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91. 发明申请

US20170009218A1 MODIFIED ALPHA-GLUCOSIDASE AND APPLICATIONS OF SAME 审中-公开
标题翻译：改良的ALPHA-GLUCOSIDASE及其应用
公开(公告)号：US20170009218A1
公开(公告)日：2017-01-12
申请号：US15278556
申请日：2016-09-28
申请人： Amano Enzyme Inc.
发明人： Satoru Ishihara
IPC分类号： C12N9/26 , C12P19/16 , C12P19/04 , C12P19/20
CPC分类号： C12N9/2408 , C12N9/1051 , C12N9/2428 , C12P19/04 , C12P19/16 , C12P19/18 , C12P19/20 , C12Y302/0102 , Y02P20/52
摘要： The object is to provide an α-glucosidase in which a transglycosylation activity predominates, and use thereof, and the like. A modified α-glucosidase consisting of an amino acid sequence in which one or two or more of the amino acid(s) is selected from a group of specific amino acids.
摘要翻译：本发明的目的是提供其中转糖基活性占优势的α-葡糖苷酶及其用途等。由氨基酸序列组成的修饰的α-葡糖苷酶，其中一个或两个或更多个氨基酸选自特定氨基酸的组。

92. 发明申请

US20170000860A1 ULTRAPURE HYPOALLERGENIC SOLUTIONS OF SACROSIDASE 有权
标题翻译：超氧化物歧化酶的超低氧解决方案
公开(公告)号：US20170000860A1
公开(公告)日：2017-01-05
申请号：US15270970
申请日：2016-09-20
申请人： QOL Medical LLC
发明人： Dayton T. Reardan , Christopher Seekamp
IPC分类号： A61K38/47 , C12N9/26
CPC分类号： A61K38/47 , A61K38/00 , A61P1/14 , C12N9/2402 , C12N9/2405 , C12N9/2431 , C12Y302/0101 , C12Y302/01026 , C12Y304/22002
摘要： One aspect provides an ultrapure, hypoallergenic sacrosidase. Another aspect provides a solution of sacrosidase in about 1:1 glycerol/water having an enzymatic activity of at least about 7500 IU/mL and a residual papain concentration that does not include an allergic reaction in a human patient when given a dose of about 2.0 mL/day.
摘要翻译：一方面提供了超纯，低过敏性的神经酰胺酶。另一方面提供了约1：1甘油/水中的神经酰胺酶溶液，其具有至少约7500IU / mL的酶活性和当给予约2.0剂量时在人类患者中不包括过敏反应的残留木瓜蛋白酶浓度 mL /天。

93. 发明申请

US20160355749A1 PROCESS FOR EXTRACTING LIPIDS FOR USE IN PRODUCTION OF BIOFUELS 审中-公开
标题翻译：用于生产生物燃料的提取脂肪的方法
公开(公告)号：US20160355749A1
公开(公告)日：2016-12-08
申请号：US15106752
申请日：2014-12-18
申请人： Kirk APT , William BARCLAY , Micah BLAZER , Jacob BORDEN , Adam BURJA , Daniel Dong , Armando DURAZO , Jean-Charles DUMENIL , Arthur EDGE , Jon HANSEN , Alexandra HOFLER , David JEFFERS , Chris LYON , Vidya PAI , Joseph William PFEIFER, III , Martin J. SELLERS , Ginger SHANK , Justin STEGE
发明人： Kirk APT , William BARCLAY , Micah BLAZER , Jacob BORDEN , Adam BURJA , Daniel Dong , Armando DURAZO , Jean-Charles DUMENIL , Arthur EDGE , Jon HANSEN , Alexandra HOFLER , David JEFFERS , Chris LYON , Vidya PAI , Joseph William PFEIFER, III , Martin J. SELLERS , Ginger SHANK , Justin STEGE
IPC分类号： C11B1/02 , C12N9/26 , C12P7/64 , C11B1/10 , C12N1/06 , C10L1/02 , C12N9/24
CPC分类号： C11B1/025 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C11B1/10 , C11B1/12 , C12N1/063 , C12N1/066 , C12N9/2411 , C12N9/2414 , C12N9/2488 , C12P7/6463 , C12Y302/01001 , Y02E50/343
摘要： Methods and systems used to extract lipids suitable in production of biofuels from a fermentation broth may include using heat to pre-treat the fermentation broth in order to more easily extract a product from oleaginous microorganisms in the broth. Additionally or alternatively, a combination of enzymes including amylase, 1-4 mannosidase, and 1-3 mannosidase may be used to break down cell walls of the oleaginous microorganisms. Residual broth water may be recycled and used as imbibition water for washing a process feedstock to extract sugar.
摘要翻译：用于提取适合于从发酵液生产生物燃料的脂质的方法和系统可包括使用热来预处理发酵液，以便更容易地从肉汤中的含油微生物中提取产物。另外或替代地，可以使用包括淀粉酶，1-4甘露糖苷酶和1-3甘露糖苷酶的酶的组合来分解含油微生物的细胞壁。残余肉汤水可以循环使用，并用作洗涤水以洗涤工艺原料以提取糖。

94. 发明授权

US09506047B2 Alpha-amylases 有权
公开(公告)号：US09506047B2
公开(公告)日：2016-11-29
申请号：US14696979
申请日：2015-04-27
申请人： NOVOZYMES A/S
发明人： Carsten Andersen , Thomas Agersten Poulsen
IPC分类号： C12N9/26 , C12N9/28 , C11D3/386 , C12P19/04 , C12P19/14 , C12P7/06 , C12P7/14 , C12P19/02
CPC分类号： C12N9/2417 , C11D3/386 , C11D3/38681 , C12N9/2414 , C12N15/8257 , C12P7/06 , C12P7/14 , C12P19/02 , C12P19/04 , C12P19/14 , C12P2203/00 , C12Y302/01001 , Y02E50/17
摘要： The present invention relates to alpha-amylases, nucleic acids encoding the alpha-amylases, methods of producing the alpha-amylases, and methods of using the alpha-amylases.

95. 发明授权

US09499841B2 Cell suitable for fermentation of a mixed sugar composition 有权
公开(公告)号：US09499841B2
公开(公告)日：2016-11-22
申请号：US14750084
申请日：2015-06-25
申请人： DSM IP ASSETS B.V.
发明人： Paul Klaassen , Bianca Elisabeth Maria Gielesen , Gijsberdina Pieternella Van Suylekom , Wilbert Herman Marie Heijne
IPC分类号： C07K14/395 , C12P7/10 , C12N1/36 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/24 , C12N9/26 , C12N9/42 , C12N9/38 , C12N9/50 , C12N9/88 , C12N9/90 , C12N9/92 , C12P5/02 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P13/00 , C12P13/08 , C12P13/12 , C12P13/20 , C12P13/22 , C12P17/10 , C12P35/00
CPC分类号： C12P7/10 , C07K14/395 , C12N1/36 , C12N9/0004 , C12N9/0006 , C12N9/10 , C12N9/1205 , C12N9/16 , C12N9/2405 , C12N9/2411 , C12N9/2437 , C12N9/2468 , C12N9/248 , C12N9/50 , C12N9/88 , C12N9/90 , C12N9/92 , C12P5/026 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P13/005 , C12P13/08 , C12P13/12 , C12P13/20 , C12P13/227 , C12P17/10 , C12P35/00 , C12Y101/01 , C12Y207/01016 , C12Y501/03004 , C12Y503/01004 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The present invention relates to a cell suitable for production of one or more fermentation product from a sugar composition comprising glucose, galactose, arabinose and xylose, wherein the cell comprises two to fifteen copies of one or more xylose isomerase gene or two to fifteen copies of one or more xylose reductase and xylitol dehydrogenase, and two to ten copies of araA, araB and araD, genes, wherein these genes are integrated into the cell genome.

96. 发明申请

US20160319316A1 METHOD FOR PRODUCING FRUCTOSE-ADDED CARBOHYDRATE 有权
标题翻译：生产蔗糖添加碳酸酯的方法
公开(公告)号：US20160319316A1
公开(公告)日：2016-11-03
申请号：US15107819
申请日：2014-12-26
申请人： B FOOD SCIENCE CO., LTD , MICROBIOPHARM JAPAN CO., LTD
发明人： Takumi TOCHIO , Naomi ITO , Saki NAKAMURA , Tadashi FUJII , Keisuke TAMURA
IPC分类号： C12P19/02 , C12P19/14 , C12N15/70 , C12N9/26
CPC分类号： C12P19/02 , C07K2319/01 , C12N9/2431 , C12N15/70 , C12P19/14 , C12P21/00 , C12Y302/01026
摘要： [Problem]To provide a production method capable of simply and efficiently producing a fructose-added carbohydrate using β-fructofuranosidase.[Solution]A method for producing a fructose-added carbohydrate, said method having a step in which a receptor substrate and a hydrate containing terminal fructose residue are brought into contact with: Escherichia coli expressing an anchor protein for expression on a cell surface and β-fructofuranosidase as one polypeptide, a composition including dead cells of the expressing Escherichia coli, or a polypeptide obtained from the expressing Escherichia coli and including an amino acid sequence of β-fructofuranosidase.

97. 发明申请

US20160319263A1 IMPROVED B-FRUCTOFURANOSIDASE 有权
标题翻译：改良的B-FRUCTOFURANOSIDASE
公开(公告)号：US20160319263A1
公开(公告)日：2016-11-03
申请号：US15107500
申请日：2014-12-26
申请人： B FOOD SCIENCE CO., LTD. , MICROBIOPHARM JAPAN CO., LTD.
发明人： Takumi TOCHIO , Saki NAKAMURA , Misa YAHARA , Tadashi FUJII , Keisuke TAMURA
IPC分类号： C12N9/26 , C12P19/14
CPC分类号： C12N9/2431 , C12P19/14 , C12Y302/01026
摘要： [Problem] To provide an improved β-fructofuranosidase which enables the production of kestose with high efficiency while reducing the amount of a by-product such as nystose produced during the production of kestose.[Solution] An improved β-fructofuranosidase comprising an amino acid sequence which is produced by introducing an amino acid mutation into an amino acid sequence for a β-fructofuranosidase having 60% or higher identity to the amino acid sequence for wild-type β-fructofuranosidase which is represented by SEQ ID NO: 2, wherein the amino acid mutation is such a mutation that, when amino acid sequence alignment is performed, a histidine (H) residue corresponding to the position 395 as numbered from the N-terminal of the amino acid sequence for the wild-type β fructofuranosidase which is represented by SEQ ID NO: 2 can be replaced by an arginine (R) residue or a lysine (K) residue.
摘要翻译： [解决方案]一种改进的β-呋喃果糖苷酶，其包含通过将氨基酸突变引入与野生型β-呋喃果糖苷酶的氨基酸序列具有60％或更高同一性的β-呋喃果糖苷酶的氨基酸序列而产生的氨基酸序列其由SEQ ID NO：2表示，其中氨基酸突变是这样的突变，当进行氨基酸序列比对时，对应于从氨基的N末端编号的位置395的组氨酸（H）残基由SEQ ID NO：2表示的野生型β呋喃果糖苷酶的酸序列可以被精氨酸（R）残基或赖氨酸（K）残基所代替。

98. 发明授权

US09469683B2 Lysosomal targeting peptides and uses thereof 有权
公开(公告)号：US09469683B2
公开(公告)日：2016-10-18
申请号：US14535505
申请日：2014-11-07
申请人： BioMarin Pharmaceutical Inc.
发明人： Jonathan H. LeBowitz , John Maga
IPC分类号： A61K38/47 , C12P21/06 , A61K38/30 , C07K14/65 , C12N9/24 , C12N9/26
CPC分类号： A61K38/47 , C07K14/65 , C07K2319/06 , C07K2319/33 , C12N9/2408 , C12Y302/0102
摘要： The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.

99. 发明申请

US20160298100A1 STABILIZATION OF ALPHA-AMYLASES TOWARDS CALCIUM DEPLETION AND ACIDIC PH 审中-公开
标题翻译：钙离子和酸性磷酸钙的稳定化
公开(公告)号：US20160298100A1
公开(公告)日：2016-10-13
申请号：US15185910
申请日：2016-06-17
申请人： NOVOZYMES A/S
发明人： Carsten Andersen
IPC分类号： C12N9/26 , C11D3/386 , C12P7/06 , C12P19/14 , C12P19/02
CPC分类号： C12N9/2417 , C11D3/386 , C11D3/38681 , C12N9/2414 , C12N15/8257 , C12P7/06 , C12P7/14 , C12P19/02 , C12P19/04 , C12P19/14 , C12P2203/00 , C12Y302/01001 , Y02E50/17
摘要： The present invention relates to variants of a parent alpha-amylase, the variant having improved stability or activity at low calcium conditions or at low pH.
摘要翻译：本发明涉及母体α-淀粉酶的变体，该变体在低钙条件下或在低pH下具有改善的稳定性或活性。

100. 发明授权

US09458442B2 Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof 有权
公开(公告)号：US09458442B2
公开(公告)日：2016-10-04
申请号：US14459876
申请日：2014-08-14
申请人： Ping Jiang , H. Michael Shepard , Lei Huang
发明人： Ping Jiang , H. Michael Shepard , Lei Huang
IPC分类号： C07K14/81 , C12N9/26 , A61K38/47 , G01N33/574 , G01N33/566 , G01N33/68 , A61K47/10 , C07K14/47
CPC分类号： C12N9/2474 , A61K38/47 , A61K47/10 , C07K14/47 , C07K2319/00 , C07K2319/30 , C07K2319/735 , G01N33/566 , G01N33/574 , G01N33/57488 , G01N33/6893 , G01N2333/705 , G01N2400/40 , G01N2800/52
摘要： Methods and diagnostic agents for identification of subjects for cancer treatment with an anti-hyaluronan agent, such as a hyaluronan-degrading enzyme, are provided. Diagnostic agents for the detection and quantification of hyaluronan in a biological sample and monitoring cancer treatment with an anti-hyaluronan agent, for example a hyaluronan-degrading enzyme, are provided. Combinations and kits for use in practicing the methods also are provided.

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