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91. 发明授权

US5101006A Polyimides and copolyimides based on halo-oxydiphthalic anhydrides 失效
标题翻译：基于卤代二氢邻苯二甲酸酐的聚酰亚胺和共聚酰亚胺
公开(公告)号：US5101006A
公开(公告)日：1992-03-31
申请号：US674802
申请日：1991-03-25
申请人： Jeffrey S. Stults , Willis T. Schwartz
发明人： Jeffrey S. Stults , Willis T. Schwartz
IPC分类号： C07C65/24 , C07D491/14
CPC分类号： C07D491/14 , C07C65/24
摘要： Novel halogenated polyimides and co-polyimides comprise recurring imide structural units of the formula ##STR1## where X is F, Cl, Br or I; Y is H, F, Cl, Br or I; and R is a divalent organic radical.
摘要翻译：新型卤化聚酰亚胺和共 - 聚酰亚胺包括式为“IMAGE”的重复酰亚胺结构单元，其中X为F，Cl，Br或I; Y是H，F，Cl，Br或I; 并且R是二价有机基团。

92. 发明授权

US5095020A Cytostatic beta-carbolines 失效
标题翻译：细胞周期蛋白
公开(公告)号：US5095020A
公开(公告)日：1992-03-10
申请号：US397859
申请日：1989-08-24
申请人： Antonius Hulkenberg , Ineke Van Wijngaarden
发明人： Antonius Hulkenberg , Ineke Van Wijngaarden
IPC分类号： A61K31/435 , A61K31/675 , A61P35/00 , A61P43/00 , C07D471/04 , C07D471/14 , C07D471/16 , C07D491/04 , C07D491/048 , C07D491/056 , C07D491/14 , C07D491/147 , C07D491/22 , C07D495/04 , C07D498/14 , C07D498/22 , C07D515/14 , C07F9/6574 , C07F9/6584 , C07H17/02
CPC分类号： C07D471/04 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D515/14 , C07F9/65842
摘要： The invention relates to a group of new .beta.-carbolines, their bio-isosteric benzofuran and benzothiophene analogues, and to the preparation of these compounds.The new compounds can be represented by the formula ##STR1## wherein R, R.sub.1 and R.sub.2 are hydrogen, or R+R.sub.1 or R.sub.1 +R.sub.2 form a saturated heterocyclic ring having 5 or 6 ring atoms, which comprise 1 or 2 oxygen atoms;R.sub.3 is hydrogen, or hydroxy optionally derivatised with a sugar radical the 4,6-hydroxy groups of which are acetalised with an -ylidene group;R.sub.4 is a group of the formula --C(R.sub.11).sub.2 --X--R.sub.12, wherein the groups R.sub.11 are hydrogen, or both groups R.sub.11 together represent a double-bonded keto oxygen atom, X is oxygen or a group NR.sub.14, wherein R.sub.14 is hydrogen or alkyl having 1-4 C-atoms, and R.sub.12 is hydrogen, alkyl having 1-4 C-atoms, alkanoyl having 1-4 C-atoms, the carbamoyl group or mono- or dialkylcarbamoyl group having 1-4 C-atoms per alkyl group;R.sub.5 is hydrogen, alkanoyl or alkyl having 1-4 C-atoms, or R.sub.4 +R.sub.5 together form a group of the formula --C(R.sub.11).sub.2 --X--Z, wherein R.sub.11 and X have the above-mentioned meanings and Z is bound to the ring nitrogen atom and is a group ##STR2## R.sub.7 and R.sub.9 independently of each other are hydrogen or alkoxy having 1-4 C-atoms, trifluoromethyl or halogen;R.sub.8 is hydrogen, alkoxy or alkanoyloxy having 1-4 C-atoms, hydroxy, halogen, benzyloxy, or R.sub.8 and R.sub.9 together constitute a dioxyalkylidene bridge;A is oxygen, sulphur or a group ##STR3## and R.sub.6 and R.sub.13 independently of each other are hydrogen or methyl, or, when A is nitrogen, R.sub.6 and R.sub.13 together may form a ring having 5-7 C-atoms. The compounds have good cytostatic properies.

93. 发明授权

US4933448A Chromogenic lactone compounds of benzopyrano-2H-pyrazoles 失效
标题翻译：苯并吡喃-2-基吡唑的显色内酯化合物
公开(公告)号：US4933448A
公开(公告)日：1990-06-12
申请号：US343094
申请日：1989-04-25
申请人： Ian J. Fletcher
发明人： Ian J. Fletcher
IPC分类号： C07D491/20 , B41M5/145 , B41M5/30 , B41M5/327 , C07D491/14 , C09B11/26 , C09B57/00
CPC分类号： C07D491/14 , B41M5/145 , B41M5/327 , B41M5/1455 , B41M5/3275
摘要： Chromogenic lactone compounds of benzopyrano-2H-pyrazoles of the formula ##STR1## in which Ar is an aryl radical which is unsubstituted or substituted by halogen, nitro, cyano, lower alkyl, lower alkoxy, lower alkylthio, lower alkoxycarbonyl, trifluoromethyl, phenoxy, phenylthio or --NX.sub.3 X.sub.4,R.sub.1 is hydrogen, lower alkyl or lower alkoxy,R.sub.2 is lower alkyl, phenyl, or phenyl which is substituted by halogen, lower alkyl or lower alkoxy, andX.sub.1, X.sub.2, X.sub.3 and X.sub.4, independently of one another, are each hydrogen, alkyl which is unsubstituted or substituted by halogen, hydroxyl, cyano, tetrahydrofuryl or lower alkoxy, or are acyl, cycloalkyl, or aralkyl or aryl, each of which is unsubstituted or substituted by halogen, cyano, nitro, trifluoromethyl, lower alkyl, lower alkoxy or lower alkoxycarbonyl, or the substituent pairs (X.sub.1 and X.sub.2) and (X.sub.3 and X.sub.4), in each case together with the common nitrogen atom, are a 5- or 6-membered, preferably saturated heterocyclic radical, and in which the ring A is unsubstituted or substituted by halogen, nitro, lower alkyl, lower alkoxy, lower alkylthio, lower alkoxycarbonyl, amino, mono(lower alkyl)amino or di(lower alkyl)amino.These novel lactone compounds are particularly suitable as color formers in pressure-sensitive or heat-sensitive recording materials, and give intense yellow, orange or red colorations.
摘要翻译：式（1）的苯并吡喃-2H-吡唑的显色内酯化合物，其中Ar是未取代或被卤素，硝基，氰基，低级烷基，低级烷氧基，低级烷硫基，低级烷氧基羰基，三氟甲基苯氧基，苯硫基或-NX3X4，R1是氢，低级烷基或低级烷氧基，R2是被卤素，低级烷基或低级烷氧基取代的低级烷基，苯基或苯基，X 1，X 2，X 3和X 4独立地是羟基，氰基，四氢呋喃基或低级烷氧基，或者是酰基，环烷基或芳烷基或芳基，其各自为未取代的或被卤素，氰基，硝基，三氟甲基，低级烷基，低级烷氧基或低级烷氧基羰基，或取代基对（X1和X2）和（X3和X4）在各种情况下与常见的氮原子一起是5-或6-元，优选饱和的杂环基，其中环A i 未取代或被卤素，硝基，低级烷基，低级烷氧基，低级烷硫基，低级烷氧基羰基，氨基，单（低级烷基）氨基或二（低级烷基）氨基取代。这些新颖的内酯化合物特别适用于压敏或热敏记录材料中的成色剂，并且产生强烈的黄色，橙色或红色着色。

94. 发明授权

US4929611A Method for immunosuppression 失效
标题翻译：免疫抑制方法
公开(公告)号：US4929611A
公开(公告)日：1990-05-29
申请号：US868749
申请日：1986-05-30
申请人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号： A01N43/38 , A61K31/00 , A61K31/33 , A61K31/40 , A61K31/407 , A61K31/435 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/453 , A61K31/4745 , A61P31/00 , A61P31/04 , A61P37/00 , A61P37/06 , C07D491/14 , C07D498/04 , C07D498/14 , C07D498/18 , C07D519/00 , C07H19/01 , C12N1/20 , C12P17/16 , C12P17/18 , C12P19/44 , C12R1/465 , C12R1/55
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55 , Y02P20/55 , Y10S435/886 , Y10S435/898
摘要： This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.

95. 发明授权

US4900737A Isoquinoline derivatives 失效
标题翻译：异喹啉衍生物
公开(公告)号：US4900737A
公开(公告)日：1990-02-13
申请号：US250216
申请日：1988-09-28
申请人： Gordon H. Phillipps , Esme J. Bailey , Michael G. Lester
发明人： Gordon H. Phillipps , Esme J. Bailey , Michael G. Lester
IPC分类号： A61K31/47 , A61P35/00 , A61P43/00 , C07D471/04 , C07D491/14
CPC分类号： C07D471/04 , C07D491/14
摘要： Compounds of formula (I) ##STR1## (wherein R.sup.1 is a hydrogen atom or a methyl group;R.sup.2 is a hydrogen atom or a hydroxyl, C.sub.1-4 alkoxy or C.sub.2-4 alkanoyloxy group;R.sup.3 is a hydrogen atom, or (when R.sup.2 is other than a hydrogen atom) optionally a hydroxyl, C.sub.1-4 alkoxy or C.sub.2-4 alkanoyloxy group, or R.sup.2 and R.sup.3 together are a methylenedioxy group;R.sup.4 is a hydrogen or halogen atom or a methyl group;R.sup.5 and R.sup.6 is each a hydrogen atom or a group --OCOCH.sub.2 NR.sup.7 R.sup.8 [where R.sup.7 and R.sup.8, which may be the same or different, each is a hydrogen atom or a C.sub.3-7 cycloalkyl group or a straight or branched C.sub.1-4 alkyl group optionally substituted by a hydroxyl group, or --NR.sup.7 R.sup.8 forms a saturated heterocyclic amino group which has 5-7 ring members and optionally contains in the ring an oxygen or sulphur atom or a group --NH-- or --N(R) where R is a C.sub.1-4 alkyl group optionally substituted by a hydroxyl group] with the proviso that when one of R.sup.5 and R.sup.6 is a hydrogen atom, the other is a group --OCOCH.sub.2 NR.sup.7 R.sup.8) may be prepared by amination of a corresponding compound where R.sup.5 and/or R.sup.6 is a group --OCOCH.sub.2 L wherein L is a displaceable leaving group. The compounds of formula (I) and their physiologically acceptable salts exhibit interesting cancer combatting properties.
摘要翻译：式（I）化合物其中R1是氢原子或甲基; R2是氢原子或羟基，C1-4烷氧基或C2-4烷酰氧基; R3是氢原子，或（当 R 2不是氢原子）任选地是羟基，C 1-4烷氧基或C 2-4烷酰氧基，或者R 2和R 3一起是亚甲二氧基; R 4是氢或卤原子或甲基; R 5和R 6各自氢原子或基团-OCOCH 2 NR 7 R 8 [其中R 7和R 8可以相同或不同，各自为氢原子或C 3-7环烷基或任选被羟基取代的直链或支链C 1-4烷基或-NR 7 R 8形成饱和杂环氨基，其具有5-7个环成员并且任选地在环中含有氧或硫原子或-NH-或-N（R）基团，其中R是任选的C 1-4烷基被羟基取代]，条件是当R 5和R 6中的一个为氢原子时，另一个为-OCOCH 2 NR 7 R 8基团）可以由上式其中R5和/或R6是基团-OCOCH2L的相应化合物，其中L是可置换的离去基团。式（I）化合物及其生理学上可接受的盐表现出有趣的抗癌作用。

96. 发明授权

US4894366A Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same 失效
标题翻译：三环化合物，其生产方法和含有它们的药物组合物
公开(公告)号：US4894366A
公开(公告)日：1990-01-16
申请号：US799855
申请日：1985-11-20
申请人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
发明人： Masakuni Okuhara , Hirokazu Tanaka , Toshio Goto , Tohru Kino , Hiroshi Hatanaka
IPC分类号： A01N43/38 , A61K31/00 , A61K31/33 , A61K31/40 , A61K31/407 , A61K31/435 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4465 , A61K31/4523 , A61K31/453 , A61K31/4745 , A61P31/00 , A61P31/04 , A61P37/00 , A61P37/06 , C07D491/14 , C07D498/04 , C07D498/14 , C07D498/18 , C07D519/00 , C07H19/01 , C12N1/20 , C12P17/16 , C12P17/18 , C12P19/44 , C12R1/465 , C12R1/55
CPC分类号： C07D498/18 , C07H19/01 , C12P17/188 , C12P19/44 , C12R1/465 , C12R1/55 , Y02P20/55 , Y10S435/886 , Y10S435/898
摘要： This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
摘要翻译：本发明涉及可用于治疗和预防移植抵抗的三环类化合物，通过髓质移植移植物抗宿主病，自身免疫性疾病，感染性疾病等，其可以由下式表示：（ I）涉及其制备方法，含有该方法的药物组合物及其用途。

97. 发明授权

US4835276A Preparation of n-formamidoyl[(s)-1-t-butoxy-3-methyl-2-amino)]1,2,3,4 tetrahydrobenzo [b]furo [2,3-c]pyridine and derivatives 失效
标题翻译： [（s）-1-叔丁氧基-3-甲基-2-氨基）] -1,2,3,4-四氢苯并[b]呋喃并[2,3-c]吡啶及其衍生物的制备
公开(公告)号：US4835276A
公开(公告)日：1989-05-30
申请号：US881992
申请日：1986-07-03
申请人： Ralph P. Volante , Richard Desmond , Ichiro Shinkai
发明人： Ralph P. Volante , Richard Desmond , Ichiro Shinkai
IPC分类号： C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147
CPC分类号： C07D491/04 , C07D491/14
摘要： The present invention is directed to an enantioselective synthesis of 1,3,4,6,7,12b(S)-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-one which is an intermediate in the production of the .alpha..sub.2 -adrenergic antagonist (2R,12bS)-N-(1,3,4,6,7,12-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin-2-yl)-N-methyl-2-hydroxy-ethanesulfonamide hydrochloride.
摘要翻译：本发明涉及对映选择性合成1,3,4,6,7,12b（S） - 六氢-2H-苯并[b]呋喃并[2,3-a]喹嗪酮-2-酮，其为中间体在制备α2-肾上腺素能拮抗剂（2R，12bS）-N-（1,3,4,6,7,12-六氢-2H-苯并[b]呋喃并[2,3-a]喹嗪子-2 - 基）-N-甲基-2-羟基 - 乙磺酰胺盐酸盐。

98. 发明授权

US4788203A Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders 失效
标题翻译：环化的N-取代四氢吡啶化合物，可用于治疗心血管疾病
公开(公告)号：US4788203A
公开(公告)日：1988-11-29
申请号：US802127
申请日：1985-11-26
申请人： George D. Hartman , Wasyl Halczenko
发明人： George D. Hartman , Wasyl Halczenko
IPC分类号： C07D401/06 , C07D405/06 , C07D409/06 , C07D471/14 , C07D491/14 , C07D491/147 , C07D495/14 , A61K31/38 , A61K31/335 , A61K31/395 , C07D471/12
CPC分类号： C07D401/06 , C07D405/06 , C07D409/06 , C07D471/14 , C07D491/14 , C07D495/14
摘要： Novel cyclized N-substituted tetrahydropyridine compounds are disclosed. The compounds have the property of inhibiting calcium induced contraction of the smooth muscle and are adaptable to being employed in the chemotherapeutic treatment of cardiovascular diseases.
摘要翻译：公开了新的环化的N-取代的四氢吡啶化合物。该化合物具有抑制钙诱导的平滑肌收缩的特性，适用于心血管疾病的化学治疗。

99. 发明授权

US4766217A Preparation of 5,6-dihydro-pyrrolo[2,1-a]isoquinolines 失效
标题翻译： 5,6-二氢 - 吡咯并[2,1-a]异喹啉的制备
公开(公告)号：US4766217A
公开(公告)日：1988-08-23
申请号：US62851
申请日：1987-06-16
申请人： Walter Losel , Otto Roos , Gerd Schnorrenberger
发明人： Walter Losel , Otto Roos , Gerd Schnorrenberger
IPC分类号： C07D471/04 , C07D491/14 , C07D491/147 , C07D401/02
CPC分类号： C07D471/04 , C07D491/14
摘要： 5,6,-dihydro-pyrrolo[2,1-a]isoquinolines of the formula ##STR1## are prepared by heating a 1-(3-furyl)-3,4-dihydro-isoquinoline of the formula ##STR2## in a primary or secondary amine to at least 80.degree. C. for several hours, the amine is removed, the reaction product is treated with dilute acid, and the reaction product is purified and isolated.
摘要翻译：通过将式“IMAGE”中的1-（3-呋喃基）-3,4-二氢 - 异喹啉加热，得到式“IMAGE”的5,6-二氢 - 吡咯并[2,1-a]异喹啉伯胺或仲胺反应至至少80℃几小时，除去胺，用稀酸处理反应产物，纯化和分离反应产物。

100. 发明授权

US4650514A (2-imidazolin-2-yl)thieno- and furo[2,3-b] and [3,2-b]pyridines and intermediates for the preparation thereof, and use of said compounds as herbicidal agents 失效
标题翻译：（2-咪唑啉-2-基）噻吩并 - 和呋喃并[2,3-b]和[3,2-b]吡啶及其制备中间体，以及所述化合物作为除草剂
公开(公告)号：US4650514A
公开(公告)日：1987-03-17
申请号：US676133
申请日：1984-11-29
申请人： Marinus Los , David W. Ladner , Barringtin Cross
发明人： Marinus Los , David W. Ladner , Barringtin Cross
IPC分类号： A01N43/08 , A01N43/90 , C07D213/80 , C07D333/36 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/22 , C07D495/04 , C07D495/14 , C07D495/22 , A01N43/10
CPC分类号： C07D213/80 , A01N43/90 , C07C255/00 , C07C327/00 , C07D333/36 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： There are provided novel (2-imidazolin-2-yl)-thieno and furo compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
摘要翻译：提供了新颖的（2-咪唑啉-2-基） - 噻吩并呋喃化合物及其制备中间体化合物，以及用于控制多种多年生植物物种的方法。

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