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101. 发明授权

US06522921B2 System and method for eliminating cross-talk due to far-field signals 有权
公开(公告)号：US06522921B2
公开(公告)日：2003-02-18
申请号：US09748722
申请日：2000-12-26
申请人： Jeffrey E. Stahmann , Rene H. Wentkowski , Andrew P. Kramer
发明人： Jeffrey E. Stahmann , Rene H. Wentkowski , Andrew P. Kramer
IPC分类号： A61N1362
CPC分类号： A61N1/368
摘要： A method and system for reducing the effects of far-field signals in a cardiac rhythm management device. Such far-field signals can be produced by contralateral ventricular depolarization and can cause cross-talk between ventricular sensing channels.

102. 发明授权

US06512952B2 Method and apparatus for maintaining synchronized pacing 有权
公开(公告)号：US06512952B2
公开(公告)日：2003-01-28
申请号：US09748794
申请日：2000-12-26
申请人： Jeffrey E. Stahmann , Andrew P. Kramer
发明人： Jeffrey E. Stahmann , Andrew P. Kramer
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/368
摘要： A device and method for cardiac rhythm management in which a cardiac site is paced in accordance with a pacing mode that employs sense signals from a different cardiac site. A protective period triggered by the sensing of intrinsic activity at the paced site is used to delay pacing by a protective delay interval without otherwise disturbing the pacing algorithm.

103. 发明授权

US06480740B2 Safety pacing in multi-site CRM devices 有权
标题翻译：多站点CRM设备中的安全起搏
公开(公告)号：US06480740B2
公开(公告)日：2002-11-12
申请号：US09748721
申请日：2000-12-26
申请人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
发明人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
IPC分类号： A61N1362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： An apparatus and method for providing pacing pulses to a second site when the pacing pulses are inhibited from being provided to a first site. A first cardiac signal and a second cardiac signal are sensed, where both the first and second cardiac signals include indications of cardiac events. A cardiac rate is determined from the cardiac events in one of the first cardiac signal or the second cardiac signal, and pacing pulses are provided to the first cardiac region in order to maintain the cardiac rate at at least a minimum rate value. A pace protection interval starts when a cardiac event is detected in the first cardiac signal. The pace protection interval inhibits delivery of pacing pulses to the first cardiac region. When pacing pulses to the first cardiac region are inhibited because of the pace protection interval, pacing pulses are provided to the second cardiac region at a safety interval timed from the inhibited pacing pulse to the first cardiac region.
摘要翻译：当起搏脉冲被禁止提供给第一部位时，用于向第二部位提供起搏脉冲的装置和方法。感测第一心脏信号和第二心脏信号，其中第一和第二心脏信号都包括心脏事件的指示。心率由第一心脏信号或第二心脏信号中的一个心脏事件确定，并且起搏脉冲被提供给第一心脏区域，以便将心率保持在至少最小速率值。当在第一心脏信号中检测到心脏事件时，起搏保护间隔开始。步速保护间隔禁止将起搏脉冲传送到第一心脏区域。当起搏脉冲到第一心脏区域由于步速保护间隔而被抑制时，起搏脉冲以从被抑制的起搏脉冲到第一心脏区域的安全间隔提供给第二心脏区域。

104. 发明授权

US06411848B1 System providing ventricular pacing and biventricular coordination 有权
公开(公告)号：US06411848B1
公开(公告)日：2002-06-25
申请号：US09837019
申请日：2001-04-18
申请人： Andrew P. Kramer , Jeffrey E. Stahmann , Rene H. Wentkowski , Kenneth L. Baker , Jesse W. Hartley , David B. Krig
发明人： Andrew P. Kramer , Jeffrey E. Stahmann , Rene H. Wentkowski , Kenneth L. Baker , Jesse W. Hartley , David B. Krig
IPC分类号： A61N1365
摘要： A cardiac rhythm management system includes techniques for computing an indicated pacing interval, AV delay, or other timing interval. In one embodiment, a variable indicated pacing interval is computed based at least in part on an underlying intrinsic heart rate. The indicated pacing interval is used to time the delivery of biventricular coordination therapy even when ventricular heart rates are irregular, such as in the presence of atrial fibrillation. In another embodiment, a variable filter indicated AV interval is computed based at least in part on an underlying intrinsic AV interval. The indicated AV interval is used to time the delivery of atrial tracking biventricular coordination therapy when atrial heart rhythms are not arrhythmic. Other indicated timing intervals may be similarly determined. The indicated pacing interval, AV delay, or other timing interval can also be used in combination with a sensor indicated rate indicator.

105. 发明授权

US06363278B1 Cardiac rhythm management system with staggered pulses for coordination therapy 有权
公开(公告)号：US06363278B1
公开(公告)日：2002-03-26
申请号：US09549862
申请日：2000-04-14
申请人： Jeffrey E. Stahmann , Andrew P. Kramer , Julio C. Spinelli
发明人： Jeffrey E. Stahmann , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1368
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3716
摘要： A cardiac rhythm management system for coordination therapy includes a pulse generator to generate pacing and discharging of recharge pulses. A pulse delivery controller coupled to the pulse generator, times the delivery of the pacing and discharging of recharge pulses in a desired sequence. A therapy circuit coupled to the pulse delivery controller, receives the timed pulses from the pulse delivery controller and delivers the timed pulses to one or more electrodes disposed in or around a heart to communicate the timed pacing and discharging of recharge pulses to different sites of a heart, to avoid any interactions resulting from the electric fields surrounding the electrodes during a multiple site pacing required by the coordination therapy.

106. 发明授权

US09814395B2 Method and apparatus for determination of physiological parameters using cervical impedance 有权
公开(公告)号：US09814395B2
公开(公告)日：2017-11-14
申请号：US13568887
申请日：2012-08-07
申请人： Jeffrey E. Stahmann , David J. Ternes , Barun Maskara , Shantha Arcot-Krishnamurthy , Juan Gabriel Hincapie Ordonez , Scott Vanderlinde
发明人： Jeffrey E. Stahmann , David J. Ternes , Barun Maskara , Shantha Arcot-Krishnamurthy , Juan Gabriel Hincapie Ordonez , Scott Vanderlinde
IPC分类号： A61B5/02 , A61B5/00 , A61B5/021 , A61B5/0215 , A61B5/0295 , A61B5/053 , A61B5/107
CPC分类号： A61B5/02007 , A61B5/021 , A61B5/0215 , A61B5/0295 , A61B5/0535 , A61B5/1076 , A61B5/4836 , A61B5/686 , A61B5/6876 , A61B5/6877 , A61B5/7203 , A61B5/7275
摘要： Implanted electrodes can be used to deliver electrical stimulation signals to areas near blood vessels, nerves, or other internal body locations. In an example, an electrode can be implanted in a cervical location and can be used to measure dimensional changes in an artery using impedance plethysmography. Measured artery dimensional changes can be used to determine one or more physiological parameters associated with a patient's health status, such as pulse transit time, relative pulse pressure, or aterial compliance, among others. These parameters can be used to monitor a patient health status or to modulate a patient's therapy, among other uses. In some examples, an electrode configured to deliver an electrostimulation signal to nerve tissue can be used to provide non-neurostimulating electrical stimulation plethysmography signals near a blood vessel.

107. 发明授权

US09375566B2 Device for reporting heart failure status 有权
标题翻译：用于报告心力衰竭状态的装置
公开(公告)号：US09375566B2
公开(公告)日：2016-06-28
申请号：US13185203
申请日：2011-07-18
申请人： Jeffrey E. Stahmann , John Hatlestad , Qingsheng Zhu
发明人： Jeffrey E. Stahmann , John Hatlestad , Qingsheng Zhu
IPC分类号： A61N1/08
CPC分类号： A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/053 , A61B5/0816 , A61B5/0826 , A61B5/091 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/686 , A61B5/746 , A61B7/02 , A61N1/08
摘要： An embodiment of a device for reporting a heart failure status of a patient comprises: a parameter acquisition module configured to acquire at least one trended heart failure parameter; a predetermined event acquisition module configured to acquire at least one predetermined event corresponding to the at least one trended heart failure parameter, wherein each of the at least one predetermined event represents an event condition where a predetermined event definition is satisfied; an alert acquisition module configured to acquire at least one heart failure status alert associated with the at least one predetermined event, wherein each of the at least one alert represents an alert condition where a predetermined alert definition is satisfied; and an output communication module configured to communicate the at least one heart failure status alert.
摘要翻译：用于报告患者的心力衰竭状态的装置的实施例包括：参数获取模块，被配置为获取至少一个趋势性心力衰竭参数; 预定事件获取模块，被配置为获取与所述至少一个趋势性心力衰竭参数相对应的至少一个预定事件，其中所述至少一个预定事件中的每一个表示满足预定事件定义的事件条件; 警报采集模块，被配置为获取与所述至少一个预定事件相关联的至少一个心力衰竭状态警报，其中所述至少一个警报中的每一个表示满足预定警报定义的警报状况; 以及输出通信模块，被配置为通信所述至少一个心力衰竭状态警报。

108. 发明授权

US09089275B2 Sensitivity and specificity of pulmonary edema detection when using transthoracic impedance 有权
标题翻译：使用经胸阻塞时肺水肿检测的灵敏度和特异性
公开(公告)号：US09089275B2
公开(公告)日：2015-07-28
申请号：US11126723
申请日：2005-05-11
申请人： Jeffrey E. Stahmann , John Hatlestad , Jesse W. Hartley
发明人： Jeffrey E. Stahmann , John Hatlestad , Jesse W. Hartley
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0537 , A61B5/4869 , A61M2230/40 , A61M2230/65 , A61N1/36521 , A61N1/37282
摘要： This patent document discusses, among other things, systems, devices, and methods for enhancing detection of pulmonary edema using, in addition to thoracic impedance, one or a combination of: physiologic information about a subject, at least one statistical parameter, a user-programmable detection level, at least one parameter associated with a previous pulmonary edema event, and patient symptom information about the subject. In one example, a (base) thoracic impedance threshold is modified to an adjusted thoracic impedance threshold. The adjusted thoracic impedance threshold provides an increased sensitivity of pulmonary edema detection as compared to the base thoracic impedance threshold. In another example, an alert is provided to a subject, a caregiver, or other user based on a pulmonary edema indication determined by the present systems, devices, and methods. In a further example, a therapy (provided to the subject) is adjusted or initiated in response to the pulmonary edema indication.
摘要翻译：该专利文献尤其涉及用于增强肺水肿检测的系统，装置和方法，除胸部阻抗之外，还包括以下之一或组合：关于受试者的生理信息，至少一个统计参数，可编程检测水平，与先前的肺水肿事件相关联的至少一个参数，以及关于受试者的患者症状信息。在一个示例中，（基底）胸部阻抗阈值被修改为经调整的胸部阻抗阈值。与基础胸廓阻抗阈值相比，经调整的胸廓阻抗阈值提供了肺水肿检测的灵敏度增加。在另一示例中，基于由本系统，设备和方法确定的肺水肿指示，向受检者，照顾者或其他用户提供警报。在另一个实例中，响应于肺水肿指示调整或启动治疗（提供给受试者）。

109. 发明授权

US08795189B2 System and method for determining pulmonary performance from transthoracic impedance measures 有权
标题翻译：用于确定经胸阻抗措施的肺功能的系统和方法
公开(公告)号：US08795189B2
公开(公告)日：2014-08-05
申请号：US12029422
申请日：2008-02-11
申请人： Quan Ni , Jesse W. Hartley , Kent Lee , Jeffrey E. Stahmann
发明人： Quan Ni , Jesse W. Hartley , Kent Lee , Jeffrey E. Stahmann
IPC分类号： A61B5/08
CPC分类号： A61B5/0809 , A61B5/0002 , A61B5/0535 , A61N1/36521 , G06F19/3418
摘要： A system and method for determining pulmonary performance from transthoracic impedance measures is provided. Transthoracic impedance measures collected by an implantable medical device are correlated to pulmonary functional measures. The pulmonary functional measures are grouped by respiratory pattern. Pulmonary performance is evaluated. Differences are determined by comparing the pulmonary functional measures for each respiratory pattern to the pulmonary functional measures for at least one previous respiratory pattern. A trend is identified from the differences. An alert is generated upon sufficient deviation of the trend from a threshold criteria.
摘要翻译：提供了一种通过经胸阻抗测量来确定肺功能的系统和方法。由可植入医疗器械收集的经胸阻抗测量与肺功能测量相关。肺功能测量按呼吸模式分组。评估肺功能。通过将每个呼吸模式的肺功能测量与至少一个之前的呼吸模式的肺功能测量进行比较来确定差异。从差异中确定出一个趋势。在趋势与阈值标准的充分偏差之后产生警报。

110. 发明授权

US08712520B2 Cardiac function management integrating cardiac contractility modulation 有权
公开(公告)号：US08712520B2
公开(公告)日：2014-04-29
申请号：US12561128
申请日：2009-09-16
申请人： Jeffrey E. Stahmann
发明人： Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36185 , A61N1/3686 , A61N1/37 , A61N1/3706 , A61N1/3708 , A61N1/3712 , A61N1/3962
摘要： An implantable cardiac rhythm/function management system integrates cardiac contractility modulation (CCM) and one or more other therapies, such as to preserve device safety, improve efficacy, enhance sensing and detection, or enhance therapy effectiveness and delivery. Examples of the one or more other therapies can include pacing, defibrillation/cardioversion, cardiac resynchronization therapy (CRT), or neurostimulation.

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