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101. 发明申请

US20090041670A1 Near Infrared Fluorescent Contrast Agent And Method For Fluorescence Imaging 审中-公开
标题翻译：近红外荧光对比剂和荧光成像方法
公开(公告)号：US20090041670A1
公开(公告)日：2009-02-12
申请号：US12147717
申请日：2008-06-27
申请人： Masayuki Kawakami , Hiroshi Kitaguchi , Kai Licha , Christin Perlitz , Hiroaki Eguchi , Natsuko Tsuda , Kazuhiro Aikawa
发明人： Masayuki Kawakami , Hiroshi Kitaguchi , Kai Licha , Christin Perlitz , Hiroaki Eguchi , Natsuko Tsuda , Kazuhiro Aikawa
IPC分类号： A61K49/00
CPC分类号： A61K49/0032 , A61K49/0052
摘要： A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R7, and R8 represent a C1-C10 alkyl group or the like; R3, R4, R5, R6, R9, R10, R11, and R12 represent a hydrogen atom, a C1-C6 alkyl group, an aryl group or the like; X1 and X2 represent a C1-C15 alkyl group or an aryl group and X1 and X2 in total have 0 to 4 carboxyl groups; m1, m2, and m3 represents 0 or 1; L1 to L7 independently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.
摘要翻译： 1.一种近红外荧光造影剂，其特征在于，在生物体组织中的透过性优异，能够对肿瘤和/或血管进行特异性成像，其特征在于，含有式（I）表示的化合物或其药学上可接受的盐，其中R1，R2，R7，并且R 8表示C 1 -C 10烷基等; R3，R4，R5，R6，R9，R10，R11和R12表示氢原子，C1-C6烷基，芳基等; X1和X2表示C1-C15烷基或芳基，X1和X2总共具有0至4个羧基; m1，m2，m3表示0或1; L1至L7独立地表示次甲基; M表示氢原子，金属或季铵盐; n表示中和电荷所需的1〜7的整数。

102. 发明申请

US20080152074A1 Radiological imaging apparatus and radiological imaging method and radiological imaging support method 失效
标题翻译：放射成像设备和放射成像方法及放射成像支持方法
公开(公告)号：US20080152074A1
公开(公告)日：2008-06-26
申请号：US11980792
申请日：2007-10-31
申请人： Kensuke Amemiya , Yuuichirou Ueno , Hiroshi Kitaguchi , Kikuo Umegaki , Shinichi Kojima , Norihito Yanagida , Kazuma Yokoi , Takashi Okazaki
发明人： Kensuke Amemiya , Yuuichirou Ueno , Hiroshi Kitaguchi , Kikuo Umegaki , Shinichi Kojima , Norihito Yanagida , Kazuma Yokoi , Takashi Okazaki
IPC分类号： G01N23/083
CPC分类号： G01T1/1648 , A61B6/00 , A61B6/037 , A61B6/5235 , G01N23/22 , G01T1/1615
摘要： A radiological imaging apparatus of the present invention includes an X-ray source for emitting an X-ray, a γ-ray detecting section for outputting a detection signal of a γ-ray, and an X-ray detecting section for outputting a detecting signal of an X-ray. The X-ray source moves around a bed for placing an examinee. The γ-ray detecting section has a plurality of radiation detectors aligned in the longitudinal direction of the bed and placed around the bed. The X-ray detecting section is positioned in a region formed between one end and the other end of the γ-ray detecting section in the longitudinal direction of the bed. The X-ray source is also positioned in the region. Since the X-ray detecting section is placed in the region, it is possible to accurately combine a PET image and an X-ray computed tomographic image.
摘要翻译：本发明的放射成像装置包括用于发射X射线的X射线源，用于输出伽马射线检测信号的伽马射线检测部分和用于输出检测信号的X射线检测部分的X射线。 X射线源围绕一张床放置一名考生。伽马射线检测部分具有沿床的纵向对齐并放置在床周围的多个辐射检测器。 X射线检测部位于沿着床的长度方向的伽马射线检测部的一端与另一端之间形成的区域。 X射线源也位于该区域。由于X射线检测部分位于该区域中，因此可以精确地组合PET图像和X射线计算机断层图像。

103. 发明授权

US07381073B2 Radiological imaging apparatus 失效
公开(公告)号：US07381073B2
公开(公告)日：2008-06-03
申请号：US11626703
申请日：2007-01-24
申请人： Kazuma Yokoi , Hiroshi Kitaguchi , Takafumi Ishitsu , Naoyuki Yamada , Kensuke Amemiya , Yuuichirou Ueno , Katsutoshi Tsuchiya , Norihito Yanagita
发明人： Kazuma Yokoi , Hiroshi Kitaguchi , Takafumi Ishitsu , Naoyuki Yamada , Kensuke Amemiya , Yuuichirou Ueno , Katsutoshi Tsuchiya , Norihito Yanagita
IPC分类号： H01R11/22 , G01T1/24
CPC分类号： G01T1/249 , G01T1/243 , H01L27/14658 , H01R12/88
摘要： A radiological imaging apparatus allowing semiconductor radiation detectors to be easily replaced with new ones and densely arranged. Terminals (31cjk) and (33cjk) are provided on a bottom surface of a detector aggregate (40mn) including a plurality of semiconductor radiation detectors (1); the terminals is connected to electrodes (3 and 4) of the detectors (1). A plurality of zero insertion force connectors (56) are provided on a connecting device (33jk) installed on a support substrate (32h). The terminals (31cjk and 33cjk) are detachably attached to the zero insertion force connectors (56) to mount the detector aggregates (40mn) that are the semiconductor radiation detectors (1), on the support substrate (32h). When the detector aggregates (40mn) are attached to the zero insertion force connectors (56), since no frictional force acts on the terminals, the size of the gap between the detector aggregates (40mn) is reduced.

104. 发明授权

US07371877B2 Glycerol ester derivative 失效
标题翻译：甘油酯衍生物
公开(公告)号：US07371877B2
公开(公告)日：2008-05-13
申请号：US10507486
申请日：2003-03-27
申请人： Kazunobu Takahashi , Hiroshi Kitaguchi , Kazuhiro Aikawa
发明人： Kazunobu Takahashi , Hiroshi Kitaguchi , Kazuhiro Aikawa
IPC分类号： C07F9/02 , A61K51/04
CPC分类号： C07D295/15 , A61K49/0466 , A61K51/1234 , C07C69/712 , C07C233/05 , C07C275/14 , C07F9/10 , C07F9/117
摘要： A compound represented by the following general formula (IA) or a salt thereof: wherein Ar1 represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar2 represents an aryl group having at least one iodine atom as a substituent; L1 and L2 independently represent a divalent bridging group of which main chain contains 6 or more carbon atoms; L3 represents a single bond or a divalent bridging group of which main chain contains 1 to 6 carbon atoms and one oxygen atom; X represents a functional group containing at least one heteroatom, provided that, when L3 is a single bond, X represents a functional group other than hydroxyl group. The compound can be used as a membrane component of liposomes, and the liposomes can be used as a contrast medium for X-ray radiography.
摘要翻译：由以下通式（IA）表示的化合物或其盐：其中Ar 1表示氢原子或具有至少一个碘原子作为取代基的芳基; Ar 2表示具有至少一个碘原子作为取代基的芳基; L 1和L 2独立地表示主链含有6个或更多个碳原子的二价桥连基团; L 3表示主链含有1〜6个碳原子和1个氧原子的单键或二价桥连基团; X表示含有至少一个杂原子的官能团，条件是当L 3为单键时，X表示除羟基以外的官能团。该化合物可以用作脂质体的膜组分，并且脂质体可以用作X射线照相术的造影剂。

105. 发明申请

US20080045574A1 Anti-Trypanosomiasis Agent 有权
标题翻译：抗锥虫病药
公开(公告)号：US20080045574A1
公开(公告)日：2008-02-21
申请号：US11576426
申请日：2005-09-29
申请人： Masataka Ihara , Kiyosei Takasu , Khanitha Pudhom , Hiroshi Kitaguchi , Masayuki Kawakami , Kozo Sato
发明人： Masataka Ihara , Kiyosei Takasu , Khanitha Pudhom , Hiroshi Kitaguchi , Masayuki Kawakami , Kozo Sato
IPC分类号： A61K31/426 , A61P33/00
CPC分类号： C07D417/14 , A61K31/428 , A61K31/4439 , A61K31/4709 , Y02A50/414
摘要： The present invention is to provide an anti-trypanosomiasis agent having a high selective toxicity, and high preventing or treating effect against trypanosomiasis, comprising a compound shown by the following general formula (1) as an active ingredient (wherein R1 and R2 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-5 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, C2-6 alkoxycarbonyl group or C2-6 alkylaminocarbonyl group, and may be bound to each other; R3, R4, and R5 each independently represents a C1-5 alkyl group or C5-8 aryl group; R6 and R7 each independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, C1-8 alkyl group, C1-5 alkoxy group, C5-8 aryl group, C5-8 aryloxy group, or C2-6 alkoxycarbonyl group, and may be bound to each other; Y and Z each independently represents an atom group necessary to form a 5- or 6-membered heterocycle; m and n each represent 0 or 1; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0).
摘要翻译：本发明提供具有高选择性毒性和对锥虫病的高预防或治疗作用的抗锥虫病药，其包含由以下通式（1）表示的化合物作为活性成分（其中R 1， / O 2和R 2各自独立地表示氢原子，卤素原子，羟基，氧原子，C 1-5烷基，C 1-5 C 5〜8芳基，C 5〜8芳氧基，C 2-6烷氧基羰基或C 2-6个亚烷基氨基羰基，并且可以彼此结合; R 3，R 4和R 5 >各自独立地表示C 1-5烷基或C 5-8芳基; R 6和R 7， SUP各自独立地表示氢原子，卤素原子，羟基，氧原子，C 1-8烷基，C 1-5烷氧基，C 1〜 5-8芳基，C 5-8芳氧基，或C 1〜并且可以相互结合; Y和Z各自独立地表示形成5-或6-元杂环所必需的原子团; m和n各自表示0或1; Q表示生理上可接受的阴离子; k表示0〜2的整数，使整个分子的电荷为0）。

106. 发明申请

US20070278414A1 Semiconductor radiological detector and semiconductor radiological imaging apparatus 有权
公开(公告)号：US20070278414A1
公开(公告)日：2007-12-06
申请号：US11705595
申请日：2007-02-13
申请人： Kazuma Yokoi , Hiroshi Kitaguchi , Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Katsutoshi Tsuchiya , Norihito Yanagita , Shinichi Kojima
发明人： Kazuma Yokoi , Hiroshi Kitaguchi , Takafumi Ishitsu , Kensuke Amemiya , Yuuichirou Ueno , Katsutoshi Tsuchiya , Norihito Yanagita , Shinichi Kojima
IPC分类号： G01T1/24
CPC分类号： G01T1/2018 , G01T1/2928
摘要： The semiconductor radiological detector 1 minimizes a dead space resulting from the draw-out of a signal line from an electrode and which allows a number of semiconductor devices to be densely arranged to improve sensitivity and spatial resolution. The semiconductor radiological detector 1 comprises a semiconductor device 2, an anode 3 attached to one surface of the semiconductor device 2, and a cathode 4 attached to the other surface of the semiconductor device 2. A signal line 5 is provided on the anode 3; the signal line 5 extends straight from the anode 3 and is connected to an X axis wire 12. Another signal line 13 is provided on the cathode 4; the signal line 13 extends straight from the cathode 4 and is connected to a Y axis wire 14.

107. 发明申请

US20070009082A1 X-ray sensor signal processor and X-ray computed tomography system using the same 有权
标题翻译： X射线传感器信号处理器和X射线计算机断层摄影系统使用相同
公开(公告)号：US20070009082A1
公开(公告)日：2007-01-11
申请号：US11519876
申请日：2006-09-13
申请人： Hiroshi Kamimura , Shigeru Izumi , Hiroshi Kitaguchi , Atsushi Yamagoshi , Katsutoshi Satoh , Noriyuki Sadaoka , Tarou Takagi , Kouji Kuwabara , Shouhei Numata
发明人： Hiroshi Kamimura , Shigeru Izumi , Hiroshi Kitaguchi , Atsushi Yamagoshi , Katsutoshi Satoh , Noriyuki Sadaoka , Tarou Takagi , Kouji Kuwabara , Shouhei Numata
IPC分类号： H05G1/60 , A61B6/00 , G01N23/00 , G21K1/12
CPC分类号： H04N5/32 , G01N23/046 , G01N2223/419 , G06F19/00 , G06Q50/22 , G06Q50/24 , H04N5/361 , Y10S378/901
摘要： An X-ray sensor signal processing circuit and method used in an industrial X-ray CT apparatus for processing an output signal of a semiconductor X-ray sensor which detects a pulsed X-ray emitted from an accelerator and passed through an object to be inspected. The circuit includes a first resistor having one terminal connected to the X-ray sensor and an other terminal connected to ground, a first condenser having one end terminal connected to a connection point of the X-ray sensor and the first resistor, an operational amplifier having an inverting input connected to an other terminal of the first condenser, and an integrator having a second resistor and a second condenser each connected to the operational amplifier in parallel. The circuit is configured so that at least bias conditions of the X-ray sensor and the first condenser are returned to a steady state after irradiation of the pulsed X-ray.
摘要翻译：一种用于处理半导体X射线传感器的输出信号的工业X射线CT装置的X射线传感器信号处理电路和方法，该半导体X射线传感器检测从加速器发出的脉冲X射线并通过待检查物体。该电路包括：第一电阻器，其一端连接到X射线传感器，另一端连接到地;第一电容器，其一端连接到X射线传感器和第一电阻的连接点，运算放大器具有连接到第一电容器的另一个端子的反相输入端和具有并联连接到运算放大器的第二电阻器和第二电容器的积分器。电路被配置为使得至少在X射线照射之后X射线传感器和第一冷凝器的偏置状态恢复到稳定状态。

108. 发明授权

US07151262B1 Radioactive gas measurement apparatus and failed fuel detection system 有权
标题翻译：放射性气体测量装置和故障燃料检测系统
公开(公告)号：US07151262B1
公开(公告)日：2006-12-19
申请号：US10872449
申请日：2004-06-22
申请人： Hiroshi Kitaguchi , Atsushi Yamagoshi , Shigeru Izumi , Tetsuya Matsui , Akihisa Kaihara
发明人： Hiroshi Kitaguchi , Atsushi Yamagoshi , Shigeru Izumi , Tetsuya Matsui , Akihisa Kaihara
IPC分类号： G01T1/20 , G01T1/24
CPC分类号： G01T1/205
摘要： To provide a radioactive gas measurement apparatus that is simply constructed and can efficiently measure Xe-133 in a radioactive gas on-line under the condition that the radioactive gas is mixed with interference N-13, an apparatus is provided for measuring a radiation emitted from Xe-133, including an anticoincidence counter circuit 13 that conducts counting if it receives an output of a main detector 1 when it does not receive outputs of scintillation detectors 2 and 9, and a gate circuit 14, a plate-shaped semiconductor detector is used as the main detector 1, and a material not emitting a characteristic X ray in the range from 70 to 90 keV is used for a shielding structure. In particular, the thickness of the semiconductor detector 1 is set to fall within a range from 2 mm to 7 mm, thereby improving the analysis precision.
摘要翻译：为了提供简单构造的放射性气体测量装置，并且可以在放射性气体与干扰N-13混合的条件下在线放射性气体中有效地测量Xe-133，提供了一种用于测量从 Xe-133，包括防错计数器电路13，如果在没有接收到闪烁检测器2和9的输出的情况下接收到主检测器1的输出，则接收计数;以及门电路14，使用板状半导体检测器作为主检测器1，并且将不发射70至90keV范围内的特征X射线的材料用于屏蔽结构。特别地，将半导体检测器1的厚度设定为2mm〜7mm的范围，提高分析精度。

109. 发明申请

US20060278828A1 RADIOACTIVE GAS MEASUREMENT APPARATUS AND FAILED FUEL DETECTION SYSTEM 有权
标题翻译：放射性气体测量装置和失效燃料检测系统
公开(公告)号：US20060278828A1
公开(公告)日：2006-12-14
申请号：US10872449
申请日：2004-06-22
申请人： Hiroshi Kitaguchi , Atsushi Yamagoshi , Shigeru Izumi , Tetsuya Matsui , Akihisa Kaihara
发明人： Hiroshi Kitaguchi , Atsushi Yamagoshi , Shigeru Izumi , Tetsuya Matsui , Akihisa Kaihara
IPC分类号： H01L27/14
CPC分类号： G01T1/205
摘要： To provide a radioactive gas measurement apparatus that is simply constructed and can efficiently measure Xe-133 in a radioactive gas on-line under the condition that the radioactive gas is mixed with interference N-13, an apparatus is provided for measuring a radiation emitted from Xe-133, including an anticoincidence counter circuit 13 that conducts counting if it receives an output of a main detector 1 when it does not receive outputs of scintillation detectors 2 and 9, and a gate circuit 14, a plate-shaped semiconductor detector is used as the main detector 1, and a material not emitting a characteristic X ray in the range from 70 to 90 keV is used for a shielding structure. In particular, the thickness of the semiconductor detector 1 is set to fall within a range from 2 mm to 7 mm, thereby improving the analysis precision.
摘要翻译：为了提供简单构造的放射性气体测量装置，并且可以在放射性气体与干扰N-13混合的条件下在线放射性气体中有效地测量Xe-133，提供了一种用于测量从 Xe-133，包括防错计数器电路13，如果在没有接收到闪烁检测器2和9的输出的情况下接收到主检测器1的输出，则接收计数;以及门电路14，使用板状半导体检测器作为主检测器1，并且将不发射70至90keV范围内的特征X射线的材料用于屏蔽结构。特别地，将半导体检测器1的厚度设定为2mm〜7mm的范围，提高分析精度。

110. 发明申请

US20060243915A1 Semiconductor radiation detector, positron emission tomography apparatus, semiconductor radiation detection apparatus, detector unit and nuclear medicine diagnostic apparatus 审中-公开
标题翻译：半导体辐射检测器，正电子发射断层摄影装置，半导体辐射检测装置，检测器单元和核医学诊断装置
公开(公告)号：US20060243915A1
公开(公告)日：2006-11-02
申请号：US11435134
申请日：2006-05-17
申请人： Kensuke Amemiya , Yuuichirou Ueno , Hiroshi Kitaguchi , Osamu Yokomizo , Shinichi Kojima , Katsutoshi Tsuchiya , Norihito Yanagita , Kazuma Yokoi
发明人： Kensuke Amemiya , Yuuichirou Ueno , Hiroshi Kitaguchi , Osamu Yokomizo , Shinichi Kojima , Katsutoshi Tsuchiya , Norihito Yanagita , Kazuma Yokoi
IPC分类号： G01T1/166
CPC分类号： G01T1/2928 , G01T1/2985
摘要： Each semiconductor radiation detector used for a nuclear medicine diagnostic apparatus (PET apparatus) is constructed with an anode electrode A facing a cathode electrode C sandwiching a CdTe semiconductor member S which generates charge through interaction with γ-rays. Then, a thickness t of the semiconductor member S sandwiched between these mutually facing anode electrode A and cathode electrode C is set to 0.2 to 2 mm. Furthermore, the devices are mounted (laid out) on substrates in such a way that the distance (distance of conductor) between the semiconductor radiation detector and an analog ASIC which processes the signal detected by this detector is shortened. Furthermore, the substrates on which the detectors are mounted are housed in a housing as a unit (detector unit).
摘要翻译：用于核医学诊断装置（PET装置）的每个半导体辐射检测器被构造成具有面向通过与γ射线相互作用产生电荷的CdTe半导体部件S的阴极电极C的阳极电极A. 然后，将夹在这些相互相对的阳极电极A和阴极电极C之间的半导体部件S的厚度t设定为0.2〜2mm。此外，这些装置以这样的方式安装（布置）在基板上，使得半导体辐射检测器和处理由该检测器检测到的信号的模拟ASIC之间的距离（导体的距离）缩短。此外，安装有检测器的基板作为一个单元容纳在壳体中（检测器单元）。

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