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91. 发明申请

US20160287839A1 Apparatus and Method for Infusing an Immunotherapy Agent to a Solid Tumor for Treatment 审中-公开
标题翻译：用于将免疫治疗剂注射到实体肿瘤用于治疗的装置和方法
公开(公告)号：US20160287839A1
公开(公告)日：2016-10-06
申请号：US15064158
申请日：2016-03-08
申请人： Surefire Medical, Inc.
发明人： David Benjamin Jaroch , James E. Chomas
IPC分类号： A61M25/00 , A61M25/04 , A61L29/04 , A61L29/14 , A61L29/08 , A61L29/06 , A61M25/10 , A61L29/16
CPC分类号： A61M25/0029 , A61F2/013 , A61L29/041 , A61L29/06 , A61L29/08 , A61L29/085 , A61L29/145 , A61L29/16 , A61L2300/426 , A61L2300/608 , A61L2400/10 , A61L2420/02 , A61L2420/08 , A61M25/04 , A61M25/10 , A61M2025/0004 , A61M2025/0042 , A61M2025/0047 , A61M2025/105 , A61M2025/1052 , A61M2202/0007
摘要： An immunotherapy delivery device is provided including a catheter and a pressure modulating device fixed adjacent the distal end of the catheter. In accord with aspects of the device, the lumen of the catheter is coated to facilitate delivery of a healthy immunotherapy agent. A method for delivering an immunotherapy agent to a tumor includes advancing the delivery device into a vessel of a patient, and infusing the agent under pressure into the vessel to penetrate the tumor. The delivery device prevents reflux of the agent toward non-treatment sites.
摘要翻译：提供免疫治疗递送装置，其包括导管和邻近导管远端固定的压力调节装置。根据该装置的方面，涂覆导管的内腔以便于递送健康的免疫治疗剂。用于将免疫治疗剂递送到肿瘤的方法包括将递送装置推进到患者的血管中，并且在压力下将药剂注入血管以穿透肿瘤。递送装置防止药剂向非处理部位的回流。

92. 发明申请

US20160220735A1 RADIOPAQUE, OPTICALLY TRANSLUCENT THERMOPLASTIC COMPOUNDS 有权
标题翻译：放射性，光学透光性热塑性化合物
公开(公告)号：US20160220735A1
公开(公告)日：2016-08-04
申请号：US14916687
申请日：2014-09-08
申请人： POLYONE CORPORATION
发明人： Jack FRAUTSCHI , Jing LIU , Jiannong XU
IPC分类号： A61L29/18 , A61L29/02 , A61L29/06
CPC分类号： A61L29/18 , A61L29/02 , A61L29/06 , A61L2400/12 , C08G2101/00 , C08K3/30 , C08K5/0008 , C08K2201/011 , C08L75/04 , C09J175/04 , G21F1/10
摘要： A radiopaque, optically translucent thermoplastic polyurethane compound is disclosed. The use of nano-sized particles of barium sulfate optionally in combination with a minor amount of certain dispersion aids allows the barium sulfate to be sufficiently dispersed within the thermoplastic polyurethane to retain optical translucency according to a defined Haze Determination Test. Medical devices, needing both visual spectrum observation before and during in-vivo medical use and radiopacity monitoring during in-vivo medical use, benefit from this compound. Optionally, a surface enhancer can also be used.
摘要翻译：公开了不透射线的光学半透明的热塑性聚氨酯化合物。任选地与少量某些分散助剂组合使用硫酸钡的纳米尺寸颗粒允许硫酸钡充分分散在热塑性聚氨酯中以根据所定义的雾度测定试验保持光学半透明度。在体内医疗使用期间和之前需要视觉光谱观察的医疗装置受益于该化合物。任选地，还可以使用表面增强剂。

93. 发明申请

US20160215108A1 NANOSTRUCTURED BACTERIA-RESISTANT POLYMER MATERIALS 审中-公开
标题翻译：纳米结构抗菌聚合物材料
公开(公告)号：US20160215108A1
公开(公告)日：2016-07-28
申请号：US14917138
申请日：2014-09-12
申请人： NORTHEASTERN UNIVERSITY
发明人： Thomas J. WEBSTER
IPC分类号： C08J5/00 , A61L31/14 , B01J3/00 , A61L29/14 , A61L29/06 , C08J3/24 , A01N25/08 , A61L31/10
CPC分类号： C08J5/00 , A01N25/08 , A61L27/50 , A61L29/06 , A61L29/14 , A61L31/10 , A61L31/14 , A61L2400/12 , A61L2400/18 , A61L2420/02 , B01J3/006 , C08J3/24 , C08J2323/06 , C08J2323/12 , C08J2325/06 , C08J2367/04 , C08J2371/10 , C08J2375/04 , C08J2379/04
摘要： Methods for creating nanostructured surface features on polymers and polymer composites involve application of low pressure during curing of solid polymer material from a solvent solution. The resulting nanoscale surface features significantly decrease bacterial growth on the surface. Polymer materials having the nanoscale structuring can be used in implantable medical devices to inhibit bacterial growth and infection.
摘要翻译：在聚合物和聚合物复合材料上形成纳米结构表面特征的方法涉及在固化聚合物材料从溶剂溶液固化过程中施加低压。所得的纳米尺度表面特征显着降低表面上的细菌生长。具有纳米尺度结构的聚合物材料可用于可植入医疗装置中以抑制细菌生长和感染。

94. 发明授权

US09381276B1 Electrochemical disinfection of implanted catheters 有权
公开(公告)号：US09381276B1
公开(公告)日：2016-07-05
申请号：US15070073
申请日：2016-03-15
申请人： SRI INTERNATIONAL , The Board of Trustees of the Leland Stanford Junior University
发明人： Jose P. Joseph , Pablo E. Garcia , Karen F. Shakespear , Sarah Young , Janus A. J. Haagensen , Sanjeev Dutta
IPC分类号： A61L29/06 , A61L29/04 , A61L29/02 , A61L29/12 , A61M25/00
CPC分类号： A61L29/06 , A61L2/03 , A61L29/02 , A61L29/04 , A61L29/041 , A61L29/126 , A61L29/14 , A61L2202/11 , A61L2202/24 , A61L2400/18 , A61M25/0017 , A61M25/0045 , A61M2025/0019 , A61M2025/0056 , A61N1/205
摘要： An implantable catheter is provided that may be disinfected without removal from the body of a patient, using an electrochemical method to generate an electric field on the catheter surface and thus destroy microorganisms in a biofilm that is present or forming. A catheter system includes the implantable catheter and a voltage source that is operably connected to electrodes on or embedded in the exterior and optionally the interior catheter surface. Methods are also provided for disinfecting the implantable catheter in vivo and for detecting or confirming the presence of a pathogenic biofilm thereon.

95. 发明申请

US20160067458A1 BALLOON CATHETER 审中-公开
标题翻译：气球导管
公开(公告)号：US20160067458A1
公开(公告)日：2016-03-10
申请号：US14843249
申请日：2015-09-02
申请人： Abbott Cardiovascular Systems Inc.
发明人： Hector Torres , Bruce Wilson , Thomas Haslinger
IPC分类号： A61M25/10 , A61L29/06
CPC分类号： A61M25/10 , A61L29/06 , A61M25/1034 , A61M2025/0183
摘要： Catheter includes an outer shaft member having a proximal section and a distal outer member. The outer shaft has an inflation lumen defined therethrough. A balloon is in fluid communication with the inflation lumen and has a proximal balloon shaft, a proximal cone portion, a working length, a distal cone portion, and a distal balloon shaft. Catheter also includes a monolithic inner tubular member extending from the outer shaft proximal section through the distal outer member and through the balloon to form a tip. The distal balloon shaft has an inner diameter and comprises a distal seal portion coupled to the inner tubular member and a proximal portion free of attachment to the inner tubular member. The length of the proximal portion of the distal balloon shaft is at least about two times the inner diameter of the distal balloon shaft. Methods of making a catheter are also provided.
摘要翻译：导管包括具有近端部分和远侧外部部件的外部轴部件。外轴具有通过其限定的充气腔。气囊与充气腔流体连通，具有近端球轴，近端锥部，工作长度，远侧锥部和远端球轴。导管还包括从外轴近端部分穿过远端外部构件并且穿过气囊延伸以形成尖端的整体式内部管状构件。远端气球轴具有内径并且包括联接到内部管状构件的远端密封部分和与内部管状构件无关的近端部分。远端球轴的近端部分的长度至少为远侧球囊轴的内径的大约两倍。还提供制造导管的方法。

96. 发明申请

US20160058983A1 Peelable Protective Sheath 审中-公开
标题翻译：剥皮保护护套
公开(公告)号：US20160058983A1
公开(公告)日：2016-03-03
申请号：US14888378
申请日：2014-05-02
申请人： C.R. BARD, INC.
发明人： Rachel Poker , Bruce Asmus
IPC分类号： A61M25/10 , B29C47/00 , A61L29/06 , A61L29/16 , A61L29/08
摘要： A peelable protective sheath and related assemblies/systems and methods are disclosed. The protective sheath may be used on a balloon catheter to protect the balloon and any coating thereon. The protective sheath may be peelable to make removal of the protective sheath easier. The peelable protective sheath may be inserted into a hemostatic valve and introducer while still disposed over the balloon of a balloon catheter to protect the balloon and any bioactive coating thereon from damage during insertion. The peelable protective sheath may be peeled from a proximal end to initiate removal. Alternatively, the peelable protective sheath may be peeled from a distal end of the peelable protective sheath as the balloon catheter is inserted through a hemostatic valve and introducer.
摘要翻译：公开了可剥离的护套和相关组件/系统和方法。护套可用于球囊导管上以保护球囊和其上的任何涂层。护套可以是可剥离的，以便更容易地去除护套。可剥离的护套可以插入止血阀和导引器中，同时仍然设置在球囊导管的球囊上，以保护球囊和其中的任何生物活性涂层免于插入期间的损伤。可剥离的护套可以从近端剥离以开始去除。或者，当球囊导管穿过止血阀和导引器插入时，可剥离的护套可以从可剥离的护套的远端剥离。

97. 发明授权

US09259514B2 Absorbable polymeric blend compositions based on copolymers prepared from mono- and di-functional polymerization initiators, processing methods, and medical devices therefrom 有权
标题翻译：基于由单功能和二官能聚合引发剂，加工方法和医疗装置制备的共聚物的可吸收聚合共混物组合物
公开(公告)号：US09259514B2
公开(公告)日：2016-02-16
申请号：US14571371
申请日：2014-12-16
申请人： Ethicon, Inc.
发明人： Sasa Andjelic , Dennis D. Jamiolkowski , Brian M. Kelly , Christopher DeFelice , Daniel Steiger
IPC分类号： C08G63/91 , A61L31/04 , A61L31/14 , A61L27/18 , A61L29/06 , A61L31/06 , A61L17/12 , C08L67/04 , A61B17/064 , C08G65/32 , A61B17/00
CPC分类号： A61L31/041 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61L17/12 , A61L27/18 , A61L29/06 , A61L31/06 , A61L31/148 , C08G63/664 , C08L67/04 , C08L2205/025 , C08L2205/03
摘要： Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
摘要翻译：公开了由组分制成的新型可吸收聚合物共混物，其中使用单官能和二官能引发剂的混合物合成至少一种组分。共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）均聚物或聚（对 - 二恶烷酮 - 共 - 乙交酯）共聚物。新型聚合物共混物提供具有尺寸稳定性的医疗装置。还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。

98. 发明授权

US09149558B2 Antimicrobial polymer compositions and the use thereof 有权
公开(公告)号：US09149558B2
公开(公告)日：2015-10-06
申请号：US12688435
申请日：2010-01-15
申请人： Modesto Erneta , Robert DiLuccio
发明人： Modesto Erneta , Robert DiLuccio
IPC分类号： A61L17/00 , A01N59/16 , A61L17/10 , A61L24/00 , A61L24/04 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/16 , C08G63/68 , C08G63/91 , C08L67/04 , C08K5/00
CPC分类号： A61L17/005 , A01N59/16 , A61L17/105 , A61L24/0015 , A61L24/046 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/606 , A61L2300/80 , C08G63/681 , C08G63/91 , C08K5/0058 , C08K5/0091 , C08L67/04 , A01N25/10 , C08L2666/54 , A01N2300/00 , C08L67/00
摘要： An antimicrobial composition comprising an ionic complex of an anionic polyester with an antimicrobial metal, wherein the anionic polyester has an ion exchange capacity from about 0.19 meq/g to about 1.0 meq/g.

99. 发明授权

US09095689B2 Non-compliant multilayered balloon for a catheter 有权
标题翻译：用于导管的不符合标准的多层气囊
公开(公告)号：US09095689B2
公开(公告)日：2015-08-04
申请号：US13775724
申请日：2013-02-25
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.
发明人： Jonathan P. Durcan
IPC分类号： A61M31/00 , A61M37/00 , A61M25/10 , A61F2/958 , A61L29/06
CPC分类号： A61M25/1029 , A61F2/958 , A61F2250/0018 , A61F2250/0063 , A61L29/06 , A61M25/10 , A61M25/104 , A61M2025/1075 , A61M2025/1084 , B29C67/0014 , C08L77/00
摘要： Balloon catheter comprises an elongate catheter shaft having a proximal section, a distal section, and an inflation lumen, and a multilayer balloon on the distal section of the shaft. The multilayer balloon comprises a first layer made of a first polymer material having a first Shore durometer hardness, a second layer made of a second polymer material having a second Shore durometer hardness lower than the first shore durometer hardness, wherein the second layer is an inner layer relative to the first layer, and an outer-most layer made of a third polymer material having a third Shore durometer hardness lower than the second Shore durometer hardness.
摘要翻译：气囊导管包括具有近端部分，远侧部分和充气腔的细长导管轴，以及在轴的远侧部分上的多层气囊。多层气囊包括由具有第一肖氏硬度硬度的第一聚合物材料制成的第一层，由第二聚合物材料制成的第二层，其具有低于第一肖氏硬度计硬度的第二肖氏硬度计硬度，其中第二层是内部层和由第三聚合物材料制成的最外层，其具有低于第二肖氏硬度计硬度的第三肖氏硬度计硬度。

100. 发明授权

US09044524B2 Absorbable polyethylene diglycolate copolymers to reduce microbial adhesion to medical devices and implants 有权
标题翻译：可吸收的聚乙二醇二乙酸酯共聚物，以减少微生物对医疗器械和植入物的粘附
公开(公告)号：US09044524B2
公开(公告)日：2015-06-02
申请号：US12609101
申请日：2009-10-30
申请人： Sasa Andjelic , Joerg Priewe
发明人： Sasa Andjelic , Joerg Priewe
IPC分类号： A61L31/06 , C08G63/02 , A61L17/00 , A61L17/12 , A61L26/00 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/06 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61K8/85
CPC分类号： A61L17/005 , A61L17/12 , A61L26/0019 , A61L26/0066 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/06 , A61L29/085 , A61L29/148 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/404 , C08L67/04 , C08L67/00
摘要： The present invention is directed to absorbable polyether esters that have been found to reduce bacterial adhesion to materials such as medical devices and implants. More specifically, the invention is directed to novel amorphous co-polymers comprising polyethylene diglycolate (PEDG) copolymerized with lactide-rich monomers.
摘要翻译：本发明涉及已经被发现可以减少细菌粘附到诸如医疗装置和植入物之类的材料的可吸收的聚醚酯。更具体地，本发明涉及包含与富含丙交酯的单体共聚的聚乙二醇二乙酸酯（PEDG）的新型无定形共聚物。

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