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91. 发明授权

US4423071A Polyol derivatives, processes for preparing the same and their uses in therapeutics 失效
标题翻译：多元醇衍生物，其制备方法及其在治疗中的应用
公开(公告)号：US4423071A
公开(公告)日：1983-12-27
申请号：US126191
申请日：1980-03-03
申请人： Michel Chignac , Claude Grain , Fernand Jammot , Charles Pigerol , Pierre Eymard , Bernard Ferrandes
发明人： Michel Chignac , Claude Grain , Fernand Jammot , Charles Pigerol , Pierre Eymard , Bernard Ferrandes
IPC分类号： C07C69/003 , A61K31/215 , A61K31/22 , A61K31/335 , A61K31/357 , A61P25/08 , A61P25/24 , C07C67/00 , C07C67/10 , C07C67/28 , C07C69/007 , C07C69/013 , C07C69/18 , C07C69/28 , C07C69/30 , C07C69/708 , C07C69/75 , C07C219/06 , C07C233/18 , C07C233/19 , C07C235/08 , C07C313/00 , C07C323/12 , C07D303/16 , C07D317/12 , C07D317/18 , C07D317/20 , C07D317/22 , C07D317/24 , C07D317/72 , C07D319/06
CPC分类号： C07D317/72 , C07C327/00 , C07D303/16 , C07D317/12 , C07D317/20 , C07D317/24 , C07D319/06
摘要： Mono-, di-, tri- and tetra-esters derived from an acid of the general formula:R--OHin which R represents an acyl radical of the general formula: ##STR1## in which n represents 0 or 1, m represents 0, 1, 2, 3 or 4, R.sub.1 and R.sub.2 each represent a straight- or branched-chain alkyl radical having from 1 to 5 carbon atoms, R.sub.3 represents hydrogen or a straight- or branched-chain alkyl radical having from 1 to 5 carbon atoms, the sum of the carbon atoms in R.sub.1 and R.sub.2 being from 4 to 10 when R.sub.3 represents hydrogen and the sum of the carbon atoms in R.sub.1, R.sub.2 and R.sub.3 being from 6 to 15 when R.sub.3 is different from hydrogen, or R.sub.1 and R.sub.2 when they are taken together represent a tetramethylene, pentamethylene or hexamethylene radical and R.sub.3 represents a straight-chain alkyl radical and an alcohol selected from the group consisting of glycerol, 2,3-epoxy-propanol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 1,2,3-butanetriol, 1,2,4-butanetriol, 1,2,3,4-butanetetrol, 2-buten-1,4-diol, 2-butyn-1,4-diol, diethyleneglycol, a cyclohexanediol preferably 1,2-cyclohexanediol, thiodiglycol, diethanolamine, N-R-substituted-diethanolamine, trimethylolpropane, pentaerythritol and an alcohol of the general formula: ##STR2## in which p represents 0 or 1, R.sub.4 represents methyl, R.sub.5 represents methyl, ethyl, 2-methyl-butyl or R.sub.4 and R.sub.5, when they are taken together represent a pentamethylene radical, with the exception of glyceryl tri-(di-n-propylacetate).These esters are useful in the treatment of central nervous system disorders and including, in particular, convulsive states and seizures, and disorders relating to the field of neuropsychiatry.
摘要翻译：衍生自以下通式的酸的单 - ，二 - ，三 - 和四 - 酯：其中R表示通式如下的酰基：其中n表示0或1，m表示0 ，1,2,3或4，R 1和R 2各自表示具有1至5个碳原子的直链或支链烷基，R 3表示氢或具有1至5个碳的直链或支链烷基原子时，R 3和R 2中的碳原子的总和为4至10，当R 3表示氢时，当R 3不同于氢时，R 1，R 2和R 3中的碳原子之和为6至15，或R 1和R 2 当它们一起表示四亚甲基，五亚甲基或六亚甲基时，R 3表示直链烷基和选自甘油，2,3-环氧丙醇，1,2-丙二醇，1,3 丙二醇，1,2-丁二醇，1,3-丁二醇，1,4-丁二醇，1,2,3-丁三醇，1,2,4-丁三醇，1,2,3,4-丁酮，2-丁醇 1,4-丁二醇，2-丁炔-1,4-二醇，二甘醇，环己二醇优选1,2-环己二醇，硫二甘醇，二乙醇胺，NR-取代二乙醇胺，三羟甲基丙烷，季戊四醇和通式如下的醇：其中p表示0或1，R4表示甲基，R5表示甲基，乙基，2-甲基 - 丁基或R4和R5，当它们一起表示五亚甲基时，除三乙酸二正丙酯）。这些酯可用于治疗中枢神经系统疾病，特别是包括惊厥状态和癫痫发作以及与神经精神病学领域有关的疾病。

92. 发明授权

US4269775A Oxime derivatives for protecting plant crops 失效
标题翻译：用于保护植物作物的肟衍生物
公开(公告)号：US4269775A
公开(公告)日：1981-05-26
申请号：US69414
申请日：1979-08-24
申请人： Henry Szczepanski , Henry Martin , Werner Fory , Georg Pissiotas
发明人： Henry Szczepanski , Henry Martin , Werner Fory , Georg Pissiotas
IPC分类号： A01N47/06 , A01N25/32 , A01N37/22 , A01N37/34 , A01N37/50 , A01N41/10 , A01N43/02 , A01N43/26 , A01N43/28 , A01N43/32 , A01N47/12 , A01P13/02 , C07C67/00 , C07C239/00 , C07C251/32 , C07C251/58 , C07C275/50 , C07C311/16 , C07C313/00 , C07C317/28 , C07C317/44 , C07C323/47 , C07D263/14 , C07D295/185 , C07D317/18 , C07D317/22 , C07D319/06 , C09K17/00 , C07D317/30 , C07C131/00
CPC分类号： C07D295/185 , A01N25/32 , A01N37/50 , A01N43/28 , A01N43/32 , C07C275/50 , C07D263/14 , C07D317/18 , C07D319/06
摘要： The invention relates to oximes of the formula ##STR1## wherein n is 0, 1 or 2 and m is 0 or 1, and wherein Ar is a phenyl radical ##STR2## a naphthyl radical substituted by R.sub.2 and R.sub.3, a 5- to 10-membered heterocyclic radical which contains not more than 3 identical or different heteroatoms N, O and/or S, and which is substituted by R.sub.2, R.sub.3 and R.sub.4 and can be substituted by oxo or thiono, or, if m is 0, Ar is a radical R--CO--, wherein R is a radical --OR.sub.5, and Q is a radical C.sub.a H.sub.2a --R.sub.8, wherein a is an integer between 1 and 6, while R and R.sub.8 are as defined in the description of the specification.These compounds can be used for protecting plant crops from the action of aggressive agrochemicals.
摘要翻译：本发明涉及式（I）的肟，其中n为0,1或2，m为0或1，Ar为苯基由R 2和R 3取代的萘基，a 5 至10元杂环基，其含有不超过3个相同或不同的杂原子N，O和/或S，并且其被R 2，R 3和R 4取代并且可以被氧代或硫代替代，或者如果m是0， Ar是一个自由基R-CO-，其中R是基团-OR5，Q是一个基团CaH 2，R 8，其中a是1-6之间的整数，而R和R 8如在本说明书的描述中所定义。这些化合物可用于保护植物作物免受侵蚀性农药的作用。

93. 发明授权

US4234490A Intermediates in the synthesis of vitamin E 失效
标题翻译：中间体合成维生素E
公开(公告)号：US4234490A
公开(公告)日：1980-11-18
申请号：US4503
申请日：1979-01-18
申请人： Richard Barner , Max Schmid
发明人： Richard Barner , Max Schmid
IPC分类号： C07C37/055 , C07C37/07 , C07C39/11 , C07D307/33 , C07D311/58 , C07D311/72 , C07D313/08 , C07D317/18 , C07D317/20 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D317/32 , C07D317/58 , C07D493/08 , C07D493/10 , C07F9/54 , C07D317/10
CPC分类号： C07D307/33 , C07C37/07 , C07C46/00 , C07D311/58 , C07D311/72 , C07D313/08 , C07D317/18 , C07D317/20 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D317/32 , C07D317/58 , C07D493/08 , C07D493/10 , C07F9/5456
摘要： A process is disclosed for producing (S)-(+)-6-hydroxy-2,5,7,8-tetramethylchroman-2-methanol from either alkyl(R)-2-benzyloxy-3-hydroxy-2-methyl-propionate or (S)-2,2,4-trimethyl-1,3-dioxolan-4-ethanol including intermediates in this synthesis.
摘要翻译：公开了从（R）-2-苄氧基-3-羟基-2-甲基-2-吡咯烷酮制备（S） - （+） - 6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-甲醇的方法，丙酸酯或（S）-2,2,4-三甲基-1,3-二氧戊环-4-乙醇，包括该合成中的中间体。

94. 发明授权

US11767307B2 Litter for promoting pet's in-litter elimination 有权
公开(公告)号：US11767307B2
公开(公告)日：2023-09-26
申请号：US16963423
申请日：2019-01-29
申请人： SPECIALITES PET FOOD
发明人： Marc-Henry Lussigny , Cécile Petel
IPC分类号： A01K1/015 , C07D317/18 , C07F9/06 , B01J20/12 , B01J20/22 , B01J20/10 , B01J20/28 , B01J20/32
CPC分类号： C07D317/18 , A01K1/0154 , A01K1/0155 , B01J20/12 , B01J20/22 , C07F9/062 , B01J20/103 , B01J20/28023 , B01J20/32
摘要： The present invention concerns a pet litter comprising a composition comprising 2,2-dimethyl-1,3-dioxolane-4-methanol. The present invention further relates to methods and uses of a composition comprising 2,2-dimethyl-1,3-dioxolane-4-methanol in pet litters, in particular for promoting in-litter elimination by pets.

95. 发明申请

US20210087161A1 LITTER FOR PROMOTING PET'S IN-LITTER ELIMINATION 有权
公开(公告)号：US20210087161A1
公开(公告)日：2021-03-25
申请号：US16963423
申请日：2019-01-29
申请人： SPECIALITES PET FOOD
发明人： Marc-Henry LUSSIGNY , Cécile PETEL
IPC分类号： C07D317/18 , A01K1/015 , C07F9/06
摘要： The present invention concerns a pet litter comprising a composition comprising 2,2-dimethyl-1,3-dioxolane-4-methanol. The present invention further relates to methods and uses of a composition comprising 2,2-dimethyl-1,3-dioxolane-4-methanol in pet litters, in particular for promoting in-litter elimination by pets.

96. 发明授权

US09975881B2 Compound 有权
公开(公告)号：US09975881B2
公开(公告)日：2018-05-22
申请号：US14980754
申请日：2015-12-28
申请人： ASTRAZENECA AB
发明人： Stephen Connolly , Mark Richard Ebden , Iain Alastair Stewart Walters , Thomas Langer , Alan Robert Steven , Craig Robert Stewart , Paula Margaret Tomlin , Andrew John Williams
IPC分类号： A61K31/506 , C07D403/12 , C07C69/92 , C07D205/04 , C07D317/20 , C07D317/24 , C07D239/56 , C07C65/21 , C07D317/18 , C07D317/26 , C07D307/12 , C07C69/78
CPC分类号： C07D403/12 , A61K31/506 , C07C65/21 , C07C69/78 , C07C69/92 , C07D205/04 , C07D239/56 , C07D307/12 , C07D317/18 , C07D317/20 , C07D317/24 , C07D317/26
摘要： There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.

97. 发明授权

US09221783B2 Phenylalkyl sulfamate compound and muscle relaxant composition comprising the same 有权
标题翻译：苯基烷基氨基磺酸酯化合物和包含其的肌肉松弛剂组合物
公开(公告)号：US09221783B2
公开(公告)日：2015-12-29
申请号：US14401990
申请日：2013-06-14
申请人： BIO-PHARM SOLUTIONS CO., LTD.
发明人： Yong Moon Choi
IPC分类号： C07D317/72 , C07D317/18 , C07D317/34
CPC分类号： C07D317/72 , C07D317/18 , C07D317/28 , C07D317/34
摘要： The present invention relates to novel phenylalkyl sulfamate compounds, a method for preventing or treating a disease associated with muscle spasm. The present invention ensures the enhancement of muscle relaxation activity essential for alleviation of muscle spasm, such that it is promising for preventing or treating various diseases associated with muscle spasm.
摘要翻译：本发明涉及新的苯基烷基氨基磺酸酯化合物，一种预防或治疗与肌肉痉挛有关的疾病的方法。本发明确保了肌肉痉挛缓解所必需的肌肉松弛活性的增强，从而有希望预防或治疗与肌肉痉挛有关的各种疾病。

98. 发明授权

US09221782B2 Compound 有权
标题翻译：复合
公开(公告)号：US09221782B2
公开(公告)日：2015-12-29
申请号：US14253288
申请日：2014-04-15
申请人： AstraZeneca AB
发明人： Stephen Connolly , Mark Richard Ebden , Iain Alastair Stewart Walters , Thomas Langer , Alan Robert Steven , Craig Robert Stewart , Paula Margaret Tomlin , Andrew John Williams
IPC分类号： A61K31/506 , C07D317/18 , C07C69/92 , C07D205/04 , C07D317/20 , C07D317/24 , C07D403/12 , C07D239/56 , C07C65/21 , C07D317/26 , C07D307/12 , C07C69/78
CPC分类号： C07D403/12 , A61K31/506 , C07C65/21 , C07C69/78 , C07C69/92 , C07D205/04 , C07D239/56 , C07D307/12 , C07D317/18 , C07D317/20 , C07D317/24 , C07D317/26
摘要： There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.
摘要翻译：提供了化合物，其为（a）式（I）或（b）的嘧啶磺酰胺或其药学上可接受的盐，化合物的结晶形式，获得化合物的方法，用于制备化合物的药物中间体，和含有该化合物的药物组合物。该化合物可用于治疗调节趋化因子受体活性有益的疾病/病症。

99. 发明申请

US20150266848A1 PHENYLALKYL SULFAMATE COMPOUND AND MUSCLE RELAXANT COMPOSITION COMPRISING THE SAME 有权
标题翻译：苯甲酸磺酸盐化合物和包含其的肌松弛组合物
公开(公告)号：US20150266848A1
公开(公告)日：2015-09-24
申请号：US14401990
申请日：2013-06-14
申请人： BIO-PHARM SOLUTIONS CO., LTD.
发明人： Yong Moon Choi
IPC分类号： C07D317/72 , C07D317/34 , C07D317/18
CPC分类号： C07D317/72 , C07D317/18 , C07D317/28 , C07D317/34
摘要： The present invention relates to novel phenylalkyl sulfamate compounds, a method for preventing or treating a disease associated with muscle spasm. The present invention ensures the enhancement of muscle relaxation activity essential for alleviation of muscle spasm, such that it is promising for preventing or treating various diseases associated with muscle spasm.
摘要翻译：本发明涉及新的苯基烷基氨基磺酸酯化合物，一种预防或治疗与肌肉痉挛有关的疾病的方法。本发明确保了肌肉痉挛缓解所必需的肌肉松弛活性的增强，从而有希望预防或治疗与肌肉痉挛有关的各种疾病。

100. 发明授权

US08901165B2 Alkoxylated glycerol acetals and their derivatives 有权
标题翻译：烷氧基化甘油缩醛及其衍生物
公开(公告)号：US08901165B2
公开(公告)日：2014-12-02
申请号：US13499324
申请日：2010-09-23
申请人： Ingo Fleute-Schlachter , Sandra Mack , Peter Kempers , Ulrich Schörken , Eckhard Paetzold , Udo Kragl
发明人： Ingo Fleute-Schlachter , Sandra Mack , Peter Kempers , Ulrich Schörken , Eckhard Paetzold , Udo Kragl
IPC分类号： A01N43/28 , A01N43/32 , C07D319/06 , C07D317/18
CPC分类号： C07D317/18 , A01N43/28 , A01N43/32 , C07D319/06 , C08G65/2606 , C08G2650/44
摘要： Described are alkoxylated glycerol acetals according to Formulas (Ia) and (Ib) wherein R1 represents a linear or branched, saturated or unsaturated and optionally substituted hydrocarbyl residue comprising 6 to 22 carbon atoms and 0 or 1 to 3 double bonds, a benzyl or furfuryl radical, R2 is selected from hydrogen, an alkyl, alkenyl or hydroxyalkyl group having 6 to 22 carbon atoms or an acyl group having 6 to 22 carbon atoms and 0 or 1 to 3 double bonds, AO represents an ethylene oxide, a propylene oxide, a butylene oxide unit, or their mixtures, and n is an integer of about 1 to about 100.
摘要翻译：描述了根据式（Ia）和（Ib）的烷氧基化甘油缩醛，其中R 1表示直链或支链，饱和或不饱和和任选取代的包含6-22个碳原子和0或1至3个双键的烃基，苄基或糠基基团，R 2选自具有6至22个碳原子的烷基，烯基或羟基烷基或具有6至22个碳原子的酰基和0或1至3个双键，AO表示环氧乙烷，环氧丙烷，环氧丁烷单元或其混合物，n为约1至约100的整数。

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