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91. 发明申请

US20160040117A1 Methods and an Apparatus for Transporting Live Cells 有权
标题翻译：用于传送活细胞的方法和装置
公开(公告)号：US20160040117A1
公开(公告)日：2016-02-11
申请号：US14821729
申请日：2015-08-08
申请人： James David Pfau
发明人： James David Pfau
IPC分类号： C12N1/04 , B01L3/00
CPC分类号： C12N1/04 , C12M45/22 , C12N1/16 , C12N1/20
摘要： The invention provides improved methods and an apparatus for transporting a starter culture of living cells including fungi, bacteria, animal and plant cells. The methods and apparatus enable on-demand feeding and on-demand supply of nutrient gas resulting in increased cell viability and improved fermentations.
摘要翻译：本发明提供改进的方法和用于运送包括真菌，细菌，动物和植物细胞的活细胞的起始培养物的装置。方法和装置使得能够按需供给和按需供应营养气体，导致增加的细胞活力和改善的发酵。

92. 发明授权

US09200250B2 Method for production of dry yeast containing S-adenosyl-L-methionine and having excellent storage stability, product produced by the method, and molded composition of the dry yeast 有权
标题翻译：生产含有S-腺苷-L-甲硫氨酸的干酵母并具有优异的储存稳定性的方法，通过该方法生产的产品和干酵母的模塑组合物
公开(公告)号：US09200250B2
公开(公告)日：2015-12-01
申请号：US12524050
申请日：2008-01-23
申请人： Kentarou Takano , Shinyo Gayama
发明人： Kentarou Takano , Shinyo Gayama
IPC分类号： C12N1/16 , C12N1/18 , A23L1/30 , C12N1/04
CPC分类号： C12N1/18 , A23L33/13 , A23L33/14 , A23V2002/00 , C12N1/04 , A23V2250/218 , A23V2250/312
摘要： The present invention relates to a method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, the method containing: adding a cyclodextrin compound to a yeast concentrate obtained from a fungus culture liquid of the yeast; and then drying the concentrate, an SAMe-containing dry yeast obtained by the production method, and a composition formed by molding the dry yeast. According to the present invention, a dry yeast containing S-adenosyl-L-methionine, which is useful as an aqueous physiologically active substance, in a high concentration excellent in storage stability and a composition obtained by molding the dry yeast can be produced conveniently and economically and can be brought into the market.
摘要翻译：本发明涉及使用具有S-腺苷-L-甲硫氨酸生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，该方法包括：将环糊精化合物加入到由酵母真菌培养液; 然后干燥浓缩物，通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的组合物。根据本发明，可以方便地制造含有S-作为生理活性物质的S-腺苷-L-甲硫氨酸的干酵母，其贮藏稳定性优异的高浓度和通过成型干酵母获得的组合物，在经济上可以进入市场。

93. 发明申请

US20150267163A1 METHOD FOR INDUCING BACTERIA TO ENTER INTO VIABLE BUT NONCULTURABLE STATE 有权
标题翻译：诱导细菌进入可变的非生态状态的方法
公开(公告)号：US20150267163A1
公开(公告)日：2015-09-24
申请号：US14436031
申请日：2013-05-31
申请人： CHINA AGRICULTURAL UNIVERSITY
发明人： Xiaojun Liao , Feng Zhao
IPC分类号： C12N1/20 , C12N1/04
CPC分类号： C12N1/20 , C12N1/04 , C12N1/36
摘要： A method induces bacteria to enter into viable, but nonculturable state. The method includes subjecting a target bacterium to high pressure carbon dioxide treatment so as to make it enter into the viable, but nonculturable state, which can be demonstrated experimentally. The viable but nonculturable state can be entered quickly, such as within one hour.
摘要翻译：一种方法诱导细菌进入可行但不可培养的状态。该方法包括使目标细菌进行高压二氧化碳处理，以使其进入活的但不可培养的状态，这可以通过实验证明。可行但不可培养的状态可以快速输入，例如在一小时内。

94. 发明申请

US20150204767A1 METHOD FOR PRODUCING CELL CONCENTRATE 有权
标题翻译：生产细胞浓度的方法
公开(公告)号：US20150204767A1
公开(公告)日：2015-07-23
申请号：US14424574
申请日：2013-08-19
申请人： KANEKA CORPORATION
发明人： Shuhei Taniguchi
IPC分类号： G01N1/40 , C12N1/04
CPC分类号： G01N1/4077 , B01D61/18 , B01D63/02 , B01D69/02 , B01D69/081 , B01D71/10 , B01D71/26 , B01D71/68 , C12M25/10 , C12M47/02 , C12N1/04 , G01N2001/4088
摘要： Provided is a simple method for producing a cell concentrate (other than human blood) in a short time with neither loss of cells nor an excessive burden on cells. Included is a method for producing a cell concentrate using an inside-out filtration system for processing a cell suspension, the system including: a cell suspension inlet port; a filtrate outlet port; a cell suspension outlet port; and hollow fiber separation membranes provided between the cell suspension inlet port and the cell suspension outlet port, wherein the membranes have a total cross-sectional area of 0.5-1.5 cm2, the membranes have an inside membrane area of 0.2 m2 or less, the suspension is flowed inside the membranes at a linear velocity of 500-1200 cm/min, and the quotient of the division of the initial filtrate flow rate from the filtrate outlet port by the flow rate into the cell suspension inlet port is 0.4-0.7.
摘要翻译：提供了在短时间内生产细胞浓缩物（人血液除外）的简单方法，既没有细胞损失也没有对细胞的过度负担。包括使用用于处理细胞悬浮液的内向外过滤系统来生产细胞浓缩物的方法，该系统包括：细胞悬浮液入口; 滤液出口; 细胞悬浮液出口; 设置在细胞悬浮液入口和细胞悬浮液出口之间的中空纤维分离膜，其中膜的总横截面积为0.5-1.5cm 2，膜的内膜面积为0.2m 2以下，悬浮液以500-1200cm / min的线速度流入膜内，并且将从滤液出口的初始滤液流速除以进入电池悬浮液入口的流量的商为0.4-0.7。

95. 发明授权

US09080158B2 Method of producing S-adenosyl-L-methionine-containing dry yeast having excellent storage stability, the product thereof and composition for oral intake 有权
标题翻译：具有优异储存稳定性的含S-腺苷-L-甲硫氨酸的干酵母的制造方法及其口服摄取用组合物
公开(公告)号：US09080158B2
公开(公告)日：2015-07-14
申请号：US12300826
申请日：2007-05-15
申请人： Kentarou Takano , Shinyo Gayama
发明人： Kentarou Takano , Shinyo Gayama
IPC分类号： C12N1/12 , C12N1/20 , A01N63/00 , C12N1/18 , A61K9/16 , A61K9/19 , C07H19/167 , C12N1/04 , C12P19/40
CPC分类号： C12N1/18 , A61K9/1617 , A61K9/19 , C07H19/167 , C12N1/04 , C12P19/40
摘要： A method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, in which an ascorbic acid compound or a salt thereof is added to a yeast concentrate separated from a fungus culture liquid of the yeast, and the concentrate is then dried, a dry yeast containing SAMe obtained by the production method, and a composition for oral ingestion formed by molding the dry yeast. A method capable of producing a dry yeast containing SAMe in a high concentration excellent in storage stability conveniently at low cost is established, and a dry yeast containing SAMe obtained by the production method and a composition for oral ingestion formed by molding the dry yeast are provided.
摘要翻译：使用具有S-腺苷-L-甲硫氨酸的生产能力的酵母生产含有S-腺苷-L-甲硫氨酸的干酵母的方法，其中将抗坏血酸化合物或其盐加入从真菌分离的酵母浓缩物中培养液，然后干燥浓缩物，通过制备方法得到的含有SAMe的干酵母和通过模制干酵母形成的用于口服摄取的组合物。建立了能够以低成本方便地生产具有优异的储存稳定性高的SAMe的干酵母的方法，并且提供了通过制备方法获得的含有SAMe的干酵母和通过模制干酵母形成的口服摄取组合物。

96. 发明申请

US20140349850A1 Coated Dehydrated Microorganisms with Enhanced Stability and Viability 审中-公开
标题翻译：涂层脱水微生物具有增强的稳定性和活力
公开(公告)号：US20140349850A1
公开(公告)日：2014-11-27
申请号：US14459003
申请日：2014-08-13
申请人： DUPONT NUTRITION BIOSCIENCES APS
发明人： Isabelle Mazeaud , Kathryn Tse , Jean-Philippe Obert , Claudette Berger , Geoffrey Babin , Patrick Chaigneau , Hans Hedegaard Jensen , Erwan Henri
IPC分类号： C12N1/04 , C09D105/00 , C09D101/28 , A23K1/00 , C08K3/32 , A01N63/00 , C05G3/00 , A23L1/30 , C12N1/20 , C08K3/34
CPC分类号： C12N1/04 , A01N63/00 , A23K10/16 , A23K10/18 , A23L29/065 , A23L33/135 , A23P10/30 , A23V2002/00 , C05G3/0023 , C05G3/0029 , C05G3/0041 , C08K3/32 , C08K3/34 , C08K2003/324 , C09D101/284 , C09D105/00 , C12N1/20
摘要： The present invention relates to coated dehydrated microorganisms comprising a dehydrated microorganism surrounded by at least one coating, said coating comprising by dry weight at least 25% of hygroscopic salt(s) and wherein the pH of the coating is compatible with viability of the coated dehydrated microorganism. The coating can be partially crystalline, the salt(s) in the coating having preferably a crystallinity degree of up to 60% once applied onto the dehydrated microorganism. The present invention also relates to liquid coating compositions, methods for coating and protecting a dehydrated microorganism. Finally, the present invention relates to a method for the preparation of food products, feed products, consumer healthcare products or agri-products as well as to a food product, feed product, a consumer healthcare product or an agri-product containing such coated dehydrated microorganisms.
摘要翻译：本发明涉及包含脱水微生物的包衣的脱水微生物，所述脱水微生物被至少一个涂层包围，所述涂层包括干重至少25％的吸湿盐，并且其中涂层的pH与涂覆的脱水的微生物。涂层可以是部分结晶的，一旦施加到脱水的微生物上，涂层中的盐优选具有高达60％的结晶度。本发明还涉及液体涂料组合物，用于涂覆和保护脱水微生物的方法。最后，本发明涉及一种食品，饲料产品，消费者保健产品或农产品的制备方法，以及食品，饲料产品，消费者保健产品或含有这样的脱水的食品的农产品微生物。

97. 发明授权

US08772014B2 Method for stabilization of biological cultures to allow biological treatment of brines 有权
标题翻译：用于稳定生物培养物以允许生物处理盐水的方法
公开(公告)号：US08772014B2
公开(公告)日：2014-07-08
申请号：US10579640
申请日：2004-11-19
申请人： Deborah J. Roberts , Dennis A. Clifford , Xiaohua Lin , Thomas Gillogly , Lee Aldridge , Stewart Lehman
发明人： Deborah J. Roberts , Dennis A. Clifford , Xiaohua Lin , Thomas Gillogly , Lee Aldridge , Stewart Lehman
IPC分类号： A62D3/10 , A62D3/02 , C12Q1/02 , C12N1/04 , C12N1/20 , C12N9/00 , C12N1/38
CPC分类号： C02F3/28 , C02F1/42 , C02F2101/12 , C02F2101/163 , C02F2103/08 , Y02E50/343
摘要： A process is disclosed for the biological treatment under anaerobic/anoxic conditions for the degradation of pollutants present in brine solution used in waste water management, in industrial waste brine solutions and in waste oil field brine solutions, especially waste brine solutions contaminated with perchlorate and nitrate. A culture capable of reducing perchlorate and nitrate in spent ion-exchange regenerant brine containing at least 30 g/L NaCl under anaerobic/anoxic conditions was used to demonstrate the process. A stabilized brine solution is also disclosed in which a culture capable of degrading a given pollutant can be proliferate.
摘要翻译：公开了一种用于在厌氧/缺氧条件下生物处理用于废水管理中使用的盐水溶液中的污染物降解，工业废盐水溶液和废油场盐水溶液，特别是被高氯酸盐和硝酸盐污染的废盐水溶液的生物处理的方法。使用能够在厌氧/缺氧条件下含有至少30g / L NaCl的废离子交换再生盐水中的高氯酸盐和硝酸盐的培养物进行培养。还公开了一种稳定的盐水溶液，其中可降解给定污染物的培养物可以增殖。

98. 发明授权

US08715639B2 Compositions and methods for microbe storage and delivery 有权
标题翻译：用于微生物储存和分送的组合物和方法
公开(公告)号：US08715639B2
公开(公告)日：2014-05-06
申请号：US12671370
申请日：2007-09-07
申请人： Hideki Suzuki , Salvatore Braico
发明人： Hideki Suzuki , Salvatore Braico
IPC分类号： A61K9/00 , A01N63/00 , A01N65/00 , C12N1/00 , C12N1/04 , C12N1/12 , C12N1/20 , C12N1/22 , C12N11/04 , C12N11/08 , C12N11/12 , C12P1/00
CPC分类号： A61K35/744 , A61K9/19 , A61K35/74 , A61K35/741 , A61L29/085 , A61L29/16 , A61L2420/06 , Y02A50/402 , Y02A50/473
摘要： The present invention relates to the field of bacteriology. In particular, the invention relates to compositions of probiotic microbes and methods for making and using such compositions, e.g. in the treatment and prevention of catheter associated urinary tract infections.
摘要翻译：本发明涉及细菌学领域。特别地，本发明涉及益生菌微生物的组合物及其制备和使用方法。在治疗和预防导尿管相关泌尿道感染。

99. 发明授权

US08617871B2 Method and culture medium for enhanced detection of Mycobacterium 有权
公开(公告)号：US08617871B2
公开(公告)日：2013-12-31
申请号：US13723905
申请日：2012-12-21
申请人： Parampal Deol , Leticia Barton , Yoany Portilla , Douglas Lovern
发明人： Parampal Deol , Leticia Barton , Yoany Portilla , Douglas Lovern
IPC分类号： C12N1/04 , C12Q1/20 , C12N1/34
CPC分类号： C12Q1/04 , C12N1/20 , C12N1/38 , C12Q1/045 , G01N2333/35
摘要： The present invention relates to an improved culture medium and method for the enhanced growth and detection of Mycobacterium growth. The invention further relates to an improved mycobacterial reagent system or kit that can be used for the enhanced growth and detection of Mycobacterium.

100. 发明申请

US20130323362A1 COMPOSITION AND METHOD FOR IMPROVING STABILITY AND EXTENDING SHELF LIFE OF PROBIOTIC BACTERIA AND FOOD PRODUCTS THEREOF 审中-公开
标题翻译：用于改善生物细菌和食品的稳定性和延长寿命的组合物和方法
公开(公告)号：US20130323362A1
公开(公告)日：2013-12-05
申请号：US13991911
申请日：2011-12-05
申请人： Adel Penhasi
发明人： Adel Penhasi
IPC分类号： A23L1/30 , C12N1/04
CPC分类号： A23L33/135 , A21D8/045 , A23P10/30 , A23P10/35 , A23V2002/00 , A61K9/4858 , A61K9/5015 , A61K9/5031 , A61K9/5036 , A61K9/5042 , A61K9/5073 , A61K35/745 , A61K2035/115 , C12N1/04 , A23V2200/3204 , A23V2250/0616 , A23V2250/5114 , A23V2250/636
摘要： A composition comprising probiotic bacteria, the composition comprising: (a) a core composition containing the probiotic bacteria and a stabilizer, wherein the total amount of probiotics in the mixture is from about 10% to about 90% by weight of the core composition; (b) an innermost coating layer, layered on said core composition, comprising at least one hydrophobic solid fat or fatty acid having a melting point lower than 60° C.; (c) an intermediate coating layer layered on said innermost coating layer, which when present in an aqueous solution in the amount of 0.1% weight/weight over the weight of the solution, has a surface tension lower than 60 mN/m, when measured at 25° C.; and (d) an outer coating layer, layered on said intermediate coating layer; wherein the composition is in the form of particles; food products containing the composition and methods of preparation thereof.
摘要翻译：一种包含益生菌的组合物，所述组合物包含：（a）含有益生菌和核心组合物的核心组合物，其中混合物中益生菌的总量为核心组合物重量的约10％至约90％; （b）层叠在所述芯组合物上的最内层，包含至少一种熔点低于60℃的疏水固体脂肪或脂肪酸; （c）层叠在所述最内层的中间涂层，当以溶液重量计为0.1重量/重量的量存在于水溶液中时，其表面张力低于60mN / m 在25°C。和（d）层叠在所述中间涂层上的外涂层; 其中所述组合物为颗粒形式; 含有组合物的食品及其制备方法。

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