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91. 发明授权

US08168168B2 Infectivity-enhanced conditionally-replicative adenovirus and uses thereof 有权
标题翻译：感染性增强的条件复制型腺病毒及其用途
公开(公告)号：US08168168B2
公开(公告)日：2012-05-01
申请号：US12636134
申请日：2009-12-11
申请人： Juan Fueyo , Candelaria Gomez-Manzano
发明人： Juan Fueyo , Candelaria Gomez-Manzano
IPC分类号： C12N15/09 , C12N15/34 , C12N7/00
CPC分类号： A61K48/0058 , A61K35/761 , A61K45/06 , A61K48/00 , A61K2300/00 , C07K16/081 , C07K2317/55 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10343 , C12N2710/10345 , C12N2810/40 , C12N2810/405 , C12N2810/6018 , C12N2810/851 , C12N2810/859 , C12N2830/008
摘要： A modified adenovirus capable of overcoming the problem of low level of coxsackie-adenovirus receptor (CAR) expression on tumor cells and methods of using such adenovirus are provided. The fiber protein of the adenovirus is modified by insertion or replacement so as to target the adenovirus to tumor cells, and the replication of the modified adenovirus is limited to tumor cells due to specific promoter control or mutations in E1a or E1b genes.
摘要翻译：提供能够克服肿瘤细胞上柯萨奇 - 腺病毒受体（CAR）表达低水平的问题的改良的腺病毒和使用这种腺病毒的方法。通过插入或替换来修饰腺病毒的纤维蛋白，以将腺病毒靶向肿瘤细胞，由于E1a或E1b基因中的特异性启动子控制或突变，修饰的腺病毒的复制受限于肿瘤细胞。

92. 发明授权

US08133481B2 Selectively replicating viral vectors 有权
标题翻译：选择性复制病毒载体
公开(公告)号：US08133481B2
公开(公告)日：2012-03-13
申请号：US12706134
申请日：2010-02-16
申请人： Muralidhara Ramachandra , Paul W. Shabram
发明人： Muralidhara Ramachandra , Paul W. Shabram
IPC分类号： A01N63/00 , A61K35/713 , A61K48/00 , C07H21/04 , C12N15/00 , C12N15/12 , C12N15/34
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10332 , C12N2710/10343 , C12N2830/00 , C12N2830/001 , C12N2830/15
摘要： The present invention provides recombinant viruses which replicate the viral genome selectively in response to the intracellular conditions of the target cell through the use a pathway-responsive promoter which substantially inhibits viral replication in the host cell based on the phenotypic or genotypic of the infected cell. In the target cell, the promoter element of the pathway-responsive promoter is inactive and thus the virus is permitted to replicate. This results in: (1) killing the cells by natural lytic nature of the virus, and/or (2) provides a therapeutic dose of a transgene product (amplified in comparison to replication incompetent vectors) to the target cell, and (3) producing a localized concentration of the virus facilitating the infection of surrounding cells to the recombinant virus. The invention further provides therapeutic and diagnostic methods of use of the vectors, pharmaceutical formulations comprising the vectors, methods of making the vectors and transformed cells comprising the vectors.
摘要翻译：本发明提供了通过使用基于感染细胞的表型或基因型基本上抑制宿主细胞中的病毒复制的途径反应性启动子来响应于靶细胞的细胞内条件而选择性复制病毒基因的重组病毒。在靶细胞中，途径反应性启动子的启动子元件是无活性的，因此病毒被允许复制。这导致：（1）通过病毒的天然裂解性质杀死细胞，和/或（2）向靶细胞提供治疗剂量的转基因产物（与复制无能载体相比扩增），和（3）产生该病毒的局部浓度，促进周围细胞感染重组病毒。本发明还提供了使用载体的治疗和诊断方法，包含载体的药物制剂，制备载体的方法和包含载体的转化细胞。

93. 发明授权

US08105574B2 Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use 有权
标题翻译：猿猴腺病毒核酸和氨基酸序列，含有其的载体和使用方法
公开(公告)号：US08105574B2
公开(公告)日：2012-01-31
申请号：US11820439
申请日：2007-06-19
申请人： James M Wilson , Guangping Gao , Soumitra Roy
发明人： James M Wilson , Guangping Gao , Soumitra Roy
IPC分类号： C12N15/00 , C12N15/34 , C12N15/11 , C12N15/63
CPC分类号： A61K39/235 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10022 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362 , C12N2710/20022 , C12N2740/16122 , C12N2740/17022 , C12N2750/14122 , C12N2760/14134 , C12N2760/16134 , C12N2760/20122 , C12N2830/002 , C12N2830/55
摘要： A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译：重组载体包含猿猴腺病毒序列和在调节序列控制下的异源基因。还公开了表达猿腺病毒基因的细胞系。提供了使用载体和细胞系的方法。

94. 发明申请

US20110305634A1 Methods and systems for adenovirus interaction with desmoglein 2 (DSG2) 有权
标题翻译：与桥粒蛋白2（DSG2）的腺病毒相互作用的方法和系统
公开(公告)号：US20110305634A1
公开(公告)日：2011-12-15
申请号：US13158246
申请日：2011-06-10
申请人： Andre Lieber , Hongjie Wang
发明人： Andre Lieber , Hongjie Wang
IPC分类号： A61K51/08 , C12N15/34 , C12N15/63 , C12N1/00 , C12N1/21 , C12N5/10 , C12N5/071 , C12N5/09 , C12N5/077 , G01N33/566 , G01N21/64 , C12Q1/02 , C07K14/08 , C07K16/18 , A61K38/16 , A61P35/00 , A61P29/00 , A61P1/04 , A61P11/06 , A61P3/00 , A61P11/00 , A61P9/12 , A61P25/00 , A61P17/06 , A61P13/12 , A61P3/10 , A61K39/44 , A61K39/385 , A61K35/76 , A61P1/00 , A61P11/08 , A61P31/06 , A61P1/18 , A61P17/00 , A61P31/14 , A61P5/14 , A61P31/00 , C12N7/00
CPC分类号： C07K14/005 , A61K38/162 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K2317/76 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , G01N33/5076 , A61K2300/00
摘要： The present invention provides compositions and methods for treating disorders associated with epithelial tissues.
摘要翻译：本发明提供了用于治疗与上皮组织相关的疾病的组合物和方法。

95. 发明申请

US20110263027A1 Adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby 有权
标题翻译：腺相关病毒（AAV）序列并分离鉴定的新序列
公开(公告)号：US20110263027A1
公开(公告)日：2011-10-27
申请号：US11985096
申请日：2007-11-14
申请人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
发明人： Guangping Gao , James M. Wilson , Mauricio R. Alvira
IPC分类号： C12N7/01 , C12N5/10 , C12N1/21 , C12N15/34 , C07K14/075 , C07K7/06 , C07K7/08 , C12N15/11 , C12N15/86 , C12N1/19
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： Adeno-associated virus 7 sequences, vectors containing same, and methods of use are provided.
摘要翻译：提供了腺相关病毒7序列，含有其的载体和使用方法。

96. 发明授权

US07906113B2 Serotype of adenovirus and uses thereof 有权
标题翻译：腺病毒血清型及其用途
公开(公告)号：US07906113B2
公开(公告)日：2011-03-15
申请号：US11586316
申请日：2006-10-25
申请人： Abraham Bout , Menzo Havenga , Ronald Vogels
发明人： Abraham Bout , Menzo Havenga , Ronald Vogels
IPC分类号： A01N63/00 , C12N15/00 , C12N15/33 , C12N15/34
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/10352 , C12N2810/6018 , C12N2830/00
摘要： Adenovirus serotypes differ in their natural tropism. The adenovirus serotypes 2, 4, 5 and 7 all have a natural affiliation towards lung epithelia and other respiratory tissues. In contrast, serotypes 40 and 41 have a natural affiliation towards the gastrointestinal tract. The serotypes described, differ in at least capsid proteins (penton-base, hexon), proteins responsible for cell binding (fiber protein), and proteins involved in adenovirus replication. This difference in tropism and capsid protein among serotypes has led to the many research efforts aimed at redirecting the adenovirus tropism by modification of the capsid proteins.
摘要翻译：腺病毒血清型的自然向性不同。腺病毒血清型2,4,5和7都具有与肺上皮细胞和其他呼吸组织的天然亲和关系。相比之下，血清型40和41与胃肠道具有天然的联系。所描述的血清型至少在衣壳蛋白（penton-base，hexon），负责细胞结合的蛋白质（纤维蛋白）以及涉及腺病毒复制的蛋白质中不同。血清型中对向性和衣壳蛋白的这种差异导致了许多研究工作，旨在通过修饰衣壳蛋白来重新定向腺病毒向性。

97. 发明授权

US07749492B2 AAV vectors and methods 有权
标题翻译： AAV载体和方法
公开(公告)号：US07749492B2
公开(公告)日：2010-07-06
申请号：US11145035
申请日：2005-06-03
申请人： Jeffrey S. Bartlett , Matthew Stachler
发明人： Jeffrey S. Bartlett , Matthew Stachler
IPC分类号： C12N15/864 , C12N15/34 , C12N15/64 , C07K14/025 , C07K14/005 , C07K1/00
CPC分类号： C12N7/00 , A61K48/00 , A61K2039/5156 , C12N9/93 , C12N15/86 , C12N2750/14143 , C12N2750/14145 , C12N2750/14152 , C12N2810/40 , C12N2810/405 , C12N2810/60 , C12N2810/854
摘要： The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation and use.
摘要翻译：本发明涉及腺相关病毒载体。特别地，它涉及具有修饰衣壳蛋白的腺相关病毒载体及其制备和使用的材料和方法。

98. 发明授权

US07718848B2 Safe production of a product of interest in hybrid seeds 有权
标题翻译：安全生产杂交种子感兴趣的产品
公开(公告)号：US07718848B2
公开(公告)日：2010-05-18
申请号：US10559430
申请日：2004-06-04
申请人： Stefan Werner , Romy Kandzia , Serik Eliby , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
发明人： Stefan Werner , Romy Kandzia , Serik Eliby , Sylvestre Marillonnet , Victor Klimyuk , Yuri Gleba
IPC分类号： C12N15/82 , C12N15/34 , A01H1/02
CPC分类号： C12N15/8216 , C12N15/8217 , C12N15/8242 , C12N15/8257
摘要： A process of the production of a product of interest in an F1 seed obtained by a hybridization of a first and a second transgenic parental plant, said hybridization generating a genetic endowment in said F1 seed for said production by combining in said F1 seed first and second partial genetic endowments of said first and second transgenic parental plants, followed by isolating said product of interest from said F1 seed or a seedling thereof.
摘要翻译：通过第一和第二转基因亲本植物的杂交获得的F1种子中感兴趣的产品的生产过程，所述杂交通过在所述F1种子中组合产生用于所述生产的所述F1种子中的遗传禀赋，第一和第二所述第一和第二转基因亲本植物的部分遗传禀赋，然后从所述F1种子或其幼苗中分离所述目的产物。

99. 发明授权

US07468181B2 Means and methods for the production of adenovirus vectors 有权
标题翻译：用于产生腺病毒载体的方法和方法
公开(公告)号：US07468181B2
公开(公告)日：2008-12-23
申请号：US10512589
申请日：2003-04-24
申请人： Ronald Vogels , Abraham Bout
发明人： Ronald Vogels , Abraham Bout
IPC分类号： A01N63/00 , C12N15/00 , C12N15/11 , C12N5/00 , C12N15/34
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/525 , A61K2039/5256 , C12N2710/10343 , C12N2810/6018 , C12N2830/002
摘要： The invention relates to methods and means for the production of adenoviral vectors on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present in the adenoviral vector and wherein the E4-orf6 gene product is compatible with one or more products of the E1 gene products provided by the complementing cell, such that the adenoviral vector can be efficiently produced by the complementing cell.
摘要翻译：本发明涉及在补体细胞系上产生腺病毒载体的方法和手段，其中编码核酸的早期区域4开放阅读框6（E4-orf6）存在于腺病毒载体中，其中E4-orf6基因产物是与互补细胞提供的E1基因产物的一种或多种产物相容，使得腺病毒载体可以由补体细胞有效产生。

100. 发明申请

US20050084497A1 Circovirus sequences associated with piglet weight loss disease (PWD) 有权
标题翻译：与小猪减肥病（PWD）相关的圆环病毒序列
公开(公告)号：US20050084497A1
公开(公告)日：2005-04-21
申请号：US10637011
申请日：2003-08-08
申请人： Andre Jestin , Emmanuel Albina , Pierre Le Cann , Philippe Blanchard , Evelyne Hutet , Claire Arnauld , Catherine Truong , Dominique Mahe , Roland Cariolet , Francois Madec
发明人： Andre Jestin , Emmanuel Albina , Pierre Le Cann , Philippe Blanchard , Evelyne Hutet , Claire Arnauld , Catherine Truong , Dominique Mahe , Roland Cariolet , Francois Madec
IPC分类号： A61K39/00 , A61K48/00 , C07K14/01 , C12N5/02 , C12N15/34 , A61K39/12
CPC分类号： A61K39/12 , A01K2217/05 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , A61K2039/552 , A61K2039/55522 , A61K2039/55566 , A61K2039/58 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2710/14143 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10051 , C12N2750/10061 , G01N33/56983 , G01N2333/01 , G01N2469/20 , Y10T428/13
摘要： The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-strucutral polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccines, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
摘要翻译：提供编码PWD圆环病毒多肽的基因组序列和核苷酸序列，例如圆环病毒结构和非结构多肽，包括序列的载体，以及由载体转化的细胞和动物。还提供了用于检测核酸或多肽的方法，以及用于诊断PWD圆环病毒感染的试剂盒。还提供了选择能够调节病毒感染的化合物的方法。还提供了药物，包括疫苗，用于预防和/或治疗由PWD圆环病毒引起的病毒感染的组合物和用于预防和/或治疗疾病的用途。

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