专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

101. 发明授权

US4868332A Circulation-active novel substituted aminomethyl-5,6,7,8-tetrahydronaphthyloxy-acetic acids and intermediates therefor 失效
标题翻译：循环活性新型取代氨基甲基-5,6,7,8-四氢萘乙酰氧基 - 乙酸及其中间体
公开(公告)号：US4868332A
公开(公告)日：1989-09-19
申请号：US123748
申请日：1987-11-23
申请人： Ulrich Niewohner , Franz-Peter Hoever , Folker Lieb , Ulrich Rosentreter , Elisabeth Perzborn , Volker-Bernd Fiedler , Friedel Seuter
发明人： Ulrich Niewohner , Franz-Peter Hoever , Folker Lieb , Ulrich Rosentreter , Elisabeth Perzborn , Volker-Bernd Fiedler , Friedel Seuter
IPC分类号： C07C49/747 , A61K31/18 , A61K31/19 , A61K31/215 , A61K31/22 , A61P7/02 , A61P9/10 , C07C45/00 , C07C67/00 , C07C69/675 , C07C213/00 , C07C217/74 , C07C231/00 , C07C231/12 , C07C235/20 , C07C253/00 , C07C255/47 , C07C307/02 , C07C311/17 , C07C311/21
CPC分类号： A61K31/215 , A61K31/18 , C07C307/02
摘要： An aminomethyl-5,6,7,8-tetrahydronaphthyl-oxyacetic acid derivative of the formula ##STR1## in which R.sup.3 is aryl or substituted aryl,R.sup.2 is hydroxyl, alkoxy, phenoxy, benzoxy or NR.sup.4 R.sup.5, andR.sup.4 and R.sup.5 each independently is hydrogen or alkyl, or one of the radicals R.sup.4 or R.sup.5 is benzyl,and physiologically acceptable salts thereof with monovalent or divalent cations which have antithrombotic, antiatherosclerotic and antiischaemic activities.
摘要翻译：其中R3是芳基或取代的芳基，R2是羟基，烷氧基，苯氧基，苯氧基或NR4R5的氨基甲基-5,6,7,8-四氢萘基 - 氧基乙酸衍生物，其中R 4和R 5各自独立地是氢或烷基，或者基团R4或R5中的一个为苄基，以及其与具有抗血栓形成，抗动脉粥样硬化和抗神经活性的单价或二价阳离子的生理上可接受的盐。

102. 发明授权

US4868331A Substituted amino-5,6,7,8-tetrahydronaphthyl-oxyacetic acids, processes for their preparation and their use as medicaments 失效
标题翻译：取代的氨基-5,6,7,8-四氢萘基氧基乙酸，其制备方法和用作药物
公开(公告)号：US4868331A
公开(公告)日：1989-09-19
申请号：US68002
申请日：1987-06-29
申请人： Ulrich Niewohner , Franz-Peter Hoever , Bodo Junge , Elisabeth Perzborn , Friedel Seuter , Volker-Bernd Fiedler
发明人： Ulrich Niewohner , Franz-Peter Hoever , Bodo Junge , Elisabeth Perzborn , Friedel Seuter , Volker-Bernd Fiedler
IPC分类号： C07C67/00 , C07C213/00 , C07C217/74 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/23 , C07C233/74 , C07C235/10 , C07C301/00 , C07C303/38 , C07C303/40 , C07C311/17 , C07D213/82
CPC分类号： C07D213/82
摘要： Antithrombotic, antiatherosclerotic and antiischaemic compounds of the formula ##STR1## in which R.sup.1 is ##STR2## or SO.sub.2 R.sup.4, R.sup.3 is aryl, substituted aryl, heteroaryl, aralkyl or the group ##STR3## R.sup.4 is aryl or substituted aryl, R.sup.2 is OH, alkoxy, phenoxy, benzoxy or NR.sup.5 R.sup.6, andR.sup.5 and R.sup.6 each independently is hydrogen or alkyl, orone of the radicals R.sup.5 or R.sup.6 is benzyl,and physiologically acceptable salts thereof with mono- and divalent cations.
摘要翻译：其中R1是<或> SO2R4，R3是芳基，取代的芳基，杂芳基，芳烷基或基团R4的抗血栓形成，抗动脉粥样硬化和抗除斑化合物，其中R 1是芳基或取代的芳基，R 2是OH，烷氧基，苯氧基，苯氧基或NR5R6，R5和R6各自独立地为氢或烷基，或者基团R5或R6中的一个为苄基，以及其与单价和二价阳离子的生理上可接受的盐。

103. 发明授权

US4853406A Polyhydrobenzi[c,d]indolesulphonamides 失效
标题翻译：聚氢化苯并[c，d]吲哚磺酰胺
公开(公告)号：US4853406A
公开(公告)日：1989-08-01
申请号：US200342
申请日：1988-05-31
申请人： Ulrich Rosentreter , Horst Boshagen , Folker Lieb , Hermann Oediger , Ulrich Niewohner , Friedel Seuter , Elisabeth Perzborn , Volker-Bernd Fiedler
发明人： Ulrich Rosentreter , Horst Boshagen , Folker Lieb , Hermann Oediger , Ulrich Niewohner , Friedel Seuter , Elisabeth Perzborn , Volker-Bernd Fiedler
IPC分类号： A61K31/40 , A61K31/403 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/08 , A61P37/08 , C07D209/90
CPC分类号： C07D209/90
摘要： Thrombocyte aggregation-inhibiting polyhydrobenz[c,d]indolesulphonamide of the formula ##STR1## in which R.sup.1 is hydrogen, aryl or alkyl,R.sup.2 is hydrogen, halogen, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, hydroxyl, aralkoxy ora group of the formula ##STR2## R.sup.3 and R.sup.4 each independently is hydrogen, alkyl, aryl, aralkyl or acyl andX is cyano or carboxyl, and salts thereof. Intermediates therefor of the formula ##STR3## are also new.
摘要翻译： R 1为氢，芳基或烷基，R 2为氢，卤素，烷基，烷氧基，三氟甲基，三氟甲氧基，羟基，芳烷氧基或基团的式（I）的血小板聚集抑制性多羟基苯并[c，d]吲哚磺酰胺式R 3和R 4各自独立地为氢，烷基，芳基，芳烷基或酰基，X为氰基或羧基，及其盐。具有公式（II）的中间体也是新的。

104. 发明授权

US4659732A Lipoxygenase inhibiting 1-arylalkyl-, 1-arylthio-, and 1-aryloxypyrazole-4,5-diones 失效
标题翻译：抑制脂氧合酶的1-芳基烷基 - ，1-芳硫基 - 和1-芳氧基吡唑-4,5-二酮
公开(公告)号：US4659732A
公开(公告)日：1987-04-21
申请号：US769928
申请日：1985-08-27
申请人： Hartmut Stegelmeier , Volker Fiedler , Mithat Mardin , Dieter Mayer , Elisabeth Perzborn , Friedel Seuter
发明人： Hartmut Stegelmeier , Volker Fiedler , Mithat Mardin , Dieter Mayer , Elisabeth Perzborn , Friedel Seuter
IPC分类号： C12N9/99 , A61K31/415 , A61P7/02 , A61P9/06 , A61P9/08 , A61P9/10 , A61P11/00 , A61P29/00 , A61P43/00 , C07D231/28
CPC分类号： C07D231/28
摘要： Combating diseases of the respiratory tract, inflammations, rheumatism, thromboembolic diseases, ischaemias and infarcts, cardiac arrhythmias and arteriosclerosis with pyrazolediones of the formula ##STR1## wherein R represents an aryl or heteroaryl radical which has 6 to 12 C atoms and optionally contains 1 to 3 identical or different substituents from the group comprising halogen, trifluoromethyl, alkyl, alkenyl, alkoxy, alkylamino, cyano, trifluoromethoxy, nitro, hydroxyl, SO.sub.n -alkyl (n=0 to 2) or SO.sub.n -trifluoromethyl ) n=0 to 2), alkyl, alkenyl and alkoxy each having up to 4 C atoms,R.sup.1 represents hydrogen or a hydrocarbon radical which has 1 to 18 C atoms and optionally contains a hydroxyl, ether, ester or carboxyl group and optionally contains 1 to 3 halogen atoms, and X represents one of the groups --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --, --S--CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 -- or ##STR2## the oxygen or sulphur atom being bonded to the radical R.
摘要翻译：通过具有下式（IMAGE）的吡唑啉酮来治疗呼吸道疾病，炎症，风湿病，血栓栓塞性疾病，缺血性和梗塞，心律失常和动脉硬化，其中R表示具有6至12个C原子的芳基或杂芳基，并且任选地包含1至 3个与卤素，三氟甲基，烷基，烯基，烷氧基，烷基氨基，氰基，三氟甲氧基，硝基，羟基，SO1-烷基（n = 0〜2）或SO-三氟甲基）相同或不同的取代基，n = 0〜2）烷基，链烯基和烷氧基各自具有至多4个C原子，R 1表示氢或具有1至18个C原子并且任选地含有羟基，醚，酯或羧基并且任选地含有1至3个卤素原子的烃基， X代表键合的氧或硫原子之一-CH2-CH2-CH2-，-O-CH2-CH2-，-S-CH2-CH2-，-CH2-CH2-，-CH2-或< 到激进的

105. 发明授权

US4657924A Nafazatrom as a lipoxygenase inhibitor 失效
标题翻译： Nafazatrom作为脂氧合酶抑制剂
公开(公告)号：US4657924A
公开(公告)日：1987-04-14
申请号：US715438
申请日：1985-03-25
申请人： Mithat Mardin , Wolf-Dieter Busse , Friedrich Hoffmeister , Friedel Seuter , Elisabeth Perzborn , Klaus Schlossmann , Dieter Mayer , Volker Fiedler
发明人： Mithat Mardin , Wolf-Dieter Busse , Friedrich Hoffmeister , Friedel Seuter , Elisabeth Perzborn , Klaus Schlossmann , Dieter Mayer , Volker Fiedler
IPC分类号： A61K31/415
CPC分类号： A61K31/415 , Y10S514/821 , Y10S514/826
摘要： A method of inhibiting lipoxygenase in a patient, for the prophylaxis and/or treatment of ischaemias and disorders in cardiac rhythm and of rheumatic, allergic and asthmatic diseases, oedemas, pulmonary embolisms, pulmonary hypertension, oxygen intoxications and ulcerations which comprises administering to such patient an effective amount of nafazatrom.
摘要翻译：一种抑制患者中脂质氧合酶的方法，用于预防和/或治疗心律和风湿性，过敏性和哮喘性疾病，oedemas，肺栓塞，肺动脉高压，氧中毒和溃疡中的局部缺血和疾病，其包括向该患者施用有效量的nafazatrom。

106. 发明授权

US4590291A Thrombin inhibitory new dihydroxybenzene ether derivatives 失效
标题翻译：凝血酶抑制新二羟基苯醚衍生物
公开(公告)号：US4590291A
公开(公告)日：1986-05-20
申请号：US385355
申请日：1982-06-07
申请人： Horst Boshagen , Ulrich Horlein , Gerd Reinhardt , Friedel Seuter , Elisabeth Perzborn
发明人： Horst Boshagen , Ulrich Horlein , Gerd Reinhardt , Friedel Seuter , Elisabeth Perzborn
IPC分类号： C07C69/92 , A61K31/085 , A61P7/02 , A61P9/08 , A61P9/10 , C07C41/00 , C07C43/17 , C07C43/20 , C07C43/225 , C07C51/00 , C07C59/31 , C07C59/64 , C07C59/68 , C07C59/90 , C07C65/24 , C07C65/40 , C07C67/00 , C07C69/736 , C07C69/76 , C07C313/00 , C07C323/20
CPC分类号： C07C65/24 , C07C59/68 , C07C59/90 , C07C65/40
摘要： An ether derivative of a dihydroxybenzene of the formula ##STR1## in which R.sup.1 is 1 to 3 identical or different substituents selected from hydrogen, halogen, trifluoromethyl, carboxyl, alkyl, alkoxy, alkylmercapto and carbalkoxy, with in each case 1 to 4 carbon atoms in the alkyl and alkoxy groups, andR.sup.2 and R.sup.3 are different and each is an alkyl or alkenyl chain in which 1 or 2 CH.sub.2 chain members are optionally replaced by O, S, CO or a phenylene group, and/or in which the chain is optionally substituted by 1 to 3 identical or different substituents selected from hydroxyl, halogen, trifluoromethyl, phenyl, carboxyl, alkyl, alkoxy, alkylmercapto, carbalkoxy, and acyl, the phenyl radical in turn optionally being substituted by halogen, trifluoromethyl, carboxyl, alkyl, alkoxy, alkylmercapto or carbaloxy, and the abovementioned alkyl, alkoxy and acyl groups in each case containing 1 to 4 carbon atoms, and in which at least one of the radicals R.sup.2 or R.sup.3 is substituted and/or in at least one of the radicals R.sup.2 or R.sup.3 1 or 2 chain members are replaced by 1 or 2 identical or different radicals selected from O, S, CO and phenylene, is effective in combating cardiac infarcations, angina pectoric, thromboembolic illnesses, in venous and arterial regions and arteriosclerosis.
摘要翻译：其中R 1是1至3个相同或不同的选自氢，卤素，三氟甲基，羧基，烷基，烷氧基，烷基巯基和烷氧基的取代基的式“IMAGE”的二羟基苯的醚衍生物，在每种情况下为1至4个碳原子在烷基和烷氧基中，且R 2和R 3不同，并且各自为烷基或烯基链，其中1或2个CH 2链成员任选被O，S，CO或亚苯基取代，和/或其中链任选地被1至3个相同或不同的选自羟基，卤素，三氟甲基，苯基，羧基，烷基，烷氧基，烷基巯基，烷氧基和酰基的取代基取代，苯基依次任选被卤素，三氟甲基，羧基，烷基，烷氧基，烷基巯基或卡巴氧基，以及上述烷基，烷氧基和酰基，每种情况下含有1至4个碳原子，并且其中至少一个基团R 2或R 3被取代和/或至少一个o 基团R 2或R 3 1或2链成员被选自O，S，CO和亚苯基的1或2个相同或不同的基团取代，有效地对抗静脉和动脉区域的心脏梗塞，心绞痛，血栓栓塞性疾病，以及动脉硬化。

107. 发明授权

US08362015B2 Aminoacyl prodrug derivatives and medicaments for treatment of thromboembolic disorders 有权
标题翻译：氨基酰基前药衍生物和治疗血栓栓塞障碍的药物
公开(公告)号：US08362015B2
公开(公告)日：2013-01-29
申请号：US12438097
申请日：2007-08-23
申请人： Hans-Georg Lerchen , Ursula Krenz , Karl-Heinz Schlemmer , Elisabeth Perzborn
发明人： Hans-Georg Lerchen , Ursula Krenz , Karl-Heinz Schlemmer , Elisabeth Perzborn
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译：本申请涉及5-氯-N - （{（5S）-2-氧代-3- [4-（3-氧代吗啉-4-基）苯基] -1,3-恶唑烷-5-基的前药衍生物）甲基）噻吩-2-甲酰胺，其制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

108. 发明申请

US20100048548A1 IMINO-OXAZOLIDINES AND USE THEREOF 审中-公开
标题翻译：咪唑啉酮及其用途
公开(公告)号：US20100048548A1
公开(公告)日：2010-02-25
申请号：US11919020
申请日：2006-04-08
申请人： Susanne Röhrig , Jens Pohlmann , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
发明人： Susanne Röhrig , Jens Pohlmann , Elisabeth Perzborn , Christoph Gerdes , Karl-Heinz Schlemmer
IPC分类号： A61K31/422 , C12N5/00 , A61K31/5377 , A61K31/506 , A61K31/445 , A61K31/44 , C07D413/14 , C07D413/10 , A61P7/00 , A61P7/02
CPC分类号： C07D413/14
摘要： The present invention relates to novel iminooxazolidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
摘要翻译：本发明涉及新的亚氨基恶唑烷，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞障碍的药物的用途。

109. 发明申请

US20050096320A1 Triazolotriazinones and the use thereof 审中-公开
标题翻译：三唑并三嗪酮及其用途
公开(公告)号：US20050096320A1
公开(公告)日：2005-05-05
申请号：US10728180
申请日：2003-12-04
申请人： Ulrich Niewohner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsby , Elisabeth Perzborn , Karl-Heinz Schlemmer
发明人： Ulrich Niewohner , Helmut Haning , Thomas Lampe , Mazen Es-Sayed , Gunter Schmidt , Erwin Bischoff , Klaus Dembowsby , Elisabeth Perzborn , Karl-Heinz Schlemmer
IPC分类号： A61K31/53 , A61K31/55 , A61K31/551 , A61P7/04 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P13/00 , A61P13/08 , A61P15/00 , A61P15/10 , A61P25/28 , A61P43/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to novel triazolotriazinones of the general formula and to a method for their production and pharmaceutical use thereof.
摘要翻译：本发明涉及通式的新型三唑并三氮嗪酮及其制备方法和药物用途。

110. 发明申请

US20050064006A1 Stents 审中-公开
标题翻译：支架
公开(公告)号：US20050064006A1
公开(公告)日：2005-03-24
申请号：US10493552
申请日：2002-10-11
申请人： Elisabeth Perzborn , Jochen Kalbe , Wolfram Ledwoch , Didier Meulien
发明人： Elisabeth Perzborn , Jochen Kalbe , Wolfram Ledwoch , Didier Meulien
IPC分类号： C07D413/14 , A61F2/84 , A61K31/5377 , A61L31/00 , A61L31/16 , A61L33/10 , A61P7/02 , A61F2/06
CPC分类号： A61L31/16
摘要： The invention concerns stents containing compounds of formula (I) and methods for making said stents as well as their use.
摘要翻译：本发明涉及含有式（I）化合物和制备所述支架及其用途的方法的支架。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式