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91. 发明授权

US5837477A T cell receptor ligands and methods of using same 失效
公开(公告)号：US5837477A
公开(公告)日：1998-11-17
申请号：US4936
申请日：1993-01-15
申请人： Ronald N. Germain , Luigi Racioppi , Franca Ronchese-Le Gros
发明人： Ronald N. Germain , Luigi Racioppi , Franca Ronchese-Le Gros
IPC分类号： A61K38/00 , A61K39/12 , A61K39/395 , A61P37/02 , C07K14/725 , C07K14/74 , C07K14/80 , C07K16/28 , G01N33/567 , G01N33/50
CPC分类号： C07K14/80 , C07K14/70539 , A61K38/00 , Y10S530/868
摘要： The present invention concerns TCR ligands with immunomodulatory properties, as well as methods of identifying such ligands and of using such ligands to modulate T cell effector responses.

92. 发明授权

US5831018A Human cytochrome B5 失效
标题翻译：人细胞色素B5
公开(公告)号：US5831018A
公开(公告)日：1998-11-03
申请号：US801972
申请日：1997-02-18
申请人： Jennifer L. Hillman , Surya K. Goli , David Gray Streeter
发明人： Jennifer L. Hillman , Surya K. Goli , David Gray Streeter
IPC分类号： A61K38/00 , C07K14/80 , C12N1/21 , C12N15/12 , C07K14/435 , C12N15/70 , C12N15/79
CPC分类号： C07K14/80 , A61K38/00
摘要： The present invention provides a human cytochrome b5 (HCB5) and polynucleotides which encode HCB5. The invention also provides genetically engineered expression vectors and host cells and a method for producing HCB5. The invention also provides for agonists, antisense molecules, antibodies, or antagonists of HCB5, and their use in the prevention and treatment of diseases associated with expression of HCB5. The invention also provides a method for detecting polynucleotides which encode HCB5.
摘要翻译：本发明提供人细胞色素b5（HCB5）和编码HCB5的多核苷酸。本发明还提供基因工程表达载体和宿主细胞以及生产HCB5的方法。本发明还提供HCB5的激动剂，反义分子，抗体或拮抗剂及其在预防和治疗与HCB5表达有关的疾病中的用途。本发明还提供了一种检测编码HCB5的多核苷酸的方法。

93. 发明授权

US5830667A Human P450 IID6 cytochrome-derived peptide fragments, anti-peptide fragment antibodies, applications thereof in the diagnosis of autoimmune hepatitis 失效
标题翻译：人P450 IID6细胞色素衍生肽片段，抗肽片段抗体，其在自身免疫性肝炎诊断中的应用
公开(公告)号：US5830667A
公开(公告)日：1998-11-03
申请号：US162149
申请日：1994-04-18
申请人： Fernando Alvarez
发明人： Fernando Alvarez
IPC分类号： A61K39/00 , A61K38/00 , A61K39/395 , C07K5/08 , C07K7/06 , C07K7/08 , C07K14/76 , C07K14/80 , C07K16/00 , C07K16/18 , C07K16/40 , C12N9/02 , C12N15/02 , C12N15/09 , C12N15/53 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/91 , G01N33/53 , G01N33/564 , G01N33/576 , C07K14/435
CPC分类号： C12N9/0077 , C07K16/40 , A61K38/00 , Y10S435/975 , Y10S436/811 , Y10S436/82 , Y10S530/868
摘要： Human P450 IID6 cytochrome-derived peptide fragments, anti peptide anti fragment antibodies and applications thereof in the diagnosis of autoimmune hepatitis and more especially in the differential diagnosis between autoimmune hepatitis and other chronic viral forms of hepatitis, such as hepatitis C or B. Said human P450 cytochrome peptide fragment contains at least one P450 IID6 cytochrome immunodominant epitope and consists of an amino acid sequence comprising from 3 to 70 amino acids. Said peptide binds specifically with anti-LKM auto-anitbodies produced in autoimmune hepatitis.
摘要翻译： PCT No.PCT / FR92 / 00539 Sec。 371日期1994年04月18日 102（e）日期1994年4月18日PCT提交1992年6月16日PCT公布。出版物WO92 / 22656 1992年12月23日人类P450 IID6细胞色素衍生肽片段，抗肽抗片段抗体及其在自身免疫性肝炎诊断中的应用，更特别是在自身免疫性肝炎与其他慢性乙型肝炎病毒形式如丙型肝炎之间的鉴别诊断中或B.所述人P450细胞色素肽片段含有至少一种P450 IID6细胞色素免疫显性表位，并由包含3-70个氨基酸的氨基酸序列组成。所述肽特异性结合自身免疫性肝炎中产生的抗LKM自身抗体。

94. 发明授权

US5820866A Product and process for T cell regulation 失效
标题翻译： T细胞调节的产物和方法
公开(公告)号：US5820866A
公开(公告)日：1998-10-13
申请号：US207481
申请日：1994-03-04
申请人： John W. Kappler , Philippa Marrack
发明人： John W. Kappler , Philippa Marrack
IPC分类号： C12N15/09 , A61K35/12 , A61K35/18 , A61K39/00 , A61K48/00 , A61P37/00 , C07K14/47 , C07K14/74 , C07K14/77 , C07K14/80 , C07K19/00 , C12N5/10 , C12N15/85 , A61K39/385
CPC分类号： C07K14/80 , C07K14/70539 , C07K14/77 , C12N15/8509 , A01K2217/05 , A01K2217/30 , A01K2267/0325 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a product and process for regulating the activity of T cells using major histocompatibility complexes (MHC) stably linked to antigenic peptides. Disclosed is an antigenic peptide covalently linked to a major histocompatibility complex (MHC) protein by a novel linker, thereby enabling the formation of a stable peptide-MHC complex, alone or in combination with additional MHC protein chains, capable of being recognized by a T cell receptor (TCR). Also disclosed is a nucleic molecule having a sequence encoding a Peptide-L-MHC molecule comprising an antigenic peptide joined by a linker to an MHC segment. The invention is additionally directed to formulations comprising an antigenic peptide joined by a linker to an MHC segment anchored in a lipid-containing substrate. Pharmaceutical reagents are also disclosed which contain an antigenic peptide joined by a linker to an MHC segment combined with a suitable carrier that is capable of presenting the Peptide-L-MHC molecule so that it is capable of being recognized by a T cell receptor.
摘要翻译：本发明涉及使用与抗原肽稳定连接的主要组织相容性复合物（MHC）来调节T细胞的活性的产物和方法。公开了通过新的接头共价连接到主要组织相容性复合物（MHC）蛋白的抗原肽，从而能够单独或与额外的MHC蛋白链组合形成稳定的肽-MHC复合物，其能够被T 细胞受体（TCR）还公开了具有编码肽-L-MHC分子的序列的核酸分子，其包含通过接头连接到MHC片段的抗原肽。本发明另外涉及包含通过接头连接到锚定在含脂质底物中的MHC区段的抗原肽的制剂。还公开了药物试剂，其含有通过接头连接到与能够呈递肽-L-MHC分子的合适载体的MHC区段的抗原肽，使得其能够被T细胞受体识别。

95. 发明授权

US5660986A Immortalized human cell lines containing exogenous cytochrome P450 genes 失效
标题翻译：含有外源细胞色素P450基因的永生化人细胞系
公开(公告)号：US5660986A
公开(公告)日：1997-08-26
申请号：US462998
申请日：1995-06-05
申请人： Curtis C. Harris , Harry V. Gelboin , Frank J. Gonzalez , Katharine C. Mace , Andrea M. A. Pfeifer
发明人： Curtis C. Harris , Harry V. Gelboin , Frank J. Gonzalez , Katharine C. Mace , Andrea M. A. Pfeifer
IPC分类号： C07K14/80 , C12N5/10 , C12N9/02 , C12N15/53 , C12N15/863 , C12Q1/26 , G01N33/50 , C12Q1/68
CPC分类号： C12N9/0071 , C07K14/80 , C12N15/86 , C12N9/0077 , C12Q1/26 , G01N33/5011 , G01N33/5014 , G01N33/5017 , C12N2500/90 , C12N2710/10243 , C12N2710/16143 , C12N2740/15043
摘要： Non-tumorigenic, stable, human bronchial and liver epithelial cell lines are provided wherein the cell lines are capable of expressing human cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identifying potential mutagens, cytotoxins, carcinogens, chemotherapeutic and chemo-preventive agents utilizing these cell lines.
摘要翻译：提供非致瘤性，稳定的人支气管和肝上皮细胞系，其中细胞系能够表达插入到细胞系中的人细胞色素P450基因。还提供了用于鉴定利用这些细胞系的潜在诱变剂，细胞毒素，致癌物，化学治疗剂和化学预防剂的方法和试剂盒。

96. 发明授权

US5652342A Heterofunctional cellular immunological reagents, vaccines containing same and methods for the use of same 失效
标题翻译：异种功能性细胞免疫试剂，含有相同的疫苗及其使用方法
公开(公告)号：US5652342A
公开(公告)日：1997-07-29
申请号：US354751
申请日：1994-12-08
申请人： Daniel H. Zimmerman , Donald A. Elliott
发明人： Daniel H. Zimmerman , Donald A. Elliott
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , C07K1/20 , C07K1/22 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/03 , C07K14/075 , C07K14/09 , C07K14/16 , C07K14/18 , C07K14/315 , C07K14/42 , C07K14/445 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/55 , C07K14/725 , C07K14/74 , C07K14/80 , C07K16/00 , C07K19/00 , G01N33/569 , C07K14/705 , A61K39/385
CPC分类号： A61K39/092 , C07K14/005 , C07K14/315 , C07K14/42 , C07K14/445 , C07K14/47 , C07K14/70539 , C07K14/80 , G01N33/56972 , A61K2039/6031 , A61K38/00 , C07K2319/00 , C12N2710/10322 , C12N2710/16222 , C12N2740/16122 , C12N2770/24022 , C12N2770/32122 , Y10S530/868
摘要： The present invention relates to a heterofunctional cellular immunological reagent comprising at least two T cell specific binding ligands covalently linked together, wherein one of the T cell specific binding ligands binds to a specific class or subclass of T cells and another of the T cell specific binding ligands is an antigen associated with disease or a causative agent of disease, or epitope thereof. The present invention also relates to vaccines containing the heterofunctional cellular immunological reagents and methods for the use of the same.
摘要翻译：本发明涉及包含共价连接在一起的至少两个T细胞特异性结合配体的异功能细胞免疫试剂，其中T细胞特异性结合配体之一与T细胞的特定类别或亚类结合，另一种T细胞特异性结合配体是与疾病或疾病的致病因子或其表位相关的抗原。本发明还涉及含有异功能细胞免疫学试剂的疫苗及其使用方法。

97. 发明授权

US5593966A Peptide derivatives of cytochrome b.sub.558 and their use as medicaments 失效
标题翻译：细胞色素b558的肽衍生物及其用作药物
公开(公告)号：US5593966A
公开(公告)日：1997-01-14
申请号：US527767
申请日：1990-05-24
申请人： Harry L. Malech , Daniel Rotrosen
发明人： Harry L. Malech , Daniel Rotrosen
IPC分类号： A61K38/00 , C07K14/80 , C07K7/00 , C07K7/06
CPC分类号： C07K14/80 , A61K38/00
摘要： Peptide derivatives with inhibitory activity on the enzyme systems involved in the oxidative burst of human phagocytic cells comprise six and seven amino acid peptide sequences from human cytochrome b.sub.558. The derivatives may be used in medicaments for the treatment of inflammatory diseases.
摘要翻译：对涉及人类吞噬细胞氧化爆发的酶系统具有抑制活性的肽衍生物包含来自人细胞色素b558的六个和七个氨基酸的肽序列。衍生物可用于治疗炎性疾病的药物中。

98. 发明授权

US5547868A Cholesterol disposal fusion enzymes 失效
标题翻译：胆固醇处理融合酶
公开(公告)号：US5547868A
公开(公告)日：1996-08-20
申请号：US75193
申请日：1993-06-09
申请人： Walter L. Miller , Jennifer A. Harikrishna , Stephen M. Black
发明人： Walter L. Miller , Jennifer A. Harikrishna , Stephen M. Black
IPC分类号： C12N1/15 , C12N1/21 , C12N9/02 , C12P33/00 , C07K14/80
CPC分类号： C12N9/0081 , C12N9/0095 , C12P33/005 , C12Y114/15006 , C12Y118/01002 , C07K2319/00
摘要： Fusion enzymes having multiple segments of different biological activity including one segment having P450scc activity and at least one segment having electron-transfer activity for transferring electrons to P450scc are described along with genetic constructs for production of such enzymes and methods for their use. Methods of their use include cholesterol degradation in vitro or in vivo as well as conversion of cholesterol to other useful steroidal products including pregnenolone.
摘要翻译：与具有P450scc活性的一个区段和具有电子转移活性的至少一个区段具有不同生物学活性的多个区段的融合酶与用于产生这些酶的遗传构建体及其使用方法一起被描述。其使用方法包括体外或体内的胆固醇降解以及胆固醇转化为其他有用的甾体产物，包括孕烯醇酮。

99. 发明授权

US5459046A Cytochrome C gene derived from hydrogen bacterium 失效
标题翻译：来自氢细菌的细胞色素C基因
公开(公告)号：US5459046A
公开(公告)日：1995-10-17
申请号：US943140
申请日：1992-09-10
申请人： Tohru Kodama , Yasuo Igarashi
发明人： Tohru Kodama , Yasuo Igarashi
IPC分类号： C07K14/80 , C12N1/19 , C12N1/21 , C12N15/31 , C12P21/06 , C12N1/14 , C12N1/20 , C12P21/04
CPC分类号： C07K14/80
摘要： The nucleotide sequence of a DNA coding for highly thermophilic cytochrome C-552, a plasmid containing said sequence, a host cell transformed with said plasmid and a process for the production of C-552 comprising culturing said host.
摘要翻译：编码高度嗜热细胞色素C-552的DNA的核苷酸序列，含有所述序列的质粒，用所述质粒转化的宿主细胞和生产C-552的方法，包括培养所述宿主。

100. 发明授权

US5223484A Peptide which regulates weight gain in mammals 失效
标题翻译：调节肥胖的蛋白质在体重上增加
公开(公告)号：US5223484A
公开(公告)日：1993-06-29
申请号：US616910
申请日：1990-11-21
申请人： Patrick J. Fleming , Ute M. Kent
发明人： Patrick J. Fleming , Ute M. Kent
IPC分类号： A61K38/00 , C07K7/08 , C07K14/80 , C07K16/18
CPC分类号： C07K16/18 , C07K14/80 , C07K7/08 , A61K38/00 , Y10S514/909 , Y10S514/91
摘要： A dodecapeptide for regulating weight gain in mammals, as defined in the sequence:CHHRKKGYADLYwherein C is cysteine, H is histidine, R is arginine, K is lysine, G is glycine, Y is tyrosine, A is alanine, D is aspartic acid and L is leucine; and the remaining amino acids are each independently glycine, alanine, valine, leucine, isoleucine, serine, threonine, cysteine, cystine, methionine, aspartic acid, glutamic acid, asparagine, glutamine, lysine hydroxylysine, histidine, arginine, phenylalanine, tyrosine, tryptophan, proline or hydroxyproline.
摘要翻译：用于调节哺乳动物体重增加的十二肽，如下列顺序所定义：CHHRKKGYADLY其中C为半胱氨酸，H为组氨酸，R为精氨酸，K为赖氨酸，G为甘氨酸，Y为酪氨酸，A为丙氨酸，D为天冬氨酸， L是亮氨酸; 其余氨基酸分别为甘氨酸，丙氨酸，缬氨酸，亮氨酸，异亮氨酸，丝氨酸，苏氨酸，半胱氨酸，胱氨酸，甲硫氨酸，天冬氨酸，谷氨酸，天冬酰胺，谷氨酰胺，赖氨酸羟赖氨酸，组氨酸，精氨酸，苯丙氨酸，酪氨酸，色氨酸，脯氨酸或羟脯氨酸。

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