷成粘合剂材料。

104. 发明申请

US20110046601A1 PUNCTURABLE MEMBRANE FOR SAFETY SYRINGE 有权
标题翻译：用于安全注射的可破裂膜
公开(公告)号：US20110046601A1
公开(公告)日：2011-02-24
申请号：US12544865
申请日：2009-08-20
申请人： Jeffrey Smith , Daniel Thayer
发明人： Jeffrey Smith , Daniel Thayer
IPC分类号： A61M5/31
CPC分类号： A61M5/288 , A61M5/3134 , A61M5/31511 , A61M5/347
摘要： A safety syringe may define a variable fluid chamber and detached needle assembly. The variable fluid chamber may be hermetically sealed off from the environment or ambient air until the needle assembly is attached to a syringe body of the safety syringe. A proximal end of the variable fluid chamber is sealed off from the environment via a seal between a piston and syringe body. The distal end of the variable fluid chamber may be sealed off from the environment via a barrier covering the distal end of the syringe body. The barrier may be punctured to allow fluid to through therethrough at or about the same time when the needle assembly is attached to the distal end portion of the syringe body.
摘要翻译：安全注射器可以限定可变流体室和分离的针头组件。可变流体室可以与环境或环境空气密封，直到针组件附接到安全注射器的注射器主体。可变流体室的近端通过活塞和注射器主体之间的密封件与环境密封。可变流体室的远端可以通过覆盖注射器主体的远端的屏障与环境密封。当针组件附接到注射器主体的远端部分时，可以或大约同时间地穿刺屏障以允许流体穿过其中。

105. 发明授权

US07704993B2 Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases 失效
标题翻译：苯扎西平衍生物和预防或治疗5ht2c受体相关疾病的方法
公开(公告)号：US07704993B2
公开(公告)日：2010-04-27
申请号：US10561071
申请日：2004-06-16
申请人： Brian Smith , Charles A. Gilson, III , Jeffrey Schultz , Jeffrey Smith
发明人： Brian Smith , Charles A. Gilson, III , Jeffrey Schultz , Jeffrey Smith
IPC分类号： A61P25/00 , A61K31/55 , C07D223/16
CPC分类号： A61K31/55 , C07D223/16
摘要： The present invention relates to certain 1-substituted-2,3,4,5-tetrahydro-3-benzazepine derivatives of Formula (I), that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the prophylaxis or treatment of 5HT2C receptor associated diseases, conditions or disorders, such as, obesity and related disorders.
摘要翻译：本发明涉及式（I）的某些1-取代-2,3,4,5-四氢-3-苯并吖庚因衍生物，其是5HT 2C受体的调节剂。因此，本发明的化合物可用于预防或治疗5HT 2C受体相关疾病，病症或障碍，如肥胖症和相关疾病。

106. 发明授权

US07572247B2 Syringe 失效
标题翻译：注射器
公开(公告)号：US07572247B2
公开(公告)日：2009-08-11
申请号：US11429301
申请日：2006-05-05
申请人： Jeffrey Smith , Daniel Thayer
发明人： Jeffrey Smith , Daniel Thayer
IPC分类号： A61M5/32
CPC分类号： A61M5/3234 , A61M2005/3151 , A61M2005/3242
摘要： A retractable needle safety syringe is provided having a braking mechanism. The braking mechanism may be disposed at a proximal portion of a syringe body of the syringe. The braking mechanism may comprise split brake members which are traversable between a braking position and a released position. At the braking position, fingers of the split brake member frictionally engage an outer surface of the shaft of a plunger of the syringe. The frictional engagement counterbalances a retraction force that urges a piston of the syringe toward a retracted position. When the split brake members are traversed to the released position, the fingers do not press against the outer surface of the shaft. As such, the retraction force may traverse the piston toward the retracted position and traverse a needle and needle holder into the body of the syringe.
摘要翻译：提供具有制动机构的伸缩针安全注射器。制动机构可以设置在注射器的注射器主体的近端部分。制动机构可以包括可在制动位置和释放位置之间移动的分离制动构件。在制动位置，分离制动部件的指状物摩擦地接合注射器的柱塞的轴的外表面。摩擦接合抵消了将注射器的活塞推向缩回位置的回缩力。当分离的制动器件被移动到释放位置时，手指不会压靠在轴的外表面上。因此，缩回力可以朝向缩回位置移动活塞，并且将针和针保持器穿过注射器的主体。

107. 发明授权

US07481796B2 Low profile retention system 失效
标题翻译：薄型保留系统
公开(公告)号：US07481796B2
公开(公告)日：2009-01-27
申请号：US10718639
申请日：2003-11-24
申请人： Srinivas Nishtala , Linda Elbert , D. H. Perkins , Stephane Gobron , Jeffrey Smith
发明人： Srinivas Nishtala , Linda Elbert , D. H. Perkins , Stephane Gobron , Jeffrey Smith
IPC分类号： A61M5/32
CPC分类号： A61M25/02 , A61B17/04 , A61M2025/028
摘要： Medical devices for retaining an end of a medical tube. Each of the devices of the present invention comprises a base and at least one tab having a portion that is moveable within the base. The base comprises an upper surface, a lower surface, at least one side cavity for receiving a tab, and an opening transverse to the upper and lower surfaces. To facilitate tube retention, the tube is inserted through the opening in the base and the tab(s) is(are) moved within the cavity(ies) such that a portion of each tab contacts and retains the tube.
摘要翻译：用于保持医用管末端的医疗装置。本发明的每个装置包括基座和至少一个突片，其具有可在基座内移动的部分。基座包括上表面，下表面，用于接收突片的至少一个侧腔和横向于上表面和下表面的开口。为了便于管保持，管被插入通过基部中的开口，并且突片在空腔内移动，使得每个突出部的一部分接触并保持管。

108. 发明申请

US20080114307A1 Puncturable membrane for safety syringe 审中-公开
标题翻译：用于安全注射器的可穿刺膜
公开(公告)号：US20080114307A1
公开(公告)日：2008-05-15
申请号：US11982808
申请日：2007-11-05
申请人： Jeffrey Smith , Daniel Thayer
发明人： Jeffrey Smith , Daniel Thayer
IPC分类号： A61M5/00 , A61M5/32 , A61M5/31
CPC分类号： A61M5/288 , A61M5/2455 , A61M5/347 , A61M2005/3117 , A61M2005/3118 , A61M2005/312 , A61M2005/3242 , A61M2039/267
摘要： A safety syringe may define a variable fluid chamber and detached needle assembly. The variable fluid chamber may be hermetically sealed off from the environment or ambient air until the needle assembly is attached to a syringe body of the safety syringe. A proximal end of the variable fluid chamber is sealed off from the environment via a seal between a piston and syringe body. The distal end of the variable fluid chamber may be sealed off from the environment via a barrier covering the distal end of the syringe body. The barrier may be punctured to allow fluid to through therethrough at or about the same time when the needle assembly is attached to the distal end portion of the syringe body.
摘要翻译：安全注射器可以限定可变流体室和分离的针组件。可变流体室可以与环境或环境空气密封，直到针组件附接到安全注射器的注射器主体。可变流体室的近端通过活塞和注射器主体之间的密封件与环境密封。可变流体室的远端可以通过覆盖注射器主体的远端的屏障与环境密封。当针组件附接到注射器主体的远端部分时，可以或大约同时间地穿刺屏障以允许流体穿过其中。

109. 发明申请

US20080105258A1 PORTABLE GAS FRACTIONALIZATION SYSTEM 有权
标题翻译：便携式气体分离系统
公开(公告)号：US20080105258A1
公开(公告)日：2008-05-08
申请号：US11928183
申请日：2007-10-30
申请人： Geoffrey Deane , Brenton Taylor , Rex Bare , Andrew Scherer , Bradley Sargent , Andrew March , Joseph Merchant , Jeffrey Smith
发明人： Geoffrey Deane , Brenton Taylor , Rex Bare , Andrew Scherer , Bradley Sargent , Andrew March , Joseph Merchant , Jeffrey Smith
IPC分类号： A62B7/00 , H01M6/42
CPC分类号： B01D53/053 , A61M16/101 , A61M16/107 , A61M2202/0208 , A61M2202/03 , A61M2205/8206 , A61M2209/084 , B01D53/0415 , B01D2253/108 , B01D2256/12 , B01D2259/40035 , B01D2259/40066 , B01D2259/402 , B01D2259/4533 , B01D2259/4541 , A61M2202/0007
摘要： A portable gas fractionalization apparatus that provides oxygen rich air to patients is provided. The apparatus is compact, lightweight, and low-noise. The components are assembled in a housing that is divided into two compartments. One compartment is maintained at a lower temperature than the other compartment. The lower temperature compartment is configured for mounting components that can be damaged by heat. The higher temperature compartment is configured for mounting heat generating components. An air stream is directed to flow from an ambient air inlet to an air outlet constantly so that there is always a fresh source of cooling air. The apparatus utilizes a PSA unit to produce an oxygen enriched product. The PSA unit incorporates a novel single ended column design in which all flow paths and valves can be co-located on a single integrated manifold. The apparatus also can be used in conjunction with a satellite conserver and a mobility cart.
摘要翻译：提供了向患者提供富氧空气的便携式气体分级装置。该设备结构紧凑，重量轻，噪音低。组件被组装在被分成两个隔间的外壳中。一个隔间保持在比另一个隔室更低的温度。较低的温室配置为安装可能受热损坏的组件。较高温度的隔间被配置用于安装发热部件。空气流被引导以恒定地从环境空气入口流到空气出口，使得总是有新鲜的冷却空气源。该装置利用PSA单元产生富氧产物。 PSA单元结合了一种新颖的单端柱设计，其中所有流动路径和阀可以位于单个集成歧管上。该装置还可以与卫星保护器和移动车一起使用。

110. 发明申请

US20080097306A1 Sterilized syringe 审中-公开
标题翻译：灭菌注射器
公开(公告)号：US20080097306A1
公开(公告)日：2008-04-24
申请号：US11511668
申请日：2006-08-29
申请人： Jeffrey Smith , Daniel Thayer , Rex O. Bare , Steve Kampff
发明人： Jeffrey Smith , Daniel Thayer , Rex O. Bare , Steve Kampff
IPC分类号： A61M5/00 , A61B19/00
CPC分类号： A61M5/1782 , A61M5/002 , A61M2005/3117
摘要： A method of maintaining sterility of fluidic medication in a fluidic medication container despite repeated extractions of the fluidic medication is provided. Also, a method of injecting a patient with fluidic medication without exposing the fluidic medication to ambient air is provided. The method may comprise the steps of providing a syringe with a sterilized variable fluid chamber with sterilized gas wherein the syringe is in a retracted position. A needle of the syringe is inserted into the fluidic medication container and the sterilized gas in the sterilized variable fluid chamber is transferred into the fluidic medication container to pressurize the same. Thereafter, fluidic medication is transferred from the fluidic medication container into the sterilized variable fluid chamber. The needle is removed from the fluidic medication container and inserted into the patient. The patient is injected with the fluidic medication in the sterilized variable fluid chamber.
摘要翻译：提供了一种在流体药物容器中维持流体药物的无菌性的方法，尽管反复提取流体药物。此外，提供了一种向流体药物注射患者而不将流体药物暴露于环境空气的方法。该方法可以包括以下步骤：向注射器提供具有灭菌气体的灭菌的可变流体室，其中注射器处于缩回位置。将注射器的针插入到流体药物容器中，并将灭菌的可变流体室中的无菌气体转移到流体药物容器中以对其加压。此后，将流体药物从流体药物容器转移到灭菌的可变流体室中。将针从流体药物容器中取出并插入患者体内。患者在灭菌的可变流体腔室中注射流体药物。

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