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101. 发明授权

US5883257A N-piperidinyl- and N-tetrahydropyridinyl-2-anthracenecarboxamides: dopamine receptor subtype specific ligands 失效
标题翻译： N-哌啶基和N-四氢吡啶基-2-蒽甲酰胺：多巴胺受体亚型特异性配体
公开(公告)号：US5883257A
公开(公告)日：1999-03-16
申请号：US994588
申请日：1997-12-19
申请人： Jun Yuan , Xi Chen
发明人： Jun Yuan , Xi Chen
IPC分类号： C07D295/12 , A61K31/44 , A61K31/445 , A61K31/451 , A61K31/495 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/28 , A61P25/30 , C07D211/14 , C07D211/28 , C07D211/70 , C07D217/02 , C07D295/13 , C07D401/12
CPC分类号： C07D295/13 , C07D211/14 , C07D211/70 , C07C2103/24
摘要： Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C.sub.1 -C.sub.6 alkoxy, --O.sub.2 CR', --NHCOR', --COR', --SO.sub.m R', where R' is C.sub.1 -C.sub.6 alkyl and wherein m is 0, 1 or 2; orR.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.10 is hydrogen or C.sub.1 -C.sub.6 alkyl; andR represents an aminoalkyl group;which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.
摘要翻译：公开了下式的化合物或其药学上可接受的酸加成盐，其中：R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9相同或不同，表示氢，C 1 -C 6 烷基，卤素，羟基，氨基，氰基，硝基，三氟甲基，三氟甲氧基，C 1 -C 6烷氧基，-O 2 CR'，-NHCOR'，-COR'，-SO m R'，其中R'是C 1 -C 6烷基，，1或2; 或R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9独立地表示-CONR'R“或-NR'R”，其中R'和R“独立地表示氢或C1-C6烷基; R 10是氢或C 1 -C 6烷基; R表示氨基烷基; 哪些化合物可用于治疗情感障碍如精神分裂症，抑郁症，阿尔茨海默氏病，运动障碍如帕金森综合征和肌张力障碍，以及其他对多巴胺能阻滞作用的药物滥用和强迫症。此外，本发明的化合物可用于治疗与使用常规精神抑制剂相关的锥体束外副作用。

102. 发明授权

US5804685A Deazapurine derivatives: a new class of CRF1 specific ligands 失效
标题翻译：去氮嘌呤衍生物：一类新的CRF1特异性配体
公开(公告)号：US5804685A
公开(公告)日：1998-09-08
申请号：US476689
申请日：1995-06-07
申请人： Jun Yuan , Alan Hutchison
发明人： Jun Yuan , Alan Hutchison
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Disclosed are compounds of the formula ##STR1## wherein Ar represents an aryl or heteroaryl group; and R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 represent organic or inorganic substituents, which compounds are highly selective partial agonists or antagonists at human CRF1 receptors and, thus, are useful in the diagnosis and treatment of treating stress related disorders such as post trumatic stress disorder (PTSD) as well as depression, headache and anxiety.
摘要翻译：公开了下式的化合物：其中Ar表示芳基或杂芳基; 并且R1，R2，R3，R4和R5代表有机或无机取代基，这些化合物是人CRF1受体的高选择性部分激动剂或拮抗剂，因此可用于诊断和治疗应激相关疾病例如post trumatic 压力障碍（PTSD）以及抑郁，头痛和焦虑。

103. 发明授权

US5703235A N-Aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands 失效
标题翻译： N-氨基烷基-2-蒽基甲酰胺; 新的多巴胺受体亚型特异性配体
公开(公告)号：US5703235A
公开(公告)日：1997-12-30
申请号：US619351
申请日：1996-03-21
申请人： Jun Yuan , Xi Chen
发明人： Jun Yuan , Xi Chen
IPC分类号： C07D295/12 , A61K31/44 , A61K31/445 , A61K31/451 , A61K31/495 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/28 , A61P25/30 , C07D211/14 , C07D211/28 , C07D211/70 , C07D217/02 , C07D295/13 , C07D401/10 , C07D295/15
CPC分类号： C07D295/13 , C07D211/14 , C07D211/70 , C07C2103/24
摘要： Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are the same or different and represent hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C.sub.1 -C.sub.6 alkoxy, --O.sub.2 CR', --NHCOR', --COR', --SO.sub.m R', where R' is C.sub.1 -C.sub.6 alkyl and wherein m is 0, 1 or 2; or R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.9 independently represent --CONR'R", or --NR'R" where R' and R" independently represent hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.10 is hydrogen or C.sub.1 -C.sub.6 alkyl; and R represents an aminoalkyl group; which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.
摘要翻译：公开了下式的化合物或其药学上可接受的酸加成盐，其中：R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9相同或不同，表示氢，C 1 -C 6 烷基，卤素，羟基，氨基，氰基，硝基，三氟甲基，三氟甲氧基，C 1 -C 6烷氧基，-O 2 CR'，-NHCOR'，-COR'，-SO m R'，其中R'是C 1 -C 6烷基，，1或2; 或R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9独立地表示-CONR'R“或-NR'R”，其中R'和R“独立地表示氢或C1-C6烷基; R 10是氢或C 1 -C 6烷基; R表示氨基烷基; 哪些化合物可用于治疗情感障碍如精神分裂症，抑郁症，阿尔茨海默氏病，运动障碍如帕金森综合征和肌张力障碍，以及其他对多巴胺能阻滞作用的药物滥用和强迫症。此外，本发明的化合物可用于治疗与使用常规精神抑制剂相关的锥体束外副作用。

104. 发明授权

US5677454A Certain methylpiperazinyl and methylpiperidinyl substituted biphenyl derivatives; novel dopamine receptor subtype selective ligands 失效
标题翻译：某些甲基哌嗪基和甲基哌啶基取代的联苯衍生物; 新型多巴胺受体亚型选择性配体
公开(公告)号：US5677454A
公开(公告)日：1997-10-14
申请号：US457633
申请日：1995-06-01
申请人： Jun Yuan , Andrew Thurkauf
发明人： Jun Yuan , Andrew Thurkauf
IPC分类号： C07C211/27 , C07D211/14 , C07D211/70 , C07D239/42 , C07D295/096 , C07D401/06 , C07D239/24 , C07D401/04 , C07D403/04
CPC分类号： C07D239/42 , C07C211/27 , C07D211/14 , C07D211/70 , C07D295/096 , C07D401/06
摘要： Disclosed are compounds of the formula: ##STR1## where S and V are various organic or inorganic substituents; G and K are the same or different and represent N or CR' where R' is an organic or inorganic substituent; R is hydrogen or an alkyl group; R.sub.1, X, Y, Z and T are organic or inorganic substituents; and R.sub.2 and R.sub.3 represent hydrogen or organic substituents; or NR.sub.2 R.sub.3 together represents a heterocyclic ring system; and the pharmaceutically acceptable salts thereof; which are highly selective partial agonists or antagonists at brain dopamine receptor subtypes and, thus, are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism.
摘要翻译：公开了下式的化合物：其中S和V是各种有机或无机取代基; G和K相同或不同，表示N或CR'，其中R'是有机或无机取代基; R是氢或烷基; R1，X，Y，Z和T是有机或无机取代基; R2和R3代表氢或有机取代基; 或NR2R3一起表示杂环体系; 及其药学上可接受的盐; 其是脑多巴胺受体亚型的高度选择性部分激动剂或拮抗剂，因此可用于诊断和治疗情感障碍如精神分裂症和抑郁症以及某些运动障碍如帕金森综合征。

105. 发明授权

US5243049A Certain pyrroloquinolinones: a new class of GABA brain receptor ligands 失效
标题翻译：某些吡咯喹啉酮：一类新的GABA脑受体配体
公开(公告)号：US5243049A
公开(公告)日：1993-09-07
申请号：US823845
申请日：1992-01-22
申请人： Kenneth Shaw , Jun Yuan
发明人： Kenneth Shaw , Jun Yuan
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： This invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein X and Y are the same or different and represent oxygen or H.sub.2 with the proviso that not both X and Y are H.sub.2 ; W represents phenyl, thienyl, or pyridyl, each of which may be unsubstituted or momo or disubstituted with organic or inorganic substituents; and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are variables representing organic and inorganic substituents.These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.
摘要翻译：本发明包括下式的化合物及其药学上可接受的无毒盐，其中X和Y相同或不同，代表氧或H 2，条件是X和Y都不是H 2; W表示苯基，噻吩基或吡啶基，其各自可以是未取代的或用有机或无机取代基进行单或二取代; 并且R1，R2，R3和R4是表示有机和无机取代基的变量。这些化合物是GABAa脑受体或其前药的高度选择性激动剂，拮抗剂或反向激动剂，并且可用于诊断和治疗焦虑，睡眠和癫痫发作，用苯二氮卓类药物过量和记忆增强。

106. 发明授权

US09247531B2 Methods for control signaling for wireless systems 有权
标题翻译：无线系统控制信令的方法
公开(公告)号：US09247531B2
公开(公告)日：2016-01-26
申请号：US12921672
申请日：2009-03-10
申请人： Mo-Han Fong , Hang Zhang , Sophie Vrzic , Robert Novak , Jun Yuan , Dong-Sheng Yu
发明人： Mo-Han Fong , Hang Zhang , Sophie Vrzic , Robert Novak , Jun Yuan , Dong-Sheng Yu
IPC分类号： H04B7/00 , H04W72/04 , H04W48/10 , H04W48/12 , H04W48/14
CPC分类号： H04W72/0406 , H04L1/1812 , H04L5/0055 , H04L5/0057 , H04W24/10 , H04W48/10 , H04W48/12 , H04W48/14 , H04W72/042 , H04W72/0446 , H04W72/0453 , H04W72/085 , H04W88/06
摘要： To effectively and efficiently provide control information, a broadcast pointer channel (BPCH) may be used to identify the type and perhaps relative location of control information that is being provided in a given frame structure, such as a sub-frame, frame, or superframe. A sub-frame (or like framing entity, such a frame or superframe) may have a BPCH and a corresponding system control information segment in which control information may reside. The system control information segment may have any number of control information blocks, wherein each control information block that is present may correspond to a particular type of control information. The BPCH is used to identify the type of control information that is present in a corresponding system control information segment, and if needed or desired, the relative locations of the various control information.
摘要翻译：为了有效和高效地提供控制信息，可以使用广播指针信道（BPCH）来识别在给定帧结构（例如子帧，帧或超帧）中提供的控制信息的类型和可能的相对位置。子帧（或类似的成帧实体，例如帧或超帧）可以具有BPCH和控制信息可以驻留在其中的对应的系统控制信息段。系统控制信息段可以具有任何数量的控制信息块，其中存在的每个控制信息块可以对应于特定类型的控制信息。 BPCH用于识别存在于对应的系统控制信息段中的控制信息的类型，并且如果需要或期望，则各种控制信息的相对位置。

107. 发明授权

US09142660B2 Method to fabricate a vertical transistor having an asymmetric gate with two conductive layers having different work functions 有权
标题翻译：制造具有不对称栅极的垂直晶体管的方法，具有不同功函数的两个导电层
公开(公告)号：US09142660B2
公开(公告)日：2015-09-22
申请号：US13611113
申请日：2012-09-12
申请人： Dechao Guo , Shu-Jen Han , Keith Kwong Hon Wong , Jun Yuan
发明人： Dechao Guo , Shu-Jen Han , Keith Kwong Hon Wong , Jun Yuan
IPC分类号： H01L21/336 , H01L29/78 , H01L21/8238 , H01L21/8234 , H01L29/49 , H01L29/66
CPC分类号： H01L29/78 , H01L21/823487 , H01L21/823885 , H01L29/4983 , H01L29/66666 , H01L29/7827
摘要： A transistor structure is formed to include a substrate and, overlying the substrate, a source; a drain; and a channel disposed vertically between the source and the drain. The channel is coupled to a gate conductor that surrounds the channel via a layer of gate dielectric material that surrounds the channel. The gate conductor is composed of a first electrically conductive material having a first work function that surrounds a first portion of a length of the channel and a second electrically conductive material having a second work function that surrounds a second portion of the length of the channel. A method to fabricate the transistor structure is also disclosed. The transistor structure can be characterized as being a vertical field effect transistor having an asymmetric gate.
摘要翻译：晶体管结构被形成为包括衬底和覆盖衬底的源极; 排水以及垂直设置在源极和漏极之间的通道。通道耦合到栅极导体，该栅极导体通过围绕该沟道的栅极电介质材料层围绕该沟道。栅极导体由具有围绕通道长度的第一部分的第一功函数的第一导电材料和具有围绕通道长度的第二部分的第二功函数的第二导电材料组成。还公开了制造晶体管结构的方法。晶体管结构可以表征为具有非对称栅极的垂直场效应晶体管。

108. 发明授权

US08916405B2 Light emitting diode (LED) using carbon materials 有权
标题翻译：发光二极管（LED）采用碳材料
公开(公告)号：US08916405B2
公开(公告)日：2014-12-23
申请号：US13270362
申请日：2011-10-11
申请人： Dechao Guo , Shu-Jen Han , Keith Kwong Hon Wong , Jun Yuan
发明人： Dechao Guo , Shu-Jen Han , Keith Kwong Hon Wong , Jun Yuan
IPC分类号： H01L21/00 , H01L33/26 , H01L33/00
CPC分类号： H01L33/0041 , H01L33/26 , H01L33/34 , H01L33/40 , H01L51/0048 , H01L51/5203 , H01L51/5296
摘要： Carbon-based light emitting diodes (LEDs) and techniques for the fabrication thereof are provided. In one aspect, a LED is provided. The LED includes a substrate; an insulator layer on the substrate; a first bottom gate and a second bottom gate embedded in the insulator layer; a gate dielectric on the first bottom gate and the second bottom gate; a carbon material on the gate dielectric over the first bottom gate and the second bottom gate, wherein the carbon material serves as a channel region of the LED; and metal source and drain contacts to the carbon material.
摘要翻译：提供了碳基发光二极管（LED）及其制造技术。一方面，提供一种LED。 LED包括基板; 衬底上的绝缘体层; 嵌入在绝缘体层中的第一底栅极和第二底栅极; 第一底栅极和第二底栅极上的栅极电介质; 在第一底栅极和第二底栅上的栅极电介质上的碳材料，其中碳材料用作LED的沟道区域; 并且金属源极和漏极接触到碳材料。

109. 发明授权

US08866214B2 Vertical transistor having an asymmetric gate 有权
标题翻译：具有非对称栅极的垂直晶体管
公开(公告)号：US08866214B2
公开(公告)日：2014-10-21
申请号：US13271812
申请日：2011-10-12
申请人： Dechao Guo , Shu-Jen Han , Keith Kwong Hon Wong , Jun Yuan
发明人： Dechao Guo , Shu-Jen Han , Keith Kwong Hon Wong , Jun Yuan
IPC分类号： H01L29/78 , H01L29/66 , H01L29/49
CPC分类号： H01L29/78 , H01L21/823487 , H01L21/823885 , H01L29/4983 , H01L29/66666 , H01L29/7827
摘要： A transistor structure is formed to include a substrate and, overlying the substrate, a source; a drain; and a channel disposed vertically between the source and the drain. The channel is coupled to a gate conductor that surrounds the channel via a layer of gate dielectric material that surrounds the channel. The gate conductor is composed of a first electrically conductive material having a first work function that surrounds a first portion of a length of the channel and a second electrically conductive material having a second work function that surrounds a second portion of the length of the channel. A method to fabricate the transistor structure is also disclosed. The transistor structure can be characterized as being a vertical field effect transistor having an asymmetric gate.
摘要翻译：晶体管结构被形成为包括衬底和覆盖衬底的源极; 排水以及垂直设置在源极和漏极之间的通道。通道耦合到栅极导体，该栅极导体通过围绕该沟道的栅极电介质材料层围绕该沟道。栅极导体由具有围绕通道长度的第一部分的第一功函数的第一导电材料和具有围绕通道长度的第二部分的第二功函数的第二导电材料组成。还公开了制造晶体管结构的方法。晶体管结构可以表征为具有非对称栅极的垂直场效应晶体管。

110. 发明授权

US08799316B1 Methods and systems for context based query formulation and information retrieval 有权
标题翻译：基于上下文的查询制作和信息检索的方法和系统
公开(公告)号：US08799316B1
公开(公告)日：2014-08-05
申请号：US13114217
申请日：2011-05-24
申请人： Ali Bahrami , Jun Yuan
发明人： Ali Bahrami , Jun Yuan
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30967
摘要： A method for context-based query formulation and information retrieval and aggregation is described. The method includes modeling one or more workflow activities utilized to perform work tasks, preparing at least one meta-querying template, to generate queries that utilize the modeled workflow activities, retrieving information relevant to the work task as determined utilizing the at least one meta-querying template, and aggregating the retrieved information for presentation to the user.
摘要翻译：描述了基于上下文的查询配置和信息检索和聚合的方法。该方法包括对用于执行工作任务的一个或多个工作流活动进行建模，准备至少一个元查询模板，以生成利用建模的工作流活动的查询，检索与使用至少一个元查询模板确定的工作任务相关的信息，查询模板，并汇总检索到的信息以呈现给用户。

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