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91. 发明授权

US09474453B2 Measuring blood flow and venous capacitance 有权
标题翻译：测量血流量和静脉电容
公开(公告)号：US09474453B2
公开(公告)日：2016-10-25
申请号：US11662610
申请日：2005-09-15
申请人： Robert P. Schnall
发明人： Robert P. Schnall
IPC分类号： A61B5/02 , A61B5/029 , A61B5/022 , A61B5/00
CPC分类号： A61B5/02241 , A61B5/029 , A61B5/6826 , A61B5/6838 , A61B5/7285 , A61B2560/0261
摘要： Non-invasively measuring a physiological parameter by applying to a subject's body part a venous occlusion plethysmographic device including a first section having a first fluid chamber and at least a second region having a second fluid chamber to engage a first region of the body part and a second region of the body part, proximal of the first region; pressurizing the first chamber to a pressure sufficient to compensate for hydrostatic pressure added to the inherent venous pressure at the maximal vertical lowering level of the body part relative to the subject's heart level; intermittently raising and lowering the pressure in the second fluid chamber to a pressure above or equal to the pressure in the first chamber, but below the arterial blood pressure; measuring changes in volume of the first region of the body part; and utilizing the measured volume changes to provide a measure of the physiological parameter.
摘要翻译：通过向受检者的身体部位施加静脉闭塞体积描记装置，非侵入性地测量生理参数，所述静脉闭塞体积描记装置包括具有第一流体室的第一部分和具有第二流体室的至少第二区域以接合身体部分的第一区域，身体部分的第二区域，第一区域的近侧; 将第一室加压到足以补偿相对于受试者的心脏水平在身体部位的最大垂直降低水平处附加到固有静脉压的静水压力的压力; 间歇地升高和降低第二流体室中的压力至高于或等于第一室中的压力但低于动脉血压的压力; 测量身体部位的第一区域的体积变化; 并且利用所测量的体积变化来提供生理参数的量度。

92. 发明授权

US09462956B2 Calculating heart rate from acceleration signals containing cardiac activity signals 有权
标题翻译：从包含心脏活动信号的加速度信号计算心率
公开(公告)号：US09462956B2
公开(公告)日：2016-10-11
申请号：US14667160
申请日：2015-03-24
申请人： Texas Instruments Incorporated
发明人： Keya R. Pandia , Sourabh Ravindran , Edwin Randolph Cole
IPC分类号： A61B5/029 , A61B5/04 , A61B5/0402 , A61B5/11 , A61B5/00 , A61B7/00
CPC分类号： A61B5/04017 , A61B5/029 , A61B5/0402 , A61B5/1102 , A61B5/113 , A61B5/6831 , A61B5/7207 , A61B5/725 , A61B5/7278 , A61B7/008 , A61B2505/07 , A61B2560/0475 , A61B2562/0219 , A61B2562/028
摘要： A heart monitor includes a single chest accelerometer (210), an analog signal conditioning and sampling section (215) responsive to said accelerometer to produce a digital signal substantially representing acceleration, and a digital processor (220) operable to filter the acceleration signal into a signal affected by body motion and to cancel the body motion signal from the acceleration signal, thereby to produce an acceleration-based cardiac-related signal. Other processes and electronic systems are also disclosed.
摘要翻译：心脏监视器包括单个胸部加速度计（210），响应于所述加速度计的模拟信号调节和采样部分（215）以产生基本上表示加速度的数字信号;以及数字处理器（220），其可操作以将加速度信号滤波为信号受体动作影响，并从加速度信号中取消体动信号，从而产生基于加速度的心脏相关信号。还公开了其它工艺和电子系统。

93. 发明授权

US09408543B1 Non-invasive method and system for characterizing cardiovascular systems for all-cause mortality and sudden cardiac death risk 有权
标题翻译：用于表征全因死亡和心源性猝死风险的心血管系统的非侵入性方法和系统
公开(公告)号：US09408543B1
公开(公告)日：2016-08-09
申请号：US13970582
申请日：2013-08-19
申请人： Analytics For Life
发明人： Sunny Gupta , Mohsen Najafi Yazdi , Timothy William Fawcett Burton , Shyamlal Ramchandani , Derek Vincent Exner
IPC分类号： A61B5/00 , A61B5/04 , A61B5/0205 , A61B5/021 , A61B5/029 , A61B5/044 , A61B5/0468 , A61B5/1455
CPC分类号： A61B5/04012 , A61B5/0205 , A61B5/021 , A61B5/026 , A61B5/029 , A61B5/04001 , A61B5/04011 , A61B5/044 , A61B5/0444 , A61B5/0452 , A61B5/0468 , A61B5/08 , A61B5/14551 , A61B5/14552 , A61B5/4836 , A61B5/7275 , G06F19/00
摘要： Methods and systems for evaluating the electrical activity of the heart to identify novel ECG patterns closely linked to the subsequent development of serious heart rhythm disturbances and fatal cardiac events. Two approaches are describe, for example a model-based analysis and space-time analysis, which are used to study the dynamical and geometrical properties of the ECG data. In the first a model is derived using a modified Matching Pursuit (MMP) algorithm. Various metrics and subspaces are extracted to characterize the risk for serious heart rhythm disturbances, sudden cardiac death, other modes of death, and all-cause mortality linked to different electrical abnormalities of the heart. In the second method, space-time domain is divided into a number of regions (e.g., 12 regions), the density of the ECG signal is computed in each region and input to a learning algorithm to associate them with these events.
摘要翻译：用于评估心脏电活动的方法和系统，以识别与随后发展的严重心律紊乱和致命性心脏事件密切相关的新型心电图。描述了两种方法，例如用于研究ECG数据的动力学和几何特性的基于模型的分析和时空分析。在第一个模型是使用修改匹配追求（MMP）算法导出的。提取各种指标和子空间，以表征严重心律紊乱，心源性猝死，其他死亡模式以及与心脏不同电异常相关的全因死亡的风险。在第二种方法中，空时域被划分成多个区域（例如，12个区域），在每个区域中计算ECG信号的密度并输入到学习算法以将它们与这些事件相关联。

94. 发明授权

US09380947B2 Method and system for monitoring hemodynamics 有权
标题翻译：监测血液动力学的方法和系统
公开(公告)号：US09380947B2
公开(公告)日：2016-07-05
申请号：US14235101
申请日：2012-07-25
申请人： Baruch Levy , Shmuel Marcovitch , Eliezer Shusman , David Rotenberg , Dan Avidor , Yoav Avidor
发明人： Baruch Levy , Shmuel Marcovitch , Eliezer Shusman , David Rotenberg , Dan Avidor
IPC分类号： A61B5/02 , A61B5/029 , A61B5/00 , A61B5/0402 , A61B5/053 , A61B5/024
CPC分类号： A61B5/0205 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/026 , A61B5/029 , A61B5/0402 , A61B5/0452 , A61B5/053 , A61B5/14535 , A61B5/412 , A61B5/4818 , A61B5/4836 , A61B5/4875 , A61B5/7228 , A61B5/7239 , A61B8/065
摘要： A system for monitoring hemodynamics of a subject is disclosed. The system comprises: a signal generating system configured for providing at least an output electric signal and transmitting the output signal to an organ of the subject. The system also comprises a demodulation system configured for receiving an input electrical signal sensed from the organ responsively to the output electric signal, and for modulating the input signal using the output signal to provide an in-phase component and a quadrature component of the input signal. The system also comprises a processing system configured for monitoring the hemodynamics based on the in-phase and the quadrature components.
摘要翻译：公开了一种用于监测受试者血液动力学的系统。该系统包括：信号发生系统，被配置为至少提供一个输出电信号并将该输出信号发送到该对象的器官。该系统还包括解调系统，被配置为响应于输出电信号接收从机构感测的输入电信号，并且使用输出信号调制输入信号，以提供输入信号的同相分量和正交分量。该系统还包括配置成基于同相和正交分量来监测血流动力学的处理系统。

95. 发明授权

US09375160B2 Systems and methods for model-based estimation of cardiac output and total peripheral resistance 有权
标题翻译：用于基于模型估计心输出量和总体外周阻力的系统和方法
公开(公告)号：US09375160B2
公开(公告)日：2016-06-28
申请号：US13607924
申请日：2012-09-10
申请人： Tushar A. Parlikar , Gireeja V. Ranade , Thomas Heldt , George C. Verghese
发明人： Tushar A. Parlikar , Gireeja V. Ranade , Thomas Heldt , George C. Verghese
IPC分类号： A61B5/02 , A61B5/029 , A61B5/021 , A61B5/024
CPC分类号： A61B5/029 , A61B5/02007 , A61B5/021 , A61B5/02405
摘要： The methods and systems for estimating cardiac output and total peripheral resistance include observing arterial blood pressure waveforms to determine intra-beat and inter-beat variability in arterial blood pressure and estimating from the variability a time constant for a lumped parameter beat-to-beat averaged Windkessel model of the arterial tree. Uncalibrated cardiac output and uncalibrated total peripheral resistance may then be calculated from the time constant. Calibrated cardiac output and calibrated total peripheral resistance may be computed using calibration data, assuming an arterial compliance that is either constant or dependent on mean arterial blood pressure. The parameters of the arterial compliance may be estimated in a least-squares manner.
摘要翻译：用于估计心输出量和总体外周阻力的方法和系统包括观察动脉血压波形以确定动脉血压中的搏动内和搏动间差异变化，并从可变性估计集中参数搏动到搏动的平均时间常数 Windkessel模型的动脉树。然后可以从时间常数计算未校准的心输出量和未校准的总外围电阻。可以使用校准数据计算校准的心输出量和校准的总外周电阻，假设动脉顺应性是恒定的或取决于平均动脉血压。可以以最小二乘法估计动脉顺应性的参数。

96. 发明申请

US20160085930A1 SYSTEM AND METHOD OF INTERACTIVE NAVIGATION OF SUBJECT'S TREATMENT 审中-公开
标题翻译：主治医师交互导航的系统与方法
公开(公告)号：US20160085930A1
公开(公告)日：2016-03-24
申请号：US14857891
申请日：2015-09-18
申请人： New N.I. Medical (2011) LTD
发明人： Igor GRANOV , Aviad LIVNEH
IPC分类号： G06F19/00 , A61B5/029 , A61B5/107 , A61B5/021
CPC分类号： G16H50/20 , A61B5/021 , A61B5/024 , A61B5/029 , A61B5/107 , G06F19/00 , G16H10/60 , G16H40/63
摘要： System and method for monitoring a subject's condition. The system comprises a data input utility for receiving medical data indicative of a first condition of a subject; a communication utility for obtaining reference data comprising at least two predefined multi-dimensional functions and a multi-parameter space within said functions corresponding to a normal condition of a subject; a processing utility for processing said medical data of a subject by identifying a plurality of individual medical parameters describing said at least two predefined multi-dimensional functions, analyzing the identified plurality of individual parameters and determining a relation between the parameters and said multi-parameter space, for determining a treatment plan for navigating the subject from said first condition to a second subject condition in which values of said plurality of medical parameters define a parametric space matching the multi-parameter space of the normal condition; and an output utility for outputting said treatment plan.
摘要翻译：用于监测受试者状况的系统和方法。该系统包括用于接收指示对象的第一状况的医疗数据的数据输入实用程序; 用于获得包括至少两个预定义多维函数的参考数据的通信实用程序和对应于对象的正常状态的所述功能内的多参数空间; 一种处理实用程序，用于通过识别描述所述至少两个预定义多维功能的多个单独的医学参数来处理对象的所述医学数据，分析所识别的多个个体参数并确定参数与所述多参数空间之间的关系用于确定用于将所述对象从所述第一状态导航到第二主题条件的治疗计划，其中所述多个医学参数的值定义与所述正常条件的多参数空间匹配的参数空间; 以及用于输出所述治疗计划的输出实用程序。

97. 发明申请

US20160073991A1 METHOD AND SYSTEM FOR IMAGE PROCESSING AND PATIENT-SPECIFIC MODELING OF BLOOD FLOW 审中-公开
公开(公告)号：US20160073991A1
公开(公告)日：2016-03-17
申请号：US14952154
申请日：2015-11-25
申请人： HeartFlow, Inc.
发明人： Charles A. Taylor
IPC分类号： A61B6/00 , A61B5/026 , A61B5/029 , G06T17/00 , A61B5/00 , A61B5/02 , G06T7/00 , A61B6/03 , A61B5/021
CPC分类号： A61B34/10 , A61B5/0035 , A61B5/004 , A61B5/0044 , A61B5/02 , A61B5/02007 , A61B5/02028 , A61B5/021 , A61B5/024 , A61B5/026 , A61B5/0263 , A61B5/029 , A61B5/055 , A61B5/1075 , A61B5/1118 , A61B5/22 , A61B5/4848 , A61B5/6852 , A61B5/7246 , A61B5/7275 , A61B5/7278 , A61B5/745 , A61B6/03 , A61B6/032 , A61B6/481 , A61B6/503 , A61B6/504 , A61B6/507 , A61B6/5205 , A61B6/5217 , A61B6/5229 , A61B8/02 , A61B8/04 , A61B8/06 , A61B8/065 , A61B8/481 , A61B8/5223 , A61B8/5261 , A61B34/25 , A61B2034/104 , A61B2034/105 , A61B2034/107 , A61B2034/108 , A61B2090/374 , A61B2090/3762 , A61B2090/3764 , A61B2576/00 , A61B2576/023 , A61M5/007 , G01R33/5601 , G01R33/5635 , G01R33/56366 , G06F17/10 , G06F17/5009 , G06F17/5018 , G06F19/00 , G06F19/12 , G06F19/26 , G06F19/321 , G06F19/324 , G06G7/60 , G06K9/00147 , G06K9/46 , G06K9/4604 , G06K9/52 , G06K9/6215 , G06K9/6267 , G06K9/6298 , G06K2009/4666 , G06T7/0012 , G06T7/0014 , G06T7/11 , G06T7/12 , G06T7/13 , G06T7/149 , G06T7/20 , G06T7/60 , G06T7/62 , G06T7/70 , G06T7/73 , G06T7/74 , G06T11/00 , G06T11/001 , G06T11/008 , G06T11/20 , G06T11/60 , G06T15/10 , G06T17/00 , G06T17/005 , G06T17/20 , G06T2200/04 , G06T2207/10012 , G06T2207/10072 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/20036 , G06T2207/20124 , G06T2207/30048 , G06T2207/30104 , G06T2210/41 , G06T2211/404 , G16H10/40 , G16H10/60 , G16H30/20 , G16H30/40 , G16H50/30 , G16H50/50 , Y02A90/22 , Y02A90/26
摘要： Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

98. 发明授权

US09282906B2 Blood volume measuring method and blood volume measuring apparatus 有权
标题翻译：血量测量方法和血容量测量仪
公开(公告)号：US09282906B2
公开(公告)日：2016-03-15
申请号：US12878336
申请日：2010-09-09
申请人： Yoshihiro Sugo , Mitsushi Hyogo
发明人： Yoshihiro Sugo , Mitsushi Hyogo
IPC分类号： A61B5/026 , A61B5/029 , A61B5/0225 , A61B5/0285
CPC分类号： A61B5/029 , A61B5/02255 , A61B5/0285
摘要： A blood volume measuring method, apparatus and program for removing an artifact when used in an apparatus for analyzing respiratory variation of the stroke volume of a patient in order to determine the fluid response of the patient or adequately set artificial ventilation is provided.
摘要翻译：提供了用于在用于分析患者的行程容积的呼吸变化的装置中用于去除伪影的血液量测量方法，装置和程序，以便确定患者的流体响应或适当地设置人造通气。

99. 发明申请

US20160066861A1 METHOD AND SYSTEM FOR QUANTIFYING LIMITATIONS IN CORONARY ARTERY BLOOD FLOW DURING PHYSICAL ACTIVITY IN PATIENTS WITH CORONARY ARTERY DISEASE 有权
标题翻译：冠状动脉疾病患者身体活动期间冠状动脉血流量限制的方法和系统
公开(公告)号：US20160066861A1
公开(公告)日：2016-03-10
申请号：US14481037
申请日：2014-09-09
申请人： HeartFlow, Inc.
发明人： Charles A. TAYLOR
IPC分类号： A61B5/00 , A61B5/021 , G06F19/00 , A61B5/029
CPC分类号： A61B5/7275 , A61B5/0044 , A61B5/021 , A61B5/029 , A61B2576/023 , G06F19/00 , G16H50/30 , G16H50/50 , Y02A90/26
摘要： Embodiments include a system for determining cardiovascular information for a patient with coronary artery disease. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create, for a given level of physical activity, a physics-based model of blood flow through the patient's heart simulated during a selected level of physical activity; determine and normalize one or more values of at least one blood flow characteristic within the patient's heart during the simulated level of physical activity; and compare the one or more normalized values of the at least one blood flow characteristic to a threshold to determine whether the level of physical activity exceeds an acceptable level of risk.
摘要翻译：实施例包括用于确定患有冠状动脉疾病的患者的心血管信息的系统。该系统可以包括至少一个计算机系统，其被配置为接收关于患者心脏的几何形状的患者特定数据，并且基于患者特定数据创建表示患者心脏的至少一部分的模型。所述至少一个计算机系统可以进一步配置为针对给定水平的身体活动，在所选择的身体活动水平期间模拟通过患者心脏的基于物理学的基于物理的模型; 在模拟的身体活动水平期间确定和归一化患者心脏内的至少一个血流特性的一个或多个值; 并且将所述至少一个血流特征的一个或多个归一化值与阈值进行比较，以确定身体活动的水平是否超过可接受的风险水平。

100. 发明授权

US09271657B2 Method and system for patient-specific modeling of blood flow 有权
公开(公告)号：US09271657B2
公开(公告)日：2016-03-01
申请号：US14222439
申请日：2014-03-21
申请人： HeartFlow, Inc.
发明人： Charles A. Taylor
IPC分类号： G06F19/00 , G06K9/00 , G06K9/20 , G06K9/36 , A61B5/02 , A61B5/026 , G06G7/60 , G06F19/26 , A61B5/00 , A61B5/029 , A61B6/03 , A61B6/00 , A61B8/06 , A61B8/08 , G01R33/563 , A61B5/107 , G06T7/00 , G06T17/00 , G06K9/62 , A61B5/021 , G06F17/50 , G06F19/12 , A61B5/024 , A61B5/22 , A61B19/00
CPC分类号： A61B34/10 , A61B5/0035 , A61B5/004 , A61B5/0044 , A61B5/02 , A61B5/02007 , A61B5/02028 , A61B5/021 , A61B5/024 , A61B5/026 , A61B5/0263 , A61B5/029 , A61B5/055 , A61B5/1075 , A61B5/1118 , A61B5/22 , A61B5/4848 , A61B5/6852 , A61B5/7246 , A61B5/7275 , A61B5/7278 , A61B5/745 , A61B6/03 , A61B6/032 , A61B6/481 , A61B6/503 , A61B6/504 , A61B6/507 , A61B6/5205 , A61B6/5217 , A61B6/5229 , A61B8/02 , A61B8/04 , A61B8/06 , A61B8/065 , A61B8/481 , A61B8/5223 , A61B8/5261 , A61B34/25 , A61B2034/104 , A61B2034/105 , A61B2034/107 , A61B2034/108 , A61B2090/374 , A61B2090/3762 , A61B2090/3764 , A61B2576/00 , A61B2576/023 , A61M5/007 , G01R33/5601 , G01R33/5635 , G01R33/56366 , G06F17/10 , G06F17/5009 , G06F17/5018 , G06F19/00 , G06F19/12 , G06F19/26 , G06F19/321 , G06F19/324 , G06G7/60 , G06K9/00147 , G06K9/46 , G06K9/4604 , G06K9/52 , G06K9/6215 , G06K9/6267 , G06K9/6298 , G06K2009/4666 , G06T7/0012 , G06T7/0014 , G06T7/11 , G06T7/12 , G06T7/13 , G06T7/149 , G06T7/20 , G06T7/60 , G06T7/62 , G06T7/70 , G06T7/73 , G06T7/74 , G06T11/00 , G06T11/001 , G06T11/008 , G06T11/20 , G06T11/60 , G06T15/10 , G06T17/00 , G06T17/005 , G06T17/20 , G06T2200/04 , G06T2207/10012 , G06T2207/10072 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/20036 , G06T2207/20124 , G06T2207/30048 , G06T2207/30104 , G06T2210/41 , G06T2211/404 , G16H10/40 , G16H10/60 , G16H30/20 , G16H30/40 , G16H50/30 , G16H50/50 , Y02A90/22 , Y02A90/26
摘要： Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

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