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91. 发明授权

US09029338B2 Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus 有权
标题翻译：脂质配制的组合物和抑制基因从埃博拉病毒表达的方法
公开(公告)号：US09029338B2
公开(公告)日：2015-05-12
申请号：US13390095
申请日：2010-08-13
申请人： Antonin de Fougerolles , Anna Borodovsky , Tatiana Novobrantseva
发明人： Antonin de Fougerolles , Anna Borodovsky , Tatiana Novobrantseva
IPC分类号： A01N43/04 , C07H21/02 , A61K48/00
CPC分类号： A61K48/0075 , A61K47/22 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/32
摘要： The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.
摘要翻译：本发明涉及用于抑制埃博拉病毒基因表达的脂质配制双链核糖核酸（dsRNA）。

92. 发明授权

US09023827B2 Active ingredient with cutaneous application obtained from metschnikowia agaves and uses for improving the state of the skin 有权
标题翻译：具有皮肤应用的活性成分，从美斯康氏菌中获得，并用于改善皮肤状态
公开(公告)号：US09023827B2
公开(公告)日：2015-05-05
申请号：US13859771
申请日：2013-04-10
申请人： Societe Industrielle Limousine d'Application Biologique
发明人： Jean Paufique
IPC分类号： A01N43/04 , A61K31/715 , A61K8/60 , A61Q19/08 , C07H3/06 , A61K8/99 , A61K8/73
CPC分类号： A61K8/60 , A61K8/736 , A61K8/99 , A61Q19/08 , C07H3/06
摘要： An active ingredient with cutaneous application obtained from Metschnikowia agaves, as well as its use for preventing and/or combating ageing of the skin and its visible manifestations, and cosmetic compositions including this active ingredient and to a cosmetic process for skin care.
摘要翻译：从Metschnikowia龙舌兰获得的具有皮肤应用的活性成分，以及其用于预防和/或防治皮肤老化和其可见表现的用途，以及包含该活性成分的化妆品组合物和用于皮肤护理的美容方法。

93. 发明授权

US09018178B2 Method for the treatment of food, feed and agricultural products with a polyene antifungal compound 有权
标题翻译：用多烯抗真菌化合物处理食品，饲料和农产品的方法
公开(公告)号：US09018178B2
公开(公告)日：2015-04-28
申请号：US12669617
申请日：2008-07-17
申请人： Pim Van Hee , Laurentius Cornelis Adrianus Van Santen , John Mark Faragher
发明人： Pim Van Hee , Laurentius Cornelis Adrianus Van Santen , John Mark Faragher
IPC分类号： A01N43/04 , A61K31/70 , A01N43/02 , A61K31/335 , A01N43/90
CPC分类号： A01N43/90 , A01N25/10 , A01N37/36 , A01N2300/00
摘要： The present invention provides an aqueous antifungal composition comprising a polyene antifungal compound and a thickening agent. The composition can be used in the protection against the development of fungi on food, feed and agricultural products.
摘要翻译：本发明提供含有多烯抗真菌化合物和增稠剂的含水抗真菌组合物。该组合物可用于防止食品，饲料和农产品上的真菌发展。

94. 发明授权

US08951565B2 Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as chitosan 有权
公开(公告)号：US08951565B2
公开(公告)日：2015-02-10
申请号：US14255297
申请日：2014-04-17
申请人： HemCon Medical Technologies, Inc.
发明人： Simon J. McCarthy
IPC分类号： A61K9/14 , A61K9/50 , A01N43/04 , C08B37/08 , F26B5/06 , F26B5/14 , A61L26/00 , A61L15/28
CPC分类号： A61L26/0023 , A61L15/28 , A61L26/0061 , A61L2400/04 , Y10T428/2982 , C08L5/08
摘要： Improved hemostatic agents take the form of granules or particles that can be used to stanch, seal, or stabilize a site of hemorrhage, including a noncompressible hemorrhage.

95. 发明授权

US08946188B2 Anti-microbial agents and uses thereof 有权
标题翻译：抗微生物剂及其用途
公开(公告)号：US08946188B2
公开(公告)日：2015-02-03
申请号：US13897807
申请日：2013-05-20
申请人： Sloan-Kettering Institute for Cancer Research , Cornell Research Foundation, Inc.
发明人： Derek Shieh Tan , Luis E. N. Quadri , Jae-Sang Ryu , Justin Scott Cisar , Julian Alberto Ferreras , Xuequan Lu
IPC分类号： A01N43/04 , A61K31/70 , C07H19/24 , C07H19/00 , C07H19/22
CPC分类号： C07H19/24 , C07H19/00 , C07H19/22
摘要： Many pathogens, including Mycobacterium tuberculosis and Yersinia pestis, rely on an iron acquisition system based on siderophores, secreted iron-chelating compounds with extremely high Fe(III) affinity. The compounds of the invention are inhibitors of domain salicylation enzymes, which catalyze the salicylation of an aroyl carrier protein (ArCP) domain to form a salicyl-ArCP domain thioester intermediate via a two-step reaction. The compounds include the intermediate mimic 5′-O—[N-(salicyl)sulfamoyl]-adenosine (salicyl-AMS) and analogs thereof. These compounds are inhibitors of the salicylate activity of MbtA, YbtE, PchD, and other domain salicylation enzymes involved in the biosynthesis of siderophores. Therefore, these compounds may be used in the treatment of infection caused by microorganisms which rely on siderphore-based iron acquisition systems. Pharmaceutical composition and methods of using these compounds to treat or prevent infection are also provided as well as methods of preparing the inventive compounds.
摘要翻译：许多病原体，包括结核分枝杆菌和鼠疫耶尔森氏菌，依赖于铁铁捕获系统，其基于铁载体，具有极高Fe（III）亲和力的分泌铁螯合化合物。本发明的化合物是结构域水解酶的抑制剂，其催化芳酰基载体蛋白（ArCP）结构域的水杨酸化以通过两步反应形成水杨酰-ArCP结构域的硫酯中间体。所述化合物包括中间体模拟5'-O- [N-（水杨基）氨磺酰基] - 腺苷（水杨基-AMS）及其类似物。这些化合物是参与铁载体生物合成的MbtA，YbtE，PchD和其他结构域水杨酸酶的水杨酸盐活性的抑制剂。因此，这些化合物可用于治疗由依赖于白藜芦醇的铁采集系统的微生物引起的感染。还提供了使用这些化合物治疗或预防感染的药物组合物和方法以及制备本发明化合物的方法。

96. 发明授权

US08926985B2 Vaccine 有权
公开(公告)号：US08926985B2
公开(公告)日：2015-01-06
申请号：US12612988
申请日：2009-11-05
申请人： Carine Capiau , Marguerite Deschamps , Pierre Michel Desmons , Craig Antonyjoseph Laferriere , Jan Poolman , Jean-Paul Prieels
发明人： Carine Capiau , Marguerite Deschamps , Pierre Michel Desmons , Craig Antonyjoseph Laferriere , Jan Poolman , Jean-Paul Prieels
IPC分类号： A61K39/385 , A61K39/116 , A61K39/00 , A61K39/02 , A61K39/09 , A61K39/102 , A01N43/04 , C07H1/00 , A61K39/095 , A61K39/155
CPC分类号： A61K47/4833 , A61K39/092 , A61K39/095 , A61K39/102 , A61K39/12 , A61K39/155 , A61K47/646 , A61K2039/55505 , A61K2039/55572 , A61K2039/6037 , A61K2039/6068 , A61K2039/6075 , A61K2039/70 , Y02A50/414 , Y02A50/484 , Y10S424/831
摘要： The present invention relates to the field of bacterial polysaccharide antigen vaccines. In particular, the present invention relates to bacterial polysaccharides conjugated to protein D from H. influenzae.

97. 发明授权

US08916532B2 Methods for enhancing utrophin production via inhibition of microRNA 有权
标题翻译：通过抑制microRNA增强utrophin产生的方法
公开(公告)号：US08916532B2
公开(公告)日：2014-12-23
申请号：US12989758
申请日：2009-04-27
申请人： Catherine Moorwood , Utpal Basu , Gopal Patel , Olga Lozynska , Tejvir S. Khurana
发明人： Catherine Moorwood , Utpal Basu , Gopal Patel , Olga Lozynska , Tejvir S. Khurana
IPC分类号： A01N43/04 , C12N15/00 , C07H21/04
CPC分类号： C12N15/113 , C07K14/4708 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2320/30
摘要： This invention provides a method for enhancing utrophin protein production in a cell by inhibiting an utrophin microRNA molecule. Moreover, the invention provides that methods for enhancing utrophin protein production in a muscle cell are used for treating a muscular dystrophy and/or other myopathies.
摘要翻译：本发明提供了通过抑制utrophin微小RNA分子来增强细胞中utrophin蛋白质产生的方法。此外，本发明提供了用于增强肌肉细胞中的utrophin蛋白质产生的方法用于治疗肌营养不良症和/或其它肌病。

98. 发明授权

US08916530B2 Individualized cancer therapy 有权
公开(公告)号：US08916530B2
公开(公告)日：2014-12-23
申请号：US12609462
申请日：2009-10-30
申请人： David Shanahan , John Nemunaitis , Neil Senzer , Phillip Maples , Donald Rao
发明人： David Shanahan , John Nemunaitis , Neil Senzer , Phillip Maples , Donald Rao
IPC分类号： A01N43/04 , A61K31/713 , C12N15/113 , C07H21/04
CPC分类号： C12N15/1135 , A61K9/1273 , A61K9/513 , A61K31/7105 , A61K31/713 , A61K48/00 , A61K48/005 , C12N2310/14 , C12N2310/531 , C12N2320/32 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57496 , G01N2800/52
摘要： In certain embodiments, the invention provides methods for treating cancer, comprising: (a) obtaining a specimen of cancer tissue and normal tissue from a patient; (b) extracting total protein and RNA from the cancer tissue and normal tissue; (c) obtaining a protein expression profile of the cancer tissue and normal tissue; (d) identifying over-expressed proteins in the cancer tissue; (e) comparing the protein expression profile to a gene expression profile; (f) identifying at least one prioritized protein target by assessing connectivity of each said over-expressed protein to other cancer-related or stimulatory proteins; (g) designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding the prioritized target protein; (h): designing a first RNA interference expression cassette to modulate the expression of at least one gene encoding a protein of higher priority in the signaling pathway in which the first protein is a component; (i) incorporating the first cassette into a first delivery vehicle; (j) providing a patient with an effective amount of the first delivery vehicle; (k) extracting total protein and RNA from the treated cancer tissue; (l) identifying over-expressed proteins in the treated cancer tissue; (m) designing a second RNA interference expression cassette to modulate the expression of a second prioritized protein in the treated tissue; (n) incorporating the second cassette into a second delivery vehicle; (o) providing the previously treated patient with an effective amount of the second delivery vehicle; (p) identifying a novel protein signal following prior treatment with protein specific knockdown; (q) identifying a gene mutation provided by gene sequencing/microarray on assessment of other protein signals; and (r) identifying of a novel protein signal as a result of determination of the gene mutation and assessment of other protein signals to, directly or indirectly, modify the expression (i.e., production) of such proteins.

99. 发明授权

US08912161B2 MicroRNA compounds and methods for modulating miR-21 activity 有权
标题翻译：微RNA化合物和调节miR-21活性的方法
公开(公告)号：US08912161B2
公开(公告)日：2014-12-16
申请号：US14444406
申请日：2014-07-28
申请人： Regulus Therapeutics, Inc.
发明人： Balkrishen Bhat
IPC分类号： C12N15/113 , A01N43/04
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/3231 , C12N2310/343 , C12N2310/35
摘要： Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield potent inhibitors of miR-21 activity. The compositions may be used to inhibit miR-21, and also to treat diseases associated with abnormal expression of miR-21, such as fibrosis and cancer.
摘要翻译：本文描述了抑制miR-21活性的组合物和方法。该组合物具有产生miR-21活性的有效抑制剂的某些核苷修饰模式。该组合物可用于抑制miR-21，并且还可用于治疗与miR-21异常表达相关的疾病，如纤维化和癌症。

100. 发明授权

US08900871B2 Method of producing induced pluripotent stem cells using inhibitors of P53 有权
标题翻译：使用P53抑制剂产生诱导多能干细胞的方法
公开(公告)号：US08900871B2
公开(公告)日：2014-12-02
申请号：US13389359
申请日：2010-08-06
申请人： Keisuke Okita , Masato Nakagawa , Shinya Yamanaka
发明人： Keisuke Okita , Masato Nakagawa , Shinya Yamanaka
IPC分类号： C12N15/00 , A01N43/04
CPC分类号： C12N15/85 , C12N5/0696 , C12N2501/40 , C12N2501/48 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/608 , C12N2502/13 , C12N2506/1361 , C12N2510/00 , C12N2800/108 , C12N2800/30
摘要： Provided is a method of producing an iPS cell, comprising bringing (a) Oct3/4 or a nucleic acid that encodes the same, (b) Klf4 or a nucleic acid that encodes the same, and (c) Sox2 or a nucleic acid that encodes the same, as well as (d1) L-Myc or a nucleic acid that encodes the same and/or (d2) a functional inhibitor of p53, into contact with a somatic cell. It is preferable that (a) a nucleic acid that encodes Oct3/4, (b) a nucleic acid that encodes Klf4, (c) a nucleic acid that encodes Sox2, (d1) a nucleic acid that encodes L-Myc and (e) a nucleic acid that encodes Lin28 or Lin28b be inserted into an episomal vector having loxP sequences placed in the same orientation on the 5′ and 3′ sides of a vector constituent essential for the replication of the vector, that (d2) a nucleic acid that encodes an shRNA against p53 be inserted into a vector ensuring transient expression (plasmid vector and the like), and that all these nucleic acids be transferred to a somatic cell.
摘要翻译：本发明提供一种iPS细胞的制造方法，其特征在于：（a）Oct3 / 4或其编码的核酸，（b）Klf4或其编码的核酸，以及（c）Sox2或所述核酸，编码相同的，以及（d1）L-Myc或编码与p53的功能性抑制剂相同和/或（d2）的核酸与体细胞接触。优选（a）编码Oct3 / 4的核酸，（b）编码Klf4的核酸，（c）编码Sox2的核酸，（d1）编码L-Myc的核酸和（e ）将编码Lin28或Lin28b的核酸插入具有放置在与载体复制必需的载体成分的5'和3'侧相同取向上的loxP序列的附加型载体中，（d2）核酸将编码针对p53的shRNA插入到确保瞬时表达（质粒载体等）的载体中，并将所有这些核酸转移到体细胞。

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