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91. 发明申请

US20040167081A1 Method for the prevention and treatment of cachexia and anorexia 有权
标题翻译：预防和治疗恶病质和厌食症的方法
公开(公告)号：US20040167081A1
公开(公告)日：2004-08-26
申请号：US10784451
申请日：2004-02-23
发明人： Bonnie Chandler Abbruzzese , Mark Anthony McCamish , Frederick Oliver Cope , Stephen Joseph Demichele
IPC分类号： A61K031/70 , A61K031/20
CPC分类号： A61K9/0029 , A23L33/12 , A23L33/16 , A23L33/175 , A23L33/40 , A23V2002/00 , A61K31/202 , A61K31/70 , A61K47/12 , A61K47/183 , Y10S426/80 , Y10S426/801 , A23V2250/187 , A23V2250/1868 , A23V2250/708 , A23V2250/712 , A23V2250/1626 , A23V2250/5046 , A23V2250/211 , A23V2200/30 , A23V2200/308 , A23V2200/02
摘要： The present invention relates to methods and nutritional compositions for the prevention and treatment of cachexia and anorexia. The methods of the invention comprise administering a composition comprising effective amounts of null-3 fatty acids such as alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid or mixtures thereof; of branched-chain amino acids valine, leucine, isoleucine or mixtures thereof; with or without reduced levels of tryptophan and 5-hydroxytryptophan; and of antioxidant system selected from the group comprising beta-carotene, vitamin C, vitamin E, selenium, or mixtures thereof.
摘要翻译：本发明涉及用于预防和治疗恶病质和厌食症的方法和营养组合物。本发明的方法包括施用包含有效量的ω-3脂肪酸如α-亚麻酸，十八碳四烯酸，二十碳五烯酸，二十二碳五烯酸，二十二碳六烯酸或其混合物的组合物; 的支链氨基酸缬氨酸，亮氨酸，异亮氨酸或其混合物; 具有或不具有降低水平的色氨酸和5-羟色氨酸; 以及选自包含β-胡萝卜素，维生素C，维生素E，硒或其混合物的组的抗氧化剂系统。

92. 发明申请

US20040122071A1 Antifungal remedy formulation for external application 有权
标题翻译：外用抗真菌药物配方
公开(公告)号：US20040122071A1
公开(公告)日：2004-06-24
申请号：US10467244
申请日：2004-01-16
发明人： Sang-Lin Kim , Hyun-Kwang Tan , Jun-Sik Kim , Ho-Beom Lee , Geun-Hong Min , Hae-Won Ryou
IPC分类号： A61K031/4196 , A61K031/20
CPC分类号： A61K9/0014 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/26
摘要： An antibacterial composition for external application, particularly, a remedial formulation for external use containing fluconazole is disclosed. The formulation comprises a base material, 0.1-5.0 percent by weight of fluconazole and 1.0-40.0 percent by weight of any one compound selected from a group consisting of fatty acid, fatty alcohol, higher fatty acid ester and lower alcohol based on weight of the base material. The composition according to the present invention has various advantages of a favorable absorption into a system through the skin of a human body and delivery of active material into horny layer of the skin, a reduced skin stimulation and an excellent stability. Therefore, the composition is efficiently useable in a medical treatment application for dermatomycosis-related infectious diseases including tinea pedis, tinea corporis, tinea cruris, tinea versicolor and/or candidiasis and the like.
摘要翻译：公开了一种用于外用的抗菌组合物，特别是含有氟康唑的外用补救制剂。该制剂包含基础材料，0.1-5.0重量％的氟康唑和1.0-40.0重量％的任何一种选自脂肪酸，脂肪醇，高级脂肪酸酯和低级醇的化合物，基于基材。根据本发明的组合物具有通过人体皮肤对体系的有利吸收以及将活性物质递送到皮肤角质层，减少的皮肤刺激和优异的稳定性的各种优点。因此，该组合物可有效地用于涉及皮肤真菌病相关感染性疾病的医疗用途，包括足癣，癣，癣，癣斑和/或念珠菌病等。

93. 发明申请

US20040116523A1 Use of c4-c10 acids for preventing gram-negative bacterial infections 审中-公开
标题翻译：使用c4-c10酸预防革兰氏阴性细菌感染
公开(公告)号：US20040116523A1
公开(公告)日：2004-06-17
申请号：US10312047
申请日：2003-02-07
发明人： Michel Yvan Popoff
IPC分类号： A61K031/20
CPC分类号： A61K31/20 , A61K31/19 , A61K31/192 , Y02A50/481 , Y02A50/483
摘要： The invention relates to the use of C4-C10 acids and/or of at least one of their salts or esters, for preparing a pharmaceutical composition intended to prevent Gram-negative bacterial infections, in particular Salmonella infections.
摘要翻译：本发明涉及C4-C10酸和/或其至少一种盐或酯的用途，用于制备旨在防止革兰氏阴性细菌感染，特别是沙门氏菌感染的药物组合物。

94. 发明申请

US20040116511A1 Wound and skin care compositions 失效
标题翻译：伤口和护肤组合物
公开(公告)号：US20040116511A1
公开(公告)日：2004-06-17
申请号：US10463207
申请日：2003-06-17
发明人： Sohail Malik
IPC分类号： A61K031/366 , A61K031/20
CPC分类号： A61K31/52 , A61K31/19 , A61K31/194 , A61K31/365 , A61K31/519 , A61K31/60 , A61K31/70 , A61K2300/00
摘要： The invention provides compositions and methods that employ compounds that can promote skin cell renewal, wound healing, proliferation of fibroblasts and/or keratinocytes, and production of collagen or fibronectin by fibroblasts. These compositions and methods are useful for rejuvenating the skin and for treating wounds as well as gum-related and skin-related conditions.
摘要翻译：本发明提供了使用可以促进皮肤细胞更新，伤口愈合，成纤维细胞和/或角质形成细胞的增殖以及通过成纤维细胞产生胶原或纤连蛋白的化合物的组合物和方法。这些组合物和方法可用于恢复皮肤和治疗伤口以及牙龈相关和皮肤相关病症。

95. 发明申请

US20040087560A1 Triterpenoid derivatives 失效
标题翻译：三萜衍生物
公开(公告)号：US20040087560A1
公开(公告)日：2004-05-06
申请号：US10296542
申请日：2003-09-10
发明人： Marian Hajduch , Jan Sarek
IPC分类号： A61K031/56 , A61K031/20
CPC分类号： A61K31/20 , A61K31/56 , C07J63/008
摘要： The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, in the preparation of a medicament for treating a patient suffering from leukaemia, cancer or other proliferative disorder. A further embodiment relates to the use a compound of formula (I) in an assay for detecting the phosphorylation state of cellular substrates. The present invention also relates to novel compounds of formula (I), and the chemical synthesis thereof. 1
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，晶体形式，复合物，水合物或可水解的酯在制备用于治疗患有白血病，癌症或其他增殖性疾病。进一步的实施方案涉及在用于检测细胞底物的磷酸化状态的测定中使用式（I）的化合物。本发明还涉及新的式（I）化合物及其化学合成。

96. 发明申请

US20040077720A1 Inhibition of antibody production employing perfluorooctanoic acid or derivatives thereof 审中-公开
标题翻译：使用全氟辛酸或其衍生物抑制抗体生产
公开(公告)号：US20040077720A1
公开(公告)日：2004-04-22
申请号：US10406011
申请日：2003-04-03
发明人： Joseph William Depierre , Sven jan Lennart Nassberger
IPC分类号： A61K031/20
CPC分类号： A61K31/20
摘要： The invention relates to a substance, and its derivatives, which specifically inhibits production of autoantibodies. Both immune responses to active immunization and endogenous production of autoantibodies are inhibited. Consequently, no circulating immunocomplexes which can give rise to deposits in tissues/organs are formed. In parallel, there is total blockage of the development of lymphoadenopathy in the form of lymphocyte proliferation.
摘要翻译：本发明涉及特异性抑制自身抗体产生的物质及其衍生物。对主动免疫的免疫应答和自身抗体的内源性生成均受到抑制。因此，不会形成可能导致组织/器官中沉积物的循环免疫复合物。同时，以淋巴细胞增殖的形式完全阻断淋巴腺病的发展。

97. 发明申请

US20040037907A1 Parenteral pimaricin as treatment of systemic infections 失效
标题翻译：肠胃外杀菌素作为全身感染的治疗
公开(公告)号：US20040037907A1
公开(公告)日：2004-02-26
申请号：US10439252
申请日：2003-05-15
发明人： Borje S. Andersson , Elias J. Anaissie
IPC分类号： A61K031/70 , A61K035/78 , A61K031/20
CPC分类号： A61K47/18 , A61K9/0019 , A61K9/08 , A61K9/107 , A61K9/19 , Y10S514/937 , Y10S514/938 , Y10S514/943 , Y10S514/97 , Y10S514/974
摘要： An antifungal composition suitable for parenteral administration to a mammal includes an amount of pimaricin or an antifungal derivative thereof that is effective to inhibit the growth of a fungal infection in a mammal; a pharmaceutically acceptable dipolar aprotic solvent; and a pharmaceutically acceptable aqueous secondary solvent. The composition can be used in methods of preventing or treating a systemic fungal infection in a mammal. The composition can be prepared by dissolving pimaricin or an antifungal derivative thereof in the pharmaceutically acceptable dipolar aprotic solvent; adding to the solution a pharmaceutically acceptable aqueous secondary solvent; and in a preferred method, by subsequently lypohilizing the composition, whereby a dry, shelf-stable composition is produced. This dry composition can be reconstituted into an aqueous solution suitable for parenteral administration.
摘要翻译：适合于向哺乳动物肠胃外给药的抗真菌组合物包括一定量的有效抑制哺乳动物真菌感染生长的派马林或其抗真菌衍生物; 药学上可接受的偶极非质子溶剂; 和药学上可接受的水性二级溶剂。该组合物可用于预防或治疗哺乳动物全身真菌感染的方法。该组合物可以通过将派马林或其抗真菌衍生物溶解在药学上可接受的偶极非质子溶剂中来制备; 向该溶液中加入药学上可接受的水性二级溶剂; 并且在优选的方法中，通过随后将组合物洗脱，由此产生干燥的，稳定的组合物。该干组合物可以重构成适合肠胃外给药的水溶液。

98. 发明申请

US20040005291A1 Methods for regulating co-stimulatory molecule expression with reactive oxygen 审中-公开
标题翻译：用活性氧调节共刺激分子表达的方法
公开(公告)号：US20040005291A1
公开(公告)日：2004-01-08
申请号：US10272432
申请日：2002-10-15
发明人： Martha Karen Newell Rogers , Robert Camley , Charles Richard Ill , Thomas Christensen , Zbigniew Celinski , Richard Trauger , Evan Newell , Elizabeth Villalobos-Menuey
IPC分类号： A61K038/20 , A61K038/19 , A61K038/18 , A61K038/21 , C12N005/08 , A61K031/20
CPC分类号： A61K31/20 , A61K35/545 , C12N5/0018 , C12N13/00 , C12N2500/05 , C12N2501/33
摘要： The invention is based in part on the discovery that the expression of co-stimulatory molecules such as B7.1, B7.2 or CD40 can be regulated using reactive oxygen species (ROS). Thus, the invention relates to methods of regulating co-stimulatory molecules by modulating reactive oxygen. The methods and products are useful, for example, for modulating antigen specific immune responses, treating disease, and for modulating cell growth.
摘要翻译：本发明部分基于如下发现：可以使用活性氧（ROS）调节共刺激分子如B7.1，B7.2或CD40的表达。因此，本发明涉及通过调节活性氧调节共刺激分子的方法。所述方法和产品例如用于调节抗原特异性免疫应答，治疗疾病和调节细胞生长是有用的。

99. 发明申请

US20040001817A1 Anti-aging nutritional supplement 审中-公开
标题翻译：抗衰老营养补品
公开(公告)号：US20040001817A1
公开(公告)日：2004-01-01
申请号：US10438247
申请日：2003-05-13
发明人： Vincent C. Giampapa
IPC分类号： A61K035/78 , A61K038/43 , A61K031/70 , A61K031/20 , A61K031/198 , A61K033/24
CPC分类号： A61K45/06 , A23L33/105 , A23L33/12 , A23L33/13 , A23L33/135 , A23L33/15 , A23L33/16 , A23L33/175 , A61K31/198 , A61K31/20 , A61K31/70 , A61K33/24 , A61K35/60 , A61K35/748 , A61K36/02 , A61K36/03 , A61K36/05 , A61K36/06 , A61K36/068 , A61K36/15 , A61K36/16 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/30 , A61K36/31 , A61K36/45 , A61K36/48 , A61K36/53 , A61K36/67 , A61K36/74 , A61K36/77 , A61K36/81 , A61K36/82 , A61K36/84 , A61K36/87 , A61K36/8998 , A61K36/9066 , A61K38/465 , A61K38/47 , A61K38/48 , A61K2300/00
摘要： An anti-aging nutritional supplement composition includes vitamins, minerals, an inflammatory process support, a blood sugar/insulin support, a botanical antioxidants, a methylating factor, a DNA repair agent, a fat metabolizer, an absorption enhancer, a brain function support, whole foods, a cellular energizer, a nucleotide precursor, amino acids, a fatty acid complex, and digestive enzymes. The composition supplies nutritional supplements necessary for proper glycation, DNA methylation, anti-oxidation, and control of inflammatory processes. The composition and the method of use provide an effective anti-aging treatment by decreasing DNA damage, increasing DNA repair, and improving immune function of human body.
摘要翻译：抗衰老营养补充剂组合物包括维生素，矿物质，炎症过程支持物，血糖/胰岛素支持物，植物抗氧化剂，甲基化因子，DNA修复剂，脂肪代谢剂，吸收促进剂，脑功能支持物，全食物，细胞激活剂，核苷酸前体，氨基酸，脂肪酸复合物和消化酶。该组合物提供适当的糖基化，DNA甲基化，抗氧化和炎症过程控制所需的营养补充剂。组合物和使用方法通过减少DNA损伤，增加DNA修复，提高人体免疫功能，提供有效的抗衰老治疗。

100. 发明申请

US20030198658A1 Carbon-substituted diketopiperazine delivery systems 失效
标题翻译：碳取代二酮哌嗪递送系统
公开(公告)号：US20030198658A1
公开(公告)日：2003-10-23
申请号：US10443713
申请日：2003-05-21
申请人： Emisphere Technologies, Inc.
发明人： Samuel J. Milstein
IPC分类号： A01N043/04 , A61K038/00 , A61K031/715 , A01N037/18 , A61K031/495 , A61K031/20
CPC分类号： A61K9/5031 , A61K9/1617 , A61K31/35 , A61K31/70 , A61K38/16 , A61K38/21 , A61K38/28 , C07C229/42 , C07C233/55 , C07C233/63 , C07C233/87 , C07C235/38 , C07C235/64 , C07C235/84 , C07C237/22 , C07C2601/02 , C07C2601/14 , C07C2601/18 , Y10S977/906 , Y10S977/926
摘要： Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-Substituted diketopiperazine. Methods for preparing these compositions and administering these compositions are also provided.
摘要翻译：提供了用于递送活性剂的组合物。这些递送组合物包括（a）活性剂; 和（b）至少一个单C取代或二-C取代的二酮哌嗪的载体。还提供了制备这些组合物并施用这些组合物的方法。

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